Abstract: This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula ##STR1## which possess useful hypotensive activity.
Abstract: The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoquinol ine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms,R.sup.3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group,and acid addition and quaternary salts thereof.Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.
Abstract: A new process for the preparation of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones from anthranilic acid derivatives is described herein. Additional reactants used in the process are 4-aminotetrazole and a trialkoxymethane or the reaction can be carried out using the imidic ester obtained from these two compounds.
Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
Type:
Grant
Filed:
June 8, 1984
Date of Patent:
March 25, 1986
Assignee:
SmithKline & French Laboratories Limited
Inventors:
Graham J. Durant, John C. Emmett, Charon R. Ganellin
Abstract: An oxoquinazoline carbamate of the formula ##STR1## in which R represents hydrogen, alkyl, alkoxy, alkoxyalkyl, alkylthio, alkylthioalkyl, halogenoalkyl or optionally substituted aryl,R.sup.1 represents alkyl,R.sup.2 represents halogenoalkyl,R.sup.3 represents alkyl or halogen andn represents a number from 0 to 4,which possess fungicidal and microbicidal activity.
Type:
Grant
Filed:
August 1, 1983
Date of Patent:
June 4, 1985
Assignee:
Bayer Aktiengesellschaft
Inventors:
Fritz Maurer, Wilhelm Brandes, Karl-Heinz Kuck, Paul Reinecke, Hans Scheinpflug
Abstract: Chromogenic quinazolines of the formula ##STR1## wherein Y is an amino-substituted phenyl radical of the formula ##STR2## or a 3-carbazolyl radical of the formula ##STR3## and Z is hydrogen, R.sub.1, --OR.sub.1 ', --SR.sub.1 ' or --NR.sub.2 R.sub.3,These compounds are particularly suitable for use as color formers in pressure-sensitive or heat-sensitive recording materials and give lightfast yellow, orange and red colorations.
Abstract: The invention relates to a method to influence, alter or control the growth, development and/or life cycle of desirable and undesirable plants, comprising: applying to same a biologically effective amount of certain substituted quinazolinones.The invention also relates to certain novel quinazolinones, useful to influence, alter or control the growth, development and/or life cycle of desirable and undesirable plants.
Abstract: Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring;R.sub.1 is hydrogen, halogen, amino, nitro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;R.sub.2 is hydrogen or alkoxy of 1 to 3 carbon atoms;D is alkylene of 3 to 4 carbon atoms or hydroxy(alkylene of 3 to 4 carbon atoms);R.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is hydrogen or alkoxy of 1 to 3 carbon atoms; andR.sub.6 is straight or branched alkyl of 1 to 6 carbon atoms or --E--R.sub.7 ;where E is straight alkylene of 2 to 4 carbon atoms or hydroxy-substituted straight alkylene of 2 to 4 carbon atoms, andR.sub.7 is ##STR2## where R.sub.8 and R.sub.
Type:
Grant
Filed:
December 4, 1981
Date of Patent:
April 12, 1983
Assignee:
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Inventors:
Joachim Heider, Volkhard Austel, Wolfgang Eberlein, Rudolf Kadatz, Christian Lillie
Abstract: Herbicidal derivatives of 5-phenoxy-4(3H)-quinazolinone-1-oxide of the formula: ##STR1## wherein X.sub.1 is trihalomethyl; X.sub.2 is halo; R.sub.1 is H or (C.sub.1 -C.sub.5) alkyl, which may be unsubstituted or substituted with hydroxy, alkoxy, cyano, halo or COO alkyl; and R.sub.2 is H.
Abstract: 3,4-Dihydro-quinazoline derivatives, such as 6-carboxy-2-(2'-ethoxy-phenyl)-3,4-dihydro-4-oxo-quinazoline, are disclosed. The compounds possess anti-allergy properties and can be used for the treatment of allergic conditions.
Type:
Grant
Filed:
November 2, 1976
Date of Patent:
February 17, 1981
Assignee:
Farmitalia Carlo Erba S.p.A.
Inventors:
Gianfederico Doria, Ciriaco Romeo, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
Abstract: 3,4-Dihydro-4-oxo-quinazoline derivatives substituted in the 2-position by a substituted phenyl group are disclosed. The derivatives possess anti-allergy properties and can be used for the treatment of allergic conditions.
Type:
Grant
Filed:
December 2, 1977
Date of Patent:
June 26, 1979
Assignee:
Carlo Erba S.p.A.
Inventors:
Gianfederico Doria, Ciriaco Romeo, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
Abstract: Isoindoline pigment of the formula ##STR1## wherein R denotes a heterocyclic aromatic radical, X.sub.1 -X.sub.4 denote hydrogen or halogen atoms or one or two of the radicals X.sub.1 -X.sub.4 denote nitro, alkyl, alkoxy or phenoxy groups and the others denote hydrogen atoms which are useful for pigmenting high molecular organic material.