Nitrogen Or -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Hetero Ring Patents (Class 548/953)
  • Azetidine-3-carboxylic acid derivatives
    Patent number: 4721793
    Abstract: The novel ester, N-benzylazetidine-3-carboxylic acid methyl ester and its use in the preparation of the corresponding free acid by a process which comprises reacting N-benzyl-3-cyanozetidine with methanol and hydrolyzing the resulting methyl ester with hot water.
    Type: Grant
    Filed: July 18, 1985
    Date of Patent: January 26, 1988
    Assignee: Shell Oil Company
    Inventors: Ronald F. Mason, Paul H. Briner
  • Pesticidal water-soluble aminoacid sulfenylated carbamates
    Patent number: 4686233
    Abstract: Pesticidal water-soluble aminoacid sulfenylated carbamates useful as broad spectrum insecticides and miticides, particularly useful as systemic insecticides.
    Type: Grant
    Filed: May 1, 1986
    Date of Patent: August 11, 1987
    Assignee: Union Carbide Corporation
    Inventors: Chennupati K. Rao, Themistocles D. D'Silva
  • .alpha.-acyloxy phosphonate angiotensin converting enzyme inhibitors
    Patent number: 4670422
    Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: June 2, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Tamara Dejneka
  • Process for preparing azetidine derivatives and intermediates thereof
    Patent number: 4665197
    Abstract: The invention provides a process for preparing azetidine-3-carboxylic acid or salts thereof; useful as chemical hybridizing agents, which comprises treating a compound of the formula ##STR1## wherein R represents a hydrogen atom or a group of formula R.sup.1 R.sup.2 CH-- wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl or optionally substituted phenyl moieties, with nitric acid and subjecting the resulting initial product to acid conditions to produce an acid-addition salt of azetidine-3-carboxylic acid, and thereafter, if desired, converting the acid-addition salt to the free acid or another salt of the acid, 1-nitrosoazetidine-3,3-dicarboxylic acid, 1-nitrosoazetidine-3-carboxylic acid and salts thereof being intermediates in the process.
    Type: Grant
    Filed: June 12, 1985
    Date of Patent: May 12, 1987
    Assignee: Shell Oil Company
    Inventors: Margaretha J. de Nie-Sarink, Ronald F. Mason
  • Ester substituted aminoalkanoylureido amino and imino acid and ester compounds
    Patent number: 4638010
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: January 20, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Acylaminoalkanoyl urethanes or thiourethanes
    Patent number: 4636522
    Abstract: Compounds of the formula ##STR1## wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: January 13, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Eric M. Gordon
  • Substituted sulfonamidobenzamides and method of treating arrhythmias
    Patent number: 4629739
    Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.
    Type: Grant
    Filed: September 23, 1985
    Date of Patent: December 16, 1986
    Assignee: Schering A.G.
    Inventors: David D. Davey, William C. Lumma, Jr., Ronald A. Wohl
  • Hydroxy substituted ureido amino and imino acids
    Patent number: 4604402
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: August 5, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Eric M. Gordon, Sesha I. Natarajan