Benzene Ring Bonded Directly To Ring Nitrogen Of The Five -membered Hetero Ring Patents (Class 548/563)
  • Patent number: 4543352
    Abstract: A class of naphthalene aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: September 24, 1985
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Patent number: 4518799
    Abstract: Novel processes for making arylpropionic acids are described. One process comprises carboxylating particular Grignard compounds which are the products of a catalyzed reaction between corresponding arylmagnesium bromides and ethylene. Furthermore, the reaction making the particular Grignard compounds is itself novel. Also, an improved method is disclosed for making coupled aryl compounds useful as intermediates for making compounds having a pharmaceutical use. For example, particular biaryls may be used to make some of the Grignard compounds herein from which the arylpropionic acids are made. Finally, an improved bromination is disclosed giving high yields of 4-bromo-2-fluoroaniline, which is thereafter coupled with benzene, then used to make the arylmagnesium bromide reacted with ethylene to obtain the particular Grignard compound and subsequent desired arylpropionic acid, i.e. 2-(2-fluoro-4-biphenylyl)propionic acid.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: May 21, 1985
    Assignee: The Upjohn Company
    Inventor: Thomas A. Hylton
  • Patent number: 4473394
    Abstract: This invention relates to pyrrole sulfonamides which are useful as herbicides. Typical of the pyrrole sulfonamides of the instant application in N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2,5-dimethyl-1H-p yrrole-3-sulfonamide.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: September 25, 1984
    Assignee: E. I. DuPont De Nemours & Company
    Inventors: John C. Budzinski, George Levitt
  • Patent number: 4471126
    Abstract: There is a method for the production of 3-phenylpyrrole derivatives having the general formula ##STR1## wherein X is halogen, nitro or haloalkyl having 1 to 3 carbon atoms;n is 0, 1 or 2; andZ is hydrogen or halogen;which comprises reacting a compound having the general formula ##STR2## wherein X and n are as previously defined; andY is hydrogen or halogen;with ammonia or aqueous ammonia in an organic solvent.A compound having the general formula [I] is useful as fungicide or intermediate thereof.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: September 11, 1984
    Assignee: Nippon Soda Company Limited
    Inventors: Akiyoshi Ueda, Humihiko Nagasaki, Yutaka Takakura, Shigeru Kojima
  • Patent number: 4456672
    Abstract: Electrophotographic recording materials which comprise an electrically conductive base, charge carrier-producing compounds (sensitizers), and compounds which are charge carrier-transporting when exposed to light, possess high photoconductivity and low conductivity in the dark, and contain, as charge carrier-transporting compounds, 1,2,3-triazoles of the fomula ##STR1## are used for reprographic purposes and for the production of electrophotographic printing plates, in particular offset printing plates.
    Type: Grant
    Filed: April 27, 1983
    Date of Patent: June 26, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz Eilingsfeld, Karl-Heinz Etzbach, Gerhard Hoffmann, Peter Neumann
  • Patent number: 4443447
    Abstract: Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein X is selected from the group consisting of --O--, --CH.sub.2 and ##STR2## m is 0 or 1; R.sub.1 is selected from the group consisting of hydrogen, nitro, amino, lower alkyl, lower alkanamido, lower N,N-dialkylamino, formamido, hydroxy, lower alkoxy, halogen, lower haloalkanamido and pyrryl; n is 1 or 2; and R.sub.2 is selected from the group consisting of hydrogen, methyl, fluoro, chloro and nitro. Acyl chlorides, esters, alkylaminoalkyl ester salts, amides and pharmaceutically acceptable carboxylate salts are also disclosed. Pharmaceutical compositions containing these compounds, methods of using these compound and synthetic intermediates are also disclosed.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: April 17, 1984
    Assignee: Riker Laboratories, Inc.
    Inventors: John F. Gerster, Richard M. Stern
  • Patent number: 4442296
    Abstract: Disclosed are novel compounds of the formula ##STR1## wherein R.sup.1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R.sup.2 is hydrogen, a tetramethylcyclopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2,2-dichlorocyclopropanecarbonyl group, or a substituted-vinylcyclopropanecarbonyl group. The compounds wherein R.sup.2 is other than hydrogen are insecticides.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: April 10, 1984
    Assignee: FMC Corporation
    Inventor: John F. Engel
  • Patent number: 4401545
    Abstract: Electrically conductive complexes of polypyrroles with nitroaromatic anions are prepared by polymerizing pyrrole, an N-alkylpyrrole and/or an N-arylpyrrole by anodic oxidation in a polar solvent, in the presence of a salt of an acidic nitroaromatic compound.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: August 30, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Herbert Naarmann, Dieter Naegele, Klaus Penzien, Johannes Schlag, Volker Kiener, Hugo Boehm
  • Patent number: 4391827
    Abstract: Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: July 5, 1983
    Assignee: Pfizer Inc.
    Inventors: Charles A. Harbert, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4339457
    Abstract: 3-(Pyrrol-1-yl)phenylmethyl esters and intermediates having the general formula ##STR1## the use of the esters as pesticides, compositions thereof and a process for preparation are disclosed and exemplified.
    Type: Grant
    Filed: October 20, 1980
    Date of Patent: July 13, 1982
    Assignee: FMC Corporation
    Inventors: Ernest L. Plummer, Raymond M. Palmere