Plural Ring Hetero Atoms In The Bicyclo Ring System, Or Ring Nitrogen Is Shared By The Two Cyclos Of The Bicyclo Ring System Patents (Class 548/453)
-
Patent number: 12227514Abstract: Disclosed is crystal form I of compound (S)—N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide.Type: GrantFiled: April 30, 2019Date of Patent: February 18, 2025Assignee: TIANJIN HEMAY PHARMACEUTICAL CO., LTD.Inventors: Donglei Zhang, Liyu Wang, Yukun Chang
-
Patent number: 12122774Abstract: Disclosed in the present invention are compounds as MYT1 inhibitors. Particularly, the present invention relates to compounds represented by general formula (1) and a preparation method therefor, as well as the use of the compounds of general formula (1), and isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof as MYT1 inhibitors. The compounds of the present invention as well as the isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof can be used for preparing drugs for treating or preventing diseases related to MYT1 protein.Type: GrantFiled: April 11, 2024Date of Patent: October 22, 2024Assignee: WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.Inventors: Yuli Xie, Yingming Wu, Lihui Qian
-
Patent number: 12042482Abstract: One of the aspects of the invention is directed toward a method of treating or preventing acute brain or nerve injury in a subject, comprising administering an effective amount of posiphen, or a pharmaceutically acceptable salt of posiphen, to the subject in need thereof. Similarly, another aspect of the invention is directed toward a use of posiphen, or a pharmaceutically acceptable salt of posiphen, for the treatment or prevention of acute brain or nerve injury. Preferably, the posiphen in the method or use of the invention is posiphen tartrate.Type: GrantFiled: August 12, 2016Date of Patent: July 23, 2024Assignee: Annovis Bio, Inc.Inventor: Maria Maccecchini
-
Patent number: 11679136Abstract: The present invention provides a composition comprising a co-culture of at least two distinct bacterial families, having differing growth and/or proliferative conditions. In some embodiments, the composition comprises a plurality of bacterial genera with high similarity to microbial flora.Type: GrantFiled: July 6, 2021Date of Patent: June 20, 2023Assignee: MYBIOTICS PHARMA LTD.Inventors: David Baram, David Daboush, Rachel Diamant
-
Patent number: 11111432Abstract: Provided herein are triangular carbon quantum dots with narrow bandwidth emission, methods of making them, and methods of using such triangular carbon quantum dots, such as in multicolored LED displays.Type: GrantFiled: January 2, 2018Date of Patent: September 7, 2021Assignee: BEIJING NORMAL UNIVERSITYInventors: Louzhen Fan, Fanglong Yuan, Shihe Yang, Zifan Xi
-
Patent number: 10610517Abstract: Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.Type: GrantFiled: March 25, 2014Date of Patent: April 7, 2020Assignees: Celgene International II SÀRL, Dana-Farber Cancer Institute, Inc.Inventors: Kenneth C. Anderson, Dharminder Chauhan, Michael A. Palladino
-
Patent number: 10312447Abstract: Objects of the present invention are to provide an organic semiconductor element in which carrier mobility is high, variation of mobility is suppressed, and temporal stability under high temperature and high humidity is excellent, and a manufacturing method thereof, to provide a novel compound suitable for an organic semiconductor, and to provide an organic semiconductor film in which mobility is high, variation of mobility is suppressed, and temporal stability under high temperature and high humidity is excellent, a manufacturing method thereof, and an organic semiconductor composition that can suitably form the organic semiconductor film. The organic semiconductor element according to the present invention is an organic semiconductor layer containing a compound having a constitutional repeating unit represented by Formula 1 and having a molecular weight of 2,000 or greater.Type: GrantFiled: September 6, 2017Date of Patent: June 4, 2019Assignee: FUJIFILM CORPORATIONInventors: Tetsu Kitamura, Yosuke Yamamoto, Fumiko Tamakuni, Yuta Shigenoi, Takashi Goto, Tetsuya Watanabe
-
Patent number: 10011814Abstract: Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.Type: GrantFiled: February 17, 2015Date of Patent: July 3, 2018Assignee: Celgene International II SàrlInventors: Kin Sing Lam, Ginger Tsueng
-
Patent number: 9828379Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.Type: GrantFiled: July 1, 2014Date of Patent: November 28, 2017Assignee: ABIDE THERAPEUTICS, INC.Inventors: Todd K. Jones, Justin S. Cisar, Cheryl A. Grice, Dong-Hui Wang, Olivia D. Weber
-
Patent number: 9670225Abstract: Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein X1, X2, X3, R1, R2, R11, and n are defined herein. These compounds are useful as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection.Type: GrantFiled: May 15, 2015Date of Patent: June 6, 2017Assignees: Purdue Research Foundation, National University Corporation Kumamoto UniversityInventors: Arun K. Ghosh, Venkateswara Rao Kalapala, Hiroaki Mitsuya
-
Patent number: 9630975Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.Type: GrantFiled: May 19, 2014Date of Patent: April 25, 2017Assignees: Tianjin Hemay Bio-Tech Co., Ltd., Tianjin Michele Sci-Tech Development Co., Ltd.Inventors: Hesheng Zhang, Guanghuai Zeng, Yifei Gao
-
Patent number: 9605169Abstract: Aqueous green inkjet ink compositions are prepared from aqueous organic pigment dispersions for use in various inkjet printing methods. In particular, these methods provide a green image or expanded color gamut for other inkjet printed colors. The aqueous organic pigment dispersion contains a green copper phthalocyanine pigment and an azo-coupled ?-ketoamide pigment and an organic pigment dispersant. The weight ratio of the green copper phthalocyanine pigment to the azo-coupled ?-ketoamide pigment is from 1:1 to 10:1. The median particle diameter of each of the green copper phthalocyanine pigment and the azo-coupled ?-ketoamide pigment is less than 85 nm. At least 95% of the total particles of each of the green copper phthalocyanine pigment and the azo-coupled ?-ketoamide pigment have a particle diameter of less than 150 nm.Type: GrantFiled: April 7, 2016Date of Patent: March 28, 2017Assignee: EASTMAN KODAK COMPANYInventors: Barbara Boland Lussier, Daniel Talbot Linehan
-
Patent number: 9481796Abstract: A method for producing a nanoparticle to separate a diketopyrrolopyrrole pigment includes separating an ?-type diketopyrrolopyrrole pigment nanoparticle having high crystallinity by carrying out separation of the diketopyrrolopyrrole pigment and crystal type transformation to the ?-type with substantially a single step. The ?-type diketopyrrolopyrrole pigment nanoparticle is separated by mixing a diketopyrrolopyrrole pigment solution having the diketopyrrolopyrrole pigment dissolved in a solvent and an alcohol solvent containing an alcohol compound solvent in a thin film fluid formed between at least two processing surfaces 1 and 2 arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. An acidic substance is contained in at least any one of the diketopyrrolopyrrole pigment solution and the alcohol solvent at this moment.Type: GrantFiled: October 21, 2014Date of Patent: November 1, 2016Assignee: M. TECHNIQUE CO., LTD.Inventor: Masakazu Enomura
-
Patent number: 9166168Abstract: An organic semiconductor polymer includes a moiety represented by the following Chemical Formula 1 and a heteroaromatic moiety having at least one of sulfur (S) and selenium (Se). In the Chemical Formula 1, R1, R2, R3a, R3b, R4a, R4b, R5a, and R5b, a1, a2, b1, and b2 are the same as described in the detailed description.Type: GrantFiled: December 19, 2013Date of Patent: October 20, 2015Assignee: Samsung Electronics Co., Ltd.Inventors: Hye Yeon Yang, Bang Lin Lee, Bon Won Koo, Joo Young Kim, Jeong Il Park, Eun Kyung Lee, Ji Youl Lee, Jong Won Chung, Ji Young Jung
-
Patent number: 9115144Abstract: Compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. Fused heterocyclic derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, or prodrugs thereof, or pharmaceutically acceptable salts thereof. In the formula (I), ring U represents C6-10 aryl or the like; R1 independently represents a hydrogen atom, a hydroxy group, C1-6 alkyl or the like; m represents an integral number from 1 to 2; ring Q represents 5-membered heteroaryl; n represents an integral number from 1 to 3; R2 independently represents a hydrogen atom, a halogen atom, C1-6 alkyl or the like.Type: GrantFiled: August 23, 2012Date of Patent: August 25, 2015Assignee: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Kazuo Shimizu, Yusuke Onda, Masato Lizuka
-
Patent number: 9051330Abstract: The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.Type: GrantFiled: March 18, 2003Date of Patent: June 9, 2015Assignee: Welichem Biotech Inc.Inventors: Genhui Chen, Jianxiong Li, John Webster, Bin Li
-
Publication number: 20150141479Abstract: The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating moderate to severe pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.Type: ApplicationFiled: February 4, 2013Publication date: May 21, 2015Inventor: Mahesh Kandula
-
Publication number: 20150132887Abstract: The present invention relates to polymers comprising a repeating unit of the formula (I), and compounds of formula (VIII), or (IX), wherein Y, Y15, Y16 and Y17 are independently of each other a group of formula (I), and their use as organic semiconductor in organic electronic devices, especially in organic photovoltaics and photodiodes, or in a device containing a diode and/or an organic field effect transistor. The polymers and compounds according to the invention can have excellent solubility in organic solvents and excellent film-forming properties. In addition, high efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when the polymers and compounds according to the invention are used in organic field effect transistors, organic photovoltaics (solar cells) and photodiodes.Type: ApplicationFiled: July 19, 2013Publication date: May 14, 2015Applicant: BASF SEInventors: Matthias Welker, Mathieu G.R. Turbiez, Natalia Chebotareva, Hans Juerg Kirner, Thomas Schaefer
-
Publication number: 20150126747Abstract: The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.Type: ApplicationFiled: May 25, 2012Publication date: May 7, 2015Inventors: Allan Krueger, Warren M. Kati, Clarence J. Maring, Rolf Wagner, Charles W. Hutchins
-
Patent number: 9018211Abstract: This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.Type: GrantFiled: January 24, 2014Date of Patent: April 28, 2015Assignee: Merck Sharp & Dohme Corp.Inventors: Alexander Pasternak, Yuping Zhu, Aurash Shahripour, Haifeng Tang, Lihu Yang, Shawn P. Walsh, Nardos H. Teumelsan
-
Patent number: 9018397Abstract: The present invention relates to compounds of the formula I wherein the substituents are as defined in claim 1, and their use as organic semiconductor in organic devices, like diodes, organic field effect transistors and/or a solar cells. The compounds of the formula I have excellent solubility in organic solvents. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when said compounds are used in semiconductor devices or organic photovoltaic (PV) devices (solar cells).Type: GrantFiled: February 26, 2013Date of Patent: April 28, 2015Assignee: BASF SEInventors: Zhimin Hao, Beat Schmidhalter, Jean-Luc Budry, Margherita Fontana, Matheiu G. R. Turbiez, Frank Bienewald, Mathias Duggeli, Oliver Frederic Aebischer, Pascal Hayoz, Marta Fondrodona Turon
-
Publication number: 20150110709Abstract: A method for producing a nanoparticle to separate a diketopyrrolopyrrole pigment includes separating an ?-type diketopyrrolopyrrole pigment nanoparticle having high crystallinity by carrying out separation of the diketopyrrolopyrrole pigment and crystal type transformation to the ?-type with substantially a single step. The ?-type diketopyrrolopyrrole pigment nanoparticle is separated by mixing a diketopyrrolopyrrole pigment solution having the diketopyrrolopyrrole pigment dissolved in a solvent and an alcohol solvent containing an alcohol compound solvent in a thin film fluid formed between at least two processing surfaces 1 and 2 arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. An acidic substance is contained in at least any one of the diketopyrrolopyrrole pigment solution and the alcohol solvent at this moment.Type: ApplicationFiled: October 21, 2014Publication date: April 23, 2015Applicant: M. Technique Co., Ltd.Inventor: Masakazu ENOMURA
-
Publication number: 20150087628Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.Type: ApplicationFiled: April 10, 2013Publication date: March 26, 2015Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
-
Patent number: 8987265Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:Type: GrantFiled: November 7, 2013Date of Patent: March 24, 2015Assignee: Bristol-Myers Squibb CompanyInventors: Tao Wang, Zhiwei Yin, Paul Michael Scola
-
Publication number: 20150076418Abstract: The invention relates to novel conjugated polymers comprising in their backbone one or more divalent donor units, like for example benzo[1,2-b:4,5-b?]dithiophene-2,6-diyl (BDT), that are linked on both sides to an acceptor unit, to methods of preparing the polymers and educts or intermediates used in such preparation, to polymer blends, mixtures and formulations containing the polymers, to the use of the polymers, polymer blends, mixtures and formulations as semiconductors organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.Type: ApplicationFiled: February 15, 2013Publication date: March 19, 2015Applicant: MERCK PATENT GMBHInventors: Nicolas Blouin, Amy Phillips, Lana Nanson, Steven Tierney, Toby Cull, Priti Tiwana, Stephane Berney, Miguel Carrasco-Orozco, Frank Egon Meyer
-
Publication number: 20150080382Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.Type: ApplicationFiled: June 24, 2014Publication date: March 19, 2015Inventors: Damian O. Arnaiz, Greg Brown, Emmanuel Claret, Arwed Cleve, David Davey, William Guilford, Seock-Kyu Khim, Thomas Kirkland, Monica J. Kochanny, Amy Liang, David Light, John Parkinson, Guo Ping Wei, Bin Ye
-
Publication number: 20150080576Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are amide compounds which can be prepared from certain heteroaryl carboxylic acids and certain diazabicycloalkanes. The compounds exhibit selectivity for, and bind with high affinity to, neuronal nicotinic receptors of the ?4?2 subtype in the central nervous system (CNS). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly CNS disorders. The compounds can: (i) alter the number of nicotinic cholinergic receptors of the brain of the patient, (ii) exhibit neuroprotective effects, and (iii) when employed in effective amounts, not result in appreciable adverse side effects (e.g. side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastrointestinal tract, and significant effects upon skeletal muscle).Type: ApplicationFiled: November 24, 2014Publication date: March 19, 2015Inventors: Anatoly Mazurov, Lan Miao, Yunde Xiao, Philip S. Hammond, Craig H. Miller, Srinivasa Rao Akireddy, Srinivasa V. Murthy, Regina C. Whitaker, Scott R. Breining, Matt S. Melvin
-
Publication number: 20150057420Abstract: A compound of formula (I), formula (II), or a combination thereof, and salts thereof is described. Each A may be independently an optionally substituted conjugated species or an optionally substituted aromatic species. Each R may be independently an optionally substituted C1-C40 linear alkyl chain, an optionally substituted branched alkyl chain, an optionally substituted alkyl chain containing heteroatoms, substituted alkyl chains, or H. Each R2 may be independently an optionally substituted C1-C40 linear alkyl chain, an optionally substituted branched alkyl chain, an optionally substituted alkyl chain containing heteroatoms, substituted alkyl chains, H, or part of a cyclic boronate ester with an other R2. Each n may be independently less than or equal to 3 and greater than or equal to 1. Each x may be independently less than or equal to 3.Type: ApplicationFiled: August 15, 2014Publication date: February 26, 2015Inventors: Mingqian He, James Robert Matthews, Weijun Niu, Arthur Lawrence Wallace
-
Publication number: 20150057443Abstract: Cycloalkyl amine compounds of Formula (I), wherein ring A is C3-C6 cycloalkyl, optionally substituted with one or more C1-C3 alkyl, and R5 is ORS2, in which RS2 is H or C1-C6 alkyl, or R5 and R6, together with the carbon atom to which they are attached, form C?O, for use in treating CNS disorders, including movement disorders, depressive disorders, sleep disorders, cognitive dysfunctions, obesity, sexual dysfunction and substance abuse.Type: ApplicationFiled: August 21, 2014Publication date: February 26, 2015Inventors: Philip Huxley, Jonathan R. Heal, Richard S. Todd
-
Publication number: 20150041724Abstract: A substituent-eliminable diketopyrrolopyrrole derivative represented by the following formula (I) is provided. In the formula (I), R represents a substituted or unsubstituted alkyl group; X represents a substituted or unsubstituted alkyl group; Ar represents a substituted or unsubstituted aromatic group or a substituted or unsubstituted heteroaromatic group; and n represents an integer of from 1 to 4.Type: ApplicationFiled: July 18, 2014Publication date: February 12, 2015Applicant: RICOH COMPANY, LTD.Inventors: Ryota Arai, Yoshiki YANAGAWA
-
Patent number: 8952178Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.Type: GrantFiled: May 14, 2010Date of Patent: February 10, 2015Assignees: Tianjin Hemay Bio-Tech Co., Ltd., Tianjin Michele Sci-Tech Development Co., Ltd.Inventors: Hesheng Zhang, Guanghuai Zeng, Yifei Gao
-
Patent number: 8946445Abstract: The present document describes novel compounds which may inhibit the activity of anti-apoptotic proteins such as Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases involving a defect in apoptosis, such as, for example, in the treatment of cancer.Type: GrantFiled: October 11, 2012Date of Patent: February 3, 2015Assignee: Nanjing Allgen Pharma Co., Ltd.Inventor: Zhaoyin Wang
-
Publication number: 20150028265Abstract: A conjugated polymer for electronic devices can include a repeated unit having the structure of formula (I)Type: ApplicationFiled: July 23, 2014Publication date: January 29, 2015Inventors: Yang Yang, Letian Dou, Wei-Hsuan Chang
-
Patent number: 8927971Abstract: Disclosed are semiconducting compounds having one or more phthalimide units and/or one or more head-to-head (H-H) substituted biheteroaryl units. Such compounds can be monomeric, oligomeric, or polymeric, and can exhibit desirable electronic properties and possess processing advantages including solution?processability and/or good stability at ambient conditions.Type: GrantFiled: April 6, 2010Date of Patent: January 6, 2015Assignee: University of Kentucky Research FoundationInventor: Mark D. Watson
-
Publication number: 20150005277Abstract: The invention is compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.Type: ApplicationFiled: June 21, 2014Publication date: January 1, 2015Inventors: Zhiwei Wang, Yunhang Guo
-
Patent number: 8906911Abstract: Disclosed herein are chemokine receptor antagonists of formula (I) wherein R1, R2, and R3 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.Type: GrantFiled: March 29, 2013Date of Patent: December 9, 2014Assignee: AbbVie Inc.Inventors: Michael D. Meyer, Xueqing Wang, Tao Guo, Robert Guo Ping Wei, Lijuan Jane Wang
-
Patent number: 8901087Abstract: The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.Type: GrantFiled: November 8, 2011Date of Patent: December 2, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Jiang Chang, Kun Liu, Ernest J. McEachern, Changwei Mu, Harold G. Selnick, Feng Shi, David J. Vocadlo, Yaode Wang, Zhongyong Wei, Yuanxi Zhou, Yongbao Zhu
-
Patent number: 8889885Abstract: A method for producing a nanoparticle to separate a diketopyrrolopyrrole pigment includes separating an ?-type diketopyrrolopyrrole pigment nanoparticle having high crystallinity by carrying out separation of the diketopyrrolopyrrole pigment and crystal type transformation to the ?-type with substantially a single step. The ?-type diketopyrrolopyrrole pigment nanoparticle is separated by mixing a diketopyrrolopyrrole pigment solution having the diketopyrrolopyrrole pigment dissolved in a solvent and an alcohol solvent containing an alcohol compound solvent in a thin film fluid formed between at least two processing surfaces 1 and 2 arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. An acidic substance is contained in at least any one of the diketopyrrolopyrrole pigment solution and the alcohol solvent at this moment.Type: GrantFiled: February 1, 2011Date of Patent: November 18, 2014Assignee: M. Technique Co., Ltd.Inventor: Masakazu Enomura
-
Patent number: 8884018Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.Type: GrantFiled: March 7, 2014Date of Patent: November 11, 2014Assignee: Vertex Pharmaceuticals IncorporatedInventors: Narendra Bhalchandra Ambhaikar, Robert Hughes, Dennis James Hurley, Elaine Chungmin Lee, Benjamin Littler, Mehdi Numa, Stefanie Roeper, Urvi Sheth
-
Patent number: 8883889Abstract: The present invention relates to a process for the direct preparation of pyrrolo[3,4-c]pyrroles (DPPs) of the formula pigment compositions containing them and their use for coloring high molecular weight organic materials, such as plastics and paints. The obtained DPPs of the formula I possess a higher color strength, a higher chroma, a purer shade and a higher opacity versus corresponding commercially available DPPs.Type: GrantFiled: January 17, 2007Date of Patent: November 11, 2014Assignee: BASF SEInventors: Vincent Ruffieux, Florence Modoux
-
Publication number: 20140326164Abstract: A method for preparing a surface modified organic pigment includes the steps of a) reacting the organic pigment in an aromatic hydrocarbon solvent with a surface modifying reagent to form a surface modified organic pigment; and b) washing and drying the surface modified organic pigment; wherein the surface modifying reagent is represented by Formula (I): wherein, X is selected from the group consisting of O, S and N—R3; Y is selected from the group consisting of —O and NR4; R1 to R4 are each independently selected from the group consisting of hydrogen, an alkyl group, an alkenyl group, an alkynyl group, a -aralkyl group, an alkaryl group, and an aryl group and s heteroaryl group; with the proviso that when Y—R1 is different from OH that at least one of R2 to R4 is substituted by at least one functional group having a pKa between 2.5 and 9.Type: ApplicationFiled: November 21, 2012Publication date: November 6, 2014Applicant: AGFA GRAPHICS NVInventors: Johan Loccufier, Nicolas Vriamont, Paul Callant
-
Publication number: 20140329836Abstract: This invention provides compounds of formula (I): wherein R1, R2, G, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.Type: ApplicationFiled: December 5, 2013Publication date: November 6, 2014Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher Blackburn, Kenneth M. Gigstad, He Xu
-
Patent number: 8877761Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disase pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.Type: GrantFiled: April 18, 2012Date of Patent: November 4, 2014Assignee: Pfizer Inc.Inventors: Hui Li, Seiji Nukui, Stephanie Anne Scales, Min Teng, Chunfeng Yin
-
Publication number: 20140309213Abstract: This invention relates to compounds of Formula I-VI having the following general structure: Z1—Y1—(CH2)n1—R—(CH2)n2—Y2—Z2 wherein R is a 6-8 membered saturated heterocyclic ring having 2 Nitrogen atoms connected with —(CH2)n1— and —(CH2)n2—, respectively, and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.Type: ApplicationFiled: October 25, 2012Publication date: October 16, 2014Inventors: Shawn P. Walsh, Alexander Pasternak, Reynalda K. DeJesus, Haifeng Tang, Barbara Pio, Aurash Shahripour, Kevin M. Belyk, Harry R. Chobanian, Yan Guo, Jessica L. Frie, Zhi-Cai Shi, Helen Chen, Timothy A. Blizzard, Brian Cato
-
Publication number: 20140296537Abstract: Compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. Fused heterocyclic derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, or prodrugs thereof, or pharmaceutically acceptable salts thereof. In the formula (I), ring U represents C6-10 aryl or the like; R1 independently represents a hydrogen atom, a hydroxy group, C1-6 alkyl or the like; m represents an integral number from 1 to 2; ring Q represents 5-membered heteroaryl; n represents an integral number from 1 to 3; R2 independently represents a hydrogen atom, a halogen atom, C1-6 alkyl or the like.Type: ApplicationFiled: August 23, 2012Publication date: October 2, 2014Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Kazuo Shimizu, Yusuke Onda, Masato Iizuka
-
Publication number: 20140288045Abstract: Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Inventors: Pingda Ren, Yi Liu, Liansheng Li, Jun Feng, Tao Wu
-
Publication number: 20140288042Abstract: This invention relates to compounds of Formula I having the following general structure: Z1—Y1—(CH2)n1—R—(CH2)n2—Y2—Z2 wherein R represents a fused bicyclic or spirocyclic aliphatic diamine and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.Type: ApplicationFiled: October 25, 2012Publication date: September 25, 2014Inventors: Shawn P. Walsh, Alexander Pasternak, Zhi-Cai Shi, Brian Cato, Esther Y. Kim
-
Publication number: 20140275155Abstract: This invention relates to bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Matthias GRAUERT, Ralf ANDERSKEWITZ, Marc GRUNDL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS
-
Publication number: 20140275010Abstract: The present invention provides quaternary salts, such as those of Formula I: as well as the use thereof in methods of treatment for cancer.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Inventors: Guo Zhu Zheng, Yuan Wang, Gregg F. Keany, Kenzo Arai, Kazunobu Kira, Xiang Liu, Nick Gearhart, Baudouin Gerard
-
Publication number: 20140275093Abstract: This invention provides compounds of formula (I): wherein ring A, X1, X2, X3, R2, R4b, R10, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.Type: ApplicationFiled: October 16, 2013Publication date: September 18, 2014Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher Blackburn, Kenneth M. Gigstad, Sean J. Harrison, He Xu