Chalcogen Attached Directly To The Hetero Ring By Nonionic Bonding Patents (Class 549/27)
  • Patent number: 4385182
    Abstract: Novel thioxanthonecarboxylic acids and thioxanthonecarboxylic acid derivatives of the formula I ##STR1## in which Y is --COOH, --CO-halogen, --CN or a carboxylic acid ester, thioester or amide group and X, Z and W are as defined in the patent claim, are described. The compounds of the formula I in which Y is other than --CO--halogen are suitable as sensitizers for photo-crosslinkable polymers or as initiators for photo-polymerization of ethylenically unsaturated compounds or for photo-chemical crosslinking of polyolefins. The acid halides of the formula I are starting materials for the preparation of the corresponding nitriles and carboxylic acid esters, thioesters and amides.
    Type: Grant
    Filed: April 28, 1981
    Date of Patent: May 24, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Fischer, Vratislav Kvita, Hans Zweifel, Louis Felder
  • Patent number: 4348530
    Abstract: Thioxanthone carboxylic acid esters, thioesters and amides with reactive functional groups of the formula ##STR1## in which X, Y, Z, n and Q are as defined in the patent claim and Q is, for example, --OCH.dbd.CH.sub.2, --OCH.sub.2 CH.dbd.CH.sub.2, --SCH.sub.2 CH.dbd.CH.sub.2 or --NHCH.sub.2 CH.dbd.CH.sub.2 (n=1), --OH, --SH, --NH.sub.2, --COOH, --COCl or --OCO--C(R").dbd.CH.sub.2, in which R" is methyl or hydrogen (n=2), are suitable for the preparation of polymers with thioxanthone radicals in side chains. The compounds (I) and also the polymers which can be prepared therefrom can be employed as sensitisers for photocrosslinkable polymers or as initiators, if desired in a mixture with amines, for the photopolymerisation of ethylenically unsaturated compounds or for the photochemical crosslinking of polyolefines.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: September 7, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Vratislav Kvita, Hans Zweifel, Martin Roth, Louis Felder
  • Patent number: 4347254
    Abstract: A compound of the formula: ##STR1## wherein A.sub.1 is a single bond or a C.sub.1 -C.sub.5 alkylene group bonding at the 2-, 2'- or 3-position, A.sub.2 is a C.sub.1 -C.sub.3 alkylene group, A.sub.3 is a C.sub.1 -C.sub.4 alkylene group, X is --O-- or --SO.sub.n -- and B is a carboxy group, a C.sub.2 -C.sub.5 alkoxycarbonyl group, a cyano group, an amino group of the formula: ##STR2## or a carbamoyl group of the formula: ##STR3## which is useful as an antiviral agent with no side effect.
    Type: Grant
    Filed: July 22, 1980
    Date of Patent: August 31, 1982
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junki Katsube, Hiromi Shimomura, Shun Inokuma, Akihiko Sugie
  • Patent number: 4324628
    Abstract: The present invention relates to a photopolymerization process comprising irradiating a photopolymerizable material with U.V. light of wave length 250 to 400 nm in the presence of a photosensitizing amount of a photoinitiator of formula I, ##STR1## in which R is hydrogen or halogenR.sub.1 is alkyl, cycloalkyl, benzyl, optionally substituted phenyl or (a) ##STR2## either R.sub.2 is optionally substituted alkyl, benzyl, C.sub.6 H.sub.5 --CH.dbd.CH--, 2-thienyl, 2-furyl, 2-(3-chloro)benzothienyl or optionally substituted phenyl, andR.sub.3 is hydrogen or R.sub.2 and R.sub.3 form a radical of formula (b) ##STR3## in which X is a direct bond, --O--, --S--, --CH.sub.2 --, ##STR4## and R.sub.4 and R' have one of the significances of R.sub.2 and R, respectively,with the proviso that when R.sub.1 is (a) R.sub.3 is hydrogen and R.sub.2 and R.sub.4 are free from halogen atoms.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: April 13, 1982
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Hans-Werner Finck, Evelyne Kalt
  • Patent number: 4312868
    Abstract: Isothiochromans are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: May 15, 1979
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventor: John M. McCall
  • Patent number: 4275209
    Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.
    Type: Grant
    Filed: December 21, 1979
    Date of Patent: June 23, 1981
    Assignee: Kefalas A/S
    Inventors: Niels Lassen, Klaus P. Bogeso, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
  • Patent number: 4267344
    Abstract: N-Substituted N-carboxyanhydrides of .alpha.-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: May 12, 1981
    Assignee: Proteinkemisk Institut. tilknyttet Akademiet for de tekniske Videnskaber
    Inventors: John B. Halstrom, Karoly G. Kovacs
  • Patent number: 4264773
    Abstract: The invention relates to 2-(4'-chloro-phenylthio)-benzonitrile, to its process of preparation and to its use for preparing 2-chlorothioxanthone.2-Chloro-thioxanthone prepared from the compound of the invention is useful as a photoinitiator for the reticulation of synthetic resins and as an intermediate for preparing pharmaceuticals.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: April 28, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Michel Bouisset, Michel Chignac, Claude Grain
  • Patent number: 4228173
    Abstract: There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: October 14, 1980
    Assignee: Fisons Limited
    Inventors: Hugh Cairns, Anthony H. Ingall
  • Patent number: 4221800
    Abstract: Certain substituted cycloalkenochromones and pharmacologically acceptable salts thereof are disclosed as being useful in the treatment of allergies. The compounds have the structure: ##STR1## X is --O--, --S--, or --SO.sub.2. Y is from 1 to 4. R.sub.1 is H or alkyl, and R.sub.2 is H, alkyl, aryl, carboxyl, alkoxy, aralkoxy, or alkoxycarbonyl. When R.sub.1 is alkyl, R.sub.2 is hydrogen, alkyl or aryl. At least one of R.sub.2 and R.sub.3 is alkoxycarbonyl, carboxyl or tetrazolyl. R.sub.3 is carboxyl, alkylthio, alkylsulfonyl, alkylsulfinyl, alkoxycarbonyl, or tetrazolyl.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: September 9, 1980
    Assignee: Miles Laboratories, Inc.
    Inventors: Brian T. Warren, John W. Spicer, Thomas Miller
  • Patent number: 4206123
    Abstract: Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. These compounds are useful for preparing corresponding amino derivatives that possess antihypertensive and CNS activity.
    Type: Grant
    Filed: January 2, 1979
    Date of Patent: June 3, 1980
    Inventor: John M. McCall
  • Patent number: 4177284
    Abstract: Compounds of formula I ##STR1## in which R.sup.1 is hydrogen, halogen, nitro, trifluoromethyl, lower alkyl or lower alkoxy; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydroxy, 1H-tetrazol-5-yl or COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl, and X is O, S, SO or SO.sub.2, are disclosed. The compounds of formula I are useful for treating allergic conditions. Methods for the preparation and use of the compounds are disclosed.
    Type: Grant
    Filed: November 28, 1977
    Date of Patent: December 4, 1979
    Assignee: Ayerst McKenna & Harrison Ltd.
    Inventors: Adolf H. Philipp, Ivo L. Jirkovsky
  • Patent number: 4166062
    Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.
    Type: Grant
    Filed: July 21, 1978
    Date of Patent: August 28, 1979
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Ruth E. TenBrink