Abstract: Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and anti-tussive activity. The compounds may be 3-phenyl-4-morpholinoalkoxy-coumarins. Administration may be by the oral or parenteral route. Intermediates useful in the production of these compounds are also disclosed.

Abstract: A compound of the formula ##STR1## or its acid addition salt with a physiologically compatible acid, a process for its preparation by a reaction selected from the group consisting of(a) reacting N-benzyl-piperazine and 5-methoxycumarilic acid(a1) at an elevated temperature in the absence of a condensation agent,(a2) at a temperature of at least 15.degree. C. in the presence of a condensation agent;(b) reacting N-benzyl-piperazine with an activated derivative of 5-methoxy-cumarilic acid;(c) N-(5-methoxycumaroyl)-piperazine with a benzyl compound selected from the group consisting of benzyl halide, benzylalkyl sulfonate and benzyl-aryl sulfonate and a pharmaceutical composition containing said compounds.

Abstract: A chromone derivative has the formula: ##STR1## in which one of the radicals R, R' is a hydrogen atom or a lower alkyl radical and the other of the radicals is an aminoalkyl oxy benzoyl group having the formula: ##STR2## The derivative can be of use in the pharmaceutical industry in drugs for treating heart disorders.

Abstract: The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.

Abstract: New benzopyrane derivatives of the general formula ##STR1## in which R is free, esterified or amidated carboxyl, Ph is 1,2-phenylene which contains the group R--CO--NR.sub.3 -- and is otherwise unsubstituted or is substituted, X is a group of the formula --CO--CR.sub.1 .dbd.CR.sub.2 --, in which R.sub.1 and R.sub.2 independently of one another are hydrogen, acyl or a substituted or unsubstituted hydrocarbon radical or a hetero-analogue thereof, or conjointly are 3-membered to 5-membered lower alkylene, and R.sub.2 can also be free or etherified hydroxyl or hydroxyl etherified by an organic carboxylic acid, and R.sub.3 is hydrogen or lower alkyl, are useful as anti-allergic agents.

Abstract: Substituted 3,6-diaminophthalides of the formula ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3 independently represents alkyl of not more than 12 carbon atoms which is unsubstituted or substituted by halogen, hydroxyl, cyano or lower alkoxy, or represents cycloalkyl, benzyl, or benzyl which is substituted by halogen, lower alkyl or lower alkoxy, and R.sub.1 can also be hydrogen and R.sub.3 can also be phenyl, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, represent a 5- or 6-membered heterocyclic radical and the ring A is unsubstituted or substituted or contains a fused, unsubstituted or substituted benzene or heterocyclic ring.These compounds are suitable in particular for use as color formers in pressure-sensitive or heat-sensitive recording materials.

Abstract: The present invention relates to compounds of the general formula: ##STR1## in which: R.sub.1 is selected from hydrogen and alkoxy having 1-7 carbon atoms,R.sub.2 is hydrogen,n is selected from zero and 1,X and Y are hydrogen atoms, andZ is hydroxy, orY and Z taken together represent an oxygen atom, or, when n=1, X and Z may represent a single bond,A represents an amino radical, and their pharmaceutically acceptable acid addition salts.These compounds are useful in particular for the treatment of asthma.

Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.

Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=ho, alkoxy, alkanoyloxy or tert. AmR=h, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=0-2Or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.

Abstract: This invention relates to certain 7a-homo-4-oxo-PGI.sub.1 compounds. These novel prostacyclin-type compounds are useful for pharmacological purposes.

Abstract: The present invention provides 5-hydroxy-PGI.sub.1, piperazinylamides, which are useful pharmacological agents. These analogs of prostaglandin I.sub.1 are useful for the stimulation of mammalian smooth muscle tissues.

Abstract: The present invention relates to certain 7,8-didehydro-PGI.sub.1 amides, which are pharmacologically active amides of the corresponding 7,8-didehydro-PGI.sub.1 acids. These novel prostacyclin type amides are endoperoxide cyclooxygenase inhibitors which prevent the conversion of unsaturated fatty acids to endoperoxides (e.g., PGG.sub.2 and PGH.sub.2). By virtue of this pharmacological property these analogs represent potent antiinflammatory agents.

Abstract: The present invention relates to new derivatives of 2-phenyl -benzo(b)thiophene mono- or disubstituted on the nitrogen atom of formula ##STR1## in which X.sup.1 to X.sup.9 which are identical or different are hydrogen, alkyl having up to 3 carbon atoms, chlorine, bromine, methoxy or methylthio, R.sup.1 is hydrogen, alkyl having up to 8 carbon atoms, optionally chlorinated or methoxylated, phenyl optionally chlorinated or methoxylated, aralkyl having in all up to 9 carbon atoms, optionally chlorinated or methoxylated on the phenyl nucleus, R.sup.2 is hydrogen, phenyl,Or a radical of the formula ##STR2## in which A is two hydrogen atoms or one oxygen atom andR.sup.3 can assume the same meanings as given for R.sup.1, the meanings assumed by R.sup.1 and R.sup.3 being independent from one another, or R.sup.1 and R.sup.2 together form the radical of a Schiff base of formula.dbd.CH--R.sup.4 (III)in which R.sup.4 is not hydrogen, but can otherwise assume the same meanings as R.sup.

Abstract: Novel halogeno-benzothiophenecarboxylic acids and a novel process for their preparation by reacting substituted or unsubstituted thiophenols with dihalogenomaleic anhydrides or derivatives thereof are described. The novel halogeno-benzothiophenecarboxylic acids are valuable intermediates for the preparation of pharmaceutical active compounds having an antiallergic action.

Abstract: Novel halogeno-benzofuranone-carboxylic acids and a novel process for their preparation by reacting substituted or unsubstituted phenols with dihalogenomaleic anhydrides or derivatives thereof are described. The novel halogeno-benzofuranone-carboxylic acids are valuable intermediates for the preparation of pharmaceutical active compounds having an antiallergic action or for the preparation of biocidal active compounds for combating plant and animal pests, in particular phytopathogenic fungi and bacteria.

Abstract: A fluorescent pigment consisting of N-substituted iminocoumarins of the general formula I, ##STR1## wherein X.sub.1 is a cyano group, a carboxamido group or an aryl or a heteroaryl radical linked directly or through a --CO or --SO.sub.2 group,X.sub.2 is an amino group, hydroxy group or an alkoxy group and when it is an amino group, may carry an optionally substituted alkylene or alkylidene group bound in ortho position to the nitrogen atom and in para position with respect to the coumarin oxygen atom,X.sub.3 is a hydrogen atom, a halogen atom or a cyano group andX.sub.4 is a functionally converted carboxyl groups. The new dyestuffs dye polyester fiber in orange or red shades with good fastness.

Abstract: This invention relates to certain structural analogs of 5,6-dihydroprostacyclin (PGI.sub.1) wherein an endocyclic double bond is present at the C-7 to C-8 position. These novel unsaturated prostacyclin type compounds are endoperoxide cyclooxygenase inhibitors which prevent the conversion of unsaturated fatty acids to endoperoxides (e.g., PGG.sub.2 and PGH.sub.2). By virtue of this pharmacological property these analogs represent potent antiinflammatory agents.

Abstract: Chromone compounds carrying a pyridyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyridyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

Abstract: The case involves novel N-pyrazinecarbonyl-N'-acylguanidines and processes for preparing same. The N-pyrazinecarbonyl-N'-acylguanidines are eukalemic agents possessing diuretic and natriuretic properties.

Abstract: The invention encompasses novel 5-substituted-2-phenylbenzo[b]thiophene-3-alkylamines and related compounds of the general formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 and R.sub.2 each independently represents H or an alkyl having from 1 to 8 carbon atoms or R.sub.1 and R.sub.2 together with N represents an azamonocyclic ring selected from the group comprising pyrrolidinyl, piperazinyl, substituted pyrrolidinyl wherein the substituent is an alkyl containing from 1 to 4 carbon atoms and substituted piperazinyl wherein the substituent is an alkyl containing from 1 to 4 carbon atoms or an alkanol wherein the alkyl moiety contains 1 to 4 carbon atoms; Y represents H, halogen or alkyl having 1 to 4 carbon atoms; X represents H, halogen, alkyl having 1 to 4 carbon atoms and alkoxy wherein the alkyl moiety contains 1 to 4 carbon atoms; and n is a positive integer from 1 to 4. These compounds possess utility as neuroleptics or anti-bacterial agents.

Abstract: N.sup.2 -substituted-L-arginine esters and amides, and the pharmaceutically acceptable acid addition salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.

Abstract: This invention relates to certain structural and pharmacological analogs of 5,6-dihydroprostacyclin (PGI.sub.1) wherein an endocyclic double bond is present at the C-6 to C-7 position. These novel unsaturated prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, smooth muscle stimulators, gastric antisecretory agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.

Abstract: This invention relates to certain structural and pharmacological analogs of 5,6-dihydro-prostacyclin (PGI.sub.1) wherein the C-4 position is substituted by oxo. These novel 4-oxo-prostacyclin-type compounds are useful for the same pharmacological purposes as prostacyclin, particularly being smooth muscle stimulators and platelet aggregation inhibitors.

Abstract: Optionally substituted 2-nitro-3-phenylbenzofuranalkanoic and -alkenoic acids which are active as antimicrobial agents, processes for their preparation and intermediates therefor are described.

Abstract: The invention relates to acetamidoxime derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 represents a branched- or straight-chain alkyl group containing from 1 to 4 carbon atoms or a phenyl group, A represents one of the groups: ##STR2## R.sub.2 represents an amino group such as, for example, a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, pyrrolidino, morpholino, piperidino or heptamethyleneimino group or a 1-piperazino group substituted in the 4-position by a straight-chain alkyl group containing from 1 to 4 carbon atoms, X represents a hydrogen or chlorine atom or a methoxy group and n is the integer 2 or 3.The compounds of formula I have been found to be potentially useful in the treatment of disorders of arterial pressure.

Abstract: The present invention is concerned with novel sulfonamide compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein Ar represents an optionally substituted phenyl group or a saturated heterocyclic group, Am represents a dialkylamino group or a saturated heterocyclic group, A represents a 3-benzofuryl or 3-benzo[b] thienyl group, substituted in the 2-position by a lower alkyl group and optionally substituted in the 5-position by a halogen atom or a lower alkoxy group, and n is the integer 2 or 3.Said compounds are effective for treating certain pathological or otherwise abnormal conditions of the heart and more particularly angina pectoris.

Abstract: The compounds are sulfonyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris.

Abstract: A compound having the general formula or an acid addition salt thereof ##STR1## in which formula R.sub.1 is selected from the group consisting ofA. an at least mononuclear heterocyclic group having 4 to 10 carbon atoms in the ring system bound to the group ##STR2## through a carbon atom and containing at least one oxygen, nitrogen or sulphur atom,B. substitution products of (A) containing at least one substituent selected from the group consisting of halogen, trifluoromethyl, hydroxy, alkoxy of 1 to 3 carbon atoms, unsubstituted amino, amino substituted by up to two alkyl groups each having 1 to 3 carbon atoms and alkyl groups having 1 to 6 carbon atoms,X is oxygen, sulphur or an NH-group,Y is an alkylene group having 1 to 3 carbon atoms in the chain, or an alkylene group having 1 to 3 carbon atoms in the chain substituted by (a) up to 3 alkyl groups each having up to 3 carbon atoms and a total of not more than 8 carbon atoms, or (b) substituted by one or two phenyl groups,R.sub.

Abstract: Chromone compounds carrying a pyrazinyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyrazinyl)-chromone.The disclosed compounds are useful in the treatment of allergies.

Abstract: Aminoalkoxybenzofurans having the formula ##STR1## wherein ##STR2## are either (1) ##STR3## and ##STR4## is monoalkylamino, dialkylamino, cycloalkylamino or heterocyclic amino, or (2) ##STR5## (H, 1, 4-methyl piperazino), ##STR6## is piperidino. The compounds possess antidysrhythmic properties.

Abstract: The invention comprises 1-amino-1-phthalidyl alkanes of the formula: ##STR1## where X = H, or CH.sub.3 O;R = ch.sub.3, c.sub.6 h.sub.5, p--CH.sub.3 OC.sub.6 H.sub.4, or p--ClC.sub.6 H.sub.4 ;R' = h, or C.sub.2 H.sub.5 ;R" = h, ch.sub.3, c.sub.2 h.sub.5, c.sub.6 h.sub.5 ch.sub.2, c.sub.6 h.sub.5, or p--CH.sub.3 OC.sub.6 H.sub.4 ;R' and R", when taken together form the radical --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --, --(CH.sub.2).sub.2 --N(C.sub.6 H.sub.5)--(CH.sub.2).sub.2 --, --(CH.sub.2).sub.2 --N(p--CH.sub.3 OC.sub.6 H.sub.4)--(CH.sub.2).sub.2 --, or --(CH.sub.2).sub.2 --N(--o-CH.sub.3 OC.sub.6 H.sub.4)--(CH.sub.2).sub.2 --,and a method for producing same which comprises dissolving .alpha.

Abstract: 2,3-Dihydrobenzofuran of formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, a lower alkyl or lower phenylalkyl or form, together with the nitrogen atom to which they are attached, a 4 to 8-membered saturated heterocyclic ring having 3 to 7 cyclic carbon atoms, a 4 to 8-membered saturated heterocyclic ring having 2 to 6 cyclic carbon atoms and two heteroatoms one of which is said nitrogen atom and the other is an oxygen atom, a sulphur atom or another nitrogen atom, said other nitrogen atom being optionally substituted by a phenyl, halophenyl, trifluromethylphenyl, lower alkylphenyl or lower alkoxyphenyl; n is 2 or 3, and the salts thereof.

Abstract: Derivatives of trans-3-hydroxy-4-amino-chroman and pharmaceutical compositions containing such derivatives are useful for effecting vasodilation in mammals, including humans.

Abstract: Compounds of the formula (I): ##STR1## and salts thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R.sub.1 so that the NR.sub.1 R.sub.2 moiety is a 5-, 6- or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is an aromatic group; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is --CH.sub.2 -- or an oxygen atom and the dotted line represents a single or double bond, are useful for inducing anorexia and for their mood-modifying effects.

Abstract: Benzopyrones of the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom or a hydroxyl, lower alkyl, alkoxy, alkylthio or trifluoromethyl radical,R.sub.2, r.sub.3, r.sub.4 and R.sub.5 each independently is hydrogen, a halogen atom, a hydroxyl radical, a lower alkyl or lower alkoxy radical, or a lower alkyl or lower alkoxy radical substituted by at least one of hydroxyl, halogen, mesyloxy or tosyloxy or by an oxirane, dioxane or dioxolane ring,A is a lower alkylene radical, andn is 0, 1 or 2,And salts thereof exhibit anti-allergic activity.