And Chalcogen Bonded Directly To A Ring Carbon Of The Five Membered Hetero Ring Which Is Not Adjacent To The Ring Nitrogen (e.g., 2,4 Pyrrolidinediones, Etc.) Patents (Class 548/544)
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Patent number: 7718186Abstract: The invention relates to novel 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B, D, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant tolerance promoter compound.Type: GrantFiled: October 21, 2005Date of Patent: May 18, 2010Assignee: Bayer CropScience AGInventors: Reiner Fischer, Stefan Lehr, Mark Wilhelm Drewes, Dieter Feucht, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne, Chris Rosinger
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Publication number: 20100111856Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z)p??I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.Type: ApplicationFiled: November 5, 2009Publication date: May 6, 2010Inventors: Herman Gill, Jagath R. Junutula, Henry B. Lowman, Jan Marik, Jeff Tinianow, Simon Williams
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Patent number: 7705037Abstract: The present invention relates to compounds of formula (I). These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new antibiotics.Type: GrantFiled: June 6, 2006Date of Patent: April 27, 2010Assignee: Novartis AGInventor: Michael Thormann
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Patent number: 7662891Abstract: To provide a compound which has a higher vulcanization efficiency and superior heat aging resistance compared to conventional compounding agents for rubber compositions and which is environmentally friendly. An amine salt compound of a carboxylic acid containing a thermal dissociation portion having the Formula (I): wherein R represents an organic group selected from a C1 to C20 alkyl group, a C3 to C10 cycloalkyl group, a C6 to C20 aryl group and a C7 to C30 alkaryl group, R1, R2 and R3 independently represent a hydrogen atom or a C1 to C20 organic group which may have a heteroatom and/or a substituent group and X represents a C2 to C20 organic group which may have a heteroatom and/or a substituent group and a compounding agent for rubber vulcanization and a rubber composition containing the same.Type: GrantFiled: December 13, 2007Date of Patent: February 16, 2010Assignee: The Yokohama Rubber Co., Ltd.Inventors: Takashi Matsuda, Wonmun Choi
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Publication number: 20100035185Abstract: A sulfonic acid onium salt represented by the following formula (1) can be used as a superior radiosensitive acid generator for resist compositions. It is possible to form a good pattern by using a resist composition containing this sulfonic acid onium salt. In formula (1), R1 represents a monovalent organic group, and Q+ represents a sulfonium cation or iodonium cation.Type: ApplicationFiled: February 14, 2008Publication date: February 11, 2010Applicant: CENTRAL GLASS COMPANY, LTD.Inventors: Yuji Hagiwara, Jonathan Joachim Jodry, Satoru Narizuka, Kazuhiko Maeda
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Publication number: 20100027192Abstract: Disclosed are coated metal oxide nanoparticles comprising a metal oxide nanoparticle having a surface; and ligands attached to the metal oxide nanoparticle surface. Also disclosed are phosphonic acid compounds comprising the structure Gn-R-Xn, wherein G is a terminal group; wherein R is a bridging group; wherein X is a phosphonic acid group; and wherein each n is, independently, 1, 2, or 3. Also disclosed are methods for preparing and using coated metal oxide nanoparticles. Also disclosed are nanocomposite compositions comprising a polymer; and a coated metal oxide nanoparticle dispersed within the polymer. Also disclosed are articles, films, and capacitors comprising a coated metal oxide nanoparticle or a nanocomposite composition. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: May 12, 2006Publication date: February 4, 2010Inventors: Joseph Perry, Simon Jones, Joshua N. Haddock, Peter Hotchkiss
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Publication number: 20100010234Abstract: Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, followed by the steps of hydrolysis and deprotection. The 4-protected hydroxyl pyroglutamic acid derivative is easy to produce from hydroxyproline. The 4-protected hydroxyl pyroglutamic acid derivative is particularly suitable for use in the efficient manufacture of monatin of high optical purity, since it can be alkylated selectively at the 4-position and stereoselectively and after its alkylation, it can easily be converted to a glutamic acid derivative.Type: ApplicationFiled: July 9, 2009Publication date: January 14, 2010Applicant: AJINOMOTO CO. INCInventor: Yusuke AMINO
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Publication number: 20090305891Abstract: The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the disclosure relates to selective herbicidal compositions comprising, firstly, the cycloalkylphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The disclosure furthermore relates to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.Type: ApplicationFiled: February 8, 2007Publication date: December 10, 2009Applicant: Bayer CropScience AGInventors: Reiner Fischer, Thomas Bretschneider, Stefan Lehr, Dieter Feucht, Eva-Maria Franken, Olga Malsam, Alfred Angermann, Guido Bojack, Christian Arnold, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger
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Publication number: 20090298828Abstract: The invention relates to new alkoxyalkyl-substituted cyclic ketoenols of the formula (I) in which A, B, D, G, W, X, Y and Z have the definitions indicated above, to a number of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or microbicides. The invention further provides selectively herbicidal, compositions which comprise alkoxyalkyl-substituted cyclic ketoenols on the one hand and a crop plant tolerance promoter compound on the other. The invention further relates to the boosting of the action of crop protection compositions comprising compounds of the formula (I) through the additions of ammonium salts or phosphonium salts and optionally penetration promoters.Type: ApplicationFiled: May 23, 2007Publication date: December 3, 2009Applicant: BAYER CROPSCIENCE AGInventors: Reiner Fischer, Stefan Lehr, Dieter Feucht, Olga Malsam, Christian Arnold, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Rolf Pontzen, Ulrich Görgens, Jan Dittgen
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Publication number: 20090286992Abstract: An iodonium compound of formula (I): where RAR1 is a C5-6 aryl group, bearing at least one substituent selected from formyl, thionoacyl, acylamidocarboxy, thionoester, azo, C2-20 alkenyl, C2-20 alkynyl, and (CH2)nRC, where RC is selected from ether, amino, azo and thioether; RAR2 is a C5-10 aryl group, optionally substituted by one or more groups selected from C1-12 alkyl, C5-12 aryl, C3-12 heterocyclyl, ether, thioether, nitro, cyano and halo, and may be linked to a solid support or fluorous tag; and X is a counteranion.Type: ApplicationFiled: May 15, 2009Publication date: November 19, 2009Inventors: Michael Andrew Carroll, Ran Yan
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Publication number: 20090275142Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.Type: ApplicationFiled: February 24, 2009Publication date: November 5, 2009Inventors: Yumei Huang, James M. Coull
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Patent number: 7612213Abstract: A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.Type: GrantFiled: June 6, 2003Date of Patent: November 3, 2009Assignee: RikenInventors: Hiroyuki Osada, Hideaki Kakeya, Yujiro Hayashi
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Publication number: 20090253917Abstract: The present invention provides 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates of the formula (I): wherein R1 is a C1-6 alkyl group, etc., R2 is a hydrogen atom or a COOR3 group, wherein R3 is a tert-C4-6 alkyl group, a 2,2,2-trichloroethyl group or a benzyl group in which the benzene ring moiety may be optionally substituted by one or two atoms or groups independently selected from the group consisting of a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a cyano group and a nitro group, and a salt thereof, which are useful as a novel intermediate for preparing tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3?-pyrrolidine derivatives such as Ranirestat being promising therapeutic agents for diabetic complications in a short process and in an economically advantageous and safe manner, and the process for preparing the same.Type: ApplicationFiled: June 13, 2007Publication date: October 8, 2009Inventor: Daisuke Tanaka
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Patent number: 7598423Abstract: This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.Type: GrantFiled: November 15, 2005Date of Patent: October 6, 2009Assignee: Eli Lilly and CompanyInventors: Thomas Daniel Aicher, Guillermo S. Cortez, Todd Michael Groendyke, Albert Khilevich, James Allen Knobelsdorf, Fredrik Pehr Marmsater, Jeffrey Michael Schkeryantz, Tony Pisal Tang, Nicholas Andrew Magnus
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Patent number: 7576102Abstract: The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.Type: GrantFiled: August 3, 2006Date of Patent: August 18, 2009Assignee: deCODE genetics ehfInventors: Vincent Sandanayaka, Jasbir Singh, Mahnaz Keyvan, Michael David Krohn, Mark E. Gurney
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Publication number: 20090156614Abstract: This invention provides new compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, prostate cancer, muscle wasting diseases and/or disorders or a bone-related diseases and/or disorders.Type: ApplicationFiled: July 19, 2007Publication date: June 18, 2009Inventors: James T. Dalton, Duane D. Miller, Igor Rakov, Casey Bohl, Michael L. Mohler
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Publication number: 20090130487Abstract: The inventive method for placing and fixing (bonding) a first object, whose surface is functionalized by compounds of formula I Y (X), A? (I), on the surface of a second object whose surface is functionalized by compounds of formula II Y (X)n A (II), wherein A and A? are functional groups enabling to be bonded at least by a link in a covalent manner to an object surface X and X? are aliphatic, linear, branched or cyclic spacers which can comprise one or several hetero, or aromatic, or heteroaromatic atoms or consist of several aromatic or heteroaromatic cycles and optionally of alternating aliphatic chains having aromatic or heteroaromatic groups, n and n?=0 or 1 and Y and Y are functions for generating one or several non-covalent bonds wherein said Y or Y? are selected such that they are complementary or can complex a metal atom or an identical metal compound.Type: ApplicationFiled: June 12, 2006Publication date: May 21, 2009Applicant: Commissariat A L'Energie AtomiqueInventors: Renaud Demadrille, Stephane Guillerez
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Publication number: 20090099192Abstract: The invention relates to novel substituted 1H-pyrrole-2,5-diones of the formula (IA) in which A?, Ar? and R? are as defined in the description, to novel compositions for controlling animal pests based on substituted 1H-pyrrole-2,5-diones of the formulae (I) and (IA) in which A, A?, Ar, Ar?, R and R? are as defined in the description, and to processes for their preparation.Type: ApplicationFiled: July 8, 2005Publication date: April 16, 2009Applicant: Bayer CropScience AGInventors: Thomas Bretschneider, Mazen Es-Sayed, Reiner Fischer, Kristian Kather, Olga Malsam, Jorg Konze, Peter Losel, Erich Sanwald, Waltraud Hempel
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Patent number: 7504430Abstract: The present invention features maleiimide compounds, pharmaceutical compositions of maleiimide compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more maleiimide compounds of the invention.Type: GrantFiled: August 22, 2006Date of Patent: March 17, 2009Assignee: The United States of America as represented by the Secretary, Department of Health and Human ServicesInventors: Maria Michejda, legal representative, Wei Yao, Brian I. Carr, Siddhartha Kar, Christopher J. Michejda
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Publication number: 20090069406Abstract: Tetramic acid analogues of Formula I and Formula II have antibacterial activity, primarily against gram-positive bacteria, and are iron chelators.Type: ApplicationFiled: September 8, 2008Publication date: March 12, 2009Inventors: Richard E. Lee, Julian Gregston Hurdle, Raghunandan Yendapally
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Publication number: 20090042967Abstract: The present invention relates to pharmaceutical agents which are agents for the prophylaxis or treatment of hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis; the pharmaceutical agents frailty suppressants, muscle strength enhancers, muscle increasing agents, cachexia suppressants, body weight decrease suppressants, agents for the prophylaxis or treatment of prostate hypertrophy, amyotrophy or muscle loss caused by a disease or an agent for reducing the prostate weight.Type: ApplicationFiled: August 6, 2008Publication date: February 12, 2009Applicant: Takeda Pharmaceutical Company LimitedInventor: Atsushi Hasuoka
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Patent number: 7459414Abstract: Compounds of formula wherein the substituents have the meanings given in claim 1, and agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as herbicides.Type: GrantFiled: March 18, 2005Date of Patent: December 2, 2008Assignee: Syngenta Crop Protection, Inc.Inventors: Thomas Maetzke, André Stoller, Sebastian Wendeborn, Henry Szczepanski
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Publication number: 20080287435Abstract: The novel active compound combinations of certain cyclic ketoenols and ethiprole have very good insecticidal and acaricidal properties.Type: ApplicationFiled: February 14, 2006Publication date: November 20, 2008Applicant: Bayer CropScience AGInventors: Reiner Fischer, Heike Hungenberg, Wolfgang Thielert
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Publication number: 20080227742Abstract: This invention relates to methods and compositions of oligonucleotide constructs having a photocleavable linker. Specifically, provided herein are methods and compositions utilizing a photocleavable linker, which when exposed to light modulates the expression of genes.Type: ApplicationFiled: November 27, 2007Publication date: September 18, 2008Inventors: Ivan Dmochowski, XinJing Tang
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Publication number: 20080220973Abstract: The invention relates to novel 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B, D, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant tolerance promoter compound.Type: ApplicationFiled: October 21, 2005Publication date: September 11, 2008Inventors: Reiner Fischer, Stefan Lehr, Mark Wilhelm Drewes, Dieter Feucht, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne, Chris Rosinger
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Patent number: 7423161Abstract: The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for preparing compounds having the formula (VIII).Type: GrantFiled: September 11, 2003Date of Patent: September 9, 2008Assignee: Rhodia ChimieInventors: Samir Zard, Fabien Gagosz, Lucie Tournier
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Publication number: 20080207734Abstract: Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.Type: ApplicationFiled: June 22, 2006Publication date: August 28, 2008Inventors: Stefan Stumpe, Roland Breves, Ursula Huchel, Frank Janssen, Andre Hatzelt
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Publication number: 20080176748Abstract: A series of herbicidal molecules derived from 3-acetyl-4-hydroxy-5-sec-butylpyrroline-2-ketone, a natural substance, and their potential use in agriculture for weed control. Through the modification of the 5-sec-butyl hydrocarbon chain and 3-acetyl group and the analysis of their biological functioning, newly designed molecules are superior to the original compound in herbicidal activity. These molecules inhibit the photosynthesis of the plants. The treated plants show significant damage in 24 hours and die within 3-5 days after the chemical treatment. In addition, the new molecule has relatively simple structure, they are easy to make and they have better physical properties. They are broad-spectrum, high potency herbicides.Type: ApplicationFiled: March 26, 2008Publication date: July 24, 2008Applicants: Nanjing Agricultural University, Nantong Jiangshan Agrochemical & Chemical Limited Liability Co., Ltd.Inventors: Sheng Qiang, Shiguo Chen, Chunlong Yang, Xinbin Dai, Yunfa Dong
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Patent number: 7402606Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.Type: GrantFiled: April 1, 2003Date of Patent: July 22, 2008Assignee: SmithKline Beecham CorporationInventors: David Gene Barrett, John G. Catalano, David Norman Deaton, Aaron Bayne Miller, John A. Ray, Vicente Samano
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Patent number: 7314932Abstract: Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrite groups, are provided.Type: GrantFiled: April 7, 2005Date of Patent: January 1, 2008Assignee: WyethInventor: Bogdan Kazimierz Wilk
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3-biphenyl-substituted-3-substituted-4-ketolactam and ketolactone and their utilization as pesticide
Patent number: 7307044Abstract: The present invention relates to novel 3-biphenyl-substituted, 3-substituted 4-keto-lactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y and Z are as defined in the disclosure, to processes for their preparation, and to their use as pesticides and/or microbicides and/or herbicides.Type: GrantFiled: November 18, 2002Date of Patent: December 11, 2007Assignee: Bayer CropScience AGInventors: Reiner Fischer, Astrid Ullmann, Thomas Bretschneider, Mark Wilhelm Drewes, Angelika Lubos-Erdelen, legal representative, Dieter Feucht, Udo Reckmann, Karl-Heinz Kuck, Ulrike Wachendorff-Neumann, Christoph Erdelen, deceased -
Publication number: 20070142432Abstract: The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.Type: ApplicationFiled: August 3, 2006Publication date: June 21, 2007Applicant: deCODE Chemistry, Inc.Inventors: Vincent Sandanayaka, Jasbir Singh, Mahnaz Keyvan, Michael David Krohn, Mark E. Gurney
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Patent number: 7179779Abstract: A novel cationic bleach activator having an enhanced hydrolytic stability is provided. The novel cationic bleach activator also leads to a reduction in strength loss of cotton fibers compared to conventional hot peroxide bleaching, and achieves this reduction in strength loss without a loss of whiteness. Bleaching compositions and detergent compositions comprising the novel cationic bleach activator also are provided. A method of bleaching cellulosic fibers, such as cotton fibers, and a method for removing a stain or discoloration from an article are further provided.Type: GrantFiled: January 6, 2006Date of Patent: February 20, 2007Assignee: North Carolina State UniversityInventors: Peter J. Hauser, David Hinks, Jung Jin Lee, Sang-Hoon Lim
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Patent number: 7115754Abstract: The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1–C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrheaType: GrantFiled: July 4, 2003Date of Patent: October 3, 2006Assignee: Applied Research Systems ARS Holding N.V.Inventors: Catherine Jorand-Lebrun, Jerome Dorbais, Anna Quattropani, Matthias Schwarz, Delphine Valognes
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Patent number: 7005439Abstract: The invention provides compounds of general formula (I) wherein m, n, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, process for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: GrantFiled: June 14, 2001Date of Patent: February 28, 2006Assignee: AstraZeneca ABInventors: Tomas Eriksson, Krister Henriksson
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Patent number: 6979685Abstract: Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.Type: GrantFiled: February 10, 2000Date of Patent: December 27, 2005Assignee: Cardiome Pharma Corp.Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Michael J. A. Walker, Richard A. Wall, Alexander B. Zolotoy
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Patent number: 6962943Abstract: The present invention relates to compounds of the formula (I) which are formed by the microorganism ST 003236 (DSM 14476) during fermentation, to a process for preparing and derivatizing them, to a pharmaceutical which comprises a compound of the formula (I) and to the use thereof for producing a pharmaceutical.Type: GrantFiled: November 8, 2002Date of Patent: November 8, 2005Assignee: Aventis Pharma Deutschland GmbHInventors: Matthias Schiell, Martin Knauf, Luigi Toti, Astrid Markus-Erb
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Patent number: 6943188Abstract: The invention provides compounds of general formula (I) wherein Q, R, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: GrantFiled: February 23, 2001Date of Patent: September 13, 2005Assignee: AstraZeneca ABInventors: Tomas Eriksson, Peter Hansen, Martin Hemmerling, Krister Henriksson, Tomas Klingstedt, Lars Pettersson, Michael Bodkin
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Patent number: 6933390Abstract: The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of further catalysts at room temperature.Type: GrantFiled: July 15, 2004Date of Patent: August 23, 2005Assignee: Warner-Lambert CompanyInventors: Hubert Barth, Klaus Steiner, Simon Schneider, Ulrich Bayer, Manfred Westermayer, Ulrike Wolfsperger, Hans-Jürgen Betche
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Patent number: 6919367Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.Type: GrantFiled: November 18, 2003Date of Patent: July 19, 2005Assignee: Cephalon, Inc.Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
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Patent number: 6894005Abstract: Compounds of formula wherein the substituents have the meanings given in claim 1, and agronomically tolerable salts, isomers and enantiomer of those compounds, are suitable for use as herbicides.Type: GrantFiled: September 5, 2000Date of Patent: May 17, 2005Assignee: Syngenta Crop Protection, Inc.Inventors: Thomas Maetzke, André Stoller, Sebastian Wendeborn, Henry Szczepanski
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Publication number: 20040186143Abstract: The present application describes modulators of MCP-1 of formula (I): 1Type: ApplicationFiled: February 11, 2004Publication date: September 23, 2004Inventors: Percy H. Carter, Matthew E. Voss
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Patent number: 6787564Abstract: The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.Type: GrantFiled: March 26, 2002Date of Patent: September 7, 2004Assignee: Institute of Materia Medica, Chinese Academy of Medical SciencesInventors: Juntian Zhang, Liang Huang, Kemei Wu, Shiming Chen
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Publication number: 20040147591Abstract: The present invention provides a compound represented by the formula (I) or a salt thereof: 1Type: ApplicationFiled: December 4, 2003Publication date: July 29, 2004Applicant: Mitsubishi Chemical CorporationInventors: Osamu Kanie, Chikako Saotome
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Publication number: 20040127365Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) 1Type: ApplicationFiled: December 8, 2003Publication date: July 1, 2004Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretshneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Publication number: 20040097471Abstract: Disclosed are compounds of the formula: 1Type: ApplicationFiled: September 24, 2002Publication date: May 20, 2004Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
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Patent number: 6727275Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.Type: GrantFiled: September 26, 2002Date of Patent: April 27, 2004Assignee: UCB, S.A./N.V.Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai
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Patent number: 6689890Abstract: Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a &ggr;-lactam, in which an &agr;-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C—H insertion, for example in the presence of a rhodium salt such as Rh2(OAc)4, by which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.Type: GrantFiled: December 18, 2002Date of Patent: February 10, 2004Assignee: University of South FloridaInventors: Kyung Woon Jung, Cheol Hwan Yoon
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Publication number: 20040019061Abstract: The invention concerns 1-H-3-arylpyrrolidine-2,4-dione derivatives of formula (I), 1Type: ApplicationFiled: July 3, 2002Publication date: January 29, 2004Inventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Kruger, Michael Ruther, Christoph Erdelen, Ulrike Wachendorff-Neumann
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Publication number: 20040002599Abstract: The invention relates to novel substituted benzoylcyclohexenones of the formula (I), 1Type: ApplicationFiled: October 21, 2002Publication date: January 1, 2004Inventors: Klaus-Helmut Muller, Hans-Georg Schwarz, Stefan Herrmann, Dorothee Hoischen, Stefan Lehr, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto, Seishi Ito, Chieko Ueno