Plural Nitrogens In The Six-membered Hetero Ring (e.g., Thiatriazines, Etc.) Patents (Class 544/7)
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Patent number: 8957211Abstract: The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.Type: GrantFiled: October 8, 2013Date of Patent: February 17, 2015Assignee: SanofiInventors: Marco Baroni, Francoise Bono, Sandrine Delbary-Gossart, Valentina Vercesi
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Patent number: 8716250Abstract: A pharmaceutical preparation treats Friedreich's ataxia and treats or prevents pathologies related thereto. In particular, the pharaceutical preparation concerns the use of diazoxide or 7-chloro-3-methyl-4H-1,2,4 benzothiadiazine 1,1-dioxide, in combination with glucose and/or leucine, for the treatment of Friedreich's ataxia (FRDA) and for the treatment or prevention of pathologies related thereto.Type: GrantFiled: July 29, 2009Date of Patent: May 6, 2014Assignee: Universita' Degli Studi di BariInventors: Carlo Marya Thomas Marobbio, Luigi Palmeri, Ferdinando Palmeri, Antonella Santoro
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Patent number: 8633315Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1a, R1b, R1c, B, W, R3, R4 and R5 are defined herein. In another embodiment, the invention provides compounds of general Formula II wherein A1, A2, A3, A4, R1a, R1b, R1c, R2, R4, R5, W, X and Z are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.Type: GrantFiled: March 22, 2012Date of Patent: January 21, 2014Assignee: Amgen Inc.Inventors: Wenge Zhong, Stephen Hitchcock, Patel F. Vinod, Michael Croghan, Bryant Yang
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Patent number: 8512755Abstract: A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.Type: GrantFiled: August 15, 2011Date of Patent: August 20, 2013Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Igor L. Medintz, Kimihiro Susumu, Michael H. Stewart
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Patent number: 8232271Abstract: Compounds having the formula I wherein R1, R2, R3a, R3b, R3c, R4, R5 and p are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.Type: GrantFiled: October 30, 2009Date of Patent: July 31, 2012Assignee: Roche Palo Alto LLCInventors: Jim Li, Alfred Sui-Ting Lui, Kristen Lynn McCaleb, Francisco Xavier Talamas
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Patent number: 7494990Abstract: The compounds of a certain formula (1), in which R1, R2, R3 and R9 have the meanings as given in the description, are novel effective PDE4 inhibitors.Type: GrantFiled: February 1, 2005Date of Patent: February 24, 2009Assignee: NYCOMED GmbHInventors: Wiro M. P. B. Menge, Geert Jan Sterk
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Patent number: 7371743Abstract: The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.Type: GrantFiled: February 11, 2005Date of Patent: May 13, 2008Assignee: Boehringer Ingelheim International GmbHInventors: Henning Priepke, Kai Gerlach, Roland Pfau, Norbert Hauel, Iris Kauffmann-Hefner, Georg Dahmann, Herbert Nar, Sandra Handschuh, Wolfgang Wienen, Annette Schuler-Metz
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Patent number: 7077899Abstract: A pigment dispersing agent of the formula (1) capable of providing a printing ink or a coating composition excellent in fluidity and dispersion stability and a dry coating excellent in gloss, a pigment composition containing the same and a pigment dispersion containing the same, wherein X1 is —NH—, —O—, —CONH—, —SO2NH—, —CH2NH—, —CH2NHCOCH2NH— or —X3—Y—X4—, X2 and X4 are —NH— or —O—, X3 is —CONH—, —SO2NH—, —CH2NH—, —NHCO— or —NHSO2—, Y is an alkylene group, an alkenylene group or an arylene group, Z is —SO3M or —COOM, R1 is a heterocyclic ring residue or an aromatic ring residue, Q is —O—R2, —NH—R2, a halogen group, —X1—R1 or —X2—Y-Z, R2 is a hydrogen atom, an alkyl group or an alkenyl group, and M is one equivalent of a monovalent to trivalent cation.Type: GrantFiled: January 14, 2004Date of Patent: July 18, 2006Assignee: Toyo Ink Mfg. Co. Ltd.Inventors: Takashi Kamikubo, Daisuke Tanabe, Tetsuya Sai
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Patent number: 6867298Abstract: The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.Type: GrantFiled: May 8, 2003Date of Patent: March 15, 2005Assignee: Massachusetts Institute of TechnologyInventors: Stephen L. Buchwald, Artis Klapars, Jon C. Antilla, Gabriel E. Job, Martina Wolter, Fuk Y. Kwong, Gero Nordmann, Edward J. Hennessy
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Publication number: 20040067937Abstract: The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH2, and R2 and R3 form; together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.Type: ApplicationFiled: October 23, 2003Publication date: April 8, 2004Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
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Patent number: 6683028Abstract: The invention relates to novel guanidine derivatives of the formula (I) in which A, R1, R2, R3 and Z are as defined in the description, to a process for their preparation and to their use for controlling animal pests.Type: GrantFiled: August 17, 2001Date of Patent: January 27, 2004Assignee: Bayer AktiengesellschaftInventors: Klaus Wagner, Christoph Erdelen, Andreas Turberg, Norbert Mencke, Olaf Hansen
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Publication number: 20030166928Abstract: The present invention relates to spiroazacyclic compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease condition associated with a monoamine receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.Type: ApplicationFiled: December 23, 2002Publication date: September 4, 2003Inventor: Nathalie Schlienger
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Patent number: 6531539Abstract: The invention is directed to organosilicon compounds of the general formula prepared by reacting triazine compounds with functional groups (e.g., chlorine) and corresponding compounds (e.g., mercapto). The organosilicon compounds can be used in rubber mixtures.Type: GrantFiled: April 5, 2001Date of Patent: March 11, 2003Assignee: Degussa AGInventors: Roland Krafczyk, Rudolf Michel, Jörg Münzenberg, Hans-Detlef Luginsland
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Patent number: 6362134Abstract: Compounds of formula (I), in which R1, R2 and R3 are as defined in claim 1, are particularly suitable as herbicides.Type: GrantFiled: July 1, 1998Date of Patent: March 26, 2002Assignee: Syngenta Investment CorporationInventors: Helmut Zondler, André Stoller
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Patent number: 6268308Abstract: Compounds of formula (I) in which Qi is an unsaturated five-membered optionally substituted or condensed heterocyclic ring and X is O, S, SO or SO2, and agronomically tolerated salts/N-oxides/isomers/enantiomers of these compounds are suitable as herbicidesType: GrantFiled: December 17, 1999Date of Patent: July 31, 2001Assignee: Syngenta Crop Protection, Inc.Inventors: André Stoller, Walter Kunz, Helmut Zondler, Christoph Lüthy, Jean Wenger
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Patent number: 5571773Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.Type: GrantFiled: June 2, 1995Date of Patent: November 5, 1996Assignee: American Cyanamid CompanyInventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
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Patent number: 5283355Abstract: Compounds of the Formula (5) and processes for their preparation and use, particularly in the manufacture of unsymmetrical triphenodioxazine dyes: ##STR1## wherein: Y is H, alkyl, substituted alkyl, alkoxy, Cl or Br;R is a group of Formula (3) ##STR2## R.sup.1 and R.sup.2 are each independently alkyl, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form an optionally substituted 4, 5 or 6 membered alicyclic or heterocyclic ring;R.sup.3 is H;Z is Cl, Br or A--NH; andA is H or the residue of a primary amine.Type: GrantFiled: October 22, 1991Date of Patent: February 1, 1994Assignee: Imperial Chemical Industries PLCInventor: William J. E. Norris
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Patent number: 5281585Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.Type: GrantFiled: November 6, 1992Date of Patent: January 25, 1994Assignee: Merck & Co., Inc.Inventors: Mark E. Duggan, Melissa S. Egbertson, Nathan Ihle, George D. Hartman, Laura M. Turchi, William F. Hoffman
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Patent number: 5167674Abstract: An improved superabrasive composition for grinding applications comprising a superabrasive material, a bismaleimide-triazine addition copolymer resin which as a cured polymer exhibits (i) a glass transition temperature (Tg) of at least about 280.degree. C. and (ii) a long term thermal resistance of at least about 180.degree. C., a free radical generating initiator, and preferably a catalyst, is disclosed. The superabrasive abrasive composition is particularly useful as a cutting edge in a high performance cutting wheel.Type: GrantFiled: April 13, 1992Date of Patent: December 1, 1992Assignee: Norton CompanyInventor: Prasad V. Ika
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Patent number: 5158959Abstract: What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.Type: GrantFiled: December 27, 1983Date of Patent: October 27, 1992Assignee: Hoechst AktiengesellschaftInventors: Rolf Geiger, Volker Teetz, Hansjorg Urbach, Bernward Scholkens, Rainer Henning
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Patent number: 4952289Abstract: Methods and apparatus for electrochemical extraction of a ligand such as molecular oxygen from a first fluid environment and for release of a ligand such as molecular oxygen, as well as ligand carrier compounds therefor comprising macrocyclic amines having the general formulas: ##STR1## where: A, B, C, D, E, and F are each nitrogen, oxygen, sulfur, or phosphorous;m, n, o, p, q, and r are each typically 2, 3, 4, 5, or 6;the R substituents are each generally H or short chain (linear or branched) alkyl, although R.sub.2 may represent ketyl (.dbd.o); andM is a suitable transition metal ion.Type: GrantFiled: May 9, 1988Date of Patent: August 28, 1990Assignee: Aquanautics CorporationInventors: Joseph P. Ciccone, Emory S. DeCastro, John B. Kerr
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Patent number: 4816583Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.Type: GrantFiled: December 9, 1987Date of Patent: March 28, 1989Assignee: Rorer Pharmaceutical CorporationInventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson, Robert A. Galemmo, Jr., Pamela J. Durham
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Patent number: 4762550Abstract: This invention relates to novel pyrazolesulfonamides, agricultural compositions thereof and the methods of their use as general and/or selective herbicides and/or plant growth regulants.Type: GrantFiled: August 13, 1987Date of Patent: August 9, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Stephen L. Hartzell
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Patent number: 4742055Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including anti-ulcerogenic and gastrointestinal cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.Type: GrantFiled: April 27, 1984Date of Patent: May 3, 1988Assignee: Rorer Pharmaceutical CorporationInventors: William L. Studt, Donald E. Kuhla, Henry F. Campbell, Stuart A. Dodson
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Patent number: 4741765Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: April 3, 1987Date of Patent: May 3, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
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Patent number: 4740231Abstract: 1-Aryl-5-alkoximinoalkylamino-pyrazoles of the formula ##STR1## in which R represents cyano or nitro, or represents an optionally substituted heterocyclic radical,R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen or alkyl, or represents optionally substituted aryl,R.sup.3 represents hydrogen, alkyl or alkenyl, or represents in each case optionally substituted aralkyl or aryl andAr represents optionally substituted phenyl or pyridyl,are active as herbicides and plant growth regulants. Compounds of the formula ##STR2## in which R" has the same definition as R other than cyano, are also active and useful as intermediates as well.Type: GrantFiled: May 22, 1986Date of Patent: April 26, 1988Assignee: Bayer AktiengesellschaftInventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
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Patent number: 4737184Abstract: Novel N-(heterocyclicaminocarbonyl) substituted thiophene-, furan- and pyrrolesulfonamides, such as N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno- [3,2-b]thiopyran-3-sulfonamide, 4,4-dioxide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno[3,2-b ]thiopyran-3-sulfonamide, 4,4-dioxide and their method-of-use as herbicides are described.Type: GrantFiled: May 10, 1985Date of Patent: April 12, 1988Assignee: E. I. Du Pont De Nemours and CompanyInventor: Robert J. Pasteris
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Patent number: 4725305Abstract: Herbicidally active novel N,N'-bis-sulphonyl guanidines of the formula ##STR1## in which M is hydrogen, a metal or an ammonium radical, andR.sup.4, R.sup.5, R.sup.40 and R.sup.41 are various organic radicals.Type: GrantFiled: November 14, 1986Date of Patent: February 16, 1988Assignee: Bayer AktiengesellschaftInventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen, Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Uwe Priesnitz, Wolfgang Roy, Hans-Joachim Santel
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Patent number: 4723988Abstract: Thiophenesulfonamides such as N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-3-(isoxazol-3-yl)-2-thiophen esulfonamide are useful as herbicides and plant growth regulants.Type: GrantFiled: March 27, 1987Date of Patent: February 9, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Rafael Shapiro
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Patent number: 4718937Abstract: The compounds of the general formula (I) ##STR1## in which X denotes O or --SO.sub.2 --, Y denotes CH or N, R.sub.1 denotes alkyl, alkenyl or (C.sub.2 -C.sub.6)-alkinyl which are optionally substituted, R.sub.2 denotes alkyl, alkenyl, alkinyl or cyclohexyl, R.sub.3 and R.sub.4 denote H or alkyl, and R.sub.5 and R.sub.6 denote H, (substituted) alkyl, (substituted) alkoxy, halogen, alkylthio, monoalkylamino or dialkylamino, and also salts thereof, possess advantageous herbicidal properties against monocotyledonous and dicotyledonous weeds and are suitable for selective use in large-scale crops. In addition, they possess a good plant growth-regulating action.Type: GrantFiled: April 9, 1986Date of Patent: January 12, 1988Assignee: Hoechst AktiengesellschaftInventors: Lothar Willms, Hilmar Mildenberger, Klaus Bauer, Helmut Burstell
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Patent number: 4704388Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.Type: GrantFiled: December 2, 1985Date of Patent: November 3, 1987Assignee: Rorer Pharmaceutical CorporationInventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson
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Patent number: 4689414Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;R.sub.5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, ##STR2## Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl-(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR3## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR4## amino, or substituted amino; m is 0 or an integer of 1 to 6;n is an integer of 1 to 6; andp is an integer of 2 to 6.Type: GrantFiled: February 24, 1986Date of Patent: August 25, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4684656Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR2## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR3## Y.sub.3 is hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.Type: GrantFiled: March 14, 1986Date of Patent: August 4, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4683228Abstract: A guanidine derivative of the formula I: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.Type: GrantFiled: January 22, 1985Date of Patent: July 28, 1987Assignees: ICI Americas Inc., Imperial Chemical Industries PLCInventors: Karin M. Kirkland, Derrick M. Mant
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Patent number: 4678499Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]-pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: January 30, 1986Date of Patent: July 7, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
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Patent number: 4668279Abstract: Novel pyridinesulfonamide compounds containing ortho-heterocyclic substituents such as N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(1H-1,2,4-triazol-1-yl)-3 -pyridinesulfonamide display utility as herbicides and plant growth regulants.Type: GrantFiled: April 22, 1985Date of Patent: May 26, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Morris P. Rorer
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Patent number: 4650893Abstract: BIS-Imido carbonate sulphones of the formula: ##STR1## in which R represents phenyl which is unsubstituted or substituted by one or two substituents, which is the same or different, selected from methyl, trifluoromethyl, nitro and cyano groups, and chlorine, flourine and bromine atoms, and p represents the integer 1, are produced by reacting a compound of formula VI ##STR2## in which R is as defined above, with thionyl chloride in the presence of an organic base. The compounds of formula II are useful in the production of 1, 2, 4, 6-thiatriazines.Type: GrantFiled: July 10, 1985Date of Patent: March 17, 1987Assignee: Hoechst UK LimitedInventors: Jeffrey D. Michael, Barry C. Ross
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Patent number: 4595683Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.Type: GrantFiled: October 23, 1984Date of Patent: June 17, 1986Assignee: William H. Rorer, Inc.Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson
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Patent number: 4585472Abstract: 1,2,4,6-Thiatriazine 1,1-dioxide ethers of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, Y, Z and n have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: May 6, 1985Date of Patent: April 29, 1986Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Bruno Wuerzer
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Patent number: 4563452Abstract: This invention relates to new derivatives of oxazinobenzothiazine-6,6-dioxide, to a process for the production thereof and to the use thereof as medicaments.The new derivatives according to the present invention correspond to the general formula I: ##STR1## wherein: R represents a linear or branched lower C.sub.1 -C.sub.4 alkyl radical, in particular the methyl and ethyl radicals,X represents an oxygen atom or a sulphur atom, andHet represents a mono- or bicyclic unsaturated heterocycle containing a nitrogen heteroatom in the ortho position relative to the link between the said heterocycle and the nitrogen atom of the oxazine ring, the said heterocycle optionally containing one or two other additional heteroatoms selected from nitrogen, oxygen and sulphur, and also being able to be substituted by one or two methyl radicals.Type: GrantFiled: June 8, 1983Date of Patent: January 7, 1986Assignee: Provesan S.A.Inventor: Jose Esteve Soler
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Patent number: 4522763Abstract: Novel N-alkoxycarbonyl- and N-alkoxythiocarbonyl-amidines and a process for the preparation of alkoxycarbonyl- and alkoxythiocarbonyl- amidines by reacting an amidine with an ester of chlorocarbonic acid or chlorothiocarbonic acid in the presence of an inorganic acid acceptor and a 2-phase aqueous/organic solvent mixture at from 0.degree. to 60.degree.0 C.The novel end products which can be prepared by this process are useful starting materials for crop protection agents, and can be used in particular for the preparation of novel, selective herbicides.Type: GrantFiled: July 14, 1982Date of Patent: June 11, 1985Assignee: BASF AktiengesellschaftInventor: Gerhard Hamprecht
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Patent number: 4497810Abstract: There are disclosed novel 1,2,4,6-thiatriazine-1,1-dioxides and related compounds which are connected to a substituted phenyl or heterocyclic group through a linear or cyclic connecting group. Processes are provided for the preparation of such compounds. The compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.Type: GrantFiled: October 14, 1983Date of Patent: February 5, 1985Assignee: Merck & Co., Inc.Inventor: Jacob M. Hoffman, Jr.
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Patent number: 4472191Abstract: 1,2,4,6-Thiatriazine-1,1-dioxides of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, Y and n have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: October 22, 1982Date of Patent: September 18, 1984Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Rolf-Dieter Acker, Hubert Sauter, Hans Theobald, Bruno Wuerzer
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Patent number: 4428766Abstract: 2H-1,2,4,6-Thiatriazine-1,1-dioxides of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and Y have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: August 24, 1982Date of Patent: January 31, 1984Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Adolf Parg, Bruno Wuerzer
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Patent number: 4426219Abstract: 2H-1,2,4,6-thiatriazine-1,1-dioxides of the formula I ##STR1## where R.sup.1, R.sup.2 and Hal have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: August 23, 1982Date of Patent: January 17, 1984Assignee: BASF AktiengesellschaftInventors: Berhard Hamprecht, Bruno Wuerzer
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Patent number: 4425152Abstract: 2H-1,2,4,6-Thiatriazin-3-one,1,1-dioxides of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: August 23, 1982Date of Patent: January 10, 1984Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Rolf-Dieter Acker, Bruno Wuerzer
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Patent number: 4397849Abstract: This invention relates to novel benzothiazine derivatives having therapeutic effect on autoimmune diseases, to processes for preparation of such derivatives, and to pharmaceutical compositions containing such derivatives, the derivatives having the formula: ##STR1## wherein R.sup.1 is lower alkyl which may have one or more substituents selected from carboxy, aryl and carboxy(lower)cycloalkyl; aryl which may have one or more substituents selected from halogen, lower alkyl, halo(lower)alkyl and lower alkoxy; haloarylamino; or heterocyclic group;R.sup.2 is hydrogen, lower alkyl, lower alkylamino(lower)alkyl, aryl or ar(lower)alkyl;R.sup.3 is hydrogen, halogen, lower alkyl or lower alkoxy; andn is an integer 0 to 2.Type: GrantFiled: December 11, 1981Date of Patent: August 9, 1983Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Tsutomu Teraji, Teruo Oku, Youichi Shiokawa
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Patent number: 4356024Abstract: A process for the preparation of a 1-amino-1,3,5-triazine-2,4(1H, 3H)-dione compounds comprising the steps of reacting an N-substituted imido-dicarboxylic acid diaryl ester with an isothiosemicarbazone at a temperature of between 50.degree. and 150.degree. C. to form a 1-alkylidene-amino-1,3,5-triazine-2,4(1H, 3H)-dione reaction product; and thereafter, hydrolyzing the reaction product in an acid medium. The reaction product need not be separated from the reaction mixture before the hydrolysis step. Certain novel 1-amino-1,3,5-triazine-2,4(1H, 3H)-dione compounds are provided. The compounds are useful as herbicides.Type: GrantFiled: February 10, 1981Date of Patent: October 26, 1982Assignee: Bayer AktiengesellschaftInventors: Karlfried Dickore', Engelbert Kuhle
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Patent number: 4353732Abstract: 3,4,5,6-Tetrahydro-thiatriazine-3,5-dione-1,1-dioxides of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given in the main text, which possess herbicidal properties.Type: GrantFiled: March 26, 1981Date of Patent: October 12, 1982Assignee: BASF AktiengesellschaftInventors: Rolf-Dieter Acker, Gerhard Hamprecht, Adolf Parg, Bruno Wuerzer
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Patent number: 4343648Abstract: 6H-1,2,4,6-Thiatriazine-1,1-dioxides of the formula ##STR1## where R.sup.1 and R.sup.2 are an aliphatic radical, a cycloaliphatic radical or a substituted aliphatic radical, R.sup.1 may also be unsubstituted or substituted phenyl, unsubstituted or substituted benzyl, or tetrahydrofurylmethyl and R.sup.2 may also be lower alkoxycarbo-lower alkoxy, lower alkylmercapto-carbo-lower alkoxy, lower alkoxy-carbo-lower alkylmercapto, lower alkylmercapto-carbo-lower alkylmercapto, unsubstituted or substituted aryl or unsubstituted or substituted benzyl,R.sup.3 is hydrogen, an aliphatic radical, a cycloaliphatic radical or substituted aliphatic radical,R.sup.4 and R.sup.5 are lower alkyl and R.sup.5 may also be hydrogen,X and Y are oxygen, sulfur, sulfinyl or sulfonyl andX.sup.1 is oxygen or sulfur, and herbicides containing these compounds.Type: GrantFiled: April 7, 1981Date of Patent: August 10, 1982Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Rolf-Dieter Acker, Bruno Wuerzer