Polycyclo-carbocyclic Ring System Having At Least Three Cyclos Patents (Class 544/294)
  • Patent number: 4316043
    Abstract: The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
    Type: Grant
    Filed: December 19, 1980
    Date of Patent: February 16, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Gerald E. Stokker, Norman P. Gould
  • Patent number: 4308266
    Abstract: The present invention provides tetraline derivatives, useful for the treatment of hypertension, a process for their preparation and compositions containing these compounds.
    Type: Grant
    Filed: September 7, 1979
    Date of Patent: December 29, 1981
    Assignee: Sandoz Ltd.
    Inventor: Max-Peter Seiler
  • Patent number: 4258181
    Abstract: This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
    Type: Grant
    Filed: May 7, 1979
    Date of Patent: March 24, 1981
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Patent number: 4237284
    Abstract: The present invention relates to reactive dye-compounds of formula I, ##STR1## in which Y is hydrogen or sulpho,X is a straight chain or branched (C.sub.2-6) alkylene group or ##STR2## in which each of A.sub.1 and A.sub.2, independently, is a direct bond or a (C.sub.1-4) alkylene group, n is 1 or 2 and the ring D is optionally substituted by up to three (C.sub.1-4) alkyl groups,with the proviso that when n is 2, the group ##STR3## is the radical of an unsymmetrical diamine, R.sub.1 is hydrogen; (C.sub.1-4) alkyl; (C.sub.2-4) alkyl substituted in the .beta.,.gamma.-or .delta.-position by hydroxy and/or carboxy; or (C.sub.5-6) cycloalkyl or (C.sub.1-4) alkyl-substituted (C.sub.5-6) cycloalkylZ is the radical of a fibre reactive group which contains a single fibre reactive componentor mixtures thereof, which compounds are in free acid or water-soluble salt form and are useful as dyestuffs for dyeing or printing hydroxy group-containing or nitrogen containing organic textile substrates.
    Type: Grant
    Filed: September 14, 1978
    Date of Patent: December 2, 1980
    Assignee: Sandoz Ltd.
    Inventor: Roland Mislin
  • Patent number: 4138558
    Abstract: Anthraquinone compounds represented by the following formula are useful as dyes: ##STR1## wherein Y stands for a hydrogen atom or a nitro group, Z stands for an oxygen or sulfur atom when Y stands for a hydrogen atom, but Z stands for an oxygen atom when Y stands for a nitro group, R.sub.1 stands for a hydrogen atom or a lower alkyl group, R.sub.3 stands for a halogen atom or a group R.sub.2 wherein R.sub.2 stands for an amino, substituted or unsubstituted lower alkylamino, substituted or unsubstituted arylamino, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted arylthio group, or a group ##STR2## Q stands for a nitrogen atom or carbon atom bearing a halogen atom when R.sub.3 stands for a halogen atom, but Q stands for a nitrogen atom when R.sub.3 stands for a group R.sub.
    Type: Grant
    Filed: May 25, 1977
    Date of Patent: February 6, 1979
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Ryuzo Orita, Mitsuru Kurosawa
  • Patent number: 4137331
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## wherein N IS THE NUMBER 2 OR 3,n' is the number 1, 2, 3 or 4, andX-x' is ethylene or vinylene,Wherein in group D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, Franz Troxler
  • Patent number: 4105662
    Abstract: Reactive dyestuffs of the formula ##STR1## WHEREIN R.sub.1, R.sub.2, R.sub.3, X, Y and Z have the meaning given in the description and their use for the dyeing and printing of materials which contain hydroxyl groups and materials which contain N, such as cotton, wool and the like, by the customary processes.
    Type: Grant
    Filed: March 9, 1977
    Date of Patent: August 8, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus von Oertzen, Hans Samuel Bien, deceased, by Gabriele Bien, legal representative
  • Patent number: 4101547
    Abstract: 1,4-Diaminoanthraquinone derivatives containing a halopyrimidinyl or haloquinoxaline-6-carbonyl reactive group are useful as reactive dyestuffs for the dyeing or printing of leather and textile materials.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: July 18, 1978
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Wolfgang Schoenauer, Karl Ulrich Steiner