Plural Ring Chalcogens In The Polycyclo Ring Sytem (e.g., Methylenedioxyphenyl Containing, Etc.) Patents (Class 548/526)
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Patent number: 4533656Abstract: Amide derivatives of the formula: ##STR1## wherein either R.sup.1 is aryl or heterocyclic and A.sup.1 is a direct link, or R.sup.1 is aryl or heterocyclic, or hydrogen or amino and A.sup.1 is alkylene; X is --CH.sub.2 -- or --CO-- or has the formula ##STR2## wherein R.sup.11 and R.sup.12, which may be the same or different, each is alkyl, or R.sup.11 and R.sup.12 are joined to form alkylene; A.sup.2 is alkylene; R.sup.2 is hydrogen, aryl or alkyl which is unsubstituted or which bears an aryl substituent; R.sup.3 is hydrogen or alkyl which is unsubstituted or which bears a halogeno, hydroxy, amino, guanidino, carboxy, carbamoyl, mercapto, alkoxy, alkylamino, dialkylamino, cyclic amino, alkylthio, alkanoylamino, alkoxycarbonyl, arylalkoxycarbonyl, aryl or heterocyclyl substituent; R.sup.4 is alkyl which is unsubstituted or which bears an aryl substituent, or R.sup.4 is phenyl or alkylphenyl; n is 0 or 1; and either R.sup.5, R.sup.6, R.sup.15 and R.sup.16 are all hydrogen, or R.sup.5 and R.sup.Type: GrantFiled: July 13, 1983Date of Patent: August 6, 1985Assignee: Imperial Chemical Industries PLCInventor: Edward R. H. Walker
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Patent number: 4522943Abstract: Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.Type: GrantFiled: April 21, 1982Date of Patent: June 11, 1985Assignee: Bristol-Myers CompanyInventors: Aldo A. Algieri, Ronnie R. Crenshaw
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Patent number: 4517184Abstract: The invention relates to novel benzodioxole derivatives of the formula I ##STR1## in which R.sub.1 represents an unsubstituted or substituted, aromatic or heteroaromatic radical, alk represents an alkylene or alkylidene radical having a maximum of 5 carbon atoms, n represents O or 1, R.sub.2 and R.sub.3 each represents, independently of the other, hydrogen, lower alkyl, lower alkoxy or halogen, and A represents the radical O-R.sub.4, wherein R.sub.4 represents hydrogen or an unsubstituted or substituted, aliphatic or araliphatic hydrocarbon radical, or A represents the radical ##STR2## in which either R.sub.5 and R.sub.6 each represents, independently of the other, hydrogen or lower alkyl, or R.sub.5 and R.sub.6 are bonded to one another and, together with the adjacent nitrogen atom, represent unsubstituted or lower alkyl-substituted tetra- or hexa-methyleneimino or 4-morpholinyl, to salts of compounds of the formula I in which A represents OR.sub.4 wherein R.sub.Type: GrantFiled: August 8, 1983Date of Patent: May 14, 1985Assignee: Ciba-Geigy CorporationInventors: Ernst Habicht, Paul Zbinden
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Patent number: 4507292Abstract: Aryl N-oxalyl-N-methyl-carbamates of the general formula ##STR1## in which X represents an alkoxy, alkenoxy, alkinoxy, aryloxy, alkylthio, alkenylthio, alkinylthio or arylthio radical, each of which may be optionally substituted, or represents a radical of the general formula --N R.sup.3 R.sup.4, wherein R.sup.3 and R.sup.4 are identical or different and represent a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl or aryl radical, each of which may be optionally substituted,or the radicals R.sup.3 and R.sup.4, together with the N atom to which they are bonded, form an optionally substituted heterocyclic ring, andR.sup.1 represents an aryl radical which is optionally substituted,are novel and find use as pesticides, especially for combating insects, acarids and nematodes.Type: GrantFiled: January 27, 1983Date of Patent: March 26, 1985Assignee: Bayer AktiengesellschaftInventors: Gerhard Heywang, Engelbert Kuhle, Wolfgang Behrenz, Ingeborg Hammann, Bernhard Homeyer
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Patent number: 4477635Abstract: Polymeric and copolymeric aminotriarylmethane dyes having polyester, polyethyleneimine, or polyurethane backbones, and a process for their preparation, are disclosed. The novel dyes are highly colored and resistant to leaching by solvents.Type: GrantFiled: January 4, 1982Date of Patent: October 16, 1984Assignee: Minnesota Mining and Manufacturing CompanyInventor: Smarajit Mitra
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Patent number: 4465848Abstract: The present specification provides novel antimicrobial analogs of spectinomycin and intermediates and processes for their preparation. Particularly described are novel 3'-diazo-secospectinomycin derivatives useful in the preparation of a variety of 3'-substituted spectinomycin analogs.Type: GrantFiled: September 13, 1982Date of Patent: August 14, 1984Assignee: The Upjohn CompanyInventors: Richard C. Thomas, Edward L. Fritzen
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Patent number: 4448970Abstract: Novel antibacterially-active analogs of the antibiotics nodusmicin and nargenicin A.sub.1. These compounds are prepared by selectively blocking active hydroxyl groups at the 9, 11 and 18 positions of nodusmicin, and the 11 and 18 positions of nargenicin A.sub.1. Antibacterially-active compounds can be used in various environments to control or eradicate susceptible bacteria. The techniques for such use are well known in the art.Type: GrantFiled: May 4, 1981Date of Patent: May 15, 1984Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4436920Abstract: Recording members having excellent light resistance are obtained by using as a dye precursor specific diarylaminofluoran compounds.Type: GrantFiled: March 11, 1982Date of Patent: March 13, 1984Assignee: Fuji Photo Film Co., Ltd.Inventors: Kozo Sato, Ken Iwakura, Akira Igarashi
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Patent number: 4436747Abstract: A new antibiotic substance, which has been named nargenicin C.sub.1, has been isolated from fermentations of a species of the genus Nocardia. Nargenicin C.sub.1 can be used as an antibacterial agent against susceptible bacteria, especially susceptible strains of Staphylococcus aureus.Type: GrantFiled: October 21, 1982Date of Patent: March 13, 1984Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4434295Abstract: The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5- ones.Type: GrantFiled: May 17, 1982Date of Patent: February 28, 1984Assignee: The Upjohn CompanyInventor: Ronald B. Gammill
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Patent number: 4413122Abstract: Aminodesoxy-1.4;3.6-dianhydrohexitol derivatives of the general formula I, ##STR1## wherein R.sup.1 and R.sup.2, in each case independently of one another, signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms or wherein R.sup.1 signifies a hydrogen atom and R.sup.2 an adamant(1)yl radical or wherein R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, (a) signify the residue of a cyclic, non-aromatic secondary amine possibly containing a further hetero atom or (b) the aden(9)yl radical possibly mono- or disubstituted on the 6-amino group or (c) the 6-alkylmercaptopurin(9)yl radical or (d) the theophyllin(7)yl radical or (e) the 6-chloropurin-9-yl radical or wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms and R.sup.2 an .omega.-theophyllin(7)ylalkyl radical or an .omega.-theobromin-1-ylalkyl radical or an .omega.Type: GrantFiled: July 20, 1981Date of Patent: November 1, 1983Assignee: Fa. Wilmar Schwabe GmbH & Co.Inventor: Klaus Klessing
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Patent number: 4363922Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: June 15, 1981Date of Patent: December 14, 1982Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4363805Abstract: Aminodesoxy-1.4;3.6-dianhydrohexitol nitrates of the general formula I, ##STR1## wherein R.sup.1 and R.sup.2 possess the meanings given in claim 1, as well as their pharmacologically acceptable acid-addition salts; processes for the preparation of said compounds, and pharmaceutical compositions containing at least one of said compounds.Type: GrantFiled: July 20, 1981Date of Patent: December 14, 1982Assignee: Firma Willmar SchwabeInventors: Klaus Klessing, Shyam S. Chatterjee, Bernard L. Gabard
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Patent number: 4360683Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: August 6, 1980Date of Patent: November 23, 1982Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4332811Abstract: Novel substituted 1,3-benzodithiol-2-N,N-dialkyliminium salts of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently of one another are each hydrogen, C.sub.1 -C.sub.5 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -alkenyl, C.sub.3 -C.sub.5 -alkynyl or the radical --(CH.sub.2).sub.n --OR, in which R is C.sub.1 -C.sub.4 -alkyl, and n is the number 2 or 3; R.sub.3 and R.sub.4 independently of one another are each C.sub.1 -C.sub.4 -alkyl, or together they are the radical --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --; and X.sup..crclbar. is a molar equivalent of an anion of an inorganic or organic acid; processes for producing these compounds, as well as compositions containing them, and their use for combating pests, particularly for combating members of the order Acarina which infest plants and animals. The novel compounds are distinguished by their special effectiveness against mites which damage plants.Type: GrantFiled: March 23, 1981Date of Patent: June 1, 1982Assignee: Ciba-Geigy CorporationInventors: Hansjakob Fah, Saleem Farooq, Alfred Grieder, Karl Scheuzger