Plural Ring Hetero Atoms In The Hetero Ring Patents (Class 549/10)
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Patent number: 11629307Abstract: A grease composition comprising a thickener and a lubricating base oil, wherein the lubricating base oil has a viscosity in the range of from 5-1000 cSt (at 40° C.). The thickener is present in an amount of 5-40 wt. %, based on total weight of the grease composition. The thickener comprises an ester terminated oligomer which has the general formula: “R1—O—[CO—R2—CO—NH—R3—NH—CO—R2—CO]n-O—R1”. “R1” represents a hydrocarbon group containing 4-22 carbon atoms. “R2” represents a hydrocarbon group containing 4-42 carbon atoms. “R3” represents a hydrocarbon group containing 2-9 carbon atoms. “n” represents an integer in the range of 1-20. The weight ratio between the lubricating base oil and the ester terminated oligomer (oil/oligomer) is larger than 1. The grease composition can be used for lubricating a mechanical component having a metal surface and/or for protecting a mechanical component having a metal surface against corrosion, wear and/or fretting.Type: GrantFiled: December 11, 2017Date of Patent: April 18, 2023Assignee: AKTIEBOLAGET SKFInventors: Dick Meijer, Sathwik Chatra Kalsanka Ramakrishna, Dries Muller
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Patent number: 11500288Abstract: Disclosed is a resin including a structural unit represented by formula (I) and a structural unit represented by formula (a2-A), and a resist composition: wherein R1 represents a hydrogen atom or a methyl group; L1 and L2 each represent —O— or —S—; s1 represents an integer of 1 to 3; s2 represents an integer of 0 to 3; Ra50 represents a hydrogen atom, a halogen atom, or an alkyl group which may have a halogen atom; Ra51 represents a halogen atom, a hydroxy group, an alkyl group, an alkoxy group, an alkylcarbonyl group or the like; Aa50 represents a single bond or *—Xa51-(Aa52-Xa52)nb—; Aa52 represents an alkanediyl group; Xa51 and Xa52 each represent —O—, —CO—O— or —O—CO—; nb represents 0 or 1; and mb represents an integer of 0 to 4.Type: GrantFiled: January 14, 2020Date of Patent: November 15, 2022Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Mutsuko Higo, Shingo Fujita, Koji Ichikawa
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Patent number: 11353790Abstract: Disclosed is a resin including a structural unit represented by formula (a1-5) and a structural unit represented by formula (I), and a resist composition: wherein Ra8 represents an alkyl group which may have a halogen atom, a hydrogen atom or a halogen atom; Za1 represents a single bond or *—(CH2)h3—CO-L54-; h3 represents an integer of 1 to 4; L51, L52, L53 and L54 each independently represent —O— or —S—; s1 represents an integer of 1 to 3; s1? represents an integer of 0 to 3; R1 represents a hydrogen atom or a methyl group; A1 represents a single bond or *—CO—O—; R2 represents a halogen atom, a hydroxy group, a haloalkyl group or an alkyl group; mi represents an integer of 1 to 3; and ni represents an integer of 0 to 4, in which mi+ni?5.Type: GrantFiled: January 14, 2020Date of Patent: June 7, 2022Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Mutsuko Higo, Shingo Fujita, Koji Ichikawa
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Patent number: 9890129Abstract: The present invention relates to a novel aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating constipation comprising the same as an active ingredient.Type: GrantFiled: August 28, 2015Date of Patent: February 13, 2018Assignee: CJ HEALTHCARE CORPORATIONInventors: Won-Hyuk Jung, Seung In Kim, Seung Hee Ji, Dong Hyun Ko, Seog Beom Song, Keun Ho Lee, Hyung Jin Jun, Dong Kyu Kim, Dong Hyun Kim
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Patent number: 8703387Abstract: A resist composition comprising a base component (A) which exhibits changed solubility in a developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the acid-generator component (B) comprising an acid generator (B1) composed of a compound represented by general formula (b1-1) shown below [wherein, X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, provided that a ring skelton of the cyclic group contains an —SO2— bond or an —O—SO2— bond, and at least one carbon atom which is not adjacent to the —SO2— bond or the —O—SO2— bond has an oxygen atom as a substituent; Q1 represents a divalent linking group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; and A+ represents an organic cation].Type: GrantFiled: May 23, 2012Date of Patent: April 22, 2014Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Akiya Kawaue, Yoshiyuki Utsumi
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Publication number: 20140054520Abstract: A novel photochromic compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability. The present invention is a chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as the basic skeleton in which a hetero ring having two hetero atoms including at least one sulfur atom is directly bonded to the 6-position and the 7-position of the indeno(2,1-f)naphtho(1,2-b)pyran structure via the hetero atom like the compound represented by the following formula (18).Type: ApplicationFiled: March 7, 2012Publication date: February 27, 2014Applicant: TOKUYAMA CORPORATIONInventors: Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Toshiaki Takahashi, Mitsuyoshi Sando, Shinobu Izumi
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Patent number: 8492562Abstract: Provided are a polymerizable compound shown below which is useful as a raw material for a polymer having less swelling in developing, a polymer obtained by polymerizing a raw material containing the above polymerizable compound, a photoresist composition which contains the above polymer and which is improved in LWR and an efficient production process for the polymerizable compound described above: wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or trifluoromethyl; R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; W represents an alkylene group having 1 to 10 carbon atoms or the like; and Y1 and Y2 represent an oxygen atom or a sulfur atom.Type: GrantFiled: February 20, 2009Date of Patent: July 23, 2013Assignee: Kuraray Co., Ltd.Inventors: Junko Sato, Osamu Nakayama, Takashi Fukumoto
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Patent number: 8481755Abstract: This invention relates to novel compounds with ester linkage(s) capped with either electron deficient olefinic linkage(s) or group(s) or reactive functional groups (termed herein as “active methylene reagents”), and curable compositions prepared therefrom.Type: GrantFiled: April 23, 2010Date of Patent: July 9, 2013Assignee: Henkel Ireland Ltd.Inventors: Ciaran B. McArdle, Ligang Zhao, Stefano Gherardi, Kevin Murnaghan
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Publication number: 20130150533Abstract: A shape-memory polymers comprising at least one monomer subunit represented by the following structural formula (1).Type: ApplicationFiled: August 25, 2011Publication date: June 13, 2013Inventors: Bridgette M. Budhlall, Amit L. Garle
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Patent number: 8431722Abstract: A cyclic alcohol of formula (II-1): wherein: R2, R3, and R4 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; or R2 and R3 or R3 and R4 combine to form an alkylene group comprising 3 to 6 carbon atoms; m is 1 or 2; R5, R6, R7, R8, R9, and R10 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; A is an oxygen atom; and B is an oxygen atom or a sulfur atom. In addition, a process for producing the cyclic alcohol of formula (II-1).Type: GrantFiled: August 10, 2012Date of Patent: April 30, 2013Assignee: Kuraray Co., Ltd.Inventors: Osamu Nakayama, Takashi Fukumoto
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Publication number: 20130053530Abstract: Disclosed is a method for preparing a poly(ethersulfonimide or ethersulfonamide) copolymer using cyclic oligomers, and more particularly, to a method for preparing a poly(ethersulfonimide or ethersulfonamide) copolymer by preparing a cyclic ether sulfone oligomer and a cyclic imide or amide oligomer and subjecting the cyclic ether sulfone oligomer and the cyclic imide or amide oligomer to ring-opening copolymerization in the presence of an alkali metal fluoride catalyst.Type: ApplicationFiled: October 7, 2010Publication date: February 28, 2013Inventors: Yong Seok Kim, Hyun Min Jung, Jong Chan Won, Jae Heung Lee
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Patent number: 8362169Abstract: Provided are 1) a polymer which is excellent in a reactivity to acid and a heat stability and which is less swollen in developing, 2) a compound shown below which is a raw material for the above polymer and 3) a photoresist composition which contains the above polymer and which is improved in LWR and excellent in a heat resistance. (wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or the like; R2 to R10 each represent independently a hydrogen atom, a linear alkyl group, a branched alkyl group or the like; and A and B each represent independently an oxygen atom or a sulfur atom).Type: GrantFiled: February 20, 2009Date of Patent: January 29, 2013Assignee: Kuraray Co., Ltd.Inventors: Osamu Nakayama, Takashi Fukumoto
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Publication number: 20120316349Abstract: A cyclic alcohol of formula (II-1): wherein: R2, R3, and R4 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; or R2 and R3 or R3 and R4 combine to form an alkylene group comprising 3 to 6 carbon atoms; m is 1 or 2; R5, R6, R7, R8, R9, and R10 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; A is an oxygen atom; and B is an oxygen atom or a sulfur atom. In addition, a process for producing the cyclic alcohol of formula (II-1).Type: ApplicationFiled: August 10, 2012Publication date: December 13, 2012Applicant: KURARAY CO., LTD.Inventors: Osamu NAKAYAMA, Takashi FUKUMOTO
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Patent number: 8329700Abstract: Pyrazine compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein m, n, p, R1, R2, R3, R4, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, Y and Z are defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.Type: GrantFiled: March 7, 2011Date of Patent: December 11, 2012Assignee: Amgen Inc.Inventors: Jennifer R. Allen, Matthew Paul Bourbeau, Ning Chen, Essa Hu, Roxanne Kunz, Shannon Rumfelt
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Publication number: 20120172555Abstract: A monomer compound has the formula (I): where each R1, R2, and R3 is independently H, F, C1-10 alkyl, fluoro-substituted C1-10 alkyl, C1-10 cycloalkyl, or fluoro-substituted C1-10 cycloalkyl, provided that at least one of R1, R2, or R3 is F; n is an integer of from 1 to 10, A is a halogenated or non-halogenated C2-30 olefin-containing polymerizable group, and G+ is an organic or inorganic cation. The monomer is the reaction product of a sultone precursor and the oxyanion of a hydroxy-containing halogenated or non-halogenated C2-30 olefin-containing compound. A polymer includes the monomer of formula (I).Type: ApplicationFiled: December 29, 2011Publication date: July 5, 2012Inventors: Suzanne M. Coley, David R. Wilson, Francis J. Timmers
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Patent number: 8124313Abstract: A compound represented by general formula (I); and a compound represented by general formula (b1-1). wherein Q1 represents a divalent linkage group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, and has an —SO2— bond in the structure thereof; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: GrantFiled: January 22, 2010Date of Patent: February 28, 2012Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Akiya Kawaue, Hideo Hada, Hiroaki Shimizu, Tsuyoshi Nakamura
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Patent number: 8067459Abstract: The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.Type: GrantFiled: October 16, 2008Date of Patent: November 29, 2011Assignee: ArQule, Inc.Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, Yanbin Liu, Chiang J. Li
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Patent number: 7982054Abstract: The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine.Type: GrantFiled: November 6, 2007Date of Patent: July 19, 2011Assignee: Pierre Fabre MedicamentInventors: Bernard Vacher, Yves Brunel, Jean-Louis Maurel
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Publication number: 20110118330Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.Type: ApplicationFiled: July 8, 2009Publication date: May 19, 2011Applicant: PURDUE RESEARCH FOUNDATIONInventor: Arun K. Ghosh
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Publication number: 20110060112Abstract: Provided are 1) a polymer which is excellent in a reactivity to acid and a heat stability and which is less swollen in developing, 2) a compound shown below which is a raw material for the above polymer and 3) a photoresist composition which contains the above polymer and which is improved in LWR and excellent in a heat resistance. (wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or the like; R2 to R10 each represent independently a hydrogen atom, a linear alkyl group, a branched alkyl group or the like; and A and B each represent independently an oxygen atom or a sulfur atom).Type: ApplicationFiled: February 20, 2009Publication date: March 10, 2011Applicant: KURARAY CO., LTD.Inventors: Osamu Nakayama, Takashi Fukumoto
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Patent number: 7902381Abstract: The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3 is an alkyl radical, a hydroxy group, or a methoxy radical, R4 is a hydrogen atom or a methyl radical and R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical, and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).Type: GrantFiled: April 8, 2005Date of Patent: March 8, 2011Assignee: Pierre Fabre MedicamentInventors: Bernard Vacher, Yves Brunel, Florence Castan-Cuisiat
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Publication number: 20100331508Abstract: Provided are a polymerizable compound shown below which is useful as a raw material for a polymer having less swelling in developing, a polymer obtained by polymerizing a raw material containing the above polymerizable compound, a photoresist composition which contains the above polymer and which is improved in LWR and an efficient production process for the polymerizable compound described above: wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or trifluoromethyl; R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; W represents an alkylene group having 1 to 10 carbon atoms or the like; and Y1 and Y2 represent an oxygen atom or a sulfur atom.Type: ApplicationFiled: February 20, 2009Publication date: December 30, 2010Applicant: KURARAY CO., LTD.Inventors: Junko Sato, Osamu Nakayama, Takashi Fukumoto
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Patent number: 7834001Abstract: Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa; W is S(O)m; wherein Ra is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb is H, alkyl, OH, ORa or OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.Type: GrantFiled: November 8, 2005Date of Patent: November 16, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Swati Bal-Tembe, Usha Ghosh, Arun Kumar Jain, Tulsidas More
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Publication number: 20100233279Abstract: Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase-mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase-mediated disorders and synthetic processes for the preparation of the compounds.Type: ApplicationFiled: June 5, 2008Publication date: September 16, 2010Inventors: Nicolas Winssinger, Sofia Barluenga
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Patent number: 7682772Abstract: A compound represented by general formula (I); and a compound represented by general formula (b1-1). [Chemical Formula 1] X-Q1-Y1—SO3?M+??(I) X-Q1-Y1—SO3?A+??(b1-1) wherein Q1 represents a divalent linkage group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, and has an —SO2— bond in the structure thereof; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: GrantFiled: November 5, 2008Date of Patent: March 23, 2010Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Akiya Kawaue, Hideo Hada, Hiroaki Shimizu, Tsuyoshi Nakamura
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Publication number: 20100019199Abstract: The invention relates to chiral compounds, methods of their preparation, and to their use in optical, electrooptical, electronic, semiconducting or luminescent components or devices, and in decorative, security, cosmetic or diagnostic applications.Type: ApplicationFiled: March 16, 2007Publication date: January 28, 2010Inventors: Louise Diane Farrand, Patricia Eileen Saxton
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Patent number: 7645782Abstract: The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.Type: GrantFiled: November 28, 2003Date of Patent: January 12, 2010Assignees: Morphochem Aktiengesellschaft fur Kombinatorische ChemieInventors: Wolfgang Richter, Lutz Weber
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Publication number: 20090318709Abstract: The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine.Type: ApplicationFiled: November 6, 2007Publication date: December 24, 2009Applicant: PIERRE FABRE MEDICAMENTInventors: Bernard Vacher, Yves Brunel, Jean-Louis Maurel
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Publication number: 20090220397Abstract: A system and method for acid-gas capture wherein organic acid-gas capture materials form hetero-atom analogues of alkyl-carbonate when contacted with an acid gas. These organic-acid gas capture materials include combinations of a weak acid and a base, or zwitterionic liquids. This invention allows for reversible acid-gas binding to these organic binding materials thus allowing for the capture and release of one or more acid gases. These acid-gas binding organic compounds can be regenerated to release the captured acid gasses and enable these organic acid-gas binding materials to be reused. This enables transport of the liquid capture compounds and the release of the acid gases from the organic liquid with significant energy savings compared to current aqueous systems.Type: ApplicationFiled: April 22, 2009Publication date: September 3, 2009Applicant: BATTELLE MEMORIAL INSTITUTEInventors: David J. Heldebrant, Clement R. Yonker, Phillip K. Koech
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Publication number: 20090176801Abstract: The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.Type: ApplicationFiled: October 16, 2008Publication date: July 9, 2009Applicant: ArQule, Inc.Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, Yanbin Liu, Chiang J. Li
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Patent number: 7553859Abstract: The present invention relates to new Macro-cycles of Formula (I), and their use for the treatment of cancer.Type: GrantFiled: July 15, 2003Date of Patent: June 30, 2009Assignees: Gesellschaft fuer Biotechnologische Forschung mbH (GBF)Inventors: Gerhard Hoefle, Wolfgang Richter
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Publication number: 20090142671Abstract: The present invention provides an optical recording composition comprising a compound denoted by general formula (I) and a holographic recording medium comprising a recording layer, wherein the recording layer comprises a compound denoted by general formula (I). In general formula (I), R1 denotes a hydrogen atom or an alkyl group, and Z1 denotes an atom group, the atom group forming a ring structure with a sulfur atom and a carbon atom which are adjacent to the atom group, and a carbon atom bonded to the sulfur atom.Type: ApplicationFiled: November 20, 2008Publication date: June 4, 2009Applicant: FUJIFILM CorporationInventor: Satoru YAMADA
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Publication number: 20090105214Abstract: Compounds of formula (I), wherein R1, R4, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of formula (I) are also described.Type: ApplicationFiled: May 23, 2006Publication date: April 23, 2009Inventors: Darren McKerrecher, Kurt Gordon Pike, Michael James Waring
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Publication number: 20080234499Abstract: The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3 is an alkyl radical, a hydroxy group, or a methoxy radical, R4 is a hydrogen atom or a methyl radical and R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical, and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).Type: ApplicationFiled: April 8, 2005Publication date: September 25, 2008Inventors: Bernard Vacher, Yves Brunel, Florence Castan-Cuisiat
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Patent number: 7169942Abstract: 1?-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.Type: GrantFiled: May 20, 2004Date of Patent: January 30, 2007Assignee: University of Tennessee Research FoundationInventors: Bob M. Moore, II, Antonio M. Ferreira, Mathangi Krishnamurthy
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Patent number: 7166226Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.Type: GrantFiled: January 28, 2005Date of Patent: January 23, 2007Assignee: Dionex CorporationInventors: L. Andy Woodruff, Andrei V. Bordunov, Christopher A. Pohl
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Patent number: 7109234Abstract: The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R3 represents an alkyl radical, a hydroxy group or a methoxy radical; R4 represents a hydrogen atom or a methyl radical; and R5 and R6, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR4 and R5 form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions saltsType: GrantFiled: March 20, 2002Date of Patent: September 19, 2006Assignee: Pierre Fabre MedicamentInventors: Bernard Vacher, Florence Castan-Cuisat, Gareth John, Bruno Legrand
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Patent number: 7053109Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: GrantFiled: July 10, 2002Date of Patent: May 30, 2006Assignee: Pharmacia & Upjohn CompanyInventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
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Patent number: 6906188Abstract: A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. Exemplary novel compounds include those according to the formula: With respect the formula, G is selected from the group consisting of R2 substituents independently are selected from the group consisting of H and lower alkyl groups; Z is selected from the group consisting of the halogens and —CN; M is selected from the group consisting of O and NR3; R3 is selected from the group consisting of H, lower alkyl, R4CO, R4OCO, and R4SO2; R4 is selected from the group consisting of H, lower alkyl, and aryl; T is selected from the group consisting of CH2, CO, HCOH and protected derivatives thereof; W is H or OR; and X and Y independently are selected from the group consisting of O, NH, S, CO, and C.Type: GrantFiled: January 29, 2003Date of Patent: June 14, 2005Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State UniversityInventors: James David White, Kurt Frederick Sundermann, Rich Garrett Carter
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Patent number: 6890715Abstract: The present invention provides a class of sensors prepared from at least a first material having a positive temperature coefficient of resistance and a second non-conductive or insulating material compositionally different than the first material that show an increase sensitivity detection limit for polar and non-polar analytes. The sensors have applications in the detection of analytes in the environment, associated with diseases and microorganisms.Type: GrantFiled: August 18, 2000Date of Patent: May 10, 2005Assignee: The California Institute of TechnologyInventors: Nathan S. Lewis, Robert H. Grubbs, Gregory Sotzing
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Patent number: 6867295Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.Type: GrantFiled: September 7, 2001Date of Patent: March 15, 2005Assignee: Dionex CorporationInventors: L. Andy Woodruff, Andrei V. Bordunov, Christopher A. Pohl
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Patent number: 6849384Abstract: Photoacid generators comprising sulfonium salt compounds represented by the following general formula (2) wherein R1 and R2 represent each an alkyl group optionally having oxo, or R1 and R2 may be cyclized together to form an alkylene group optionally having oxo; R3, R4 and R5 represent each hydrogen or a linear, branched, monocyclic, polycyclic or crosslinked cyclic alkyl group; and Y? represents a counter ion.Type: GrantFiled: July 23, 2001Date of Patent: February 1, 2005Assignee: NEC CorporationInventors: Shigeyuki Iwasa, Katsumi Maeda, Kaichiro Nakano, Etsuo Hasegawa
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Patent number: 6831179Abstract: A process for the stereoselective preparation of insecticide 6,7,8,9,10,10-hexahalo-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide of the general formula I: wherein X is a halogen such as fluorine, chlorine or bromine. The process comprises reacting 1,4,5,6,7,7-hexahalo-5-norbornene-2,3-dimethanol of the general formula IV: wherein X is as defined above, with a cyclic sulfite ring forming reagent optionally in an inert organic solvent at ambient to 139° C., wherein the reaction is carried out in the presence of a stereo isomer directing agent comprising an isomer of the compound of the formula I different from the desired isomer. The molar ratio of the stereoisomer directing agent to the dimethanol compound of the formula IV is at least 0.07.Type: GrantFiled: October 10, 2003Date of Patent: December 14, 2004Assignee: Excel Industries LimitedInventors: Ashwin Champraj Shroff, Abhijit Premvallabh Purohit, Sanjay Dhirajlal Vadodaria
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Patent number: 6794520Abstract: Methylene dithiepane silanes according to Formula I in which R1 is a saturated or unsaturated aliphatic or alicyclic hydrocarbon radical with 1 to 10 carbon atoms, which can be interrupted by one or more oxygen and/or sulphur atoms and can contain one or more ester, carbonyl, amide and/or urethane groups, or is an aromatic or heteroaromatic hydrocarbon radical with 6 to 18 carbon atoms, the hydrocarbon radicals being able to be substituted or unsubstituted; R2 has one of the meanings given for R1 or is absent; R3 has one of the meanings given for R1 or is absent; R4 is equal to —(CHR6)n—, —Y—CO—NH—(CHR6)n—, —Y—CO—NH—R5—, —(CHR6)n—S—R5—, —S—R5—, —CO—O—R5— or is absent, with n being equal to 1 to 4, R6 is hydrogen, C1 to C10 alkyl or C6 to C10 aryl, R5 has one of the meanings given for R1 and Y stands for an O or S atom or is absent; with R5 and R6 being ablType: GrantFiled: September 7, 2000Date of Patent: September 21, 2004Assignee: Ivoclar AGInventors: Norbert Moszner, Sabine Stein, Thomas Völkel, Volker Rheinberger
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Publication number: 20040127552Abstract: The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R3 represents an alkyl radical, a hydroxy group or a methoxy radical; R4 represents a hydrogen atom or a methyl radical; and R5 ?and R6, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR4 and R5 form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions salts.Type: ApplicationFiled: September 22, 2003Publication date: July 1, 2004Inventors: Bernard Vacher, Florence Castan-Cuisiat, John Gareth, Bruno Legrand
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Publication number: 20040092751Abstract: A process for the stereoselective preparation of insecticide 6,7,8,9,10,10-hexahalo-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide of the general formula 1: 1Type: ApplicationFiled: October 10, 2003Publication date: May 13, 2004Inventors: Ashwin Champraj Shroff, Abhijit Premvallabh Purohit, Sanjay Dhirajlal Vadoraria
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Publication number: 20030235782Abstract: The present invention relates to a novel photoresist composition that can be developed with an aqueous alkaline solution, and is capable of being imaged at exposure wavelengths in the deep ultraviolet. The invention also relates to a process for imaging the novel photoresist as well as novel photoacid generators.Type: ApplicationFiled: May 16, 2003Publication date: December 25, 2003Inventors: Munirathna Padmanaban, Takanori Kudo, Sangho Lee, Ralph R. Dammel, M. Dalil Rahman
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Publication number: 20030224290Abstract: A high resolution resist material comprising an acid generator is provided so that high sensitivity and high resolution for high energy rays of 300 nm or less, small line-edge roughness, and excellence in heat stability and storage stability are obtained. Moreover, a pattern formation method using this resist material are provided. Specifically, a novel compound of the following general formula (1); and a positive resist material comprising this compound preferably as a photo acid generator, and a base resin; are provided. This positive resist material may contain a basic compound or a dissolution inhibitor. Further, the present invention provides a pattern formation method comprising the steps of applying this positive resist material on a substrate, then heat-treating the material, exposing the treated material to a high energy ray having a wavelength of 300 nm or less via a photo mask, optionally heat-treating the exposed material, and developing the material using a developer.Type: ApplicationFiled: April 28, 2003Publication date: December 4, 2003Inventors: Tomohiro Kobayashi, Satoshi Watanabe, Tsunehiro Nishi, Youichi Ohsawa, Katsuhiro Kobayashi
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Publication number: 20030203929Abstract: Laulimalide and epothilone derivatives useful as microtubule stabilizing agents, and in the treatment of cancers are disclosed. Methods of making the compounds and using the compounds as therapeutic agents in treating cancers also are disclosed.Type: ApplicationFiled: March 5, 2003Publication date: October 30, 2003Inventor: Arun K. Ghosh
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Patent number: 6576766Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutic compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (1) as defined herein.Type: GrantFiled: August 17, 2000Date of Patent: June 10, 2003Assignee: Ariad Pharmaceuticals, Inc.Inventors: Manfred Weigele, Regine Bohacek, Virginia A. Jacobsen, Karina Macek, Michael G. Yang, Noriyuki H. Kawahata, Rajeswari Sundaramoorthi, Yihan Wang, Craig S. Takeuchi, George P. Luke, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer