Abstract: The application relates to novel substituted piperidines of the general formula (II) in which R1, R2?, R2?, R4?, X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.
Type:
Application
Filed:
March 30, 2006
Publication date:
October 29, 2009
Inventors:
Peter Herold, Robert Mah, Vincenzo Tschinke, Nathalie Jotterand, Dirk Behnke, Aleksandar Stojanovic, Stefan Stuz, Michael Quirmbach, Stjepan Jelakovic
Abstract: The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.
Type:
Application
Filed:
December 27, 2006
Publication date:
October 8, 2009
Inventors:
Shoji Fukumoto, Nobuyuki Matsunaga, Taiichi Ohra, Norio Ohyabu, Tomoaki Hasui, Takashi Motoyaji, Christopher Stephen Siedem, Tony Pisal Tang, Lisa A. Demeese, Cassandra Gauthier
Abstract: An ultraviolet absorbent represented by the following Formula (1) or (6): wherein, Het1 represents a monovalent five- or six-membered aromatic heterocyclic residue; Xa and Xb each independently represent a heteroatom; Ya to Yc each independently represent a heteroatom or a carbon atom; the ring formed from carbon atom, Xa, Xb, Ya to Yc may have a double bond at any position and has at least one fused ring; wherein, Het6 represents a monovalent five- or six-membered aromatic heterocyclic residue; X6a and X6b each independently represent a heteroatom; Y6a, Y6b and Y6c each independently represent a heteroatom or a carbon atom; L6 represents a bi- to octa-valent connecting group; n is an integer of 2 or more, and m is an integer of 0 or more.
Abstract: The present disclosure relates to the dyeing of keratin materials using thiol/disulfide styryl tetrahydroquinolinium fluorescent dyes. Disclosed herein is a dye composition comprising a thiol/disulfide styryl tetrahydroquinolinium fluorescent dye and a dyeing process with, for instance, a lightening effect on keratin materials such as hair, using said composition. Disclosed herein are thiol fluorescent dyes and the uses thereof in lightening keratin materials. This composition can be used to obtain a lightening effect which can be resistant and visible on dark keratin fibers.
Type:
Application
Filed:
September 19, 2008
Publication date:
May 21, 2009
Inventors:
Andrew GREAVES, Nicolas DAUBRESSE, Franco MANFRE
Abstract: A phosphorus containing monomer, a polymer thereof, an electrode for a fuel cell including the polymer, an electrolyte membrane for a fuel cell including the polymer, and a fuel cell including the electrode.
Abstract: A naphthoxazine benzoxazine-based monomer is represented by Formula 1 below: In Formula 1, R2 and R3 or R3 and R4 are linked to each other to form a group represented by Formula 2 below, and R5 and R6 or R6 and R7 are linked to each other to form a group represented by Formula 2 below, In Formula 2, * represents the bonding position of R2 and R3, R3 and R4, R5 and R6, or R6 and R7 of Formula 1. A polymer is formed by polymerizing the naphthoxazine benzoxazine-based monomer, an electrode for a fuel cell includes the polymer, an electrolyte membrane for a fuel cell includes the polymer, and a fuel cell uses the electrode.
Abstract: Benzoxazine monomers comprising at least one pendant group are described. (Co)Polymers comprising at least one benzoxazine monomer having at least one pendant group are also described. In a preferred embodiment, the pendant group is located in a side chain of the benzoxazine monomer or polymer. Methods for preparing the benzoxazine monomers and polymers are described. Compositions comprising the benzoxazine monomers and polymers have numerous uses including optical materials, and in electronic materials as electrically insulating materials, and as fireproof materials.
Abstract: A phosphorous containing benzoxazine-based monomer, a polymer thereof, an electrode for a fuel cell including the same and an electrolyte membrane for a fuel cell, and a fuel cell including the same.
Type:
Application
Filed:
September 11, 2008
Publication date:
March 12, 2009
Applicant:
Samsung Electronics Co., Ltd.
Inventors:
Seongwoo CHOI, Jungock Park, Wonmok Lee
Abstract: The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
Type:
Application
Filed:
January 18, 2007
Publication date:
January 29, 2009
Inventors:
Peter Herold, Robert Mah, Vincenzo Tschinke, Dirk Behnke, Nathalie Jotterand, Aleksandar Stojanovic, Stefan Stutz, Stjepan Jelakovic, Michael Quirmbach
Abstract: Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Type:
Application
Filed:
February 10, 2006
Publication date:
January 1, 2009
Inventors:
Michael J. Rice, Bryon A. Merrill, Philip D. Heppner
Abstract: The present invention relates to 4?-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid and its pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
Type:
Grant
Filed:
July 20, 2007
Date of Patent:
October 7, 2008
Assignee:
SmithKline Beecham Corporation
Inventors:
Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
Abstract: The use of tetrahydrobenzoxazines I where R1 is a hydrocarbyl radical and R2, R3, R4 and R5 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals, and where R2 to R5 may also form a second and a third tetrahydrooxazine ring, with the proviso that at least one of the substituents has from 4 to 3000 carbon atoms and the remaining substituents, when they are hydrocarbyl radicals, each have from 1 to 20 carbon atoms, as stabilizers for stabilizing inanimate organic material, especially turbine fuels, against the action of light, oxygen and heat.
Type:
Application
Filed:
July 18, 2006
Publication date:
August 21, 2008
Applicant:
BASF Aktiengesellschaft
Inventors:
Arno Lange, Helmut Mach, Hans Peter Rath, Dietmar Posselt
Abstract: Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.
Type:
Application
Filed:
September 20, 2007
Publication date:
July 3, 2008
Inventors:
Kevin Shreder, Yi Hu, Allister Fraser, Yasushi Kohno, Akihiko Kojima, Junichi Ishiyama
Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
Type:
Grant
Filed:
March 28, 2006
Date of Patent:
February 5, 2008
Assignee:
Cylene Pharmaceuticals, Inc.
Inventors:
Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terence Moran
Abstract: A compound represented by Formula 1 and an organic light emitting device including the same: where Ar is a substituted or unsubstituted C6-C26 aryl group; X is O, S, R1 and R2 are hydrogen, a halogen, a C1-C12 alkyl group, a C6-C26 aryl group, or a substituted group thereof; R3, R4, R5, R6, R7 and R8 are each independently hydrogen or a substituted or unsubstituted C1-C12 alkyl group; R9 through R22 are each independently hydrogen, a C1-C30 alkyl group, a C1-C30 alkoxy group, a C6-C30 aryl group, a C6-C30 arylalkyl group, a C6-C30 aryloxy group, a C5-C30 heteroaryl group, a C5-C30 heteroarylalkyl group, a C5-C30 heteroaryloxy group, a C5-C20 cycloalkyl group, a C5-C30 heterocycloalkyl group, or a substituted group thereof. An organic light emitting device using the compound has low operating voltage, high color purity, and high efficiency.
Abstract: Disclosed is an azaoxa heterocyclic compound represented by the following formula (I): (wherein, each symbol is defined the same as in the specification) and a method for preparing the same. This compound of the present invention is prepared by the reaction of a phenolic compound, an aromatic diamine compound and an aldehyde compound. The azaoxa heterocyclic compound of the present invention can be used as a hardening resin or a hardener for an epoxy resin, polyether and a resin containing active hydrogen atoms, wherein the composition formed by the azaoxa heterocyclic compound and the epoxy resin is useful in the application of laminates, adhesive, semiconductor packaging materials and phenolic resin forming materials.
Abstract: An improved organophotoreceptor includes an electrically conductive substrate and a photoconductive element on the electrically conductive substrate where the photoconductive element comprises: a) a charge transport material having the following formula: where X is a linking group; Y1 and Y2 are, each independently, a phenothiazine group, a phenoxazine group, or a phenazine group; R1, R2, R3, and R4 are, each independently, an alkyl group, an alkenyl group, a heterocyclic group, or an aromatic group; and R5 and R6 are, each independently, a hydrogen, an alkyl group, an alkenyl group, a heterocyclic group, or an aromatic group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.
Type:
Grant
Filed:
February 27, 2004
Date of Patent:
March 13, 2007
Assignee:
Samsung Electronics Co., Ltd.
Inventors:
Almantas Danilevicius, Gintaras Buika, Ramunas Lygaitis, Juozas V. Grazulevicius, Robertas Maldzius, Edmundas Montrimas, Zbigniew Tokarski, Nusrallah Jubran
Abstract: The present invention relates to novel ultraviolet light absorbers of the benzoxazinone, oxanilide, benzylidene malonate, quinazoline and benzotriazole classes. The invention also relates to polymer and photographic compositions stabilized against the deleterious effects of light induced degradation which comprise the novel ultraviolet light absorbers.
Type:
Grant
Filed:
August 5, 2002
Date of Patent:
February 6, 2007
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Ramanathan Ravichandran, Stephen Daniel Pastor, Deborah Judd, Joseph Edmund Babiarz, Andrew Brian Naughton, Mervin Gale Wood, Anthony David Debellis, Rong Xiong, Robert Edward Detlefsen, Joseph Suhadolnik
Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula ?where R1 and R2 are, each independently, an alkyl group, an alkenyl group, an alkynyl group, an aromatic group, or a heterocyclic group; R3 and R4 are, each independently, H, an alkyl group, an alkenyl group, an alkynyl group, an aromatic group, or a heterocyclic group; X1 and X2 are, each independently, a linking group; Y1 and Y2, each independently, comprise an arylamine group; and Z is a bridging group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.
Type:
Grant
Filed:
April 30, 2004
Date of Patent:
January 30, 2007
Assignee:
Samsung Electronics Co., Ltd.
Inventors:
Zbigniew Tokarski, Nusrallah Jubran, Vytautas Getautis, Jonas Sidaravicius, Edmundas Montrimas, Maryte Daskeviciene, Valentas Gaidelis, Vygintas Jankauskas, Albina Stanisauskaite
Abstract: An ultraviolet radiation absorbent for thermoplastic polymer materials such as polyethylene terephthalate or polycarbonate contains cyclic imino ester compound of a specified structure in an amount of over 99.5 weight % and less than 100 weight % and having an acid value in the range of 1×10?3–1 and/or a chlorine ion content in the range of 1×10?1–1×103 ppm.
Type:
Grant
Filed:
April 5, 2005
Date of Patent:
January 9, 2007
Assignees:
Takemoto Yushi Kabushiki Kaisha, Teijin Dupont Films Japan Limited
Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
Type:
Grant
Filed:
April 7, 2004
Date of Patent:
November 28, 2006
Assignee:
Cylene Pharmaceuticals, Inc.
Inventors:
Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terrance Moran
Abstract: The invention relates to an organic electroluminescent device which contains 2,5-diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure or doped manner. The ring A is a triple unsaturated benzene ring wherein R4? and R8? are zero or ring A is a double unsaturated ring respectively provided with a double bond in the 1,2 position and 4,5 position, and wherein R10 is a nitrile radical —CN or a radical C(?X1)—X2R1, R11 is a nitrile radical —CN or a radical —C(?X3)—X4R5, X1 and X3 are oxygen, sulfur or imino, X2 and X4 are oxygen, sulfur or optionally substituted amino, R1–R8, R4? and R8? are H, C1–20-alkyl, aryl, heteroaryl, R4 and R8 can be halogen, nitro, cyanogen or amino, R2–R4, R6–R8, R4? and R8? can be trifluoromethyl or pentafluorophenyl, and wherein certain radicals can form a saturated or unsaturated ring.
Type:
Grant
Filed:
August 21, 2002
Date of Patent:
September 26, 2006
Assignee:
Sensient Imaging Technologies GmbH
Inventors:
Andreas Richter, Jens Schoenewerk, Gerhard Diener
Abstract: An ultraviolet radiation absorbent for thermoplastic polymer materials such as polyethylene terephthalate or polycarbonate contains cyclic imino ester compound of a specified structure in an amount of over 99.5 weight % and less than 100 weight %, having the melt beginning temperature obtained by melting point measurement in differential thermal analysis within the range of 300–310° C. and/or the weight loss beginning temperature obtained by thermogravimetric measurement within the range of 270–305° C.
Type:
Grant
Filed:
November 14, 2002
Date of Patent:
June 6, 2006
Assignees:
Takemoto Yushi Kabushiki Kaisha, Teijin DuPont Films Japan Limited
Abstract: Compounds of formula (I) or (II), wherein R1 is C1–C18alkyl; C5–C12cycloalkyl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups; C5–C22aryl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups; or C7–C30aralkyl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups, and the radicals R2 to R13 are each independently of the others hydrogen; —NO2; dialkylamino; alkylthio; alkylsulfonyl; halogen; C1–C18alkyl; C1–C18alkoxy; C1–C18alkoxyalkyl; C5–C12cycloalkyl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups; C5–C22aryl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups; or C7–C30aralkyl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups, are suitable as flame-proofing agents for thermoplastic or thermosetting polymers
Type:
Grant
Filed:
November 20, 2001
Date of Patent:
May 30, 2006
Assignee:
Huntsman Advanced Materials Americas Inc.
Abstract: An ultraviolet radiation absorbent is produced by a method including specified Step A, Step B and Step C. Step A is a process of causing an amidation of anthranilic acid and terephthaloyl dichloride in the presence of a solvent and an alkali to generate N,N?-bis(o-carboxyphenylterephthalamid) and separating a solid component containing N,N?-bis(o-carboxyphenylterephthalamid) generated by this amidation. Step B is a process of separating a solid component containing cyclic imino ester compound of a specified kind. Step C is a process of processing the solid component separated in Step B with an alkaline solution and further washing with water to obtain the ultraviolet radiation absorbent for thermoplastic polymers containing cyclic imino ester compound of the specified kind.
Type:
Grant
Filed:
June 30, 2004
Date of Patent:
June 21, 2005
Assignees:
Takemoto Yushi Kabushiki Kaisha, Teijin DuPont Films Japan Limited
Abstract: The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
Abstract: An ultraviolet radiation absorbent for thermoplastic polymer materials such as polyethylene terephthalate or polycarbonate contains cyclic imino ester compound of a specified structure in an amount of over 99.5 weight % and less than 100 weight % and having an acid value in the range of 1×10−3-1 and/or a chlorine ion content in the range of 1×10−1-1×103 ppm.
Abstract: An improved organophotoreceptor includes an electrically conductive substrate and a photoconductive element on the electrically conductive substrate where the photoconductive element comprises:
Type:
Application
Filed:
February 27, 2004
Publication date:
December 2, 2004
Inventors:
Almantas Danilevicius, Gintaras Buika, Ramunas Lygaitis, Juozas V. Grazulevicius, Robertas Maldzius, Edmundas Montrimas, Zbigniew Tokarski, Nusrallah Jubran
Abstract: An ultraviolet radiation absorbent for thermoplastic polymer materials such as polyethylene terephthalate or polycarbonate contains cyclic imino ester compound of a specified structure in an amount of over 99.5 weight % and less than 100 weight % and having an acid value in the range of 1×10−3-1 and/or a chlorine ion content in the range of 1×10−1-1×103 ppm.
Type:
Grant
Filed:
November 12, 2002
Date of Patent:
October 26, 2004
Assignees:
Takemoto Yushi Kabushiki Kaisha, Teijin DuPont Films Japan Limited
Abstract: The present invention relates to novel ultraviolet light absorbers of the benzoxazinone, oxanilide, benzylidene malonate, quinazoline and benzotriazole classes. The invention also relates to polymer and photographic compositions stabilized against the deleterious effects of light induced degradation which comprise the novel ultraviolet light absorbers.
Type:
Application
Filed:
May 17, 2004
Publication date:
September 30, 2004
Inventors:
Ramanathan Ravichandran, Stephen Daniel Pastor, Deborah Judd, Joseph Edmund Babriarz, Andrew Brian Naughton, Mervin Gale Wood, Anthony David Debellis, Rong Xiong, Robert Edward Detlefsen, Joseph Suhadolnik
Abstract: There is provided a process for the preparation of a compound of formula (I): which process comprises reaction of a compound of formula (II): with either a compound of formula (III): or acrylamide, followed, in the latter case, by reaction of the resulting intermediate of formula (IV): with an alcohol of formula R2—OH and an agent that promotes, or agents that in combination promote, rearrangement and oxidation of the compound of formula IV to an intermediate isocyanate, which may then react with the alcohol of formula R2—OH, and wherein R1, R2 and R16 have meanings given in the description.
Type:
Application
Filed:
April 22, 2004
Publication date:
September 16, 2004
Inventors:
Lal Cheema, David Cladingboel, Rhona Sinclair
Abstract: In accordance with the present invention, there are provided novel benzoxazine compounds and thermosetting resin compositions prepared therefrom. Invention compositions are particularly useful for increasing adhesion at interfaces within microelectronic packages. Invention benzoxazines are useful for the preparation of invention compositions with properties which are associated with increased adhesion at interfaces, such as, for example, low shrinkage on cure and low coefficient of thermal expansion (CTE). In another aspect of the invention, there are provided die-attach pastes having increased interfacial adhesion. Invention die-attach pastes include benzoxazine-containing thermosetting resin compositions. In further aspects of the invention, there are provided methods for enhancing adhesive strength of thermosetting resin compositions and methods for enhancing adhesion of a substrate bound to a metallic surface by a thermosetting resin composition.
Type:
Grant
Filed:
November 13, 2001
Date of Patent:
June 1, 2004
Assignee:
Henkel Corporation
Inventors:
Stephen M. Dershem, Puwei Liu, Farhad G. Mizori
Abstract: Disclosed are guanidine and biguanidine derivatives which have anti-viral and anti-bacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial methods utilizing such compounds.
Abstract: This invention provides compounds of Formula (I),
where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
Type:
Grant
Filed:
March 28, 2001
Date of Patent:
August 19, 2003
Assignee:
Wyeth Holdings
Inventors:
Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
Abstract: The invention relates to a process for preparing triphendioxazine compounds by cyclizing the intermediates (IV)
in the presence of manganese oxide and sulfuric acid to form compounds of the general formula (I)
a process for condensing compounds of the general formula (II)
with compounds of the general formula (III) to form the chlorine-free intermediates (IV)
and also compounds of the general formula (IV).
Type:
Grant
Filed:
March 6, 2001
Date of Patent:
January 28, 2003
Assignee:
Clariant Finance (BVI) Limited
Inventors:
Bansi Lal Kaul, Bruno Piastra, Pascal Steffanut
Abstract: A high char yield polybenzoxazine is formed by mixing (i) a benzoxazine compound, (ii) a furan compound, (iii) a benzoxazine-furan compound or combinations thereof, wherein the mixture has a benzoxazine ring to furan ring ratio from about 0.001 to about 10 and then heating the mixture for a sufficient time to form the polybenzoxazine.
Type:
Grant
Filed:
November 3, 2000
Date of Patent:
November 19, 2002
Assignee:
Dow Global Technologies Inc.
Inventors:
Marvin L. Dettloff, Jerry E. White, Marty J. Null
Abstract: A cyanine dye having the formula
wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.
Type:
Grant
Filed:
April 2, 2001
Date of Patent:
August 20, 2002
Assignee:
NEN Life Science Products, Inc.
Inventors:
Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
Abstract: The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives, which are substituted in the 7-position by a 2-oxa-5,8-diazabicyclo[4.3.0]-non-8-yl) radical, and their pharmaceutically utilizable hydrates and/or salts for the therapy of Helicobacter pylori infections and the gastroduodenal disorders associated therewith.
Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.
Abstract: A process for improving the heat stability of Pigment Violet 23 by conditioning crude Pigment Violet 23 in the presence of about 1 to 10 wt. % of Pigment Violet 23 by-products (1), (2) and (3).
Type:
Application
Filed:
January 5, 2001
Publication date:
July 11, 2002
Inventors:
Norman W. Smith, Terrence R. Chamberlain, Barbara N. Berg, George McLaren, Russell J. Schwartz
Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
Type:
Grant
Filed:
December 2, 1997
Date of Patent:
November 6, 2001
Assignees:
Reddy-Cheminor, Inc., Dr. Reddy's research foundation
Abstract: A cyanine dye having the formula
wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.
Type:
Grant
Filed:
November 24, 1999
Date of Patent:
May 1, 2001
Assignee:
NEN Life Science Products, Inc.
Inventors:
Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
Abstract: A cyanine dye having the formula
wherein R1--R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.
Type:
Grant
Filed:
November 24, 1999
Date of Patent:
March 20, 2001
Assignee:
NEN Life Science Products, Inc.
Inventors:
Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
Abstract: A cyanine dye having the formula
wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.
Type:
Grant
Filed:
November 24, 1999
Date of Patent:
March 6, 2001
Assignee:
NEN Life Science Products, Inc.
Inventors:
Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow