Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.5 is hydrogen or an aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or monocyclic aryl substituted aliphatic group bonded to the carbonyl carbon through a carbon-to-carbon linkage. The compounds are useful as intermediates in the preparation of 4-substituted imidazo[1,2-a]quinoxalines.

Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups.

Abstract: The present invention provides a novel cyclization process useful for the production of the peptide moiety of an ergotalkaloid.

Abstract: Compounds of the formula ##STR1## WHEREIN R is hydrogen, chlorine, or fluorine; andR.sup.1 is hydrogen, methyl, ethyl, propyl, or isopropyl;Or a non-toxic acid addition salt thereof; exert an anti-hypertensive effect.

Abstract: Compounds of the formula ##STR1## wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals.

Abstract: Solutions of certain hydrogenated ergopeptide alkaloids in mixtures of pharmacologically acceptable alcohols and water have improved stability. Preferred solvents are mixtures of ethanol, propylene glycol and glycerol containing from 15-40% wt. of water and having dielectric constants between 34 and 46. With these solutions it is not essential to carry out the filing operation under an inert atmosphere.

Abstract: New 4-halo derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R.sub.1 is hydrogen, lower alkyl or a salt forming ion; R.sub.2 is hydrogen, lower alkyl, halogen or lower alkoxy; and X is halogen.The new compounds are useful as intermediates and as anti-inflammatory agents.

Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl,R.sub.3 and R.sub.5 are, independently, hydrogen or methyl,R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.6 and R.sub.7 together form a single bond, orR.sub.6 and R.sub.7 are each hydrogen,R.sub.6 is methoxy, andR.sub.7 is hydrogen,Are useful in the treatment of hypertension, angina pectoris, depressions, neuroses and psychoses.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl of 2 to 8 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms, andR.sub.2 is branched alkyl of 3 or 4 carbon atoms or benzyl,Useful as agents for the treatment of migraine, hypotonia and orthostatic disorders.

Abstract: Compounds of the formula ##STR1## WHEREIN R is hydrogen (lower)alkyl, phen(lower)-alkyl, benzoyl(lower)alkyl, or p-halobenzoyl-(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)-alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hyptotensive effect in hypertensive animals.