N-hydrocarbyl Piperazines Patents (Class 544/404)
  • Patent number: 10301254
    Abstract: The present invention includes polycationic amphiphilic compounds of formula VII useful as antimicrobial agents. The present invention further includes novel polymers of polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 28, 2019
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: William M. Wuest, Kevin P. C. Minbiole
  • Patent number: 9802150
    Abstract: The present invention relates to a method for using, as a carbon dioxide absorbent, a secondary amine having a nitrile group, that is, a 3-(alkylamino)propionitrile compound. The absorbent based on the 3-(alkylamino)propionitrile compound and the carbon dioxide absorption method and separation method using same, according to the present invention, not only have an excellent carbon dioxide absorption capacity and a rapid carbon dioxide absorption rate, but also allow absorbent regeneration even at a considerably low temperature compared with a conventional alkanolamine-based absorbent and thus can significantly reduce the entire energy consumption required for an absorption process, and can also prevent recovered carbon dioxide from being contaminated with moisture and absorbent vapor, owing to the low regeneration temperature.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: October 31, 2017
    Assignee: University-Industry Cooperation Foundation Of Kyung Hee University
    Inventors: Hoon Sik Kim, Young-Seop Choi, Youngeun Cheon, Heehwan Kim
  • Patent number: 9644066
    Abstract: The present invention describes cyclic amine compounds useful for catalysts for polyurethane form-forming compositions. The cyclic amine compounds of the invention provide distinct benefits for reaction compositions, methods, and polyurethane foams based on their desirable physical and catalytic properties.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 9, 2017
    Assignee: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Dwight D. Latham, Phillip S. Athey, Stephen W. King
  • Publication number: 20150114884
    Abstract: Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.
    Type: Application
    Filed: October 31, 2013
    Publication date: April 30, 2015
    Applicant: General Electric Company
    Inventors: Alagarsamy Subbiah, Rebika Mayanglambam Devi, Nimeshkumar Kantilal Patel, Muthukumar Nagu, Rhomit Ghosh, Sathees Kesavan, Ashok Shankar Shetty, Manish Joshi
  • Publication number: 20150018548
    Abstract: A process for producing N-methyl or N,N-dimethyl amines, which comprises using amine compound, nitro-containing compound or nitrile compound as a starting material, carbon dioxide as a methylating agent and hydrogen gas as a reducing agent, and allowing them to react in a sealed reactor for 6 to 48 h in a reaction medium at a reaction temperature of 80 to 180 ° C. in the presence of a composite catalyst, so as to provide N-methyl or N,N-dimethyl amines. The process of the present invention is simple and under relative mild reaction conditions. By means of the process of the invention, the target products can be prepared at low cost with a high yield. The catalysts used have a high catalytic activity and can be separated from the reaction system simply and reused. Furthermore, the whole process of the present invention is environmental-friendly and facilitates the cycling use of carbon dioxide.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 15, 2015
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Feng SHI, Xinjiang Cui, Hangkong Yuan, Yan Zhang, Youquan Deng
  • Patent number: 8933223
    Abstract: A process for preparing a cyclic tertiary amine of the formula I where A is a C4-alkylene group, a C5-alkylene group or a —(CH2)2—B—(CH2)2— group, where B is oxygen (O) or an N—R1 radical and R1 is C1-C5-alkyl, aryl or C5-C7-cycloalkyl, and the radical R2 is a linear or branched C2-C16-alkyl, C5-C7-cycloalkyl or C7-C20-aralkyl, in which (i) an amino alcohol II from the group consisting of 1,4-aminobutanol, 1,5-aminopentanol, aminodiglycol (ADG) and aminoethylethanolamine of the formula IIa where R1 is as defined above or hydrogen (H), in which case R1=R2 in the amine I, is reacted with a primary or secondary alcohol R2OH (III) at a temperature in the range from 150 to 270° C. in the liquid phase in the presence of a copper-comprising heterogeneous catalyst in a reactor.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: January 13, 2015
    Assignee: BASF SE
    Inventors: Christof Wilhelm Wigbers, Johann-Peter Melder, Bernd Stein, Harald Meiβner
  • Patent number: 8927712
    Abstract: Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a catalyst molding, where the reaction is carried out in the liquid phase at an absolute pressure in the range from 150 to 250 bar and the amination is carried out by means of a catalyst molding, the precursor of which can be prepared according to a process in which (i) an oxidic material comprising copper oxide, aluminum oxide and lanthanum oxide is provided, (ii) pulverulent metallic copper and/or copper flakes and optionally graphite is added to the oxidic material, (iii) the mixture resulting from step ii is shaped to give a molding, where the oxidic material is obtainable by simultaneous or successive precipitation of the component copper oxide, of the component aluminum oxide and of the component lanthanum oxide and subsequent dry
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: January 6, 2015
    Assignee: BASF SE
    Inventors: Roland Bou Chedid, Johann-Peter Melder, Ulrich Abel, Roman Dostalek, Bernd Stein
  • Patent number: 8884015
    Abstract: Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a supported, metal-containing catalyst, where the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and, in the range from 0.2 to 5.0% by weight, oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 95 to 145 bar.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: November 11, 2014
    Assignee: BASF SE
    Inventors: Roland Bou Chedid, Johann-Peter Melder, Ulrich Abel, Roman Dostalek, Bernd Stein
  • Publication number: 20140294718
    Abstract: Disclosed is an sorbent for removing sulfur dioxide (SO2) contained in combustion flue gases or in the atmosphere by using a diamine-based ionic liquid or a diamine compound supported by a polymer resin. To be specific, the present invention relates to a method of using a tertiary diamine compound immobilized on a polymer surface as a SO2 sorbent and also relates to a novel sorbent for absorbing or adsorbing a sulfur dioxide hydrate (SO2.H2O) formed by a bond between SO2 and water.
    Type: Application
    Filed: November 22, 2013
    Publication date: October 2, 2014
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyun Joo LEE, Seung Rok LIM, Kean Im LEE, Chang Soo KIM, Hoon Sik KIM, Ji Sik CHOI, Sang Deuk LEE
  • Patent number: 8674099
    Abstract: The invention relates to compounds of formula (I) wherein the substituents are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester, N-oxide thereof; processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: March 18, 2014
    Assignee: Novartis AG
    Inventors: Pascal Furet, Diana Graus Porta, Vito Guagnano
  • Publication number: 20130324732
    Abstract: Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a supported, metal-containing catalyst, where the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and, in the range from 0.2 to 5.0% by weight, oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 95 to 145 bar.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 5, 2013
    Inventors: Roland Bou Chedid, Johann-Peter Melder, Ulrich Abel, Roman Dostalek, Bernd Stein
  • Publication number: 20130324731
    Abstract: Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a catalyst molding, where the reaction is carried out in the liquid phase at an absolute pressure in the range from 150 to 250 bar and the amination is carried out by means of a catalyst molding, the precursor of which can be prepared according to a process in which (i) an oxidic material comprising copper oxide, aluminum oxide and lanthanum oxide is provided, (ii) pulverulent metallic copper and/or copper flakes and optionally graphite is added to the oxidic material, (iii) the mixture resulting from step ii is shaped to give a molding, where the oxidic material is obtainable by simultaneous or successive precipitation of the component copper oxide, of the component aluminum oxide and of the component lanthanum oxide and subsequent dr
    Type: Application
    Filed: May 31, 2013
    Publication date: December 5, 2013
    Inventors: Roland Bou Chedid, Johann-Peter Melder, Ulrich Abel, Roman Dostalek, Bernd Stein
  • Publication number: 20130299391
    Abstract: Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 14, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Alagarsamy Subbiah, Rebika Mayanglambam Devi, Nimeshkumar Kantilal Patel, Muthukumar Nagu, Romit Ghosh, Sathees Kesavan
  • Patent number: 8501035
    Abstract: An absorption medium for removing acid gases from a fluid stream comprises an aqueous solution (A) of an alkali metal salt of an N,N-di-C1-C4-alkylaminocarboxylic acid and (B) N-hydroxyethylpiperazine. The absorption medium has a low vapor pressure and an increased resistance to oxygen. Preferred fluid streams are combustion exhaust gases or biogas.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: August 6, 2013
    Assignee: BASF SE
    Inventors: Christian Riemann, Torsten Katz, Georg Sieder, Gerald Vorberg, Erika Dengler
  • Patent number: 8361426
    Abstract: Absorption medium for acid gases comprising an oligoamine (A) of the general formula (I) and a piperazine derivative (B) of the general formula (II) in which the weight ratio of oligoamine (A) to the piperazine derivative (B) is 0.2 to 25, and also process for removing acid gases from a gas stream by contacting the gas stream at a pressure of 0.05 to 10 MPa abs with an aqueous solution of said absorption medium which is brought to and maintained at a temperature of 20 to 80° C.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: January 29, 2013
    Assignee: BASF SE
    Inventors: Ute Lichtfers, Robin Thiele, Susanna Voges, Georg Sieder, Oliver Spuhl, Hugo Rafael Garcia Andarcia
  • Publication number: 20120095221
    Abstract: A process for preparing a cyclic tertiary amine of the formula I where A is a C4-alkylene group, a C5-alkylene group or a —(CH2)2—B—(CH2)2— group, where B is oxygen (O) or an N—R1 radical and R1 is C1-C5-alkyl, aryl or C5-C7-cycloalkyl, and the radical R2 is a linear or branched C2-C16-alkyl, C5-C7-cycloalkyl or C7-C20-aralkyl, in which (i) an amino alcohol II from the group consisting of 1,4-aminobutanol, 1,5-aminopentanol, aminodiglycol (ADG) and aminoethylethanolamine of the formula IIa where R1 is as defined above or hydrogen (H), in which case R1?R2 in the amine I, is reacted with a primary or secondary alcohol R2OH (III) at a temperature in the range from 150 to 270° C. in the liquid phase in the presence of a copper-comprising heterogeneous catalyst in a reactor.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 19, 2012
    Applicant: BASF SE
    Inventors: Christof Wilhelm Wigbers, Johann-Peter Melder, Bernd Stein, Harald Meißner
  • Publication number: 20120000790
    Abstract: A method and ionic liquid for the electrorecovery of metal from a metal salt including at least one metal ion. The method includes the steps of dissolving the metal salt in an ionic liquid, the ionic liquid including an ionic liquid cation and an ionic liquid anion; whereby the metal ion of the metal salt forms a metal complex in solution with at least the ionic liquid cation; and subjecting the metal complex to an electrical potential between a cathode and anode to recover metal at the cathode. The ionic liquid includes an ionic liquid cation and an ionic liquid anion, wherein the ionic liquid cation has an affinity for the metal ion which is at least about equal to that of the ionic liquid anion for the metal ion.
    Type: Application
    Filed: March 17, 2010
    Publication date: January 5, 2012
    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Theo Rodopoulos, Michael David Horne, Thomas Ruether
  • Publication number: 20100326277
    Abstract: The present invention provides a novel piperazinium trifluoroacetate compound prepared by reacting piperazine with trifluoroacetic acid and a carbon dioxide absorbent prepared by dissolving the compound in an ionic liquid or organic solvent. According to the present invention, the carbon dioxide absorbent has excellent carbon dioxide absorption capacity and low solvent loss, and the energy consumption required for the carbon dioxide absorption and desorption is significantly reduced.
    Type: Application
    Filed: November 4, 2009
    Publication date: December 30, 2010
    Applicants: HYUNDAI MOTOR COMPANY
    Inventors: Sung Yeup Chung, Ki Chun Lee, Seok Jin Choi, Hoon Sik Kim, Jelliarko Palgunadi, Je Eun Kang
  • Publication number: 20100256249
    Abstract: To provide a method for producing a low-odor polyester-type flexible polyurethane foam which is excellent in formability and free from scorch in the interior of the foam, and further discharges substantially no volatile amine compound from a product, in the production of a polyester-type flexible polyurethane foam, and to provide a catalyst composition to be used for the production method.
    Type: Application
    Filed: October 23, 2008
    Publication date: October 7, 2010
    Inventor: Yoshihiro Takahashi
  • Patent number: 7737127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 15, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • Patent number: 7317101
    Abstract: A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: January 8, 2008
    Assignee: Sandoz GmbH
    Inventors: Gerd Ascher, Johannes Ludescher
  • Patent number: 7022845
    Abstract: A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×105 Pa and 1.07×105 Pa while methanol produced during the reaction is distilled off as it is formed.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: April 4, 2006
    Assignee: Group SNPE
    Inventors: Elisabeth Borredon, Berhard Chabaud, Antoine Gaset, Sophie Thiebaud-Roux, Samedy Ouk
  • Patent number: 6943250
    Abstract: Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality is part of a heterocyclic radical and includes a protecting group.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: September 13, 2005
    Assignee: FMC Corporation
    Inventor: Thorsten Werner Brockmann
  • Patent number: 6900313
    Abstract: The invention relates to chiral ionic liquids of the general formula [A]n+[Y]n?, whereby n=1 or 2, the anion [Y]n? is the anion of an organic or inorganic proton acid and the cation [A]+ an optically active organic ammonium cation with up to 50 carbon atoms, at least one chirality center and at least one functional group that can produce a coordination by forming hydrogen bridges or by providing free electron pairs. At least one chirality center is provided with a distance of up to 5 atomic bonds from the functional group. The invention also relates to a method for producing said chiral ionic liquids and to the use thereof in methods for the asymmetric synthesis, the asymmetric catalysis and for separating racemates.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: May 31, 2005
    Inventors: Peter Wasserscheid, Wilhelm Keim, Carsten Bolm, Andreas Bösmann
  • Patent number: 6809202
    Abstract: The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: October 26, 2004
    Assignee: Torrey Pines Institute for Molecular Studies
    Inventors: Adel Nefzi, John M. Ostresh, Richard A. Houghten
  • Patent number: 6776911
    Abstract: The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When applied to silica-based chromatography, it offers important advantages in all cases in which it is necessary to modulate the interaction of analytes with the stationary phase. In capillary zone electrophoresis (CZE), such compounds will eliminate or invert the electroendoosmostic (EEO) flow, greatly simplifying the analysis of negatively-charged compounds and permitting the analysis of bio(macro)molecules via the direct use of naked capillaries.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: August 17, 2004
    Inventors: Attilio Citterio, Roberto Sebastiano, Cecilia Gelfi, Pier Giorgio Righetti
  • Publication number: 20040122181
    Abstract: The present invention relates to vulcanization accelerators constituted by compounds, derived from secondary amines, belonging to the class of enamines and to a process for their preparation.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Applicant: Great Lakes Chemical Italia S.r.L.
    Inventors: Fabio Broussard, Mauro Adovasio, Corrado Collierotti, Gianbattista Taroni, Jose Roncalli
  • Patent number: 6734177
    Abstract: The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said salts.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: May 11, 2004
    Assignee: Novartis AG
    Inventors: Frederick R. Kinder, Jr., Prasad K. Kapa, Eric M. Loeser
  • Patent number: 6683181
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: January 27, 2004
    Assignee: Pharmacia and Upjohn Comapny
    Inventors: Valerie A. Vaillancourt, Sandra Staley, Audris Huang, Richard Allen Nugent, Ke Chen, Sajiv K. Nair, James A. Nieman, Joseph Walter Strohbach
  • Patent number: 6603003
    Abstract: A novel method for the synthesis of piperazine and its derivatives of formula 1, wherein R is selected from hydrogen, or a lower alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; R1 is selected from hydrogen, a methyl group, a phenyl group optionally substituted with an alkyl group having 1 to 6 carbon atoms, or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; and R2 is selected from hydrogen, or a methyl group, or a fluoromethyl group; comprising the steps: a. reacting an ester of formula 11 with substituted or unsubstituted ethylenediamine of formula 7 to give 3,4-dehydropiperazine-2-one and its derivatives of formula 12, wherein R, R1, R2 are as defined above and R6 is a C1 to C4 linear or branched alkyl group; and b. reacting the 3,4-dehydro-piperazine-2-one and its derivatives of formula 12 with a reducing agent to yield the piperazine and its derivatives of formula 1.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: August 5, 2003
    Assignee: Sun Pharmaceutical Industries LTD
    Inventors: Sonny Sebastian, Hetal Virendra Patel, Rajamannar Thennati
  • Publication number: 20020169319
    Abstract: Process for the preparation of n-butylamines where n-butenylamines are firstly prepared by reacting 1,3-butadiene in the form of a 1,3-butadiene-containing mixture obtained during the cracking of petroleum fractions or during the dehydrogenation of LPG or LNG or from GTL technology with a primary amine and/or a secondary amine under hydroaminating conditions, and the resulting butenylamine(s) are then reacted in a second process stage under hydrogenating and transalkylating conditions.
    Type: Application
    Filed: December 26, 2001
    Publication date: November 14, 2002
    Inventors: Frank Funke, Ulrich Steinbrenner, Peter Zehner, Ralf Bohling, Wolfgang Harder
  • Patent number: 6441172
    Abstract: The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl group and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: August 27, 2002
    Assignee: Torrey Pines Institute for Molecular Studies
    Inventors: Adel Nefzi, John M. Ostresh, Richard A. Houghten
  • Patent number: 6384097
    Abstract: An amine catalyst for production of a polyurethane and a polyisocyanurate is provided which comprises a quaternary ammonium compound represented by General Formula (1): where R1 to R6 are independently a linear or branched saturated hydrocarbon group of 1 to 4 carbon atoms; R7 and R8 are independently a linear or branched, saturated or unsaturated hydrocarbon group of 2 to 12 carbon atoms; n is a number of 0 to 3, provided that at n=0 any one of R1, R2 and R3, and R5 and/or R6 may be linked together to form a heterocycle, or at n=1, 2, or 3, R5 or R6 and R4 may be linked together to form a heterocycle; A is a carbonate group or an organic acid group; and X is number of 1 to 2. The catalyst has high activity in formation of polyurethane foams and polyisocyanurate foams, having less odor, and producing foams of high fire retardance, having high curability, high retarding effect, and low corrosiveness.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: May 7, 2002
    Assignee: Tosoh Corporation
    Inventors: Katsumi Tokumoto, Yutaka Tamano, Shuichi Okuzono
  • Publication number: 20020009748
    Abstract: Mixtures of chemical compounds are provided having antibacterial and other utility. The mixtures are formed, preferably in solution phase, from the reaction of a purine or pyrimiding heterocyclic scaffold with a set of related chemical substituients, optionally through employment of a tether moiety. Libraries formed in accordance with the invention have utility per se and are articles of commerce. They can be used to screen for pesticides, drugs and other biologically active compounds.
    Type: Application
    Filed: May 13, 1998
    Publication date: January 24, 2002
    Inventor: PHILLIP DAN COOK
  • Publication number: 20010049440
    Abstract: This invention relates to a process for the selective preparation of cis-2,6-dimethylpiperazine by reacting (i) a diisopropanolamine mixture comprising compounds having the formulas HN(CH2CH(OH)CH3)2, HN(CH(CH3)CH2OH)2, and HN(CH(CH3)CH2OH)(CH2CH(OH)CH3) or (ii) 1,2-diaminopropane with ammonia and hydrogen in the presence of a hydrogenation catalyst.
    Type: Application
    Filed: August 8, 2001
    Publication date: December 6, 2001
    Inventor: Rudiger Schubart
  • Patent number: 6307102
    Abstract: An amine catalyst-for production of a polyurethane and a polyisocyanurate is provided which comprises a quaternary ammonium compound represented by General Formula (1): where R1 to R6 are independently a linear or branched saturated hydrocarbon group of 1 to 4 carbon atoms; R7 and R8 are independently a linear or branched, saturated or unsaturated hydrocarbon group of 2 to 12 carbon atoms; n is a number of 0 to 3 provided that at n=o any one of R1, R2 and R3, and R5 and/or R6 may be linked together to form a heterocycle, or at n=1, 2, or 3, R5 or R6 and R4 may be linked together to form a heterocycle; A is a carbonate group or an organic acid group; and X is number of 1 to 2. The catalyst has high activity in formation of polyurethane foams and polyisocyanurate foams, having less odor, and producing foams of high fire retardance, having high curability, high retarding effect, and low corrosiveness.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: October 23, 2001
    Assignee: Tosoh Corporation
    Inventors: Katsumi Tokumoto, Yutaka Tamano, Shuichi Okuzono
  • Patent number: 6191277
    Abstract: Compounds of Formula I are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is a heterocycle, amide, sulfonamide or carbamate and Z is an acyl or a functionalized acyl. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid phase support, are also disclosed.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: February 20, 2001
    Assignee: Pharmacopeia, Inc.
    Inventors: Roland Ellwood Dolle, III, Cullen Lee Cavallaro, Timothee Felix Herpin
  • Patent number: 5977359
    Abstract: The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:A.sub.1) --O--CO--A.sub.2) --CH.sub.2 --O--CO--A.sub.3) --O--CH.sub.2 --CO--A.sub.4) --O--CH.sub.2 --CH.sub.2 --A.sub.5) --N(R.sub.1)--CO--A.sub.6) --N(R.sub.1)--CO--CO--A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --A.sub.8) --O--CH.sub.2 --in which:R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; andAm is a nitrogen-containing heterocycle.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 2, 1999
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Patent number: 5895816
    Abstract: In a process for preparing alkylamines by reacting amines and aliphatic aldehydes in the presence of free hydrogen on a fixed bed catalyst in a reactor in which amines and aldehydes are mixed in the catalyst bed after being fed in in separate streams, only the aldehyde stream or only the amine stream is preheated during the feeding in.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: April 20, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz-Josef Kneuper, Rolf Lebkucher, Horst Neuhauser, Andreas Henne, Rainer Becker
  • Patent number: 5886175
    Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: March 23, 1999
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • Patent number: 5780470
    Abstract: Certain indanyl piperazines are useful as melatonergic agents and can treat various CNS disorders. They are use useful in treating sleep disorders and other conditions related to circadian rhythms.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: July 14, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald J. Mattson, John D. Catt
  • Patent number: 5626724
    Abstract: In a process for the recovery of N-ethylpiperazine by distillation from mixtures with N,N'-diethylpiperazine, piperazine, ethanol, water and accompanying substances, water is added in a manner such that, at the location of the addition of the water, the piperazine concentration is greater than the N-ethylpiperazine concentration. The water may be added to the reflux to the top of the column.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: May 6, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Dieter Malsch, Douglas Hutton, Ernst Lang
  • Patent number: 5495018
    Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • Patent number: 5495032
    Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R.sup.3, R.sup.4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar-protic or a polar-aprotic solvent. The resulting compounds are useful as antibiotics.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • Patent number: 5463130
    Abstract: A process for the preparation of peralkylated amines of the general formula I ##STR1## in which R.sup.1, R.sup.2 denote C.sub.1 -C.sub.200 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.20 alkylcycloalkyl, C.sub.4 -C.sub.20 cycloalkylalkyl, C.sub.2 -C.sub.20 alkoxyalkyl, aryl, C.sub.7 -C.sub.20 alkylaryl, C.sub.7 -C.sub.20 aralkyl, C.sub.2 -C.sub.8 hydroxyalkyl, C.sub.2 -C.sub.8 mercaptoalkyl, C.sub.8 -C.sub.20 phenoxyalkyl, C.sub.2 -C.sub.8 aminoalkyl, C.sub.2 -C.sub.8 (NHR.sup.4)alkyl, C.sub.2 -C.sub.8 (NR.sup.4 R.sup.5)alkyl or together form a saturated or unsaturated C.sub.2 -C.sub.6 alkylene chain optionally mono- to tri-substituted by C.sub.1 -C.sub.4 alkyl and optionally interrupted by oxygen or nitrogenX denotes a C.sub.2 -C.sub.20 alkylene or C.sub.2 -C.sub.20 alkenylene or C.sub.4 -C.sub.8 cycloalkylene chain optionally mono- to penta-substituted by R.sup.3, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 dialkylamino, phenoxy, diphenylamino and/or C.sub.2 -C.sub.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: October 31, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Tom Witzel, Eberhard Fuchs, Horst Zimmermann
  • Patent number: 5420272
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: May 30, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • Patent number: 5414087
    Abstract: Disclosed is a one-step method for preparing N-alkylpiperazines which eliminates the initial preparation and isolation of piperazine which comprises reacting a carbonyl compound and an amine in the presence of hydrogen over a metallic hydrogenation-dehydrogenation catalyst from Group VIII of the Periodic Table such as, for example, nickel, copper, cobalt, chromium, palladium, platinum or ruthenium, alone or in combination with other Group VIII metals or transition metals selected from the group consisting of manganese, iron, zinc, copper and chromium.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: May 9, 1995
    Assignee: Huntsman Corporation
    Inventors: George P. Speranza, James H. Templeton
  • Patent number: 5347003
    Abstract: Methods are provided whereby an N-C-N compound is regenerated from a product of a sulfur scavenging reaction, in which said N-C-N compound removes a sulfur atom from a sulfur compound, to form the original N-C-N compound. The N-C-N compound is represented by the formula (I): ##STR1## The product includes a hetero compound having sulfur, carbon and nitrogen atoms in its backbone. In one embodiment, the product is mixed with (1) a nitrogen compound represented by the formula (II): ##STR2## and (2) an alkaline compound selected from alkali metal, alkaline earth metal and transition metal compounds, to form a solution, slurry or dispersion. The hetero compound is reacted with the nitrogen compound in the presence of the alkaline compound, such that a sulfur atom of the hetero compound is replaced by a nitrogen atom of the nitrogen compound. If necessary, the pH of the solution may be adjusted to about 8 to about 13 to facilitate the reaction. In alternative embodiments, the product also includes an amine complex.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: September 13, 1994
    Assignee: Quaker Chemical Corporation
    Inventors: Edward A. Trauffer, Robert D. Evans
  • Patent number: 5328902
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: July 12, 1994
    Assignee: American Cyanamid Co.
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Patent number: 5296633
    Abstract: The methylated tertiary amines are selectively prepared by reacting a primary or secondary amine, or a nitrile or aminonitrile, including an aminoalcohol, etheramine, a polyamine or fatty polyamine or amidoamine, or amidopolyamine or dinitrile, with hexamethylenetetramine ("HMTA"), under hydrogen pressure at a temperature no greater than about 160.degree. C. and in the presence of a catalytically effective amount of a hydrogenation catalyst, e.g., nickel deposited onto appropriate support substrate therefor.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: March 22, 1994
    Inventor: Stephane Fouquay