Carbocyclic Ring Bonded Directly At 2-position Patents (Class 544/289)
  • Patent number: 4681886
    Abstract: This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula ##STR1## which possess useful hypotensive activity.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: July 21, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Peter W. Sprague
  • Patent number: 4677109
    Abstract: The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoquinol ine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms,R.sup.3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group,and acid addition and quaternary salts thereof.Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.
    Type: Grant
    Filed: April 10, 1985
    Date of Patent: June 30, 1987
    Assignee: Richter Gedeon Vegyeszeti Syar R.T.
    Inventors: Gabor Bernath, Jeno Kobor, Janos Lazar, Gabor Motika, Elemer Ezer, Gyorgy Hajos, Eva Palosi, Laszlo Denes, Laszlo Szporny
  • Patent number: 4644065
    Abstract: A new process for the preparation of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones from anthranilic acid derivatives is described herein. Additional reactants used in the process are 4-aminotetrazole and a trialkoxymethane or the reaction can be carried out using the imidic ester obtained from these two compounds.
    Type: Grant
    Filed: May 15, 1984
    Date of Patent: February 17, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Anna P. Vinogradoff
  • Patent number: 4578459
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: March 25, 1986
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Patent number: 4521420
    Abstract: An oxoquinazoline carbamate of the formula ##STR1## in which R represents hydrogen, alkyl, alkoxy, alkoxyalkyl, alkylthio, alkylthioalkyl, halogenoalkyl or optionally substituted aryl,R.sup.1 represents alkyl,R.sup.2 represents halogenoalkyl,R.sup.3 represents alkyl or halogen andn represents a number from 0 to 4,which possess fungicidal and microbicidal activity.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: June 4, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fritz Maurer, Wilhelm Brandes, Karl-Heinz Kuck, Paul Reinecke, Hans Scheinpflug
  • Patent number: 4480096
    Abstract: Chromogenic quinazolines of the formula ##STR1## wherein Y is an amino-substituted phenyl radical of the formula ##STR2## or a 3-carbazolyl radical of the formula ##STR3## and Z is hydrogen, R.sub.1, --OR.sub.1 ', --SR.sub.1 ' or --NR.sub.2 R.sub.3,These compounds are particularly suitable for use as color formers in pressure-sensitive or heat-sensitive recording materials and give lightfast yellow, orange and red colorations.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: October 30, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Ian J. Fletcher
  • Patent number: 4431440
    Abstract: The invention relates to a method to influence, alter or control the growth, development and/or life cycle of desirable and undesirable plants, comprising: applying to same a biologically effective amount of certain substituted quinazolinones.The invention also relates to certain novel quinazolinones, useful to influence, alter or control the growth, development and/or life cycle of desirable and undesirable plants.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Prithvi R. Bhalla, Bryant L. Walworth
  • Patent number: 4379788
    Abstract: Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring;R.sub.1 is hydrogen, halogen, amino, nitro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;R.sub.2 is hydrogen or alkoxy of 1 to 3 carbon atoms;D is alkylene of 3 to 4 carbon atoms or hydroxy(alkylene of 3 to 4 carbon atoms);R.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is hydrogen or alkoxy of 1 to 3 carbon atoms; andR.sub.6 is straight or branched alkyl of 1 to 6 carbon atoms or --E--R.sub.7 ;where E is straight alkylene of 2 to 4 carbon atoms or hydroxy-substituted straight alkylene of 2 to 4 carbon atoms, andR.sub.7 is ##STR2## where R.sub.8 and R.sub.
    Type: Grant
    Filed: December 4, 1981
    Date of Patent: April 12, 1983
    Assignee: Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Heider, Volkhard Austel, Wolfgang Eberlein, Rudolf Kadatz, Christian Lillie
  • Patent number: 4377408
    Abstract: Herbicidal derivatives of 5-phenoxy-4(3H)-quinazolinone-1-oxide of the formula: ##STR1## wherein X.sub.1 is trihalomethyl; X.sub.2 is halo; R.sub.1 is H or (C.sub.1 -C.sub.5) alkyl, which may be unsubstituted or substituted with hydroxy, alkoxy, cyano, halo or COO alkyl; and R.sub.2 is H.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: March 22, 1983
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: James J. Steffens
  • Patent number: 4251531
    Abstract: 3,4-Dihydro-quinazoline derivatives, such as 6-carboxy-2-(2'-ethoxy-phenyl)-3,4-dihydro-4-oxo-quinazoline, are disclosed. The compounds possess anti-allergy properties and can be used for the treatment of allergic conditions.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: February 17, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
  • Patent number: 4159330
    Abstract: 3,4-Dihydro-4-oxo-quinazoline derivatives substituted in the 2-position by a substituted phenyl group are disclosed. The derivatives possess anti-allergy properties and can be used for the treatment of allergic conditions.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: June 26, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
  • Patent number: 4116959
    Abstract: Isoindoline pigment of the formula ##STR1## wherein R denotes a heterocyclic aromatic radical, X.sub.1 -X.sub.4 denote hydrogen or halogen atoms or one or two of the radicals X.sub.1 -X.sub.4 denote nitro, alkyl, alkoxy or phenoxy groups and the others denote hydrogen atoms which are useful for pigmenting high molecular organic material.
    Type: Grant
    Filed: September 20, 1976
    Date of Patent: September 26, 1978
    Assignee: Ciba-Geigy Corporation
    Inventor: Jost von der Crone