Abstract: Isoindole derivatives of the formula ##STR1## wherein A, Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and n are as hereinafter set forth, as well as intermediates, are described. The end products of formula I are useful as appetite-suppressants.

Abstract: 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES HAVING THE FORMULA ##STR1## wherein R is C.sub.1-3 alkyl, halogen or hydrogen; R.sub.1 is phenyl or C.sub.1-3 alkyl; R' is hydrogen when R.sub.1 is alkyl and is the same as R when R.sub.1 is phenyl; R.sub.2 is hydrogen or C.sub.1-3 alkyl; n is 2-4; n' is 1-4; and A is a group comprising a trivalent organic function which may be acid, ester, nitrile or amide, in which latter case the nitrogen of the amide is part of the ring, and more particularly COOH, COONa, COOCH.sub.3 or COOC.sub.2 H.sub.5. These derivatives or their addition salts with pharmaceutically acceptable acids, have high psychostimulating activity.