Abstract: A novel series of optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-5-yl)carboxamides is provided for use as inhibitors of allergic reactions. The compounds exhibit antiallergy activity by both oral and parenteral routes of administration.

Abstract: The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxyquinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.

Abstract: Substituted pyrrolo[1,2-c] quinazolines useful for their cardiovascular activities and as antiasthmatic agents.

Abstract: 2,3,8,9-Tetrahydro-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidines of the structure ##STR1## are provided wherein R is hydrogen, lower alkyl, halogen, acyl, cyano, carboxyl, trifluoromethyl or lower alkoxy, n is 0 or 2 and m is 2 or 3. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.

Abstract: 2,3,8,9-Tetrahydro-5H,6H-pyrano[4,3-d]thiazolo[3,2-a]pyrimidines of the structure ##STR1## are provided wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, halogen, cyano, carbethoxy, carboxyl, trifluoromethyl or lower alkoxy, and n is 2 or 3, and m is 0 to 2. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.

Abstract: A series of novel pyrimido[2,1-a]isoquinoline derivatives is provided for use as inhibitors of allergic reactions. The compounds exhibit antiallergy activity by both oral and parenteral routes of administration.

Abstract: The invention concerns novel fused ring indole derivatives of the formula ##STR1## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein n represents 1 or 2 and R.sup.1 represents hydrogen, hydroxyl, lower alkyl, lower alkoxy, trifluoromethyl, halogen, amino or mono- or di-(lower)alkylamino. The compounds are useful as anti-depressant agents.

Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.

Abstract: Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and R.sup.1 is hydrogen, alkyl of 1-3 carbons, phenyl optionally substituted by R.sup.4 or ##STR2## R.sup.2 is ##STR3## hydrogen, lower alkyl or phenyl optionally substituted by R.sup.4 with the proviso that at lest one of R.sup.1 and R.sup.2 is ##STR4## R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl optionally substituted by R.sup.4 ; and R.sup.4 and R.sup.5 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (C1, Br and F), nitro, and trifluoromethyl; R.sup.6 is hydrogen, lower alkyl, alkanoyl, aroyl, aralkanoyl, aralkyl or phenyl; and R.sup.7, R.sup.8, m and n are as defined hereinafter.These compounds are useful as anti-allergics.

Abstract: Compounds are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, alkyl of 1 to 3 carbons, 1-(hydroxyimino)alkyl, alkanoylamino, amino, or ##STR2## wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.2 is 1-(hydroxyimino)alkyl, alkanoylamino, amino, ##STR3## hydrogen, lower alkyl or phenyl (optionally substituted by R.sup.4) wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R.sup.4), dialkylaminoalkyl, hydroxyalkyl, ##STR4## (wherein R.sup.6 is hydrogen or alkyl, and R.sup.7 is alkyl); with the proviso that R.sup.1 or R.sup.2 is 1-(hydroxyimino)alkyl, alkanoylamino or amino, when R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl; and R.sup.4 and R.sup.5 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl. The above compounds are useful as anti-allergy agents and antiinflammatory agents.

Abstract: Compounds are provided having the structure ##STR1## wherein R.sup.1 is alkylamino, dialkylamino, or ##STR2## wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.2 is alkylamino, dialkylamino or ##STR3## wherein alkyl in the above groups contains 1 to 4 carbons; at least one of R.sup.1 and R.sup.2 being alkylamino or dialkylamino; R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R.sup.8), or ##STR4## (wherein R.sup.6 is amino, alkylamino or dialkylamino, and R.sup.7 is alkyl); and R.sup.4, R.sup.5 and R.sup.8 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl.

Abstract: Compounds of the formula ##STR1## where A is a heterocyclic group containing a pyridone moiety and R to R.sup.5 are each hydrogen or substituents conventionally encountered in dyes. The compounds are eminently suitable for coloring resins and for dyeing textile materials, particularly polyester textile materials.