Plural Hetero Atoms In The Hetero Ring Patents (Class 548/951)
  • Patent number: 5508428
    Abstract: A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: ##STR1## wherein Q represents a partial structure of formula II: ##STR2## wherein all substituents are defined in the specification.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: April 16, 1996
    Assignee: Daiichi Phamaceutical Co., Ltd.
    Inventors: Isao Hayakawa, Shohgo Atarashi, Masazumi Imamura, Youichi Kimura
  • Patent number: 5409921
    Abstract: Compounds characterized generally as thiazetidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is a thiazetidinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from--(CH.sub.2).sub.q --C.tbd.C-Vwherein V is selected from hydrido and methyl; wherein R.sub.6 is cyclohexylmethyl; wherein R.sub.7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: April 25, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, Robert E. Manning
  • Patent number: 5315004
    Abstract: This invention relates to a process for preparing a dimer by the steps of: (a) cyclodimerizing a polyisocyanate in the presence of a dimerization catalyst which is covalently bound to an insoluble inorganic matrix by contacting said polyisocyanate with said catalyst at a temperature of between about 20 and about 135.degree. C. in a reaction to form an uretidione-containing cyclodimerized isocyanate wherein a portion of the isocyanate moieties comprising said polyisocyanate are converted to uretidione groups, and (b) separating said catalyst from said cyclodimerized isocyanate in order to stop said reaction after a desired amount of isocyanate moieties in said polyisocyanate have been converted to uretidione moieties.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: May 24, 1994
    Assignee: Olin Corporation
    Inventors: Stephen L. Goldstein, Anthony D. Hamer, Lawrence E. Katz, Michael J. McGeary, Curtis P. Smith
  • Patent number: 5217706
    Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: June 8, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Raghavan Rajagopalan, Rebecca A. Wallace, Muthunadar P. Periasamy
  • Patent number: 5212301
    Abstract: Introduction of a fluoro substituent into an aromatic ring adjacent an electron donating group is difficult producing mixed isomers and low yields of desired products.A process for the introduction of a fluoro substituent into a substantially adjacent position to an electron-donating group into an aromatic compound in high yield is disclosed.The fluoroaromatic compounds are useful as synthetic intermediates for example in the manufacture of agrochemicals, pharmaceuticals and dyestuffs.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: May 18, 1993
    Assignee: Imperial Chemical Industries PLC
    Inventors: John S. Moilliet, Richard D. Chambers, Michael H. Rock
  • Patent number: 5196499
    Abstract: The present invention relates to a series of novel silicone ester quaternary polymers which are substantive to fiber and provide outstanding softening properties to various fibers, hair and skin. The compounds of the present invention are prepared by the esterification of a terminal hydroxyl group which is present on a silicone polymer with monochloroacetic acid, and in a subsequent step, reacting the chloro ester so produced with a tertiary amine to produce the desired quaternary compound.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: March 23, 1993
    Assignee: Siltech, Inc.
    Inventor: Anthony J. O'Lenick, Jr.
  • Patent number: 5153294
    Abstract: The present invention relates to a series of novel ester containing quaternary silicone polymers, useful in softening hair, and fiber and conditioning skin. The compounds of the present invention are prepared by the esterification reaction of chloroacetic acid with a pendant hydroxyl group which is present on a silicone polymer. In a preferred embodiment the hydroxy containing silicone polymer has been alkoxylated with ethylene oxide, propylene oxide or mixtures thereof.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: October 6, 1992
    Assignee: Siltech Inc.
    Inventor: Anthony J. O'Lenick, Jr.
  • Patent number: 5149766
    Abstract: The present invention relates to a process for the preparation of uretdione group containing polyisocyanates comprising reacting monomeric aromatic diisocyanates in the presence of 1,2-dimethylimidazole used as a catalyst in an inert organic solvent whereby the weight ratio of solvent to diisocyanate lies in a range of from 0.1:1 to 2:1.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: September 22, 1992
    Assignee: BASF Aktiengesellschaft
    Inventor: Bernd Bruchmann
  • Patent number: 5142054
    Abstract: Disclosed are new 1,3-dioxenones having the formulae ##STR1## in an optically pure state, a process for preparing same and the use thereof.
    Type: Grant
    Filed: February 12, 1991
    Date of Patent: August 25, 1992
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Kurt Schaffner, Martin Demuth
  • Patent number: 5103004
    Abstract: Heterocyclically substituted N-sultamsulfonamides, processes for their preparation and their use as herbicides and plant growth regulators.Compounds of the formula I or their salts ##STR1## wherein R.sup.1 and R.sup.2 denote H, halogen, alkyl, alkenyl, alkynyl or alkoxy, which can be substituted, or denote --(CH.sub.2).sub.n --COOR.sup.11 ;R.sup.3 denotes H, alkyl, alkenyl or alkynyl;R.sup.4 denotes a heterocyclic radical of the formulae ##STR2## where E is CH or N; X is O or S and a, b, c, d, e in each case denote 0, 1 or 2, with the proviso that c+d+e.gtoreq.2, possess excellent herbicidal and plant growth-regulating properties.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: April 7, 1992
    Assignee: Hoesch Aktiengellschaft
    Inventors: Lothar Willms, Klaus Bauer, Hermann Bieringer, Helmut Burstell
  • Patent number: 5077432
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or alkyl or R.sub.3 and R.sub.4 taken together with the nitrogen atoms to which they are attached form a 1,2-diazacyclobutane, 1,2-diazacyclopentane, 1,2-diazacyclohexane, or 1,2-diazacycloheptane ring and Y, and Y.sub.2 are either hydrogen or hydroxy but are not the same; are useful chemical intermediates for the preparation of .beta.-lactam antibiotics.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: December 31, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Robert Zahler, Stefan Jendrzejewski
  • Patent number: 5030724
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof. R.sub.3 and R.sub.4 are the same or different and each is hydrogen or alkyl or R.sub.3 and R.sub.4 taken together with the nitrogen atoms to which they are attached form a 1,2-diazacyclobutane, 1,2-diazacyclopentane, 1,2-diazacyclohexane, or 1,2-diazacycloheptane ring.Y.sub.1 and Y.sub.2 are either hydrogen or OR.sub.11 but are not the same.R.sub.11 is hydrogen, alkanoyl of from one to ten carbon atoms, substituted alkanoyl of from two to ten carbon atoms, phenylcarbonyl, (substituted phenyl) carbonyl, heteroarylcarbonyl, phenylalkanoyl, (substituted phenyl) alkanoyl, or heteroarylalkanoyl.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: July 9, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Robert Zahler, Stefan Jendrzejewski
  • Patent number: 4996316
    Abstract: A process for the preparation of tertiary N,N-dimethylamines by the reaction of primary amines, formaldehyde, and hydrogen under pressure and at elevated temperature in the presence of a nickel-containing hydrogenation catalyst in the liquid phase. The hydrogenation catalyst is suspended in a solvent, the nickel concentration is 0.1 to 10% by weight, based on the primary amine. The starting materials are separate from each other, brought to 80.degree. to 150.degree. C. and 1 to 15 MPa and fed into the catalyst suspension simultaneously with stirring and reacted in one step to form the tertiary N,N-dimethylamines.
    Type: Grant
    Filed: December 24, 1988
    Date of Patent: February 26, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jurgen Weber, Detlef Kampmann, Claus Kniep
  • Patent number: 4977141
    Abstract: Non-peptidyl compounds characterized generally as aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: December 11, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, John S. Baran
  • Patent number: 4968676
    Abstract: Cyclohexylamines of the formula ##STR1## where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical, R.sup.1 and R.sup.2 are hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, cycloalkyl, cycloalkenyl or arylalkyl, or R.sup.1 and R.sup.2 together form an alkylene group and, together with the N atom, form a ring, and acid addition salts thereof, with the exception of compounds in which X is a single bond, Y is cyclohexyl, R.sup.1 and R.sup.2 are hydrogen or methyl, and the compounds in which X is C.sub.6 -, C.sub.7 - and C.sub.8 -alkyl, Y is hydrogen and R.sup.1 and R.sup.2 together with the N atom whose substituents they are form a 2,6-dimethylmorpholine radical, and fungicides containing such cyclohexylamines.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: November 6, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernhard Zipperer, Ernst Buschmannm, Norbert Goetz, Ulrich Schirmer, Eberhard Ammermann, Ernst-Heinrich Pommer
  • Patent number: 4800077
    Abstract: The present invention deals with novel quaternary compounds and their application as softening, anti-tangle, and conditioning agents. The properties of these novel quaternary compounds which make them well suited for these applications is their substantivity to fibers, hair and skin and that they are very mild to the skin and eyes.The compounds of the invention conform to the formula: ##STR1## wherein: R is C.sub.6 to C.sub.20 ;R' is the same or different than R and is from C.sub.6 to C.sub.20,EO is an ethylene oxide residue;PO is a propylene oxide residue;x,y,z are integers and independently are from 0 to 10.
    Type: Grant
    Filed: January 13, 1988
    Date of Patent: January 24, 1989
    Assignee: GAF Corporation
    Inventors: A. J. O'Lenick, Jr., Wayne C. Smith
  • Patent number: 4697011
    Abstract: N-fluoro-N-perfluoromethyl sulfonamide compounds are provided as fluorinating agents for the fluorination of organic compounds by either the direct electrophilic fluorination of organic compounds or by the fluorination of organic compound carbanions.
    Type: Grant
    Filed: July 18, 1986
    Date of Patent: September 29, 1987
    Assignee: Research Corporation
    Inventor: Darryl D. DesMarteau
  • Patent number: 4686268
    Abstract: Copolymers of average molecular weight within the range from about 1,000 to about 50,000, preferably from about 1,000 to about 10,000, are provided containing the repeating polymeric unit having the formula (I) and the repeating polymeric unit having the formula (II): ##STR1##
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: August 11, 1987
    Assignee: Morisawa & Co., Ltd.
    Inventor: Seoh Won Kang