Halogen Attached Directly To The Diazine Ring By Nonionic Bonding Patents (Class 544/334)
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Patent number: 11495753Abstract: A novel organic compound is provided. That is, a novel organic compound that is effective in improving reliability of a light-emitting element is provided. The organic compound includes a condensed ring including a pyrimidine ring and is represented by General Formula (G1). In General Formula (G1), A represents a group having 6 to 100 carbon atoms and includes at least one of an aromatic ring and a heteroaromatic ring. The aromatic ring and the heteroaromatic ring may each include a substituent. Furthermore, Q represents oxygen or sulfur. A ring X represents a substituted or unsubstituted naphthalene ring or a substituted or unsubstituted phenanthrene ring.Type: GrantFiled: March 7, 2018Date of Patent: November 8, 2022Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Miki Kurihara, Hideko Yoshizumi, Satomi Watabe, Hiromitsu Kido, Satoshi Seo
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Patent number: 11351168Abstract: The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.Type: GrantFiled: March 20, 2020Date of Patent: June 7, 2022Assignee: Celgene CAR LLCInventors: Juswinder Singh, Russell C. Petter, Richland Wayne Tester, Arthur F. Kluge, Hormoz Mazdiyasni, William Frederick Westlin, III, Deqiang Niu, Lixin Qiao
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Publication number: 20150126516Abstract: A piperidine compound represented by the following Formula (1): wherein ring A, ring B, and ring C are the same or different and each represent a benzene ring or a nitrogen-containing heteroaromatic ring; W represents a C1-C4 alkylene or alkenylene group; X, Y, and Z are the same or different and each represent a halogen atom, a C1-C6 alkyl group, a halo C1-C6 alkyl group, a C1-C6 alkoxy group, or a halo C1-C6 alkoxy group; m, n, and p are the same or different and each represent an integer of 0 to 5; when m is greater than or equal to 2, the Xs are the same or different; when n is greater than or equal to 2, the Ys are the same or different; and when p is greater than or equal to 2, the Zs are the same or different has an excellent controlling efficacy against pests.Type: ApplicationFiled: April 12, 2013Publication date: May 7, 2015Inventor: Sadayuki Arimori
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Publication number: 20150018349Abstract: In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: March 27, 2014Publication date: January 15, 2015Applicant: University of Utah Research FoundationInventors: David J. Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Sunil Sharma
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Patent number: 8933225Abstract: Disclosed are processes and synthetic intermediates for the synthesis of compounds of formula (V) wherein the variables have the definitions contained herein. Such compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.Type: GrantFiled: August 1, 2008Date of Patent: January 13, 2015Assignee: Millennium Pharmaceuticals, Inc.Inventors: Ian Armitage, Eric L. Elliott, Marianne Langston, Steven P. Langston, Quentin J. McCubbin, Hirotake Mizutani, Matthew Stirling, Lei Zhu
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Publication number: 20140350032Abstract: The present invention relates to a compound characterized by the following Formula I: or a pharmaceutically acceptable salt thereof, wherein X, Y, and Z are as described herein. Compounds of the present invention are useful for the treatment of HIV.Type: ApplicationFiled: December 14, 2012Publication date: November 27, 2014Inventors: Nianhe Han, Brian Alvin Johns, Jun Tang
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Publication number: 20140275539Abstract: Provided herein are stabilized radioiodinated and astatinated compounds, and to methods for their preparation.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Ground Fluor Pharmaceuticals, Inc.Inventor: Stephen G. DiMagno
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Publication number: 20140135497Abstract: This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.Type: ApplicationFiled: November 5, 2013Publication date: May 15, 2014Applicant: Boehringer Ingelheim International GmbHInventors: Li Liu, Deniz Akalay, Weitong Dong, Jianqing Feng, Christian Wolfgang Hemp, Jun Lu, Le Xie, Jinsong Yang
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Patent number: 8703767Abstract: In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: April 1, 2012Date of Patent: April 22, 2014Assignee: University of Utah Research FoundationInventors: David J. Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Sunil Sharma
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Patent number: 8697256Abstract: A composition comprising a phosphorescent compound, and a compound having a structure containing three or more repeating units having a dipole moment dimension of 1.0 Debye or more connected in series, wherein, based on the total number of dimer structures composed of any two repeating units connected in series contained in the above-described structure, the proportion of the number of dimer structures in which the dimension D2 of the dipole moment of the dimer structure, the dimension D1a of the dipole moment of the first repeating unit constituting the dimer structure and the dimension D1b of the dipole moment of the second repeating unit constituting the dimer structure satisfy a relation represented by the following formula (A): D1a<D2 and D1b<D2??(A) is 50% or more.Type: GrantFiled: July 28, 2009Date of Patent: April 15, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Nobuhiko Akino, Kenta Tanaka, Hideyuki Higashimura
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Patent number: 8686156Abstract: The present application relates to novel heterocyclic compounds, to their use for controlling animal pests including arthropods and in particular insects, and to processes for preparing the novel compounds.Type: GrantFiled: May 3, 2011Date of Patent: April 1, 2014Assignee: Bayer CropScience AGInventors: Martin Füβlein, Thomas Bretschneider, Reiner Fischer, Peter Jeschke, Adeline Köhler, Joachim Kluth, Friedrich August Mühlthau, Arnd Voerste, Yoshitaka Sato
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Patent number: 8680270Abstract: The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.Type: GrantFiled: November 21, 2007Date of Patent: March 25, 2014Assignee: Viamet Pharmaceuticals, Inc.Inventors: Robert J. Schotzinger, William J. Hoekstra
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Patent number: 8623877Abstract: The present disclosure relates to a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I). wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.Type: GrantFiled: November 6, 2012Date of Patent: January 7, 2014Assignee: SanofiInventors: Zhongli Gao, Ryan Hartung
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Patent number: 8606529Abstract: The application relates to methods and systems for analysis of dissociation behavior of nucleic acids and identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. Methods and systems are also disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.Type: GrantFiled: March 26, 2012Date of Patent: December 10, 2013Assignee: Canon U.S. Life Sciences, Inc.Inventors: Deborah Boles, Kenton C. Hasson, Sami Kanderian
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Publication number: 20130245018Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).Type: ApplicationFiled: May 3, 2013Publication date: September 19, 2013Applicant: PIMCO 2664 LIMITEDInventors: Iain Robert Greig, Rose Mary Sheridan, Raymond Fisher, Matthew John Tozer, Juha Andrew Clase, Andrew Smith, Andrew Robert Tuffnell, Robert Jurgen Van 't Hof
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Patent number: 8536186Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.Type: GrantFiled: August 4, 2009Date of Patent: September 17, 2013Assignee: CHDI Foundation, Inc.Inventors: John Wityak, Leticia M. Toledo-Sherman, Celia Dominguez, Stephen Martin Courtney, Christopher John Yarnold, Paula C. De Aguiar Pena, Andreas Scheel, Dirk Winkler
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Patent number: 8461170Abstract: The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the treatment of cancer.Type: GrantFiled: August 2, 2011Date of Patent: June 11, 2013Assignee: Astrazeneca ABInventors: Brian Aquila, Victor Kamhi, Bo Peng, Timothy Pontz, Jamal Carlos Saeh, Kumar Thakur, Bin Yang
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Patent number: 8435968Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).Type: GrantFiled: September 18, 2009Date of Patent: May 7, 2013Assignee: PIMCO 2664 LimitedInventors: Iain Robert Greig, Rose Mary Sheridan, Raymond Fisher, Matthew John Tozer, Juha Andrew Clase, Andrew Smith, Andrew Robert Tuffnell, Robert Jurgen Van 't Hof
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Patent number: 8431697Abstract: The present invention provides triallyl isocyanurate comprising a less amount of corrosive substances by identifying the corrosive substances among impurities included in the triallyl isocyanurate. Triallyl isocyanurate of the present invention comprises an organic chlorine compound represented by the following general formula (I) in an amount of not more than 100 ppm: wherein R1 and R2 are respectively a chlorine atom or an allyoxy group with the proviso that at least one of R1 and R2 is a chlorine atom.Type: GrantFiled: November 2, 2011Date of Patent: April 30, 2013Assignee: Nippon Kasei Chemical Company LimitedInventor: Mabuko Yamaura
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Patent number: 8426592Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.Type: GrantFiled: August 3, 2012Date of Patent: April 23, 2013Assignee: President and Fellows of Harvard CollegeInventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
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Publication number: 20130079359Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.Type: ApplicationFiled: August 23, 2012Publication date: March 28, 2013Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Pascale A.J. POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio Perez FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
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Publication number: 20130079361Abstract: Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.Type: ApplicationFiled: September 24, 2010Publication date: March 28, 2013Inventors: Robert A. Mitchell, John O. Trent, Pooran Chand, Gilles Hugues Tapolsky
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Publication number: 20130065912Abstract: Pesticide compositions and their use in controlling pests are provided.Type: ApplicationFiled: October 30, 2012Publication date: March 14, 2013Applicant: DOW AGROSCIENCES LLCInventor: Dow AgroSciences LLC
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Publication number: 20130060032Abstract: A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.Type: ApplicationFiled: October 10, 2012Publication date: March 7, 2013Inventors: Koji HAGIYA, Kazuaki SASAKI
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Publication number: 20130059847Abstract: In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: April 1, 2012Publication date: March 7, 2013Inventors: David J. Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Sunil Sharma
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Patent number: 8372974Abstract: The present invention relates to a method of making pyrimidines of formula (III), wherein X1, X2, R1 and R2 have the meanings as defined herein.Type: GrantFiled: March 19, 2009Date of Patent: February 12, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Guenter Linz, Adil Duran, Gerd Kraemer
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Publication number: 20120289403Abstract: The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.Type: ApplicationFiled: November 11, 2010Publication date: November 15, 2012Inventors: Sebastian Soergel, Ralph Paulini, Steffen Gross, Carsten Beyer, Matthias Pohlman, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Douglas D. Anspaugh, Sarah Thompson, Vincent Salgado
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Publication number: 20120277432Abstract: A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I); (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide or an organic sulfonyl anhydride; and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulfonamide.Type: ApplicationFiled: June 14, 2012Publication date: November 1, 2012Applicant: ASTRAZENECA UK LTD.Inventors: Akio Matsushita, Mizuho Oda, Yasuhiro Kawachi, Jun-ichi Chika
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Publication number: 20120245124Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein X1, X2, R1, R2, Rx, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.Type: ApplicationFiled: March 23, 2012Publication date: September 27, 2012Applicant: ABBOTT LABORATORIESInventors: Bruce Clapham, Phil B. Cox, Michael J. Dart, Arthur Gomtsyan, Tammie K. Jinkerson, Ryan G. Keddy, Michael E. Kort, Philip R. Kym, Mark Matulenko, Robert G. Schmidt, Clara I. Villamil, Eric A. Voight, Kevin R. Woller
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Patent number: 8273897Abstract: Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are reduced to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description:Type: GrantFiled: September 5, 2008Date of Patent: September 25, 2012Assignee: Bayer Cropscience AGInventors: Norbert Lui, Stefan Antons
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Publication number: 20120232271Abstract: A new method for the preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid compounds of Formula 1 is disclosed wherein R1 is H or an optionally substituted carbon moiety. Also disclosed is the method comprising additional steps to prepare optionally substituted 4-pyrimidinecarboxylic acids and esters using the compound of Formula 1 as an intermediate.Type: ApplicationFiled: May 22, 2012Publication date: September 13, 2012Applicant: E I DU PONT DE NEMOURS AND COMPANYInventor: RAFAEL SHAPIRO
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Publication number: 20120208820Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.Type: ApplicationFiled: January 31, 2012Publication date: August 16, 2012Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
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Patent number: 8222257Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.Type: GrantFiled: March 30, 2006Date of Patent: July 17, 2012Assignee: The Regents of the University of CaliforniaInventors: Karl Y. Hostetler, James R. Beadle, Hyunah Choo
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Patent number: 8198442Abstract: A new method for the preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid compound of Formula 1 is disclosed wherein R1 is H or an optionally substituted carbon moiety.Type: GrantFiled: April 28, 2006Date of Patent: June 12, 2012Assignee: E.I. du Pont de Nemours and CompanyInventor: Rafael Shapiro
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Patent number: 8188301Abstract: The present invention relates to the use of compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-disubstituted phenyl-1-pyrrolidinols for the treatment of central nervous system disorders.Type: GrantFiled: June 4, 2008Date of Patent: May 29, 2012Assignee: NSAB, Filial af NeuroSearch Sweden AB, SverigeInventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson, Nicholas Waters, Susanna Waters
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Publication number: 20120122857Abstract: The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicant: NOVARTIS AGInventors: Guido BOLD, Andrea VAUPEL, Carole Pissot SOLDERMANN, Paul W. MANLEY
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Patent number: 8180572Abstract: The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for resolving a denaturation curve of a sample containing a first and second nucleic acid into a resolved denaturation curve for the first nucleic acid and a resolved denuration curve for the second nucleic acid.Type: GrantFiled: October 24, 2008Date of Patent: May 15, 2012Assignee: Canon U.S. Life Sciences, Inc.Inventor: Weidong Cao
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Patent number: 8145433Abstract: The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. In another aspect, methods and systems are disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.Type: GrantFiled: October 24, 2008Date of Patent: March 27, 2012Assignee: Canon U.S. Life Sciences, Inc.Inventors: Deborah Boles, Kenton C. Hasson, Sami Kanderian
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Patent number: 8133886Abstract: The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumor diseases.Type: GrantFiled: March 13, 2007Date of Patent: March 13, 2012Assignee: Novartis AGInventors: Guido Bold, Andrea Vaupel, Carole Pissot Soldermann, Paul W Manley
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Publication number: 20120053053Abstract: The present invention relates to substituted pyrimidine derivatives, as well as N-oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener. The invention further relates to intermediates useful in the preparation of such compounds, and to processes for their preparation.Type: ApplicationFiled: February 11, 2010Publication date: March 1, 2012Applicant: SYNGENTA CROP PROTECTION, LLCInventors: Mohamed Abdelouahab Boussemghoune, William Guy Whittingham, Caroline Louise Winn, Harry Glithro, Mary Bernadette Aspinall
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Publication number: 20120053170Abstract: The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of the intermediate products.Type: ApplicationFiled: March 22, 2010Publication date: March 1, 2012Applicant: SANOFIInventors: Jérome Arigon, Claude Bernhart, Monsif Bouaboula, Romain Combet, Sandrine Hilairet, Samir Jegham
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Publication number: 20110288296Abstract: The application relates to a reagent of the general formula R1R2N—ZnY LiY??(I) wherein R1, R2 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; Halon, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx; wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, orType: ApplicationFiled: February 11, 2010Publication date: November 24, 2011Inventors: Paul Knochel, Marc Mosrin
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Patent number: 8013155Abstract: Disclosed a method for preparing a compound of Formula 1, wherein R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; comprising contacting a compound of Formula 2 with a persulfate oxidant in the presence of a strong sulfur- or phosphorus-containing mineral acid and an oxidation resistant solvent. Also disclosed are methods for preparing the compound of Formula 2 from a compound of Formula 5 as well as compounds of Formula 6 and salts thereof, wherein R is NH2, Cl or OH; X is H or Cl; R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; provided that when R is NH2 or Cl, then X is Cl; which are useful a process intermediates.Type: GrantFiled: May 12, 2006Date of Patent: September 6, 2011Assignee: E. I. du Pont de Nemours and CompanyInventor: Gary David Annis
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Publication number: 20110190297Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.Type: ApplicationFiled: October 6, 2009Publication date: August 4, 2011Inventors: Edward McDonald, Julian Blagg, Mark Pichowicz, Simon Ross Crumpler
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Publication number: 20110172189Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).Type: ApplicationFiled: September 18, 2009Publication date: July 14, 2011Applicant: PIMCO 2664 LIMITEDInventors: Iain Robert Greig, Rose Mary Sheridan, Raymond Fisher, Matthew John Tozer, Juha Andrew Clase, Andrew Smith, Andrew Robert Tuffnell, Robert Jurgen Van 't Hof
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Publication number: 20110160455Abstract: A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I); (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide or an organic sulfonyl anhydride; and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulfonamide.Type: ApplicationFiled: September 23, 2010Publication date: June 30, 2011Applicant: AstraZeneca UK Ltd.Inventors: Akio Matsushita, Mizuho Oda, Yasuhiro Kawachi, Jun-ichi Chika
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Patent number: 7960391Abstract: A compound of general formula (I): A process for preparing this compound. A fungicide composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.Type: GrantFiled: May 2, 2006Date of Patent: June 14, 2011Assignee: Bayer Cropscience AGInventors: Darren Mansfield, Pierre-Yves Coqueron, Heiko Rieck, Philippes Desbordes, Alain Villier, Marie-Claire Grosjean-Cournoyer, Pierre Genix
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Publication number: 20110127467Abstract: A composition comprising a phosphorescent compound, and a compound having a structure containing three or more repeating units having a dipole moment dimension of 1.0 Debye or more connected in series, wherein, based on the total number of dimer structures composed of any two repeating units connected in series contained in the above-described structure, the proportion of the number of dimer structures in which the dimension D2 of the dipole moment of the dimer structure, the dimension D1a of the dipole moment of the first repeating unit constituting the dimer structure and the dimension D1b of the dipole moment of the second repeating unit constituting the dimer structure satisfy a relation represented by the following formula (A): D1a<D2 and D1b<D2??(A) is 50% or more.Type: ApplicationFiled: July 28, 2009Publication date: June 2, 2011Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, SUMATION CO., LTD.Inventors: Nobuhiko Akino, Kenta Tanaka, Hideyuki Higashimura
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Publication number: 20110124651Abstract: There is provided a fluorine-containing organosulfur compound having an excellent control effect on harmful arthropods, which is represented by the formula (I): wherein m represents 0 or 1; n represents 0, 1 or 2; A represents an optionally substituted 6-membered aromatic heterocyclic group; R1 to R4 are the same or different and represent a hydrogen atom, a C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and Q represents a C1-C5 haloalkyl group containing at least one fluorine atom, or a fluorine atom.Type: ApplicationFiled: August 22, 2008Publication date: May 26, 2011Inventors: Koji Kumamoto, Hiroyuki Miyazaki
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Publication number: 20110118283Abstract: There are provided compounds of the formula wherein R1, R2, R3, R3, R4, R5 are as described herein and enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.Type: ApplicationFiled: October 6, 2010Publication date: May 19, 2011Inventors: Qingjie Ding, Nan Jiang, Jin-Jun Liu, Jing Zhang, Zhuming Zhang