Nitrogen Or Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/37)
  • Patent number: 8946451
    Abstract: The invention relates to lipoic acid acylated salicylate derivatives; compositions comprising an effective amount of a lipoic acid acylated salicylate derivative; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a lipoic acid acylated salicylate derivative.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: February 3, 2015
    Assignee: Catabasis Pharmaceuticals, Inc.
    Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu
  • Publication number: 20140221316
    Abstract: This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
    Type: Application
    Filed: August 15, 2012
    Publication date: August 7, 2014
    Applicant: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Patent number: 8722900
    Abstract: The present invention relates to processes for making cabazitaxel, cabazitaxel analogues and intermediates thereof. The invention provides novel compounds useful in the synthesis of cabazitaxel.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: May 13, 2014
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: TsungYu Hsiao, Julian Paul Henschke, HsinChang Tseng
  • Publication number: 20130244267
    Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.
    Type: Application
    Filed: September 6, 2012
    Publication date: September 19, 2013
    Inventors: Ellen May Sletten, Carolyn Ruth Bertozzi
  • Publication number: 20130116444
    Abstract: The present invention relates to processes for making cabazitaxel, cabazitaxel analogues and intermediates thereof. The invention provides novel compounds useful in the synthesis of cabazitaxel.
    Type: Application
    Filed: October 30, 2012
    Publication date: May 9, 2013
    Applicant: Scinopharm Taiwan, LTD.
    Inventor: Scinopharm Taiwan, LTD.
  • Patent number: 8198317
    Abstract: The present invention provides novel methylenedioxy phenolic compounds and their derivatives, methods of making them and methods of using them to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as well as Type I and Type II Diabetes and Dyslipidemia patients at risk for hypertension, stroke, cardiovascular and renal disease.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: June 12, 2012
    Assignees: The Ohio State University Research Foundation, Invasc Therapeutic, inc.
    Inventors: Sampath Parthasarathy, Sanjay Rajagopalan, Desikan Rajagopal
  • Patent number: 8114858
    Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: February 14, 2012
    Assignee: Antibe Therapeutics Inc.
    Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
  • Patent number: 7939612
    Abstract: A radically polymerizable compound having a group represented by formula (1) (In the formula, R1 to R3 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, X represents an alkylene group having 1 to 4 carbon atoms.) and a radically polymerizable double bond and a composition for an optical material comprising the same have a high refractive index and excellent transparency and are hard to be oxidized in thermal curing and useful as an optical material with little tinting.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: May 10, 2011
    Assignee: Showa Denko K.K.
    Inventors: Keisuke Ohta, Yasuyuki Oyama, Kazufumi Kai
  • Patent number: 7910568
    Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: March 22, 2011
    Assignee: Antibe Therapeutics Inc.
    Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
  • Publication number: 20100210607
    Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 19, 2010
    Applicant: ANTIBE THERAPEUTICS INC.
    Inventors: JOHN WALLACE, GIUSEPPE CIRINO, VINCENZO SANTAGADA, GIUSEPPE CALIENDO
  • Publication number: 20100168216
    Abstract: The present invention relates to new prostaglandin derivatives having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Application
    Filed: March 6, 2008
    Publication date: July 1, 2010
    Applicant: CTG PHARMA S.R.L.
    Inventors: Piero Del Soldato, Giancarlo Santus, Anna Sparatore
  • Patent number: 7741359
    Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: June 22, 2010
    Assignee: Antibe Therapeutics Inc.
    Inventors: John Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
  • Publication number: 20090270574
    Abstract: A radically polymerizable compound having a group represented by formula (1) (In the formula, R1 to R3 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, X represents an alkylene group having 1 to 4 carbon atoms.) and a radically polymerizable double bond and a composition for an optical material comprising the same have a high refractive index and excellent transparency and are hard to be oxidized in thermal curing and useful as an optical material with little tinting.
    Type: Application
    Filed: January 26, 2007
    Publication date: October 29, 2009
    Applicant: SHOWA DENKO K.K.
    Inventors: Keisuke Ohta, Yasuyuki Oyama, Kazufumi Kai
  • Publication number: 20090233886
    Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
    Type: Application
    Filed: February 10, 2009
    Publication date: September 17, 2009
    Applicant: ANTIBE THERAPEUTICS INC.
    Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
  • Publication number: 20090215881
    Abstract: Cosmetic and therapeutic, in particular dermatological bioprecursors have the formula [A]n—PP—[B]m wherein PP is a polyphenol radical in which each hydroxyl function is protected by a group A or a group B, A is a saturated or unsaturated, substituted or unsubstituted alkyl radical having 1 to 20 carbon atoms which is bonded to the polyphenol, n is an integer not less than 1, and B is a precursor of a biologically active molecule, which is also bonded to the polyphenol, and m is an integer also not less than 1.
    Type: Application
    Filed: June 16, 2006
    Publication date: August 27, 2009
    Applicants: CHANEL PARFUMS BEAUTE
    Inventors: Sabine Delaire, Adrien Adao, Jean-Roger Desmurs, Mirjana Gelo-Pujic, Laurent Saint-Jalmes, Tarek Kassem
  • Publication number: 20090036516
    Abstract: Compounds of general formula: wherein R?, R, x and z have the meaning reported in the specification, are useful for treating inflammatory diseases including metabolic syndrome, diabetes, obesity, dyslipidemia, and insulin resistance.
    Type: Application
    Filed: December 21, 2005
    Publication date: February 5, 2009
    Applicant: CTG PHARMA S.R.L.
    Inventors: Urs Scherrer, Anna Sparatore
  • Publication number: 20080207564
    Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 28, 2008
    Applicant: ANTIBE THERAPEUTICS INC.
    Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vicenzo Santagada, Stefano Fiorucci
  • Publication number: 20080090875
    Abstract: A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 17, 2008
    Applicant: CJC Corporation
    Inventors: Il Hwan Cho, Myeong Yun Chae, Young Hoon, Kyu Jeong Yeon, Chun Seon Lyu, Jong Hoon Kim, Sung Hak Jung, Sang Wook Park, Hyung Chul Ryu, Ji Young Noh, Hyun Jung Park, Jie Eun Park, Young Mee Chung
  • Patent number: 7285664
    Abstract: A compound having a formula selected from the group consisting of wherein the substituents are as defined in the specification. The compounds are useful as intermediates in the preparation of compounds of formula (I), which are useful for inhibiting NO synthase and regenerate antioxidants.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: October 23, 2007
    Assignee: S.C.R.A.S. Societe de Conseils de Recherches et d'Applications Scientifiques
    Inventors: Jeremiah Harnett, Michel Auguet
  • Patent number: 7169324
    Abstract: Disclosed herein are a gelling agent composed of a functional amino acid compound having a tetrathiafulvalenyl group, and a production method of a gelling agent, comprising reacting a tetrathiafulvalene derivative with an amino acid derivative in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 4-(N,N-dimethylamino)pyridine to obtain a functional amino acid compound having a tetrathiafulvalenyl group.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: January 30, 2007
    Assignee: JSR Corporation
    Inventors: Takashi Kato, Tetsu Kitamura, Norihiro Mizoshita, Yusuke Tochigi
  • Patent number: 6528627
    Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 4, 2003
    Assignee: NeoRx Corporation
    Inventor: Sudhakar Kasina
  • Patent number: 6497730
    Abstract: The invention relates to novel methylene-dioxybenzenes comprising at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphatic chains comprising at least one quaternized saturated ring and aliphatic chains comprising at least one quaternized unsaturated ring, to their use as oxidation dye precursors for the oxidation dyeing of keratin fibres, to dye compositions containing them and to oxidation dyeing processes using them.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: December 24, 2002
    Assignee: L'Oreal S.A.
    Inventors: Alain Genet, Alain Lagrange
  • Publication number: 20020161235
    Abstract: The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound is a) a compound containing one or more sulfhydryl groups linked to at least one aromatic ring or a heteroaromatic ring with a nitrogen in the ring structure, which ring is substituted by one or more substituents bearing a terminal —ONO2 group; b) a 5-membered ring heterocyclic compound containing a sulfur atom and a nitrogen atom, which ring is substituted by one or more substituents bearing a terminal —ONO2 group; c) a 5-membered ring compound containing two conjugate S-atoms, which ring is linked to one or more substituents bearing a terminal—ONO2 group; or d) a compound containing an acyclic —S—S group, linked to at least one aromatic ring or a heteroaromatic ring with a nitrogen in the ring structure, which ring is substituted by one or more substituents bearing a terminal —ONO2 group.
    Type: Application
    Filed: January 9, 2002
    Publication date: October 31, 2002
    Inventor: Abdullah Haj-Yehia
  • Patent number: 6472488
    Abstract: Polymerizable compositions from novel monomers that correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: October 29, 2002
    Assignee: Essilor International Compagnie Generale D'Optique
    Inventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
  • Patent number: 6307062
    Abstract: The novel monomers correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: October 23, 2001
    Assignee: Essilor International Compagnie Generale d'Optique
    Inventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
  • Patent number: 6046228
    Abstract: The present invention is directed to pharmaceutical compositions including a saturated 1,2-dithiaheterocyclic compound having antiviral activity. The present invention also provides a kit containing the pharmaceutical composition and methods of treating or preventing viral disease using the composition, as well as methods for inactivating retrovirus in a body fluid.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: April 4, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: William G. Rice, Robert R. Schultz, David C. Baker, Louis E. Henderson
  • Patent number: 5789394
    Abstract: Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6, alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof are disclosed. Members of this series of analogues possess anti-viral activity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: August 4, 1998
    Inventors: Nghe Nguyen-Ba, Miguel Quimpere, Laval Chan Chung Kong, William L. Brown, Gervais Dionne
  • Patent number: 5718845
    Abstract: Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: February 17, 1998
    Assignee: Enichem S.p.A.
    Inventors: Kevin J. Drost, Pushkara Rao Varanasi, Kwan-Yue Alex Jen, Michael Anthony Drzewinski
  • Patent number: 5661176
    Abstract: Disclosed are (2-one (or thione)-1,3-dithiole-4,5-diyl)bis(thiomethylthiocyanate) compounds corresponding to the formula: ##STR1## wherein Z is oxygen or sulfur, compositions containing said compounds and their use as antimicrobial and marine antifouling agents.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: August 26, 1997
    Assignee: The Dow Chemical Company
    Inventors: Duane R. Romer, Weishi W. Wu, Ravi B. Shankar, R. Garth Pews
  • Patent number: 5631277
    Abstract: Disclosed is (2-thione-1,3-dithiole 4,5-diyl) bis(thiocyanate), its preparation and its use as an antimicrobial and marine antifouling agent.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: May 20, 1997
    Assignee: The Dow Chemical Company
    Inventors: Duane R. Romer, Weishi W. Wu, Ravi B. Shankar, R. Garth Pews
  • Patent number: 5530141
    Abstract: 2,4-Diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i.e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase.A method to treat disorders mediated by PAF or leukotrienes is also disclosed, that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: June 25, 1996
    Assignee: Center for Innovative Technology
    Inventors: T. Y. Shen, David M. Goldstein
  • Patent number: 5470871
    Abstract: The present invention relates to therapeutic compositions based on compounds chosen from the formulae: ##STR1## in which: X is chosen from .dbd.S, .dbd.O, .dbd.SO, .dbd.N--OH, .dbd.N--R.sub.5, .dbd.N--NH--CONH.sub.2, .dbd.N--NH--CSNH.sub.2 and ##STR2## A is chosen from the ##STR3## group, a group of formula ##STR4## a C.dbd.O group, a group C.dbd.N--R.sub.4 and a CHOH group, and their pharmaceutically acceptable salts.These compositions may be used as free-radical trapping agents.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: November 28, 1995
    Assignee: Laboratoires de Therapeutique Moderne
    Inventors: Marie-Odile Christen, Jean-Louis Burgot
  • Patent number: 5252289
    Abstract: Water-soluble 1,2-dithiole-3-thione derivatives are prepared by reacting a polyoxyalkylated starting material with sulfur. These derivatives are useful as corrosion inhibitors, particularly in aqueous environments.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: October 12, 1993
    Assignee: Petrolite Corporation
    Inventor: Bernardus A. Oude Alink
  • Patent number: 5190573
    Abstract: Cyclohexenone oxime ethers ##STR1## where R.sup.1 is alkyl;A is substituted or unsubstituted alkylene or alkenylene, where methylene is replaced by an oxygen atom, a sulfur atom, a sulfoxyl group, a sulfonyl group or --NR.sup.a --,Z is phenyl or a 5- or 6-membered heteroaromatic structure;X is substituted or unsubstituted amino, nitro, cyano, halogen, alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, carboxyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, substituted or unsubstituted benzyloxycarbony or phenyl;n is 0 to 3, or 1 to 5 where X is halogen;R.sup.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: March 2, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulf Misslitz, Norbert Meyer, Juergen Kast, Norbert Goetz, Albrecht Harreus, Bruno Wuerzer, Helmut Walter, Karl-Otto Westphalen, Matthias Gerber
  • Patent number: 5096920
    Abstract: The use of 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are optionally substituted in the phenyl ring as active substances in hepato-protective medicaments and new 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are substituted in the phenyl ring are described.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: March 17, 1992
    Assignee: Kali-Chemie Pharma GmbH
    Inventors: Dominique Biard, Marie-Odile Christen, Patrick Dansette, Daniel Jasserand, Daniel Mansuy, Amor Sassi
  • Patent number: 5084567
    Abstract: Compounds of the formula I ##STR1## in which X.sub.1, X.sub.2 and X.sub.3, independently of one another, are S or Se, R.sub.1 and R.sub.2, independently of one another, are H, linear or branched C.sub.1 -C.sub.18 alkyl-X.sub.4 - or R.sub.1 and R.sub.2 together are ##STR2## in which X.sub.4 is S or Se, z is 0 and n is an integer from 2 to 6 or z is 1 and n is an integer from 1 to 4, R.sub.4 and R.sub.5, independently of one another, are H or C.sub.1 -C.sub.6 alkyl, and R.sub.3 is linear or branched C.sub.1 -C.sub.12 alkyl or phenyl.The compounds can be converted into unsymmetrically substituted chalcogenofulvalenes, from which electrically conducting charge-transfer complex salts can be prepared.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: January 28, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Carl W. Mayer, John Zambounis
  • Patent number: 4973710
    Abstract: Water-soluble 1,2-dithiole-3-thione derivatives are prepared by reacting a polyoxyalkylated starting material with sulfur. These derivatives are useful as corrosion inhibitors, particularly in aqueous environments.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: November 27, 1990
    Assignee: Petrolite Corporation
    Inventor: Bernardus A. Oude Alink
  • Patent number: 4900842
    Abstract: The invention pertains to organic compounds of the tetrahiafulvalene type made amphiphillic by substitution of the radicals R.sup.1 and R.sup.2 meeting one of the following conditions:R.sup.1 is a hydrophilic group and R.sup.2 is a hydrophobic group,R.sup.1 is a hydrophobic group and R.sup.2 is a hydrophilic group,R.sup.1 is an aromatic group and R.sup.2 is a group having a long carbon-containing chain with a hydrophobic nature and a hydrophilic end.These organic compounds can form Langmuir-Blodgett films which are made anisotropically conductive by doping.
    Type: Grant
    Filed: February 9, 1988
    Date of Patent: February 13, 1990
    Assignee: Thomson-CSF
    Inventors: Philippe Robin, Albert Robert, Francoise Bertho, Patrick Batail
  • Patent number: 4898986
    Abstract: Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: February 6, 1990
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Satoshi Horii, Hiroshi Fukase
  • Patent number: 4760078
    Abstract: A novel 1,2-dithiol-3-thione derivative which has an immunomodulating property, which is expressed by the formula (I): ##STR1## wherein R denotes hydrogen, halogen, lower alkoxy group, lower alkyl group, amino group, lower alkyl-substituted amino group or lower alkoxycarbonyl group.
    Type: Grant
    Filed: March 5, 1987
    Date of Patent: July 26, 1988
    Assignee: Mitsui Toatsu Chemicals Inc.
    Inventors: Itaru Yamamoto, Akira Matsubara, Kanji Tomiya, Osamu Mizuno, Mitsuhiro Sakaguchi, Mikio Kumakura
  • Patent number: 4612036
    Abstract: Cyclohexane-1,3-dione derivatives of the formula ##STR1## where A is an unsubstituted or substituted, saturated or unsaturated 4-membered to 7-membered ring which contains 1 or 2 sulfinyl or sulfonyl groups, R.sup.1 is hydrogen, methoxycarbonyl, ethoxycarbonyl, methyl or cyano, R.sup.2 is alkyl and R.sup.3 is alkyl, alkenyl, haloalkenyl or propargyl, and salts of these compounds are used for controlling undesirable plant growth.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: September 16, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Dieter Jahn, Rainer Becker, Michael Keil, Bruno Wuerzer
  • Patent number: 4578220
    Abstract: A novel charge transfer complex of an N,N'-biscyanoquinone bisimine of the formula ##STR1## and a fulvalene derivative of the formula ##STR2## where, in formula I, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another are --H, --CH.sub.3, --C.sub.2 H.sub.5, --OCH.sub.3, --OC.sub.2 H.sub.5, --Cl and/or --Br, and one of the radicals R.sup.1 and R.sup.2 and/or one of the radicals R.sup.3 and R.sup.4 may furthermore be phenyl or tert.-butyl, or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together form ##STR3## and the fused-on aromatic ring is unsubstituted or substituted, and, in formula (II), R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently of one another are each --H, --CH.sub.3, --C.sub.2 H.sub.5, phenyl, methylphenyl or methoxyphenyl, or R.sup.5 and R.sup.6 and/or R.sup.7 and R.sup.8 together form ##STR4## where n=3, 4 or 5, ##STR5## and X and Y indendently of one another are each S or Se.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: March 25, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Siegfried Huenig, Alexander Aumueller
  • Patent number: 4517010
    Abstract: There is provided a new class of derivatives of 2-nitro-5-(substituted-phenoxy) benzoyl compounds that have pre- and post-emergence herbicidal activity. The derivatives include certain substituted phenyl esters, phenyl thioesters; heterocyclic esters; substituted alkyl and alkylthio esters; carbonates and thiocarbonates; benzoyl phosphonates; substituted alkanones and substituted amides.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: May 14, 1985
    Assignee: Rhone-Poulenc Inc.
    Inventor: Robert J. Theissen
  • Patent number: 4500709
    Abstract: This invention relates to novel compounds useful as intermediates in the preparation of cephalosporin compounds of antibacterial activity, having the formula ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino, andR.sup.2 is hydrogen or a saturated or unsaturated aliphatic hydrocarbon residue,a derivative at the carboxy group thereof and salt thereof.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: February 19, 1985
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Takashi Ogino, Kiyoshi Tsuji
  • Patent number: 4486447
    Abstract: Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.
    Type: Grant
    Filed: June 24, 1983
    Date of Patent: December 4, 1984
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4435421
    Abstract: Sulfur-containing bis-amino carbamate compounds exhibit outstanding acaricidal, nematocidal and insecticidal activity.
    Type: Grant
    Filed: November 3, 1978
    Date of Patent: March 6, 1984
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4400389
    Abstract: Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: August 23, 1983
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4382816
    Abstract: There are provided herbicidal trithione derivatives of benzoic acids.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: May 10, 1983
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: James T. Bahr
  • Patent number: 4362746
    Abstract: Derivatives of 1,2,3,4-tetrahydro-1,4-methanonaphthalene, and the use of h compounds to control viral infections, particularly influenza virus, in warm-blooded animals are disclosed. Pharmaceutical compositions containing an antiviral effective amount of the novel compounds and a pharmaceutically acceptable carrier are also disclosed.
    Type: Grant
    Filed: January 21, 1981
    Date of Patent: December 7, 1982
    Assignees: Canada Packers Inc., The Institute of Microbiology and Hygiene of the University of Montreal
    Inventors: Kekhusroo R. Bharucha, Kam C. Tin, Iva Ajdukovic, Djordje Ajdukovic
  • Patent number: 4303669
    Abstract: Novel hybrid 1,3-dione-carbamate compounds which exhibit utility as insecticides and acaricides. Also included are insecticidal and acaricidal compositions containing these compounds and a method of controlling insects and acarids.
    Type: Grant
    Filed: March 25, 1980
    Date of Patent: December 1, 1981
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva