Nitrogen Attached Directly Or Indirectly To The Diazine Ring By Nonionic Bonding Patents (Class 544/311)
-
Patent number: 6573268Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.Type: GrantFiled: March 24, 2000Date of Patent: June 3, 2003Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli, Ranga Madhavan Gurram, Rajagopalan Ramanujam, Ranjan Chakrabarti, Sarma K. S. Pakala
-
Publication number: 20030100755Abstract: A compound of the formula: 1Type: ApplicationFiled: October 25, 2002Publication date: May 29, 2003Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
-
Publication number: 20030096990Abstract: A process for producing 3-phenyl-2,4(1H,3H)-pyrimidinediones having the general formula I and their salts 1Type: ApplicationFiled: September 26, 2001Publication date: May 22, 2003Applicant: ISHIHARA SANGYO KAISHA, LTD.Inventors: Mark Read, Masamitsu Tsukamoto, Sandeep Gupta
-
Patent number: 6562759Abstract: The invention relates to novel substituted phenyluracils of the general formula (I) in which A represents alkanediyl or alkenediyl, each of which has 2 to 5 carbon atoms and each of which is optionally substituted by cyano, halogen or by in each case optionally halogen- or C1-C4-alkoxy-substituted C1-C4-alkyl, C1-C4-alk-oxy-carbonyl or C2-C4-alkenyl or interrupted by O (oxygen), or represents cyclohexane-1,2-diyl or 1,2-phenylene, Q1 represents O (oxygen) or S (sulphur), Q2 represents O (oxygen) or S (sulphur), R1 represents hydrogen, amino or optionally cyano-, halogen- or C1-C4-alkoxy-substituted alkyl having 1 to 4 carbon atoms, R2 represents optionally halogen-substituted alkyl having 1 to 4 carbon atoms, R3 represents hydrogen, halogen or optionally halogen-substituted alkyl having 1 to 4 carbon atoms, R4 represents hydrogen, cyano, carbamoyl, thiocarbamoyl or halogen, R5 represents cyano, carbamoyl, thiocarbamoyl or in each case optionally halogen-substituted alkyl or alkoxy haType: GrantFiled: January 10, 2002Date of Patent: May 13, 2003Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
-
Publication number: 20030087921Abstract: Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: 1Type: ApplicationFiled: September 12, 2002Publication date: May 8, 2003Applicant: 3-Dimensional Pharmaceuticals, Inc.Inventors: Tianbao Lu, Bruce E. Tomczuk, Thomas P. Markotan, Colleen Siedem
-
Patent number: 6548449Abstract: The invention relates to novel substituted phenyluraciles of the general formula (I) in which m, n, Q and R1-7 are each as defined in the description, and to processes for their preparation and to their use as herbicides.Type: GrantFiled: September 5, 2000Date of Patent: April 15, 2003Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Markus Dollinger, Mark Wilhelm Drewes, Ingo Wetcholowsky, Randy Allen Myers
-
Patent number: 6531600Abstract: A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): or if appropriate a pharmaceutically acceptable salt thereof, wherein R1 and R2 each independently represent alkyl or a moiety of formula (a): —(CH2)m−A (a) wherein m represents zero or an integer 1, 2 or 3; A represents a substituted or unsubstituted cyclic hydrocarbon radical; and R3 represents a halogen atom, a nitro group, or a group −NR4R5 wherein R4 and R5 each independently represents hydrogen, alkyl or alkylcarbonyl or R4 and R5 together with the nitrogen to which they are attached forming an optionally substituted, heterocyclic group; certain novel compounds falling within formula (I) and compositions comprising such compounds.Type: GrantFiled: November 8, 2000Date of Patent: March 11, 2003Assignee: Beecham Group p.l.c.Inventors: Barbara Ann Spicer, Harry Smith, Harald Maschler
-
Patent number: 6528513Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.Type: GrantFiled: December 15, 2000Date of Patent: March 4, 2003Assignee: Tularik INCInventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
-
Patent number: 6525050Abstract: Compounds of the formula: (where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.Type: GrantFiled: March 1, 2001Date of Patent: February 25, 2003Assignee: Agouron Pharmaceuticals, Inc.Inventors: William H. Romines, III, Michael D. Varney, Cynthia L. Palmer, Ted M. Bleckman
-
Patent number: 6518425Abstract: Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.Type: GrantFiled: May 15, 2000Date of Patent: February 11, 2003Assignees: Emory University, Triangle Pharmaceuticals, Inc.Inventors: George R. Painter, Dennis C. Liotta, Merrick R. Almond, Darryl G. Cleary, Josè D. Soria, Marcos Sznaidman
-
Patent number: 6515124Abstract: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.Type: GrantFiled: January 5, 2001Date of Patent: February 4, 2003Assignee: Hoffman-La Roche Inc.Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
-
Patent number: 6489332Abstract: A compound useful as an A1 adenosine receptor antagonist has the formula: wherein R1 is selected from the group consisting of C1-C8 alkyl; R2 is of the formula: wherein is an integer ranging from 1 to 8; R5 is H or (CH2)p, wherein p is an integer ranging from 1 to 8 and R6 is H or (CH2)mOH, wherein m is an integer ranging from 1 to 8; R3 is of the formula: —(CH2)qC6H4—R7 wherein q is an integer ranging from 1 to 8; and wherein R7 is selected from the group consisting of H, NH2, (CH2)tOH, wherein t is an integer ranging from 1 to 8; and R9COOH, wherein R9 is an alkyl or alkylidene group having 1 to 8 carbon atoms; and R4 is of the formula: wherein Rs is selected from the group consisting of H; NH2; (CH2)rOH, wherein s is an integer ranging from 1 to 8; and R10COOH wherein R10 is an alkyl or alkylidene group having 1 to 8 carbon atoms; and r is an integer ranging from 1 to 8.Type: GrantFiled: March 18, 1999Date of Patent: December 3, 2002Assignee: Endacea, Inc.Inventor: Constance F. Neely
-
Patent number: 6476224Abstract: The invention relates to a process for preparing ar(alk)yluracils of the general formula (I) in which A represents a single bond or represents alkanedlyl, Ar represents optionally substituted aryl, R1 represents optionally substituted alkyl and R2 represents hydrogen, halogen or alkyl, and to novel intermediates for this purpose and to processes for their preparation.Type: GrantFiled: February 14, 2001Date of Patent: November 5, 2002Assignee: Bayer AktiengesellschaftInventors: Bernd Gallenkamp, Reinhard Lantzsch, Lothar Rohe, Lubbertus Mulder
-
Patent number: 6472414Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X, are as defined herein.Type: GrantFiled: May 18, 1999Date of Patent: October 29, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
-
Patent number: 6465650Abstract: The invention provides a processes for the preparation of a compound of Formula I, or a salt thereof wherein PG is a urethane- or trityl-type protective group; X is NH, O, or S; Y is CH2, O, or NH; and B′ is a base customary in nucleotide chemistry. The processes include reacting a compound of Formula (II) with a compound of Formula (III) a compound of Formula (V) B′—CH2—CO—R2 (V), a monohaloacetic acid derivative in a suitable solvent with an auxiliary base, or a compound of Formula (VII) B′—CH2—CO—R3 (VII), and converting the resulting compounds to that of Formula I.Type: GrantFiled: February 18, 2000Date of Patent: October 15, 2002Assignee: Aventis Pharma Deutschland GmbHInventors: Gerhard Breipohl, Eugen Uhlmann, Jochen Knolle
-
Patent number: 6458952Abstract: The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: GrantFiled: May 18, 2000Date of Patent: October 1, 2002Assignee: Pharmacia CorporationInventors: Michael South, Darin E. Jones, Melvin L. Rueppel
-
Patent number: 6448203Abstract: The invention relates to novel substituted aryluracils of the formula (I): to processes for their preparation and to their use as crop protection agents.Type: GrantFiled: October 7, 1999Date of Patent: September 10, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Markus Dollinger, Christoph Erdelen
-
Patent number: 6444616Abstract: The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) in which R1, R2, R3, R4 and R5 are each as defined in the description, to a process for their preparation and to their use as herbicides.Type: GrantFiled: August 1, 2000Date of Patent: September 3, 2002Assignee: Bayer AktiengesellschaftInventors: Mark-Wilhelm Drewes, Roland Andree, Markus Dollinger
-
Patent number: 6440984Abstract: There are provided compositions and methods comprising compounds of formula I: wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.Type: GrantFiled: November 29, 2000Date of Patent: August 27, 2002Assignee: BASF AktiengesellschaftInventors: William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
-
Patent number: 6437126Abstract: The invention is directed to a process for the preparation of a substituted phenyluracil of the formula: The process broadly comprises reacting a carbonylphenyluracil of the formula: with an amino compound, an alcohol or a mercaptan. The resultant products are useful as herbicides.Type: GrantFiled: April 24, 2001Date of Patent: August 20, 2002Assignee: Bayer AktiengesellschaftInventors: Mark Wilhelm Drewes, Roland Andree, Markus Dollinger
-
Patent number: 6432962Abstract: Heteroaryl aminobenzophenones of general formula I inhibit interleukin-1&bgr; and TNF-&agr; and may therefore be useful in the therapy of inflammatory diseases and conditions.Type: GrantFiled: May 21, 2001Date of Patent: August 13, 2002Assignee: Leo Pharmaceutical Products Ltd. A/SInventor: Anne Marie Horneman
-
Patent number: 6432879Abstract: The invention relates to novel substituted phenyluracils of the general formula (I) in which the radicals n, Q, R1 to R6 are each as defined in the description, and to processes for this preparation and to their use as herbicides.Type: GrantFiled: May 23, 2000Date of Patent: August 13, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
-
Patent number: 6432963Abstract: Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning; X: O, S, NR1, CO, NR1CO, CONR1, C═N—OR1 or a bond, Y: a lower alkylene group which may be substituted by OR1 or —NHR1, or a bond, Z: O, NR2 or a bond, A: H, or a lower alkyl which may have a substituent, a —CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent, B: an aryl which may have a substituent or a heteroaryl group which may have a substituent, R1, R2: H, a lower alkyl or a —CO-lower alkyl group].Type: GrantFiled: June 15, 2000Date of Patent: August 13, 2002Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroyuki Hisamichi, Ryo Naito, Souichirou Kawazoe, Akira Toyoshima, Kazuhito Tanabe, Eiichi Nakai, Atsushi Ichikawa, Akiko Orita, Makoto Takeuchi
-
Patent number: 6417141Abstract: The invention relates to novel aminouracils of the general formula (I) in which, Q, R1, R2, R3, R4, R5, R6 and R7 are each as defined in the description, to their use as herbicides and to novel intermediates.Type: GrantFiled: January 21, 1998Date of Patent: July 9, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Otto Schallner, Markus Dollinger, Hans-Joachim Santel
-
Patent number: 6417192Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.Type: GrantFiled: June 28, 2000Date of Patent: July 9, 2002Assignee: SmithKline Beecham p.l.c.Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
-
Publication number: 20020061887Abstract: The present invention relates to compounds of the formula I 1Type: ApplicationFiled: November 28, 2001Publication date: May 23, 2002Applicant: Aventis Pharma Deutschland GmbHInventors: Ursula Schindler, Karl Schonafinger, Hartmut Strobel
-
Patent number: 6387849Abstract: Novel hydroximic acid derivatives I and salts thereof, where X=O, S; Y=O, S; R1=H, C1-C4-alkyl, NH2, C1-C4-alkylamino or di(C1-C4-alkyl)amino; R2=C1-C3-haloalkyl; R3=H, halogen, C1-C4-alkyl; R4=H, halogen; R5=CN, halogen; R6=C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where the phenyl ring of this group may be unsubstituted or may carry 1-3 substituents; R7=a C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where these 4 groups may be unsubstituted or may carry 1 to 2 substituents; Use: As herbicides; for the desiccation/defoliation of plants.Type: GrantFiled: September 21, 1999Date of Patent: May 14, 2002Assignee: BASF AktiengesellschaftInventors: Olaf Menke, Gerhard Hamprecht, Markus Menges, Robert Reinhard, Peter Schäfer, Cyrill Zagar, Karl-Otto Westphalen, Ulf Misslitz, Helmut Walter
-
Publication number: 20020052497Abstract: Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.Type: ApplicationFiled: October 9, 2001Publication date: May 2, 2002Applicant: Targacept, Inc.Inventors: William Scott Caldwell, Gary Maurice Dull, Balwinder Singh Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared Miller Wagner, Peter Anthony Crooks
-
Patent number: 6380387Abstract: Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.Type: GrantFiled: November 21, 2000Date of Patent: April 30, 2002Assignee: Hoffmann-La Roche Inc.Inventors: Achyutharao Sidduri, Jefferson Wright Tilley
-
Patent number: 6372691Abstract: The present invention relates to a method for controlling weeds in corn field which comprises applying a herbicidal composition comprising 2-[2-chloro-4-fluoro-5-{3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl}phenoxy]propionic acid ester as an active ingredient to corn fields after seeding corn. According to the present method, kinds of weeds in corn fields can be controlled widely and no problematic phytotoxicity to corn is caused.Type: GrantFiled: December 14, 2000Date of Patent: April 16, 2002Assignee: Sumitomo Chemical Company, LimitedInventor: Nobuaki Mito
-
Patent number: 6372750Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing themType: GrantFiled: April 5, 2001Date of Patent: April 16, 2002Assignees: Dr. Reddy's Research Foundation, Reddy-Cheminor, Inc.Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli, Ranga Madhavan Gurram, Rajagopalan Ramanujam, Ranjan Chakrabarti, Sarma K. S. Pakala
-
Patent number: 6362337Abstract: The invention relates to substituted phenyluracils of the general formula (I) in which the radicals R1 to R5, Q and n are each as defined in the description, and to processes for their preparation and to their use as herbicides.Type: GrantFiled: June 22, 2001Date of Patent: March 26, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Otto Schallner, Katharina Voigt, Markus Dollinger, Hans-Joachim Santel
-
Patent number: 6355796Abstract: An improved process and intermediate compounds for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula I and an improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula VType: GrantFiled: February 3, 2000Date of Patent: March 12, 2002Assignee: BASF AktiengesellschaftInventor: Venkataraman Kameswaran
-
Patent number: 6355799Abstract: Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions containing these as active ingredients which are useful as herbicides for general or selective pre-emergent or post-emergent control of undesired plant species and defoliants at very low concentrations of these biologically active compounds.Type: GrantFiled: April 27, 2000Date of Patent: March 12, 2002Assignee: ISK Americas IncorporatedInventors: Sandeep Gupta, Shao-Yong Wu, Masamitsu Tsukamoto, David A. Pulman, Bai-Ping Ying
-
Patent number: 6344460Abstract: The present invention provides compounds comprising propynyl uracils having the formula wherein R1 is hydrogen, chlorine, bromine, iodine, fluorine, —CN, substituted or unsubstituted linear or branched C1-C4 alkyl, —NO2, methoxy, ethoxy, n-propoxy, or iso-propoxy; R2 is iodine or bromine; and R3 is propynyl, 3-iodopropynyl, 3-bromopropynyl, substituted or unsubstituted 2-furanyl, substituted or unsubstituted 3-furanyl, substituted or unsubstituted 2-pyrrolidinyl, substituted or unsubstituted 3-pyrrolidinyl, D-ribose, or deoxyribose. Another embodiment of the invention encompasses propynyl uracils having the formula wherein R4 is hydrogen, chlorine, bromine, iodine, fluorine, —CN, substituted or unsubstituted linear or branched C1-C4 alkyl, —NO2, methoxy, ethoxy, n-propoxy, or iso-propoxy; R5 is hydrogen or propynyl; and R6 is iodine or bromine. Also, methods of preparing these propynyl uracils are provided.Type: GrantFiled: March 13, 2000Date of Patent: February 5, 2002Assignee: Lonza Inc.Inventor: Peter C. Nirchio
-
Publication number: 20020013466Abstract: The present invention relates to an uracil compound of the formula [I]: 1Type: ApplicationFiled: December 5, 2000Publication date: January 31, 2002Inventors: Yoshitomo Tohyama, Yuzuru Sanemitsu, Tomohiko Gotou
-
Patent number: 6342504Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.Type: GrantFiled: December 21, 1999Date of Patent: January 29, 2002Assignee: Corvas International, Inc.Inventors: Terence Kevin Brunck, Susan Y. Tamura, Joseph Edward Semple, Robert John Ardecky, Yu Ge, William Charles Ripka
-
Patent number: 6339155Abstract: The uracil compounds represented by the formula [V]: wherein R1 represents C1-C5 perfluoroalkyl group and Q represents an aromatic group, can be produced by making the amide compounds represented by the formula [II]: wherein R1 and Q have the same meanings defined above, or its hydrate react with a cyanate salt in the presence of a protonic acid.Type: GrantFiled: November 13, 2000Date of Patent: January 15, 2002Assignee: Sumitomo Chemical Company, LimitedInventors: Minoru Takano, Hirofumi Mishima
-
Patent number: 6339044Abstract: N-Cyanoaryl nitrogen heterocycles having sulfur-containing groups of the formula (1), in which Q1 represents oxygen or sulfur, R1 represents hydrogen or halogen, R2 represents halogen, cyano, nitro, amino or the grouping —N(A1)SO2A, in which A represents, in each case, optionally substituted alkyl, alkenyl, alkinyl, dialkylamino, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, and A1 represents hydrogen, formyl or, in each case optionally substituted, alkyl, alkenyl, alkinyl, alkylcarbonyl, alkoxycarbonyl or alkylsulphonyl, or together with A represents alkanediyl, R3 represents hydrogen, halogen, cyano or optionally substituted alkyl, R4 represents optionally substituted alkyl or together with R3 represents alkanediyl, and Z represents one of the groups in which Q2 represents oxygen or sulfur and R5 represents hydrogen or, in each case optionally substituted, alkyl, alkenyl, alkinyl or alkylcarbonyl, and salts of compounds of the formula (1) with the proType: GrantFiled: March 27, 1998Date of Patent: January 15, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Hans-Joachim Santel, Markus Dollinger, Christoph Erdelen
-
Publication number: 20010049371Abstract: Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF&agr; and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.Type: ApplicationFiled: February 9, 2001Publication date: December 6, 2001Inventors: George Muller, Hon-Wah Man
-
Patent number: 6316449Abstract: The instant invention is a series of compounds which are MCP-1 receptor antagonists of Formula I Also included in the invention are intermediates and processes for the preparation of the compounds as well as methods of using the compounds as agents for the treatment of atherosclerosis, chronic and acute inflammatory disease, chronic and acute immune disorders and transplant rejection as well as for preventing infection by HIV, treating infection by HIV, delaying the onset of AIDS, or treating AIDS.Type: GrantFiled: April 25, 2000Date of Patent: November 13, 2001Assignee: Millennium Pharmaceuticals, Inc.Inventors: Larry Don Bratton, Steven Robert Miller, Bruce David Roth, Bharat Kalidas Trivedi, Paul Charles Unangst
-
Patent number: 6316459Abstract: O-Benzyloxime ethers of the formula I where X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cyano R3, R4 are hydrogen, cyano, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkynyl, alkoxy, haloalkoxy, alkylthio, benzylthio, alkylcarbonyl, substituted or unsubstituted phenylcarbonyl, substituted or unsubstituted benzylcarbonyl, alkoxycarbonyl, substituted or unsubstituted phenoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl, N(R6)2, where R6 is H, alkyl, substituted or unsubstituted phenyl, —CO—N(R7)2, where R7 is H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted arylthio, substituted or unsubstituted hetaryl, substituted or unsubstituted hetaryloxy, substituted or unsubstituted hetarylthio, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyType: GrantFiled: October 25, 1994Date of Patent: November 13, 2001Inventors: Siegbert Brand, Uwe Kardorff, Reinhard Kirstgen, Bernd Mueller, Klaus Oberdorf, Hubert Sauter, Gisela Lorenz, Eberhard Ammermann, Christoph Kuenast, Albrecht Harreus
-
Patent number: 6306866Abstract: There are provided compositions and methods comprising compounds of formula I: wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.Type: GrantFiled: March 6, 1998Date of Patent: October 23, 2001Assignee: American Cyanamid CompanyInventors: William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
-
Patent number: 6303783Abstract: There are provided 1-(3-heterocyclyphenyl)isothio-urea, -isourea, -guanidine and -amidine compounds of formula I Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.Type: GrantFiled: August 4, 1999Date of Patent: October 16, 2001Assignee: American Cyanamid Co.Inventor: Gary Mitchell Karp
-
Patent number: 6300280Abstract: The invention relates to novel substituted aminophenyluracils of the general formula (I) to a process for their preparation and to their use as herbicides and insecticides.Type: GrantFiled: January 14, 1998Date of Patent: October 9, 2001Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Markus Dollinger, Hans-Joachim Santel, Christoph Erdelen
-
Patent number: 6294535Abstract: The invention relates to novel uracil derivatives having excellent inhibiting effects on human derived thymidine phosphorylates and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators and antitumor agents containing such novel compounds, and a process for their preparation and use are described.Type: GrantFiled: December 9, 1999Date of Patent: September 25, 2001Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Shingo Yano, Yukio Tada, Hideki Kazuno, Tsutomu Sato, Junichi Yamashita, Norihiko Suzuki, Tomohiro Emura, Masakazu Fukushima, Tetsuji Asao
-
Patent number: 6294542Abstract: The present invention relates to a novel pyrimidinone compounds and the pharmaceutical acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, thereby, being useful in treating cardiovascular disease caused by binding angiotensin II to its receptor.Type: GrantFiled: December 20, 1999Date of Patent: September 25, 2001Assignee: Boryung Pharmaceutical Co. Ltd.Inventors: Jae-hyoung Lee, Kyung-jin Jang, Byoung-wug Yoo, Ji-han Kim, Jae-seog Kang, Sang-lin Kim
-
Patent number: 6281219Abstract: The present invention provides compounds of Formula I methods for their preparation and their use as acaricidal and insecticidal agents.Type: GrantFiled: July 12, 1999Date of Patent: August 28, 2001Assignee: American Cyanamid Co.Inventors: Salvatore John Cuccia, William Wakefield Wood, Brian Lee Buckwalter, John Francis Chiarello, Linda Barbara Fleming
-
Patent number: 6277789Abstract: The invention relates to substituted phenyluracils of the general formula (I) in which the radicals R1 to R5, Q and n are each as defined in the description, and to processes for their preparation and to their use as herbicides.Type: GrantFiled: March 1, 2000Date of Patent: August 21, 2001Inventors: Roland Andree, Otto Schallner, Katharina Voigt, Markus Dollinger, Hans-Joachim Santel
-
Patent number: RE37979Abstract: The disclosure concerns pyrimidine derivatives represented by the following general formulas [I] and [I′] and having antiviral activity, particularly antiretroviral activity such as anti-HIV activity: and pharmaceutical compositions having antiviral activity and comprising the above-described derivative(s) as an active ingredient.Type: GrantFiled: October 23, 1997Date of Patent: February 4, 2003Assignee: Mitsubishi Chemical CorporationInventors: Tadashi Miyasaka, Hiromichi Tanaka, Erik Desiré DeClercq, Masanori Baba, Richard Thomas Walker, Masaru Ubasawa