Abstract: The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
Type:
Grant
Filed:
December 19, 1980
Date of Patent:
February 16, 1982
Assignee:
Merck & Co., Inc.
Inventors:
Edward J. Cragoe, Jr., Gerald E. Stokker, Norman P. Gould
Abstract: The present invention provides tetraline derivatives, useful for the treatment of hypertension, a process for their preparation and compositions containing these compounds.
Abstract: This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
Abstract: The present invention relates to reactive dye-compounds of formula I, ##STR1## in which Y is hydrogen or sulpho,X is a straight chain or branched (C.sub.2-6) alkylene group or ##STR2## in which each of A.sub.1 and A.sub.2, independently, is a direct bond or a (C.sub.1-4) alkylene group, n is 1 or 2 and the ring D is optionally substituted by up to three (C.sub.1-4) alkyl groups,with the proviso that when n is 2, the group ##STR3## is the radical of an unsymmetrical diamine, R.sub.1 is hydrogen; (C.sub.1-4) alkyl; (C.sub.2-4) alkyl substituted in the .beta.,.gamma.-or .delta.-position by hydroxy and/or carboxy; or (C.sub.5-6) cycloalkyl or (C.sub.1-4) alkyl-substituted (C.sub.5-6) cycloalkylZ is the radical of a fibre reactive group which contains a single fibre reactive componentor mixtures thereof, which compounds are in free acid or water-soluble salt form and are useful as dyestuffs for dyeing or printing hydroxy group-containing or nitrogen containing organic textile substrates.
Abstract: Anthraquinone compounds represented by the following formula are useful as dyes: ##STR1## wherein Y stands for a hydrogen atom or a nitro group, Z stands for an oxygen or sulfur atom when Y stands for a hydrogen atom, but Z stands for an oxygen atom when Y stands for a nitro group, R.sub.1 stands for a hydrogen atom or a lower alkyl group, R.sub.3 stands for a halogen atom or a group R.sub.2 wherein R.sub.2 stands for an amino, substituted or unsubstituted lower alkylamino, substituted or unsubstituted arylamino, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted arylthio group, or a group ##STR2## Q stands for a nitrogen atom or carbon atom bearing a halogen atom when R.sub.3 stands for a halogen atom, but Q stands for a nitrogen atom when R.sub.3 stands for a group R.sub.
Abstract: This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## wherein N IS THE NUMBER 2 OR 3,n' is the number 1, 2, 3 or 4, andX-x' is ethylene or vinylene,Wherein in group D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.
Abstract: Reactive dyestuffs of the formula ##STR1## WHEREIN R.sub.1, R.sub.2, R.sub.3, X, Y and Z have the meaning given in the description and their use for the dyeing and printing of materials which contain hydroxyl groups and materials which contain N, such as cotton, wool and the like, by the customary processes.
Type:
Grant
Filed:
March 9, 1977
Date of Patent:
August 8, 1978
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus von Oertzen, Hans Samuel Bien, deceased, by Gabriele Bien, legal representative
Abstract: 1,4-Diaminoanthraquinone derivatives containing a halopyrimidinyl or haloquinoxaline-6-carbonyl reactive group are useful as reactive dyestuffs for the dyeing or printing of leather and textile materials.
Type:
Grant
Filed:
June 25, 1976
Date of Patent:
July 18, 1978
Assignee:
Sandoz Ltd.
Inventors:
Roland Mislin, Wolfgang Schoenauer, Karl Ulrich Steiner