Abstract: The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particulary, the invention concerns new compounds of the formula (VI) ##STR1## wherein R.sup.1 is hydrogen or a group suitable for a temporary protection or amides,X is hydroxyl, halogen, cyano or an --O--SO.sub.2 --R.sup.2 group, in whichR.sup.2 is lower alkyl or aryl,Y.sup.1 and Y.sup.2 together form a group suitable for a temporary protection of a keto group.The new compounds possess anaphylactic properties and are valuable intermediates of thienamycin synthesis. Their preparation and the new intermediates obtained during their preparation are also within the scope of the invention.

Abstract: The invention relates to new heterocyclic compounds containing a C-acetyl group and a process for their preparation. More particularly, the invention concerns new compounds of the formula (III). ##STR1## in which R is a protecting group suitable for temporary protection of amines and amides or an aryl group, and Z is alkyl.The compounds are intermediates in the preparation of penicillins.

Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR2## The compounds are useful as hypertensive agents.

Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.4 are independently selected from hydrogen and lower alkyl; R.sup.3 is hydrogen, lower alkyl or amino lower alkyl; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR2## are disclosed. The compounds are useful as anti-hypertensive agents.

Abstract: This invention relates to the new thiazolidine and pyrrolidine compounds represented by the following general formula ##STR1## wherein p1 Q.sup.1 and Q.sup.2 are methylene or sulfur atom; Z is alkylene containing 1 to 3 carbon atoms;R.sup.1 is hydrogen, alkyl, aryl or heterocycle;R.sup.2 is hydrogen, alkyl, acyl, aryl, heterocycle or mercapto radical;R.sup.3 is hydrogen or alkyl;R.sup.4 is hydrogen, alkyl, aryl, pyrroridine ring formed with R.sup.3, or thiazolidine ring formed with R.sup.3 ;R.sup.5 is hydroxy or amino, which may be substituted by alkyl or aryl.The compounds of this invention are synthesized by the condensation of sulfur-containing acyl thiazolidine carboxylic acid or sulfur-containing acyl pyrrolidine carboxylic acid with amino acid.The compounds of this invention are useful for antihypertensive agent.

Abstract: Disulfide compounds which have the general formula ##STR1## and salts thereof used for reducing blood pressure and for preventing or relieving diabetic complications, processes for manufacturing thereof, compositions comprising them and pharmaceutically acceptable excipients, and administering methods are mentioned.

Abstract: The invention relates to urea compounds which are useful as antihypertensives.

Abstract: Process for the preparation of peptides including higher polypeptides utilizing indenylmethoxycarbonyl blocking groups and products produced thereby.

Abstract: 1-[(2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives of the formula ##STR1## wherein R, R.sup.1, and R.sup.2, each independently, represent hydrogen or a (C.sub.1 -C.sub.4)alkyl radical, n represents the integer 1, 2, 3, 4, or 5, and, in each of the n (CR'.sub.2) groups, R' represents hydrogen or (C.sub.1 -C.sub.4)alkyl, are described as well as the process for their manufacture, the intermediates for their synthesis and their use as antihypertensive agents.

Abstract: Chiral Schiff bases according to the general formula: ##STR1## and transition metal complexes thereof, wherein C.sup.* is an asymmetric carbon atom, R.sup.1 and R.sup.2, which may be the same or different are alkyl, aralkyl, aryl or alkaryl, R.sup.3 is hydrogen, alkyl, aralkyl, aryl or alkaryl, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or lower alkyl or, where n is 1, may with the cyclic ring to which CR.sup.4 R.sup.

Abstract: Improved yields of Benzoxepino- or Benzthiapino[4,3-b]pyrrole-2-acetic acids have been achieved from processes based on modifications performed on a pyrrole carboxylic ester rather than on a pyrrole-.alpha.-oxoacetate.

Abstract: Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl or arylalkyl;n is 1 or 2; andp is 1 or 2inhibit the action of angiotensin converting enzyme.

Abstract: Disclosed is a process for preparing the antibiotic 6-hydroxymethyl-2-(.beta.-aminoethylthio)-1-carbadethiapen-2-em-3-carboxyl ic acid (I) ##STR1## and its pharmaceutically acceptable salt and ester derivatives. An intermediate for the production of these compounds are compounds of the formula ##STR2## wherein R.sup.5 and R are readily removable protecting groups.

Abstract: A process is disclosed wherein an optically active N-mercaptoalkanoylamino acid is prepared by(1) reacting an optically active .beta.-hydroxyalkanoic acid, with a halogenating reagent to prepare an optically active .beta.-haloalkanoyl halide(2) reacting the .beta.-haloalkanoyl halide with an amino acid to produce an optically active N-.beta.-haloalkanoylamino acid and(3) reacting the N-.beta.-haloalkanoylamino acid with a reagent capable of converting the halogen into the thiol group, the configuration of the formulas (II), (III), (IV), (V), and (VI) being retained in all the optically active compounds throughout the process to prepare the compound represented by formula (I). The product of the present invention, for example, N-(3-mercapto-2-D-methylpropanoyl)-L-proline inhibits the enzymatic conversion of angiotensin I into angiotensin II and therefore is useful for relieving angiotensin-related hypertension.

Abstract: This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity.

Abstract: There are described novel compounds which include a silver halide developing function, a colorless ligand which is a radical of an iminodiacetic acid and a radical containing an onium group. The compounds are useful in photography as silver halide developing agents and also may be complexed with metals to form dye developers.

Abstract: The invention relates to a novel process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid through the N-acylation of L-proline.According to the process of the invention L-proline is acylated with a 3-halogen-2-methylpropionyl chloride of the formula III ##STR1## wherein Hal is a halogen atom, preferably chlorine or bromine, the obtained 1-[3-halogen-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid, wherein Hal is as stated above, is reacted with an alkali thiosulfate or alkali trithiocarbonate and the reaction product is hydrolized with an acid.The process of the invention is very economical as compared with the known processes. The desired product is prepared from methacrylic acid in 4 reaction steps with a total yield of 25 percent and from L-proline in 2 reaction steps with a total yield of 30 percent.

Abstract: A method of purifying by separation of mercaptoacyl amino acid from mercaptoacyl amino acid dimer comprising,providing a first solution of impure mercaptoacyl amino acid in a fluid container means,contacting said first solution with a metal whereby said mercaptoacyl amino acid precipitates yielding a second solution and a purified mercaptoacyl amino acid precipitate,separating said purified mercaptoacyl amino acid precipitate from said second solution.

Abstract: This invention relates to novel analogs of proline terminal tripeptides and related compounds and is typified by ##STR1## The compounds are potent inhibitors of angiotensin converting enzyme and as such are useful as antihypertensive agents.