Additional Hetero Ring Containing Patents (Class 544/60)
  • Patent number: 6743794
    Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: June 1, 2004
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Jeffrey Daniel Cohen, Joseph Michael Gruber, Douglas Webb Johnson, Louis Nickolaus Jungheim, Julian Stanley Kroin, Peter Ambrose Lander, Ho-Shen Lin, Mark Christopher Lohman, Brian Stephen Muehl, Bryan Hurst Norman, Vinod Francis Patel, Michael Enrico Richett, Kenneth Jeff Thrasher, Sreenivasarao Vepachedu, Wesley Todd White, Yongping Xie, Jeremy Schulenburg York, Brandon Lee Parkhurst, Qiupang Wang
  • Patent number: 6743792
    Abstract: The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represents 0, 1, 2, 3 or 4; R1 represents hydrogen, C1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, mercapto, C1-6alkylthio, C3-7cycloalkyl, aryl or C1-6alkyl substituted with mono- or di(C1-6alkyl)-amino, C1-6alkyloxy, aryl or Het; R2 represents cyano or a radical of formula —C(═X)—Y—R5; wherein X represents O or S; Y represents O, S, NR6 or a direct bond; R5 represents hydrogen; C3-7cycloalkyl; aryl or optionally substituted C1-6alkyl; and where Y is a direct bond, R5 may also be halo or Het; R3 and R4 each independently represents halo, haloC1-6alkyl, C1-6alkyl, hydroxy, C1-6alkyloxy, C1-6alkylcarbonyloxy, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, C1-6alkylsulfinyl, haloC1-6alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di(C1-6alkyl)amino o
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: June 1, 2004
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eddy Jean Edgard Freyne, Gustaaf Maria Boeckx, Jean Pierre Frans Van Wauwe, Gaston Stanislas Marcella Diels
  • Patent number: 6743798
    Abstract: The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: June 1, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Achim Feurer, Cristina Alonso-Alija, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Elke Stahl
  • Patent number: 6743788
    Abstract: Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: June 1, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier Francesco Cirillo, Victor Kamhi, John Robinson Regan, Michele Tsang
  • Publication number: 20040102627
    Abstract: This invention relates to 3-amino piperadine derivatives, their intermediates and methods of manufacture.
    Type: Application
    Filed: November 20, 2003
    Publication date: May 27, 2004
    Applicant: Pfizer Inc.
    Inventor: David H.B. Ripin
  • Publication number: 20040102494
    Abstract: The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them.
    Type: Application
    Filed: July 3, 2003
    Publication date: May 27, 2004
    Applicants: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories Inc.
    Inventors: Natesan Selvakumar, Jagattaran Das, Sanjay Trehan, Javed Iqbal, Magadi Sitaram Kumar, Ramanujam Rajagopalan, Mamidi Naga Venkata Srinivasa Rao
  • Publication number: 20040102432
    Abstract: The invention provides compounds of formula (I): as modulators of chemokine and H1 receptor activity. The compounds are especially useful in the treatment of asthma and rhinitis.
    Type: Application
    Filed: February 13, 2003
    Publication date: May 27, 2004
    Inventors: Hitesh Sanganee, Brian Springthorpe
  • Patent number: 6740650
    Abstract: The invention provides compounds of formula I: wherein R1-R8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: May 25, 2004
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Leroy Fong Liu, Younong Yu
  • Publication number: 20040097731
    Abstract: Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNF&agr; and IL-1 mediated diseases such as rheumatoid arthritis and diseases of bone metabolism, e.g. osteoporosis.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 20, 2004
    Inventor: Laszlo Revesz
  • Publication number: 20040097497
    Abstract: The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases (“PKs”), in particular CDK2. The compounds of the present invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical composition containing these compounds and methods of preparing these compounds are also described.
    Type: Application
    Filed: August 27, 2003
    Publication date: May 20, 2004
    Applicant: Sugen, Inc.
    Inventors: Peng Cho Tang, Chung Chen Wei, Ping Huang, Jingrong Cui
  • Publication number: 20040097730
    Abstract: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein R2 is R3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C 1-4 alkyl, 4) C 3-7 cycloalkyl, 5) CF3, 6) OCF3, 7) C 1-4 alkoxy, and 8) cyano; and R12 is a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 1 heteroatom is N, and at most 1 of the heteroatoms is S, said ring being unsubstituted or substituted, at any one ring atom, with CH3.
    Type: Application
    Filed: August 1, 2003
    Publication date: May 20, 2004
    Inventors: Mary Beth Young, Philippe G. Nantermet, Harold G. Selnick, Peter D. Williams
  • Publication number: 20040097498
    Abstract: Novel imidazotrizinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.
    Type: Application
    Filed: February 6, 2003
    Publication date: May 20, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Thomas Lampe, Helmut Haning, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Publication number: 20040097729
    Abstract: Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as herbicides.
    Type: Application
    Filed: December 6, 2002
    Publication date: May 20, 2004
    Inventors: Andrew Edmunds, Alain De Mesmaeker, Christoph Luthy, Jurgen Schaetzer
  • Publication number: 20040097564
    Abstract: Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula I: 1
    Type: Application
    Filed: September 25, 2003
    Publication date: May 20, 2004
    Inventor: Martin Gall
  • Publication number: 20040097485
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
    Type: Application
    Filed: September 19, 2003
    Publication date: May 20, 2004
    Applicant: Tularik Inc.
    Inventors: Simon A. Burkitt, Mario G. Cardozo, Timothy D. Cushing, Michael R. DeGraffenreid, Christopher N. Farthing, Xiaolin Hao, Juan C. Jaen, Xian Yun Jiao, David J. Kopecky, Marc Labelle, Sarah E. Lively, Dustin L. McMinn, Sven P. Rasmussen, Youngsook Shin, Andrew Smith, Marie-Louise Smith
  • Publication number: 20040092518
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Application
    Filed: October 14, 2003
    Publication date: May 13, 2004
    Inventor: Shalini Sharma
  • Publication number: 20040092564
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 13, 2004
    Applicant: Wyeth
    Inventors: Ping Zhou, Michael Gerard Kelly
  • Publication number: 20040092505
    Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
    Type: Application
    Filed: April 14, 2003
    Publication date: May 13, 2004
    Inventors: Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
  • Publication number: 20040092517
    Abstract: Compounds of the formula (I) in which R1 is CN, or C(═NH)—NH2, CON(R3)2 or [C(R4)2]nN(R3)2, each of which is unsubstituted or monosubstituted by C(═O)R3, COOR3, or3 or by a conventional amino-protecting group, or W is —NR3CO—, —NR3COC(R4)2, NR3C(R4)2) or —C(R4)2NR3C(4)2—, X is —C(R3)2—, —[C(R3)2]2—, —C(R—3)2O— or —C(R3)2NR3, Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl, T is OR3, N(R3)2, N(R3)2CON(R3)2, a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic radical having from 1 to 4 N, O and/sor S atoms which is unsubstituted or monosubstituted, disubstituted or trisubstituted, or a phenyl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.
    Type: Application
    Filed: September 3, 2003
    Publication date: May 13, 2004
    Inventors: Werner Mederski, Horst Juraszyk, Dieter Dorsch, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes, Bertram Cezanne
  • Publication number: 20040087584
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 6, 2004
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard A. Schumacher, Allen T. Hopper, Ashok Tehim
  • Publication number: 20040087582
    Abstract: Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
    Type: Application
    Filed: December 18, 2003
    Publication date: May 6, 2004
    Inventors: Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Bertram Cezanne, Johannes Gleitz, Christopher Barnes
  • Publication number: 20040087789
    Abstract: The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.
    Type: Application
    Filed: June 27, 2003
    Publication date: May 6, 2004
    Inventors: Lilia M. Beauchamp, Thomas A. Krenitsky, James L. Kelley
  • Patent number: 6730681
    Abstract: A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: May 4, 2004
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Mark Stuart Chambers, Ian James Collins, Simon Charles Goodacre, David James Hallett, Philip Jones, Linda Elizabeth Keown, Robert James Maxey, Leslie Joseph Street
  • Publication number: 20040082563
    Abstract: Novel compounds of the formula (I) formula (I) in which W, E, X, Y, T, R1, R2, R2′, and R2″ are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.
    Type: Application
    Filed: September 16, 2003
    Publication date: April 29, 2004
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • Publication number: 20040082589
    Abstract: Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: 1
    Type: Application
    Filed: October 23, 2003
    Publication date: April 29, 2004
    Inventors: Carlo Farina, Stefania Gagliardi, Giuseppe Giardina, Mario Grugni, Marisa Martinelli, Guy Marguerite Marie Gerard
  • Publication number: 20040082780
    Abstract: Compounds having the general structure 1
    Type: Application
    Filed: August 8, 2003
    Publication date: April 29, 2004
    Inventors: Elizabeth M. Doherty, Jiawang Zhu, Markian Stec, Mark H. Norman, Hui-Ling Wang, Christopher H. Fotsch, Ning Chen, Partha P. Chakrabarti, Celia Dominguez, James Richard Falsey, Christopher Hulme, Jodie Katon, Thomas Nixey, Vassil I. Ognyanov, Liping H. Pettus, Robert Michael Rzasa
  • Publication number: 20040082577
    Abstract: Amino methyl imidazoles of Formula I are provided: 1
    Type: Application
    Filed: August 21, 2003
    Publication date: April 29, 2004
    Applicant: Neurogen Corporation
    Inventors: Andrew Thurkauf, He Zhao, Suoming Zhang, Yang Gao
  • Publication number: 20040082575
    Abstract: Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-&bgr; over ER-&agr;. Methods are disclosed for modulating ER-&bgr; in cell and/or tissues expressing the same, including cells and/or tissue that preferentially ER-&bgr;. Methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natureal hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.
    Type: Application
    Filed: May 7, 2003
    Publication date: April 29, 2004
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Shripad S. Bhagwat, Leah Marie Gayo-Fung, Bernd M. Stein, Qi Chao, Anthony R. Gangloff, Jeffrey A. McKie, Kenneth D. Rice
  • Publication number: 20040082562
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Application
    Filed: June 19, 2003
    Publication date: April 29, 2004
    Inventors: Henry H. Gu, T.G. Murali Dhar, Edwin J. Iwanowicz
  • Publication number: 20040082779
    Abstract: Provided are MC4-R binding compounds of the formula XVII: 1
    Type: Application
    Filed: June 16, 2003
    Publication date: April 29, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thomas H. Marsilje
  • Patent number: 6727360
    Abstract: The present invention relates to processes for the production of &agr;-aryl-&bgr;-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: April 27, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Philip Ma
  • Publication number: 20040077642
    Abstract: The present invention relates to new compounds of the formula (I) a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, as well as intermediates used in the preparation of said active compounds.
    Type: Application
    Filed: August 19, 2003
    Publication date: April 22, 2004
    Inventors: Stefan Berg, Sven Hellberg
  • Publication number: 20040077852
    Abstract: The invention relates to novel pyrrolidyl-substituted para-phenylenediamine derivatives, to dye compositions containing them and to the process for dyeing keratin fibers using these compositions.
    Type: Application
    Filed: July 7, 2003
    Publication date: April 22, 2004
    Inventors: Stephane Sabelle, Laure Ramos, Madeleine LeDuc
  • Publication number: 20040077851
    Abstract: Disclosed are cannabimimetic aminoalkylindole compounds and methos for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoinds. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual and to treat a condition in an animal or individual.
    Type: Application
    Filed: July 25, 2003
    Publication date: April 22, 2004
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Publication number: 20040077641
    Abstract: Novel pyridylpyrimidines of the formula 1
    Type: Application
    Filed: August 19, 2003
    Publication date: April 22, 2004
    Inventors: Thomas Bretschneider, Mazen Es-Sayed, Rudiger Fischer, Fritz Maurer, Christoph Erdelen, Peter Losel
  • Publication number: 20040077626
    Abstract: The present invention describes difluororthioacetamide oxazolidinones as novel antibacterial agents, and antimicrobial combination therapies for combating infective diseases caused by gram-positive and gram-negative bacteria.
    Type: Application
    Filed: June 16, 2003
    Publication date: April 22, 2004
    Inventors: Jackson Boling Hester, Wade J. Adams, Jeffrey Charles Stevens, Mikhail Fedor Gordeev, Upinder Singh, Carole Scott
  • Publication number: 20040077853
    Abstract: The invention provides compounds of formula VI 1
    Type: Application
    Filed: February 18, 2003
    Publication date: April 22, 2004
    Applicant: Pfizer Inc.
    Inventors: John A. Lowe, Robert A. Volkmann
  • Publication number: 20040077854
    Abstract: The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble. Said compounds are notably for use as pharmaceutically active compounds. The present invention also related to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation.
    Type: Application
    Filed: October 10, 2003
    Publication date: April 22, 2004
    Inventors: Serge Halazy, Dennis Church, Stephen J. Arkinstall, Marco Biamonte, Montserrat Camps, Jean-Pierre Gotteland, Thomas Rueckle
  • Publication number: 20040072850
    Abstract: The present invention relates to compounds of formula I: 1
    Type: Application
    Filed: June 27, 2003
    Publication date: April 15, 2004
    Inventors: Ronald Knegtel, Michael Mortimore, John Studley, David Millan
  • Publication number: 20040072840
    Abstract: The invention relates to the compounds of formula: 1
    Type: Application
    Filed: September 16, 2003
    Publication date: April 15, 2004
    Inventors: Jean-Philippe Ducoux, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto
  • Publication number: 20040072827
    Abstract: A 5-membered cyclic compound of the formula: 1
    Type: Application
    Filed: December 30, 2002
    Publication date: April 15, 2004
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Publication number: 20040072833
    Abstract: Tri-heterocyclic compound of formula (I) 1
    Type: Application
    Filed: June 30, 2003
    Publication date: April 15, 2004
    Inventors: Hisao Nakai, Yoshifumi Kagashimi
  • Publication number: 20040072837
    Abstract: The present invention relates to pharmaceutically active ornithine compounds, particularly to pharmaceutically acceptable ammonium salts of N&dgr;-acyl derivatives of N&agr;(4-amino-4-deoxypteroyl)-L-omithine compounds; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such ammonium salts. The ammonium salts provided by the invention exhibit superior chemical stability than corresponding acidic N&dgr;-acyl derivatives of N&dgr;-acyl derivatives of N&agr;(4-amino-4-deoxypteroyl)-L-ornithine compounds.
    Type: Application
    Filed: April 14, 2003
    Publication date: April 15, 2004
    Inventors: Andre Rosowsky, Henry Bader, Peter Blumbergs, Ming-Teh Lin
  • Publication number: 20040072828
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Application
    Filed: September 17, 2003
    Publication date: April 15, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Stephen J. O'Connor, Gaetan H. Ladouceur, William H. Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia N. Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek B. Lowe, Steven R. Magnuson, Ning Qi, Tatiana E. Shelekhin, Quanrong Shen, Roger A. Smith, Ming Wang
  • Patent number: 6720317
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: April 13, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Bing-Yan Zhu, Zhaozhong Jon Jia, Wenrong Huang, Yonghong Song, James Kanter, Robert M. Scarborough
  • Publication number: 20040067939
    Abstract: The present invention provides glucokinase activators of formula I: 1
    Type: Application
    Filed: September 30, 2003
    Publication date: April 8, 2004
    Inventor: Wendy Lea Corbett
  • Publication number: 20040067980
    Abstract: The present invention relates to compounds of the formula I, 1
    Type: Application
    Filed: June 4, 2003
    Publication date: April 8, 2004
    Inventors: Otmar Klingler, Melitta Just, Kuniya Sakurai, Naoyuki Fukuchi
  • Publication number: 20040063691
    Abstract: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
    Type: Application
    Filed: September 24, 2002
    Publication date: April 1, 2004
    Inventors: Roger A. Smith, Stephen J. O'Connor, Stephan-Nicholas Wirtz, Wai C. Wong, Soongyu Choi, Harold C.E. Kluender, Ning Su, Gan Wang, Furahi Achebe, Shihong Ying
  • Publication number: 20040063699
    Abstract: A novel GPR14 antagonist. The GPR14 antagonist comprises a compound represented by the formula (I) or a salt thereof wherein Ar represents optionally substituted aryl; X represents a spacer; n is an integer of 1 to 10; R represents an optionally substituted hydrocarbon group, etc., provided that R may be bonded to Ar, etc. to form a ring; and Y represents optionally substituted amino, etc.
    Type: Application
    Filed: January 2, 2003
    Publication date: April 1, 2004
    Inventors: Naoki Tarui, Takashi Santo, Hiroyuki Watanabe, Kazuyoshi Aso, Yuji Ishihara
  • Publication number: 20040063939
    Abstract: The invention relates to a process for preparing hydroxyindolylglyoxylamides in high yields and particularly pure form.
    Type: Application
    Filed: July 31, 2003
    Publication date: April 1, 2004
    Inventors: Hans-Joachim Jansch, Helge Hartenhauer, Hans Stange, Norbert Hofgen, Jurgen Schafer