Double Bonded Divalent Chalcogen Containing Patents (Class 544/54)
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Patent number: 4725305Abstract: Herbicidally active novel N,N'-bis-sulphonyl guanidines of the formula ##STR1## in which M is hydrogen, a metal or an ammonium radical, andR.sup.4, R.sup.5, R.sup.40 and R.sup.41 are various organic radicals.Type: GrantFiled: November 14, 1986Date of Patent: February 16, 1988Assignee: Bayer AktiengesellschaftInventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen, Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Uwe Priesnitz, Wolfgang Roy, Hans-Joachim Santel
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Patent number: 4715984Abstract: Dihydroazines of the formula IR.sub.1 --A.sup.1 --Z.sub.1 --A.sub.2 --R.sup.2 Iwherein R.sup.1, R.sup.2, A.sup.1, A.sup.2 and Z.sub.1 have the meanings specified herein may be used as components of liquid crystalline phases.Type: GrantFiled: January 22, 1986Date of Patent: December 29, 1987Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Joachim Krause, Wachtler, Bernhard Scheuble
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Patent number: 4713456Abstract: A process for the preparation of a 5-acylpyrimidine of the formula ##STR1## in which R is an organic radical comprising reacting a methyl ketone of the formulaR--CO--CH.sub.3in a first stage with a formylating reagent in the presence of a base to form an enolketone of the formulaR--CO--CH.dbd.CH--OR.sup.10in which R.sup.10 represents hydrogen or a base radical, thereafter reacting the enolketone in 2nd and 3rd stages with formamidine or a formamidine salt, and with an amino-formylating agent, and, in a 4th stage heating to cyclize the compound formed.The end products, some of which are new, are intermediates for making herbicides.Type: GrantFiled: August 26, 1985Date of Patent: December 15, 1987Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Graham Holmwood
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Patent number: 4711884Abstract: This invention is directed to compounds of the formula ##STR1## wherein X is a thiazine or thiazepine of the formula ##STR2## These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.Type: GrantFiled: December 27, 1983Date of Patent: December 8, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4710500Abstract: The present invention relates to novel indole derivatives which have interesting pharmacodynamic effects indicating pronounced activity in the treatment of psychic disorders, especially psychoses and, at the same time, a low degree of undesired side effects.Moreover, the invention relates to methods for the preparation of said indole derivatives, pharmaceutical compositions containing same, and methods for the treatment of psychic disorders, especially psychoses, by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.The novel indole derivatives of the present invention are represented by the following formula: ##STR1## wherein R is phenyl, optionally substituted with halogen, lower alkyl or trifluoromethyl, or a hetero aromatic group, such as 2-thienyl, 3-thienyl, 2-furoyl, 3-furoyl, 2-thiazol, 2-oxazol, 2-imidazole, 2-pyridyl, 3-pyridyl or 4-pyridyl; R.sup.Type: GrantFiled: April 1, 1986Date of Patent: December 1, 1987Assignee: H. Lundbeck A/SInventor: Jens K. Perregaard
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Patent number: 4707179Abstract: Herbicidally active pyridinesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical display utility as herbicides and plant growth regulants.Type: GrantFiled: February 17, 1987Date of Patent: November 17, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mark E. Thompson
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Patent number: 4707178Abstract: Herbicidally active pyrazolesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical having utility as herbicides and plant growth regulants.Type: GrantFiled: December 22, 1986Date of Patent: November 17, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mark E. Thompson
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Patent number: 4707479Abstract: 1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the blood-sugar level and the circulation and as coronary therapeutic agents and anti-arrhythmic agents.Type: GrantFiled: December 5, 1985Date of Patent: November 17, 1987Assignee: Bayer AktiengesellschaftInventors: Horst Meyer, Gerhard Franckowiak, Ulrich Rosentreter, Rainer Gross, Gunter Thomas, Matthias Schramm, Michael Kayser, Friedel Seuter, Elisabeth Perzborn, Martin Bechem
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Patent number: 4704389Abstract: This invention relates to aromatic .omega.-alkylimino-tetrahydro-6H-1,3-thiazine-6-one derivatives, to a process for the preparation of same, and to their use as anxiolytic and antihypertensive agents.Type: GrantFiled: January 16, 1987Date of Patent: November 3, 1987Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Maurice W. Gittos, Marcel Hibert
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Patent number: 4687845Abstract: A method for the preparation of a thiazine derivative, having insecticidal properties, of the formula ##STR1## where each R is hydrogen or an appropriate aromatic or aliphatic substituent and X is hydrogen, halogen or lower alkyl, the method comprising reacting together a sulphur donor, a compound of the formula Y.sub.2 C.dbd.CXNO.sub.2 where Y is halogen (preferably chlorine) or another appropriate leaving group and a compound of the formulaH.sub.2 NCR.sub.2 CR.sub.2 CR.sub.2 OSO.sub.3 H.Type: GrantFiled: January 13, 1986Date of Patent: August 18, 1987Assignee: Fine Organics LimitedInventors: John Hollowood, Arthur Jackson, Graham Heyes
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Patent number: 4681874Abstract: Novel thiazinephosphonic acid derivatives (I): ##STR1## wherein R.sup.1 and R.sup.2 each is lower alkoxy, lower alkynyloxy, lower alkylthio, arylthio (e.g., monocyclic aromatic group), or lower alkylamino; R.sup.3 and R.sup.4 each is hydrogen or lower alkyl; R.sup.5, R.sup.6, and R.sup.7 each is hydrogen, lower alyl, lower alkoxy, halogen, or trifluoromethyl; and X is oxygen or sulfur, are disclosed. A method for the production thereof, and pesticides comprising said compounds (I) are provided.Type: GrantFiled: September 6, 1985Date of Patent: July 21, 1987Assignee: Shionogi & Co., Ltd.Inventors: Yoshio Hayase, Mitsuhiro Ichinari, Junji Taguchi, Takeo Ishiguro, Toshio Takahashi
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Patent number: 4666902Abstract: Tetrahydropyridazinones of the formula I ##STR1## wherein R denotes an optionally substituted carbocyclic or heterocyclic radical, R.sup.1 denotes hydrogen; alkyl; aralkyl, which is optionally substituted in the aryl part; or acyl, and R.sup.2 denotes hydrogen; alkyl, which can optionally be substituted; or optionally substituted phenyl; and their acid addition compounds, if these can be prepared.The tetrahydropyridazinone derivatives of the formula I according to the invention and their physiologically acceptable salts exhibit useful pharmacological actions.Type: GrantFiled: June 8, 1984Date of Patent: May 19, 1987Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Melitta Just, Piero Martorana, Helmut Bohn, Rolf-Eberhard Nitz
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Patent number: 4659734Abstract: A compound of the formula ##STR1## R.sub.1 is hydrogen, alkali metal, alkaline earth metal, lower alkyl, pivaloyloxymethyl or phthalidyl;R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are hydrogen, halogen, lower alkoxy or ##STR2## wherein R.sub.6 and R.sub.7 are lower alkyl or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are attached form a five- to seven-membered unsubstituted or substituted heterocyclic ring containing said nitrogen atom as the sole hetero atom or containing nitrogen, sulfur or oxygen as additional hetereo atoms;A is a saturated or unsaturated hydrocarbon chain of one to five carbon atoms, unsubstituted or substituted by lower alkyl; lower alkoxy; lower alkylthio; hydroxy; halogen; lower alkyl substituted by halogen, amino, loweralkoxycarbonyl, carboxy, lower-alkoxy, loweralkylthio, loweracyloxy or hydroxy; loweralkylamino; carboxy; nitro; cyano; carbonyl; imino; or by substituted or unsubstituted phenyl, phenylthio, phenylamino or phenoxy; andR.Type: GrantFiled: August 15, 1983Date of Patent: April 21, 1987Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiroshi Enomoto, Masahiro Kise, Masakuni Ozaki, Masahiko Kitano, Iwao Morita
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Patent number: 4654339Abstract: Novel 3-amino-tetrahydro-1,3-thiazine-2,4-diones as well as skin treating compositions on the basis of a physiologically compatible carrier and customary additions containing these novel 3-amino-tetrahydro-1,3-thiazin-2,4-dione derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily on the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a strengthening of the skin protection, in particular against sun rays, cold and the contact with harmful environmental substances of all kinds. Moreover, the skin treating compositions are suitable for prophylactically fighting the so-called ageing of skin.Type: GrantFiled: October 9, 1984Date of Patent: March 31, 1987Assignee: Wella AktiengesellschaftInventors: Wolfgang Hanefeld, Rudi Rothlisberger, Friedrich Noser
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Patent number: 4652649Abstract: A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## wherein the substituents are defined hereinbelow.Type: GrantFiled: February 20, 1985Date of Patent: March 24, 1987Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
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Patent number: 4647557Abstract: This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds.More particularly this invention provides novel heterocyclic compounds the hetero ring of which has two hetero atoms, the same or different, substituted with a free or substituted amino group.These compounds are useful as active ingredients of drugs.Type: GrantFiled: December 23, 1983Date of Patent: March 3, 1987Inventors: Gerard Moinet, Michel Schaeffer, Pierre Bessin, Jacqueline Bonnet
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Patent number: 4643997Abstract: New 3-carbamoyl- and 3-thiocarbamoyl-tetrahydro-1,3-thiazine-2-thiones are disclosed as skin treatment compositions based upon physiologically-compatible carriers and a content of these compounds as active substance for increasing the skin protection, in particular against sun radiation and contact with environmental substances of all types. The skin treatment compositions are also suitable for prophylactic control of so-called aging skin. The compositions are applied to the skin one or two times daily for about 3-4 weeks.Type: GrantFiled: January 24, 1985Date of Patent: February 17, 1987Assignee: Wella AktiengesellschaftInventors: Wolfgang Hanefeld, Rudi Rothlisberger, Friedrich Noser
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Patent number: 4638064Abstract: Unsaturated heterocyclic carbonyl-containing compounds, such as 2-oxathiolone, are prepared by the oxylation of saturated heterocyclic carbonyl-containing precursors of the above compounds in a C.sub.1-4 alcohol or carboxylic acid solvent in the presence of a supporting electrolyte followed by dehydroxylation of the oxylated intermediate.The products formed may be polymerized or copolymerized with other ethylenically unsaturated monomers to prepared resins, films, etc. or they may be employed as reaction intermediates.Type: GrantFiled: April 1, 1985Date of Patent: January 20, 1987Assignee: The Dow Chemical CompanyInventors: Pen-Chung Wang, James M. Renga
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Patent number: 4625025Abstract: Disclosed is a process for producing a heterocyclic compound having a nitromethylene group as the side chain, of the formula ##STR1## wherein Y represents a hydrogen atom, a halogen atom or a lower alkyl group, R represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aralkyl group, an alkenyl group, an alkynyl group or an acyl group, and n represents an integer of 2, 3 or 4,which comprises reacting a 2,2,2-trihalo-1-nitroethane compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.Type: GrantFiled: August 10, 1984Date of Patent: November 25, 1986Assignee: Ube Industries, Ltd.Inventors: Fumio Iwata, Katsumasa Harada, Ryoji Sugise
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Patent number: 4617295Abstract: Oxime N-alkyl-N-.alpha.-(alkylthio-phosphorothio)acyl carbamates represented the structure: ##STR1## wherein the R represents various imino radicals, Q is oxygen or sulfur and the numbered R groups represent various alkyl substituents, which exhibit superior insecticidal and miticidal activity.Type: GrantFiled: October 3, 1985Date of Patent: October 14, 1986Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4616019Abstract: Naphthyridine compounds having the formula: ##STR1## wherein Z is an amine or an aliphatic heterocyclic group, R is a phenyl group or an aromatic heterocyclic group and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity.Type: GrantFiled: October 4, 1985Date of Patent: October 7, 1986Assignee: Abbott LaboratoriesInventor: Daniel T. Chu
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Patent number: 4602940Abstract: This invention relates to ortho-heterocyclic benzene sulfonylureas which are useful as herbicides and growth regulants.Type: GrantFiled: May 20, 1985Date of Patent: July 29, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: Anthony D. Wolf
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Patent number: 4595539Abstract: Certain 2-substituted-2-penem-3-carboxylic acid compounds and pharmaceutically-acceptable salts thereof can be prepared from the appropriate xanthate or trithiocarbonate by desulfurization and addition of an electrophilic sulfur compound followed by halogenation and ring closure. The corresponding desulfurized and halogenated olefinic intermediates are disclosed.Type: GrantFiled: June 10, 1983Date of Patent: June 17, 1986Assignee: Pfizer Inc.Inventor: Ernest S. Hamanaka
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Patent number: 4587048Abstract: The present invention relates to a novel process for the manufacture of 4-thioazetidinone compounds of the formula ##STR1## in which R.sub.1.sup.a represents an amino-protecting group and R.sub.1.sup.b represents hydrogen or an acyl radical Ac, or in which R.sub.1.sup.a and R.sub.1.sup.b together represent a bivalent acyl radical, R.sub.2.sup.A represents an etherified hydroxy group, R.sub.3 represents methyl, hydroxy, etherified or esterified hydroxy, cyano, tertiary amino or nitro, X represents hydrogen or halogen, and Y represents a group --SR.sub.4 or --SO.sub.2 --R.sub.5 in which R.sub.4 represents an optionally substituted heteroaryl radical or the acyl radical of an organic carboxylic or thiocarboxylic acid and R.sub.5 represents an optionally substituted hydrocarbon radical, or, when R.sub.3 represents hydroxy or methyl, tautomers thereof. Compounds of the formula I are manufactured by reacting compounds of the formula III with a nitrosating agent and a compound of the formula IV.Type: GrantFiled: April 20, 1984Date of Patent: May 6, 1986Assignee: Ciba-Geigy CorporationInventor: Gottfried Sedelmeier
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Patent number: 4587250Abstract: Novel thiazaspirane derivatives of the general formula ##STR1## including salts thereof with physiologically acceptable acids and bases, processes for their preparation and medicaments containing them.Type: GrantFiled: February 8, 1983Date of Patent: May 6, 1986Assignee: Luitpold-Werk Chemischpharmazeutische Fabrik GmbH & Co.Inventors: Rainer Klauser, Eike Meinetsberger, Klaus Bichlmayer
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Patent number: 4576749Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof).Type: GrantFiled: April 13, 1984Date of Patent: March 18, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Robert Zahler, William H. Koster, William A. Slusarchyk
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Patent number: 4555261Abstract: This invention relates to a novel class of sulfonamides and their use as herbicides and plant growth regulants.Type: GrantFiled: November 1, 1984Date of Patent: November 26, 1985Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wallace C. Petersen
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Patent number: 4532322Abstract: A method for the preparation of a thiazine derivative of the formula ##STR1## where each R is independently selected from hydrogen or a lower alkyl having 1 to 4 carbon atoms, the method comprising reacting together a sulphur donor which is selected from sulfur, ammonium or alkali metal sulfides, ammonium or alkali metal hydrosulfides, or hydrogen sulfide, 1,1-bis(methylthio)-2-nitroethene and a compound of the formulaH.sub.2 NCR.sub.2 CR.sub.2 CR.sub.2 OSO.sub.3 Hwhere each R is as defined above.A preferred method is for the preparation of tetra-2-(nitromethylene)-2H-1,3-thiazine which possesses broad spectrum insecticidal activity, and is also useful as an intermediate in the synthesis of other insecticides.Type: GrantFiled: May 23, 1984Date of Patent: July 30, 1985Assignee: Fine Organics LimitedInventors: Arthur Jackson, Graham Heyes
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Patent number: 4531002Abstract: A process for preparing insecticidal N-acyl-tetrahydro-2-nitromethylene-2H-1,3-thiazines, intermediates involved therein and certain of the products.Type: GrantFiled: August 17, 1984Date of Patent: July 23, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4529726Abstract: A 3-acyl-2-nitromethylene-tetrahydro-2H-1,3-thiazines of the general formula: ##STR1## in which R represents an optionally ring-substituted benzyl group; a cycloalkyl group optionally substituted by halogen and/or alkyl; or an alkyl, alkenyl or alkynyl group of 2 or more carbon atoms optionally substituted by one or more of the same or different substituents selected from halogen, optionally substituted phenyl, phthalimido, alkoxy, haloalkoxy, alkoxyalkoxy, hydroxy, thiol, cycloalkyl optionally substituted by halogen and/or alkyl, and groups of the formula--COR.sup.1, --X.CO.R.sup.1 or --CO.X.R.sup.Type: GrantFiled: February 8, 1984Date of Patent: July 16, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4525474Abstract: Insecticidal 2-(nitromethylene)-tetrahydro-2H-1,3-thiazines substituted on the nitrogen atom of the ring by a hydroxy- or formyloxy-substituted alkylsulfonyl moiety.Type: GrantFiled: September 14, 1984Date of Patent: June 25, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4521536Abstract: Substituted 2-nitromethylene-tetrahydro-2H-1,3-thiazines of formula: ##STR1## in which n is 0 or 1; m is 0 or 1; X is oxygen or sulphur; and R is alkyl, alkenyl or alkynyl optionally substituted by one or more of the same or different substituents selected from halogen atoms and hydroxy, thiol, acyloxy, acylthio, alkoxy, alkoxyalkoxy, haloalkoxy, and optionally substituted phenyl groups; have useful pesticidal properties.Type: GrantFiled: February 8, 1984Date of Patent: June 4, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4518597Abstract: This invention is directed to novel benzoxazin-2-ones of the formula ##STR1## wherein A is a sulfur atom or an SO, SO.sub.2, R--N.dbd.S, or R--N.dbd.SO.sub.2 group where R is a hydrogen atom or an acyl group;D is an alkylene group;R.sub.1 is an alkyl, phenylalkyl, cycloalkyl, or phenyl group;R.sub.4 is a hydrogen atom or an alkyl group;R.sub.5 is a hydrogen or halogen atom or a nitro or alkyl group; andR.sub.6 is a hydrogen or halogen atom or an alkyl group,having valuable pharmacological properties, particularly an antithrombotic activity. The compounds of Formula I may be prepared by the methods used for analogous compounds.Type: GrantFiled: June 6, 1984Date of Patent: May 21, 1985Assignee: Dr. Karl Thomae GmbHInventors: Berthold Narr, Josef Nickl, Erich Muller, Josef Roch, Walter Haarmann, Johannes-Maximilian Weisenberger
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Patent number: 4512988Abstract: Compounds of the formula ##STR1## and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.Type: GrantFiled: March 1, 1984Date of Patent: April 23, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Harold N. Weller, III, Eric M. Gordon, Donald S. Karanewsky, Denis E. Ryono
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Patent number: 4503222Abstract: Sulphenyl nitromethane derivatives of formula: ##STR1## in which R.sup.1 represents an alkyl group or a cycloalkyl-alkyl group; and R.sup.2 represents an alkyl group optionally substituted by one or more halogen atoms or an aryl group optionally substituted by one or more halogen atoms or by one or more alkyl or alkoxy groups, exhibit pesticidal, in particular insecticidal activity. They are prepared by reacting the corresponding nitromethylene carboxylate with a sulphenyl halide R.sup.2 --S--Hal in the presence of a base.Type: GrantFiled: January 17, 1984Date of Patent: March 5, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4501874Abstract: This invention is novel compounds containing one or more 2,3-epoxyalkyl carbamate moieties wherein the carbamate nitrogen is tertiary; prepared by a process which comprises(A) contacting an epihalohydrin carbonate with a secondary amine-containing compound wherein the secondary amine has a pKa of between 6 and 12, in a polar organic solvent under conditions such that a 3-halo-2-hydroxyalkyl carbamate wherein the carbamate nitrogen is tertiary is prepared; and(B) contacting the 3-halo-2-hydroxyalkyl carbamate with an alkali metal hydroxide, alkaline earth metal hydroxide, a secondary amine with a pH of 8 or grater, or an ion-exchange resin with pendant moieties containing hydroxide moieties or a secondary amine moiety with a pH of 8 or greater, in a lower alkanol solvent under conditions such that the 3-halo-2-hydroxy moieties are converted to 2,3-epoxyalkyl moieties so as to prepare a 2,3-epoxyalkyl carbamate.Type: GrantFiled: May 2, 1984Date of Patent: February 26, 1985Assignee: The Dow Chemical CompanyInventor: Joseph W. Hanafin
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Patent number: 4501742Abstract: 3-formyl-2-nitromethylene-2H-1,3-thiazine, and its use as a pesticide.Type: GrantFiled: February 8, 1984Date of Patent: February 26, 1985Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4495355Abstract: A novel optically active diamide derivative represented by the following general formula is provided, which is useful as a starting material for asymmetric synthesis of optically active compounds, ##STR1## wherein R.sup.1 is an acyclic or cyclic, divalent atomic group containing at least one carbon atom which will, upon substitution of one of the heterocyclic groups in the formula with a nucleophilic reagent, stand as an asymmetric center in the substitution product; R.sup.2 is a substituent which has such a configuration and a molecular size that the regioselectivity in the substitution reaction of the heterocyclic group with the nucleophilic reagent can be determined by a stereo-chemical interaction thereof with the substituent R.sup.1, the steric configuration of the two asymmetric carbon atoms to which the R.sup.2 substituents are attached being identical; X is a sulfur atom or an oxygen atom; and n is an integer which is 1 or 2.Type: GrantFiled: December 9, 1982Date of Patent: January 22, 1985Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Eiichi Fujita, Yoshimitsu Nagao, Takao Ikeda, Takehisa Inoue
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Patent number: 4486427Abstract: Insecticidal 2-(halonitromethylene)-tetrahydro-2H-1,3-thiazines substituted on the nitrogen atom of the ring by a sulfonyl moiety.Type: GrantFiled: March 17, 1983Date of Patent: December 4, 1984Assignee: Shell Oil CompanyInventors: Herbert Estreicher, Samuel B. Soloway
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Patent number: 4483856Abstract: Insecticidal 2-(nitromethylene)-tetrahydro-2H-1,3-thiazines substituted on the nitrogen atom of the ring by a sulfonyl moiety.Type: GrantFiled: March 24, 1983Date of Patent: November 20, 1984Assignee: Shell Oil CompanyInventors: Martin Harris, Derek A. Wood
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Patent number: 4482712Abstract: Substituted 1-thia-3-aza-4-ones having utility as plant fungicides, herbicides and terrestrial and aquatic plant growth regulators, together with methods for the use thereof and compositions containing the compounds.Type: GrantFiled: November 21, 1983Date of Patent: November 13, 1984Assignee: Eli Lilly and CompanyInventor: Eriks V. Krumkalns
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Patent number: 4460579Abstract: This invention is directed to compounds of the formula ##STR1## wherein X is a thiazine or thiazepine selected from ##STR2## These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.Type: GrantFiled: February 28, 1983Date of Patent: July 17, 1984Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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N-(Alkylsulfonyl)-L-proline amide and N-(alkylsulfonyl)-2-carboxylic acid amide-indoline derivatives
Patent number: 4438031Abstract: Disclosed herein are (lower)alkylsulfonyl derivatives of various proline amides, thiazolidine carboxylic acid amides and indoline-2-carboxylic acid amides, among others, which inhibit angiotensin converting enzyme and are antihypertensive agents.Type: GrantFiled: February 24, 1982Date of Patent: March 20, 1984Assignee: American Home Products CorporationInventors: Michael W. Winkley, Scott J. Childress -
Patent number: 4436739Abstract: Substituted 1-thia-3-aza-4-ones having utility as plant fungicides, herbicides and terrestrial and aquatic plant growth regulators, together with methods for the use thereof and compositions containing the compounds.Type: GrantFiled: December 4, 1981Date of Patent: March 13, 1984Assignee: Eli Lilly and CompanyInventor: Eriks V. Krumkalns
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Patent number: 4434288Abstract: This invention concerns a process for preparing 2-amino-1,5(6)-substituted-benzimidazole compounds by reacting a 1-unsubstituted-2-amino-5(6)-substituted-benzimidazole compound with a sulfonyl chloride or a haloalkyl isothiocyanate in the presence of an alkali metal hydroxide or carbonate, water, and a water-miscible nonhydroxylic solvent.Type: GrantFiled: April 8, 1982Date of Patent: February 28, 1984Assignee: Eli Lilly and CompanyInventor: James H. Wikel, II
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Patent number: 4420479Abstract: 1-Substituted-2-amino-5(or 6) olefinic benzimidazoles and intermediates therefor are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and a method of treating viral infections are provided.Type: GrantFiled: April 8, 1982Date of Patent: December 13, 1983Assignee: Eli Lilly and CompanyInventors: Tina M. Morwick, Charles J. Paget, James H. Wikel
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Patent number: 4414211Abstract: 5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.Type: GrantFiled: March 14, 1980Date of Patent: November 8, 1983Assignee: McNeilab, Inc.Inventor: Chris R. Rasmussen
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Patent number: 4407799Abstract: Compounds of 2-substituted-phenyl-1,3-perhydrothiazine-4-one having the formula (I) ##STR1## wherein R represents a lower alkyl group of 1 to 3 carbon atoms and n denotes an integer of 1 to 3 possess anti-peptic ulcer activity.Type: GrantFiled: October 7, 1981Date of Patent: October 4, 1983Assignee: Kureha Kagaku Kogyo Kabushiki KaishaInventors: Takao Kawasaki, Daisaku Immaru, Yoshiaki Osaka, Tadashi Tsuchiya, Saichi Ono
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Patent number: 4380633Abstract: Methine dyes from tetrahydroquinoline compounds containing N-thioether substituents, in general produce bright yellow shades when applied to polyester fabrics by conventional dyeing procedures, have improved properties such as dyeability, fastness to light, resistance to sublimation, insensitivity to pH changes, and dye at the boil and under pressure to the same depth of shade. These compounds are particularly useful in the thermal fixation technique for dyeing polyester materials.Type: GrantFiled: December 1, 1980Date of Patent: April 19, 1983Assignee: Eastman Kodak CompanyInventors: Clarence A. Coates, Jr., Max A. Weaver
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Patent number: 4369314Abstract: New oxacephalosporin derivative of the general formula: ##STR1## in which R.sub.1 is a protective radical, R.sub.2 is either a radical of the general formula: ##STR2## [in which R.sub.5 is hydrogen, alkyl, vinyl, protected carboxyalkyl or a protective radical and R.sub.6 is a protective radical] or an .alpha.-carboxyarylacetyl radical and R" is hydrogen or methoxy in the 7.alpha.-position, or alternatively R.sub.2 is a protective radical and R" is either hydrogen or methoxy in the 7.alpha.-position or hydrogen in the 7.beta.-position, and R.sub.3 and R.sub.4 are optionally substituted alkyl, or phenyl, or form a heterocyclic ring with the nitrogen atom, their E and Z forms and mixtures thereof and also their preparation.These new products are useful as intermediates for the preparation of biologically active oxacephalosporins.Type: GrantFiled: November 19, 1981Date of Patent: January 18, 1983Assignee: Rhone-Poulenc IndustriesInventors: Daniel Farge, Pierre L. Roy, Claude Moutonnier, Bernard Plau, Jean-Francois Peyronel