Heavy Metal Or Aluminum Containing Patents (Class 549/3)
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Patent number: 5877320Abstract: The present invention is drawn to complexes of dibenzyl-organotin compounds having nitrogen or sulfur containing heterocyclic ligands. Said complexes are useful as cytotoxic agents.Type: GrantFiled: December 27, 1996Date of Patent: March 2, 1999Assignee: Council of Scientific and Industrial ResearchInventors: Sujit Roy, Purnima M. Samuel, Prakash V. Diwan, P. Kanta Rao, Uday T. Bhalerao
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Patent number: 5856520Abstract: A novel substituted benzenedithiol metal complex represented by the general formula (1) is provided. The substituted benzenedithiol metal complex is useful as a singlet oxygen quencher and as an optical data recording medium per se. ##STR1## wherein M is a transition metal; A.sup.+ is a quaternary ammonium group; and R is an organic group selected from the group consisting of organic groups represented by the formulae (i), (ii), (iii) and (iv): ##STR2## (wherein R.sup.1 is an alkyl group having 1 to 4 carbon atoms), ##STR3## (wherein n is 3, 4 or 5), ##STR4## (wherein R.sup.2 is one of a hydrogen atom and a substitutent having 1 to 4 carbon atoms).Type: GrantFiled: October 20, 1997Date of Patent: January 5, 1999Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Kazuyoshi Hirako, Satoshi Kimura, Michio Suzuki
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Patent number: 5840897Abstract: A metalorganic complex of the formula:MA.sub.y Xwherein:M is a y-valent metal;A is a monodentate or multidentate organic ligand coordinated to M which allows complexing of MA.sub.y with X;y is an integer having a value of 2, 3 or 4; each of the A ligands may be the same or different; andX is a monodentate or multidentate ligand coordinated to M and containing one or more atoms independently selected from the group consisting of atoms of the elements C, N, H, S, O and F.The metal M may be selected from the group consisting of Cu, Ba, Sr, La, Nd, Ce, Pr, Sm, Eu, Th, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Bi, Tl, Y, Pb, Ni, Pd, Pt, Al, Ga, In, Ag, Au, Co, Rh, Ir, Fe, Ru, Sn, Li, Na, K, Rb, Cs, Ca, Mg, Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W. A may be selected from the group consisting of .beta.-diketonates and their sulfur and nitrogen analogs, .beta.-ketoesters and their sulfur and nitrogen analogs, cyclopentadienyls, alkyls, perfluoroalkyls, alkoxides, perfluoroalkoxides, and Schiff bases.Type: GrantFiled: June 7, 1995Date of Patent: November 24, 1998Assignee: Advanced Technology Materials, Inc.Inventors: Peter S. Kirlin, Duncan W. Brown, Thomas H. Baum, Brian A. Vaarstra, Robin A. Gardiner
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Patent number: 5811411Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C and are part of an aromatic ring that is thiophene;A is selected from --C(X)-amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--;X is O or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;R, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are herein defined;or an agronomic salt thereof.Type: GrantFiled: November 22, 1996Date of Patent: September 22, 1998Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
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Patent number: 5693667Abstract: A compound, composition, and method for controlling Take-all disease of plants by applying a fungicide of the formula: ##STR1## wherein Z.sub.1 and Z.sub.2 are carbons of a furan ring; A is selected from the group consisting of --C(X)-amine wherein the amine is substituted with a first and a second amine substituent or with an alkylaminocarbonyl and a hydrogen, --C(O)--SR.sub.3 ; --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ; Q is C, Si, Ge, or Sn; W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W may also be selected from --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--; X is O or S; n is 0, 1, or 2; m is 0 or 1; p is 0, 1, or 2;wherein two R.sub.Type: GrantFiled: December 28, 1994Date of Patent: December 2, 1997Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
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Patent number: 5681953Abstract: Fluoroaluminate compounds of formula M.sup.+n (AlF.sub.4).sub.n.sup.- wherein n is 1 to 3 and M.sup.+n is N(R.sub.2).sub.4, P(R.sub.2).sub.4, As(R.sub.2).sub.4, HN(R.sub.2).sub.3, H.sub.2 N(R.sub.2).sub.2, H.sub.3 N(R.sub.2), (R.sub.2).sub.3 P.dbd.N.dbd.P(R.sub.2).sub.3, S?N(R.sub.2).sub.2 !.sub.3, ##STR1## (R).sub.2 N--(C(R).sub.2).sub.k --N(R).sub.3, and ZH.sub.m.sup.+m wherein Z is a base capable of accepting m protons, and various cyclic and aryl groups are disclosed as well as processes for their preparation.Type: GrantFiled: April 28, 1995Date of Patent: October 28, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventors: Richard Leslie Harlow, Norman Herron, David Lincoln Thorn
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Patent number: 5668192Abstract: Novel onium borates of an element of Groups 15 to 17 of the Periodic Table, or borates of an organometallic complex of an element of Groups 4 to 10 of the Periodic Table, well suited for the photochemical/electron beam cationic initiation of polymerization/crosslinking, the anionic borate moiety of which having the formula:[BX.sub.a R.sub.b ].sup.-in which a and b are integers ranging from 0 to 4 and a+b=4; the symbols X are each a halogen atom when a ranges up to 3 and an OH functional group when a ranges up to 2; and the symbols R, which may be identical or different, are each a phenyl radical substituted by at least one element or electron-withdrawing substituent or by at least two halogen atoms, or an aryl radical containing at least two aromatic ring members, or such aryl radical bearing at least one electron-withdrawing substituent.Type: GrantFiled: April 18, 1996Date of Patent: September 16, 1997Assignee: Rhone-Poulenc ChimieInventors: Frederic Castellanos, Jacques Cavezzan, Jean-Pierre Fouassier, Christian Priou
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Patent number: 5622821Abstract: The invention provides lanthanide chelates capable of intense luminescence. The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, or derivatives thereof e.g. carbostyril 124 (7-amino-4-methyl-2-quinolone), coumarin 120 (7-amino-4-methyl-2-coumarin), coumarin 124 (7-amino-4-(trifluoromethyl)-2-coumarin), aminomethyltrimethylpsoralen, etc.The chelates form high affinity complexes with lanthanides, such as terbium or europium, through chelator groups, such as DTPA. The chelates may be coupled to a wide variety of compounds to create specific labels, probes, diagnostic and/or therapeutic reagents, etc. The chelates find particular use in resonance energy transfer between chelate-lanthanide complexes and another luminescent agent, often a fluorescent non-metal based resonance energy acceptor.Type: GrantFiled: June 29, 1994Date of Patent: April 22, 1997Assignee: The Regents of the University of CaliforniaInventors: Paul R. Selvin, John Hearst
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Patent number: 5616750Abstract: A compound of formula (I): ##STR1## n which M is a transition metal ion; A is a counter-ion if required;r, s and t are independently 0 to 3 such that r+s+t is in the range of 1 to 3;R.sup.a, R.sup.b, R.sup.c are each independently hydrogen or CH.sub.2 OR' where R' is hydrogen or an organic group;B and E are independently oxygen, CH.sub.2, NR.sup.d in which R.sup.d is alkyl, hydrogen, alkylcarbonyl, or arylcarbonyl or SO.sub.n where n is 0 or an integer 1 or 2, with the proviso that B and E are not simultaneously CH.sub.2 and that when B is oxygen, NR.sup.d or SO.sub.n, then r cannot be 0, and when E is oxygen, NR.sup.d or SO.sub.n, then t cannot be 0;R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are independently hydrogen, alkyl or alkoxy.Type: GrantFiled: October 6, 1993Date of Patent: April 1, 1997Assignee: SmithKline Beecham plcInventors: David Bell, David Miller, Robin P. Attrill
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Patent number: 5614596Abstract: A process for the preparation of polymetallooxanes employing inexpensive metal sources such as sand, alumina, and rutile involves dissolving one or more group IIIa, IVa, IVb metaloxy compounds such as metal oxides, metal hydroxides, or hydrates thereof with a di- or polyhydroxyl functional compound in the presence of an amine or alkanolamine. The polymetallooxane products are anionic, neutral, or mixed neutral/anionic moieties, which, when anionic, contain a metallic counterion (cation) or an ammonium or phosphonium ion. Mixed polymetallooxanes, as well as homo polymetallooxanes which may be prepared by the subject process, are suitable for use in preparing coatings, fibers, powders, ceramics, and glasses while being easily processable and economic to manufacture.Type: GrantFiled: January 12, 1995Date of Patent: March 25, 1997Assignee: Regents of University of MichiganInventors: Richard M. Laine, Clint R. Bickmore, Kurt F. Waldner
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Patent number: 5565558Abstract: Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the polypeptide cytokines, alpha-interferon, beta-interferon, and gamma-interferon are described.Type: GrantFiled: December 30, 1994Date of Patent: October 15, 1996Inventor: Kilmer S. McCully
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Patent number: 5534638Abstract: This describes the following five novel organic substances: Bis (ethylenedithio) tetrathiafulvalene (henceforth to be called BEDT-TTF) compounded with cyanometalate anions in what is called Tetracyano Nickel acid Bis (Ethylenedithio) Tetrathiafulvalene salt.hydrate expressed by (BEDT-TTF).sub.4 [Ni(CN).sub.4 ].H.sub.2 O, Tetracyano Platinum acid Bis (Ethylenedithio) Tetrathiafulvalene salt.hydrate that is expressed by (BEDT-TTF).sub.4 [Pt(CN).sub.4 ].H.sub.2 O, Cyanide Palladium Bis (Ethylenedithio) Tetrathiafulvalene salt that is expressed by (BEDT-TTF)-[Pd(CN).sub.2 ], Tetracyano Palladium acid Bis (Ethylenedithio) Tetrathiafulvalene salt.hydrate that is expressed by (BEDT-TFF).sub.4 [Pd(CN).sub.4 ].H.sub.2 O and Tetracyano Palladium acid Bis (Ethylenedithio) Tetrathiafulvalene salt that is represented by (BEDT-TTF).sub.4 [Pd(CN).sub.4 ]. BEDT-TTF, acting as a common constituent in the crystals of all of the above substances, provides the properties of an insulator, a metal or a superconductor.Type: GrantFiled: April 26, 1995Date of Patent: July 9, 1996Assignee: International Superconductivity Technology CenterInventors: Hatsumi Mori, Izumi Hirabayashi, Shoji Tanaka, Takehiko Mori, Yusei Maruyama, Hiroo Inokuchi
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Patent number: 5532373Abstract: An aluminate complex represented by formula (I): ##STR1## with the groups in the aluminate complex as defined in the specification, and which is capable of radical generation upon photoexcitation; a photopolymerizable composition comprising an ethylenically unsaturated polymerizable compound and the aluminate complex; and an image-forming material comprising a support, an organoaluminum compound anion represented by formula (I'): ##STR2## with the groups in the organoaluminum compound anion as defined in the specification, and a photobleachable dye; are disclosed.Type: GrantFiled: September 22, 1994Date of Patent: July 2, 1996Assignee: Fuji Photo Film Co., Ltd.Inventors: Hirotaka Matsumoto, Jun Yamaguchi, Naoto Yanagihara, Hisashi Yamamoto
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Patent number: 5530139Abstract: A condensed heterocyclic compound having a structure represented by formula (I): ##STR1## wherein the substituents are as defined in the specification herein.Type: GrantFiled: May 31, 1994Date of Patent: June 25, 1996Assignee: Showa Denko Kabushiki KaishaInventors: Yoshihiro Saida, Yoshiaki Ikenoue, Reiko Ichikawa
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Patent number: 5525736Abstract: A process for the production of a 5-7 membered ring cyclic sulfonium salt compound, including a 5-7 membered ring cyclic sulfonium salt compound having a non-nucleophilic anion, is described. Members of the latter group are potentially useful as initiators for cationic polymerizations. The process comprises reacting a 1.4-, 1.5-, or 1.6-diol compound or a 5-7 membered ring cyclic ether compound with a mercapto compound and a strong protonic acid yielding the cyclic sulfonium salt compound. Some compounds described are also novel compounds per se.Type: GrantFiled: February 23, 1995Date of Patent: June 11, 1996Assignee: Ciba-Geigy CorporationInventors: Jan-Erik Nystrom, Per Engelhardt, Katarina Beierlein, Mikael Sellen, Bjorn Elman, Jan Vagberg, Martin Nylof
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Patent number: 5496961Abstract: Organosilicon compounds having Si-bonded hydrogen atoms are reacted with organic compounds having aliphatic multiple bonds in the presence of triazene oxide-transition metal complexes. The triazene oxide-transition metal complexes are activated by heating at temperatures of from 50.degree. C. to 250.degree. C. and/or by irradiation with light.Type: GrantFiled: May 10, 1995Date of Patent: March 5, 1996Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Josef Wolferseder, Bernward Deubzer
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Patent number: 5446002Abstract: 2,4-Heteroatom-substituted-molybdena-3,3-dioxocyclopentane hydro-conversion catalysts are disclosed. In some embodiments, inexpensive bulk catalysts in accordance with the present invention are synthesized from bulk triglyceridic epoxides or fatty acids.Type: GrantFiled: June 8, 1994Date of Patent: August 29, 1995Assignee: Amoco CorporationInventors: Simon G. Kukes, Thomas J. Karol, Joseph T. Joseph
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Patent number: 5418298Abstract: This invention relates to polymetallooxanes having the moiety: ##STR1## wherein n is 1.5, 2, 3, 4, 5 or 6, M.sup.1 is selected from the group consisting of Si, Ge, Sn, Al, Ga, Ti, Zr, or Hf, R.sup.1 and R.sup.2 are selected from the group consisting of H, OH, C.sub.1-8 alkyl, C.sub.1-6 alkoxy, C.sub.2-8 alkene, C.sub.6-12 aryl, C.sub.1-8 hydroxyalkyl, C.sub.1-8 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.4-20 heteroaromatic, C.sub.1-10 alkylsilane, C.sub.1-10 alkylsiloxane or combinations thereof, O' is bonded to M.sup.1, another M.sup.1 atom, M.sup.2 or H, wherein M.sup.2 is a group I or II metal of the Periodic Table, and R.sup.3 is independently selected from the group consisting of (CR.sub.2).sub.y, O'--(CR.sub.2 CR.sub.2).sub.y N(CR.sub.2).sub.y --, --(CR.sub.2 CR.sub.2).sub.y N.sub.R (CR.sub.2).sub.y --, O'--[(CR.sub.2 CR.sub.2).sub.y O].sub.y --(CR.sub.2).sub.y, C.sub.1-8 alkyl, C.sub.1-6 alkoxy, C.sub.2-8 alkene, C.sub.6-12 aryl, C.sub.1-8 hydroxyalkyl, C.sub.1-8 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.Type: GrantFiled: March 19, 1993Date of Patent: May 23, 1995Assignee: Regents of the University of MichiganInventors: Richard M. Laine, Brian L. Mueller, Tom Hinklin
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Patent number: 5409893Abstract: The invention concerns a coordination complexes with R.sup.111 as central metal attached to a heterocyclic ligand in the apical position trans to a sulfoxide and their pharmaceutical compositions useful in antitumor therapy either alone or in combination with platinum complexes.Type: GrantFiled: December 13, 1991Date of Patent: April 25, 1995Assignee: Boehringer Mannheim Italia, S.p.A.Inventors: Enzo Alessio, Giovanni Mestroni, Sabrina Pocar, Gianni Sava, Silvano Spinelli
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Patent number: 5391727Abstract: This invention provides gold(I) complexes comprising sulfur- and selenium-substituted macrocyclic polyether ligands, photographic elements containing the compounds, and emulsions containing the compounds. The compounds include monomers and dimers having the following formulas, respectively:[AuL].sup.+ X.sup.- or [AuL].sub.2.sup.2+ 2X.sup.-wherein X.sup.- is any suitable anion such as tetrafluoroborate, nitrate, etc., and wherein L is a macrocyclic ligand containing at least two thioether and/or selenoether linkages and comprising from about 12 to about 30 members in the ring. The general structural formula for the macrocyclic compounds L may be represented as follows: ##STR1## wherein Q.sub.1 and Q.sub.2 are each independently sulfur or selenium, and R.sub.1 and R.sub.Type: GrantFiled: August 13, 1993Date of Patent: February 21, 1995Assignee: Eastman Kodak CompanyInventor: Joseph C. Deaton
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Patent number: 5374699Abstract: A thermosetting resin composition which comprises (A-2) a vinyl polymer having at least one each of 2-oxo-1,3-dioxolan-4-yl group and a carboxyl group together on the polymer and a catalyst (B) effective for ring-opening the 2-oxo-1,3-dioxolan-4-yl group and curing said vinyl polymer, and related resin compositions.Type: GrantFiled: February 7, 1994Date of Patent: December 20, 1994Assignee: Dainipponink and Chemicals, Inc.Inventors: Goro Iwamura, Hiroshi Kinoshita, Asako Kometani
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Patent number: 5371259Abstract: Compounds of the formula I are described[R.sup.1 (Fe.sup.II R.sup.2 .sub.a ].sub.q.sup.+an anX.sup.-q (I)in which a is 1 or 2, n is 1 or 2, R.sup.1 is a substituted or unsubstituted .pi.-arene, R.sup.2 is a substituted or unsubstituted .pi.-arene or cyclopentadienyl anion or indenyl anion, q is an integer from 1 to 3, and X is FSO.sup.-.sub.3 or a q-valent anion of an organic sulfonic acid or of a carbocyclic acid; R.sup.1 can also be a polymeric, aromatic ligand. The invetion particularly relates to the compounds of the formula I wherein a is 1 and q is 1 and X.sup.Type: GrantFiled: April 8, 1993Date of Patent: December 6, 1994Assignee: Ciba-Geigy CorporationInventors: Kurt Meier, Roger P.-E. Salvin
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Patent number: 5348950Abstract: A platinum(II) complex represented by the general formula (A), ##STR1## in which R.sub.1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R.sub.2 and R.sub.3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R.sub.2 and R.sub.3, together, may form --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --, and X and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating a tumor.Type: GrantFiled: June 5, 1992Date of Patent: September 20, 1994Assignee: Toray Industries, Inc.Inventors: Go Hata, Tatsuya Kaneko, Hideki Kawai, Masato Mutoh, Hideyuki Hashimoto
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Patent number: 5326759Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.Type: GrantFiled: November 1, 1993Date of Patent: July 5, 1994Assignee: American Cyanamid CompanyInventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
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Patent number: 5318962Abstract: Water-soluble complexes having the formula: ##STR1## and stereoisomers thereof, where Z.sup.1 and Z.sup.2 are halogens, and X.sup.1 and X.sup.2 are selected from the group consisting of sulfate, phosphate, nitrate, and monocarboxylate, or are jointly dicarboxylate, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.Type: GrantFiled: August 7, 1992Date of Patent: June 7, 1994Assignee: Board of Regents, The University of Texas SystemInventors: Abdul R. Khokhar, Zahid H. Siddik, Robert A. Newman
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Patent number: 5312913Abstract: An electrically conductive complex obtained by reacting a thia-and/or selenafulvalenyl group-containing compound as an electron donor with an electron acceptor, and having an electron donar/electron acceptor molar ratio of 1/0.1 to 1/10, the thia-and/or selenafulvalenyl group-containing compound having the formula (I), ##STR1## wherein each of X.sub.1, X.sub.2, X.sub.3, X.sub.4, X'.sub.1, X'.sub.2, X'.sub.3 and X'.sub.4 is independently S or Se, Y is an electron donating or electron accepting group having a size which is not so large as to prevent molecular overlapping, m is an integer of 0 to 4, each of Z.sub.1, Z.sub.2, Z'.sub.1 and Z'.sub.2 is independently a hydrogen atom, C.sub.n H.sub.2n+1 in which n is an integer of 1 to 5, or alternatively, a combination of Z.sub.1 with Z.sub.2 or Z'.sub.2 and is C.sub.n H.sub.2n in which n is an integer of 1 to 5, or X(C.sub.n H.sub.2n).sub.n' X in which X is S or Se and n' is an integer of 1 to 3, and each of R.sub.1, R.sub.2, R.sub.3, R'.sub.1, R'.sub.2 and R'.sub.Type: GrantFiled: September 29, 1992Date of Patent: May 17, 1994Assignee: Idemitsu Kosan Co., Ltd.Inventors: Makoto Mizutani, Kazushige Kawabata, Keiji Tanaka
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Patent number: 5312805Abstract: An organic super-conductive material and a process for producing the same are disclosed, the material comprising a polymer having dispersed therein an organic super-conductive substance comprising an electron donor and an electron acceptor.Type: GrantFiled: August 4, 1993Date of Patent: May 17, 1994Assignee: Sumitomo Electric Industries, Ltd.Inventors: Yoshinobu Ueba, Yoshiyuki Okamoto
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Patent number: 5306600Abstract: Titanocenes of the formula I ##STR1## in which R.sup.1 are cyclopentadienyl.sup..crclbar. groups and R.sup.2 and R.sup.3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by an acyloxy group are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.Type: GrantFiled: November 12, 1992Date of Patent: April 26, 1994Assignee: Ciba-Geigy CorporationInventors: Eginhard Steiner, Harry Beyeler, Martin Riediker, Vincent Desobry, Kurt Dietliker, Rinaldo Husler
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Patent number: 5302587Abstract: A novel platinum (II) complex represented by the following formula (A): ##STR1## wherein R.sub.1 represents C.sub.1 -C.sub.5 lower hydrocarbon group, R.sub.2 and R.sub.3 represents hydrogen atom or C.sub.1 -C.sub.3 lower hydrocarbon group, the configuration of 1,2-diaminocyclohexane being cis, trans-l- or trans-d-. Since the platinum (II) complex has a strong anti-tumor activity and its toxicity is low, it is useful as an agent for treating malignant tumor.Type: GrantFiled: September 9, 1991Date of Patent: April 12, 1994Assignee: Toray Industries, Inc.Inventors: Go Hata, Masato Mutoh, Hideyuki Hashimoto
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Patent number: 5288903Abstract: Preparation of 3-pentenoic acid by the reaction of 3-pentenoylchloride, water and butadiene. 3-chloro-1-butene and 1-chloro-2-butene are also formed. Preferably the 3-pentenoylchloride is formed by the reaction of chlorobutene with carbon monoxide using a palladium catalyst.Type: GrantFiled: July 26, 1993Date of Patent: February 22, 1994Assignee: E. I. du Pont de Nemours and CompanyInventors: Emilio E. Bunel, Chen-Chou Chiang, Michael B. D'Amore, Erik J. Schaumann, Leon S. Scott
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Patent number: 5225207Abstract: New complexes of general formula (I) in whichR.sub.1 and R.sub.2 together form a saturated or unsaturated polycyclic carbocyclic radical containing 7 to 12 carbon atoms, or a saturated or partially saturated mono-, bi- or tricyclic heterocyclic radical containing 5 to 11 chain members and a hetero-atom chosen from oxygen, sulphur or nitrogen, which latter atom can optionally be substituted by an alkoxycarbonyl radical, and,X.sub.1 and X.sub.2 represent chlorine atoms or together formeither a radical of structure: ##STR1## in which n is 0 to 2 and R.sub.6 and R.sub.7, which are identical or different, are hydrogen atoms or, when n=1, can be alkyl radicals or form, together with the carbon atom to which they are attached, a cyclobutyl radical,or a radical of structure: ##STR2## in which n, R.sub.6 and R.sub.7 are defined as above, or their salts where such exist, and their hydrates, their preparation and the pharmaceutical compositions which contain them.Type: GrantFiled: October 15, 1991Date of Patent: July 6, 1993Assignee: Laboratoire Roger BellonInventors: Michel Barreau, Jean-Claude Chottard, Jean-Bernard Le Peco, Patrick Mailliet
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Patent number: 5220037Abstract: Novel sulfonium salts useful as photoinitiators for cationic polymerization and for producing relief patterns and relief images have the general formula (I) ##STR1## where A.sup..crclbar. is a non-nucleophilic counterion,x is 1, 2 or 3,R is a hydrocarbon radicalR' is arylene or substituted arylene, andR" is ##STR2## where R.sup.1, R.sup.2 and R.sup.3 are each alkyl or monohalogenated or polyhalogenated alkyl orR.sup.1 and R.sup.2 are each hydrogen or alkyl, and R.sup.3 is phenyl, alkenyl or cycloalkenyl, orR.sup.1 is hydrogen, and R.sup.2 and R.sup.3 form ethylenically unsaturated ring, orR.sup.1 and R.sup.2 are each hydrogen, alkyl, cycloalkyl or aryl, and R.sup.3 is alkoxy orR.sup.1 is hydrogen or alkyl and R.sup.2 and R.sup.3 are each alkoxy, aryloxy or substituted aryloxy.Type: GrantFiled: January 27, 1992Date of Patent: June 15, 1993Assignee: BASF AktiengesellschaftInventors: Reinhold Schwalm, Andreas Boettcher
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Patent number: 5192642Abstract: Titanocenes of the formula I ##STR1## in which R.sup.1 are cyclopentadienyl.sup..crclbar. groups and R.sup.2 and R.sup.3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by an acyloxy group are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.Type: GrantFiled: May 23, 1990Date of Patent: March 9, 1993Assignee: Ciba-Geigy CorporationInventors: Eginhard Steiner, Harry Beyeler, Martin Riediker, Vincent Desobry, Kurt Dietliker, Rinaldo Husler
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Patent number: 5179213Abstract: A process of separating one or more seleced species of ions from a solution containing the ions comprises contacting the solution with a novel composition of matter comprising a hydrocarbon chain covalently bonded to a macrocyclic compound, wherein the macrocyclic compound has at least four --A--C--C-- linkages in which A for each such linkage, is independently selected from the group consisting of O, O--CH.sub.2, S, SH.sub.2, NR, and NRCH.sub.2, with R being independently selected from the group consisting of hydrogen, alkyl and benzyl, and wherein the hydrocarbon chain has an end group ##STR1## with X being independently selected from the group consisting of lower alkyl, benzyl, phenyl, halogen, O--CH.sub.3, O--C.sub.2 H.sub.5 and O-matrix, and with matrix being independently selected from the group consisting of silica, silica gel, glass, glass fibers, titania, zirconia, alumina and nickle oxide.Type: GrantFiled: May 1, 1990Date of Patent: January 12, 1993Assignee: Brigham Young UniversityInventors: Jerald S. Bradshaw, Reed M. Izatt, Virginia B. Christensen, Ronald L. Bruening
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Patent number: 5159088Abstract: Novel sulfonium salts suitable for use as photoinitiators for cationic polymerization and for photoresists have the general formula (I) ##STR1## where X is 1, 2 or 3,R is a hydrocarbon radicalR.sup.1 is hydrogen, alkyl, alkoxy, halogen or nitro,R.sup.2 is a monovalent radical containing more than 6 carbon atoms,Y is a single bond or a bridge member andA.sup..crclbar. is a non-nucleophilic counterion.Type: GrantFiled: July 12, 1990Date of Patent: October 27, 1992Assignee: BASF AktiengesellschaftInventor: Reinhold Schwalm
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Patent number: 5116862Abstract: The present invention provides a class of novel substituted bicyclooctanes which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the control of pests and methods for their preparation are also disclosed.Type: GrantFiled: July 21, 1988Date of Patent: May 26, 1992Assignee: The Wellcome Foundation LimitedInventors: John B. Weston, John P. Larkin, Ian H. Smith
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Patent number: 5101053Abstract: Radiation sensitive sulfonium salts which contain (1) a sulfonium initiator portion, (2) a spacer portion, and (3) a reactive group portion. The spacer portion has the formula "-o-w- x-z-" wherein "w" is a single bond or one of --C(O)--, --C(O)O--, --C(O)S--, --C(O)NH-- --C(O)N(alkyl)--, --C(S)--, --C(S)S--,--S(O)--, --S(O)(O)--, or --S(O)(O)O--; "X" is an unsubstituted or substituted alkylene radical; and "Z" is --O--, --NH--, --N(C,--C.sub.6 -alkyl)--, or --N(phenyl)--. The reactive group portion is --CH.dbd.CH.sub.2 or --C(O)--C(Y).dbd.CH.sub.2 wherein "Y" is H, C.sub.1 -.sub.6 -alkyl, or phenyl. The sulfonium salts find use in curing monomers which can be subjected to cationic polymerization.Type: GrantFiled: January 9, 1990Date of Patent: March 31, 1992Assignee: BASF AktiengesellschaftInventor: Andreas Boettcher
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Patent number: 5082952Abstract: The invention relates to a process for the preparation of .pi.-arene-iron complexes of the general formula I[R.sup.1 (R.sup.2 Fe.sup.II).sub.a ].sub.b.sup.+a (LQ.sub.m).sup.-b (I)whereina is 1 or 2,b is an integer from 1 to 3,m is an integer corresponding to the valency of L+b,L is a divalent to heptavalent metal or non-metal,Q is a halogen atom,R.sup.1 is a .pi.-arene, an O- or S-heteroarene or a pyrrole or an indole andR.sup.2 is a cyclopentadienyl anion or an indenyl anion.The .pi.-arene-iron complexes of formula I are obtained by ligand exchange at elevated temperatures from .pi.-arene-iron complexes of formula II[R.sup.3 (R.sup.2 Fe.sup.II).sub.a ].sub.b.sup.+a (LQ.sub.m).sub.a.sup.-b (II)wherein R.sup.3 is a condensed .pi.-arene which differs from R.sup.1. The .pi.-arene-iron complexes of formula I are suitable as photoinitiators for curable compositions containing cationically polymerizable organic materials.Type: GrantFiled: May 27, 1986Date of Patent: January 21, 1992Assignee: Ciba-Geigy CorporationInventor: Kurt Meier
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Patent number: 4980347Abstract: A platinum complex represented by the formula: ##STR1## where X is ##STR2## wherein R.sup.1 is a (C1-18) alkyl group, a (C1-18)alkenyl group or a group --Z--R.sup.4 in which Z is --CH.dbd.CH-- or a (C1-5)alkylene group, and R.sup.4 is a phenyl group, a hydroxyphenyl group, a (C7-12)alkoxyphenyl group, a halogenophenyl group, a nitrophenyl group, or (C8-13)alkoxycarbonylphenyl group, a cyclohexyl group having a (C1-5)alkyl substituent, ##STR3## R.sup.2 is hydrogen or a (C1-18)alkyl group, R.sup.3 is hydrogen or a (C1-3) alkyl group, R.sup.2 and R.sup.3 are linked together to form a (C2-7)alkylene group; the dotted line indicates that the bond may be either a single bond or a double bond; the chain line indicates a conjugated system; the 1,2-diaminocyclohexane moiety has a cis-, trans-l- or trans-d-configuration; and Y is an anion. This platinum complex is useful in the treatment of tumors.Type: GrantFiled: April 13, 1989Date of Patent: December 25, 1990Assignee: Toray IndustriesInventors: Masaji Ohno, Masato Mutoh, Go Hata, Keiichi Matsunaga, Satoshi Hanada
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Patent number: 4954414Abstract: A composition including a cationic transition metal coordination complex and a borate anion, wherein said composition is capable of absorbing actinic radiation and producing free radicals which can initiate free radical addition polymerization of a free radical addition polymerizable or crosslinkable monomer is disclosed. The compositions are particularly useful as visible light photoinitiators.Type: GrantFiled: November 8, 1988Date of Patent: September 4, 1990Assignee: The Mead CorporationInventors: Paul C. Adair, Peter Gottschalk
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Patent number: 4935408Abstract: A compound of the formula: ##STR1## in which R.sup.1 represents alkyl, cycloalkyl or aralkyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents dichlorophenyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR2## wherein R.sup.2 represents halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is cycloalkyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR3## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is aralkyl, m represents 1 or 2, and X represents halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR4## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.Type: GrantFiled: May 6, 1988Date of Patent: June 19, 1990Assignees: Shionogi & Co., Ltd., Nitto Kasei Co., Ltd.Inventors: Hideyuki Imazaki, Masazumi Fujikawa, Katsuaki Oba, Fusaharu Kumayama, Toshio Takahashi
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Patent number: 4921317Abstract: The present invention relates to a metal complex compound useful in an infrared absorbent prepared by coordinating two bidentate ligands of the following formula (iii): ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a hydrogen atom, a cyano group, or a substituted or unsubstituted alkyl, aryl or heterocyclic group, which may be the same or different.The present invention is further directed to an infrared absorbing composition comprising a metal complex compound prepared by coordinating two bidentate ligands of formula (iii) above to a center metal and neutralizing a complex ion with a cation.The present invention is also directed to an infrared absorbing article which comprises a metal complex compound prepared by coordinating two bidentate ligands of formula (iii) above to a center metal and neutralizing such a complex with a phosphonium cation.Type: GrantFiled: July 6, 1988Date of Patent: May 1, 1990Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshiaki Suzuki, Gouichi Hayashi
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Patent number: 4914215Abstract: Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.Type: GrantFiled: August 25, 1989Date of Patent: April 3, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mark M. Goodman, Furn F. Knapp, Jr.
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Patent number: 4912100Abstract: A platinum complex represented by the formula: ##STR1## wherein R.sup.1 is a (Cl-18) alkyl group, a (Cl-18)-alkenyl group or a group ----X--R.sup.5 in which X is --CH.dbd.CH-- or a (Cl-5)alkylene group, and R.sup.5 is a phenyl group, a hydroxyphenyl group, a (C7-12) alkoxyphenyl group, a halogenophenyl group, a nitrophenyl group, or (C8-13)alkoxycarbonylphenyl group, a cyclohexyl group having a (Cl--5)alkyl substituent, ##STR2## R.sup.2 is a (Cl-18 alkyl group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 are linked together to form a (C2-7)alkylene group, R.sup.4 is OH or NO.sub.3 ; the dotted line indicates that the bond may be either a single bond or a double bond; the chain line indicates a conjugated system; n is a number of from 1 to 2, and the 1,2-diaminocyclohexane moiety has a cis-, trans-l- or trans-d-configuration. This platinum complex is useful in the treatment of tumors.Type: GrantFiled: October 13, 1987Date of Patent: March 27, 1990Assignee: Toray Industries, Inc.Inventors: Masaji Ohno, Masato Mutoh, Hisao Kondo, Keiichi Matsunaga
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Patent number: 4906754Abstract: Preparation of ethylene copolymers from ethylene and polar and/or non-polar comonomers in the presence of selected nickel-containing catalysts.Type: GrantFiled: September 1, 1987Date of Patent: March 6, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventor: Ulrich Klabunde
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Patent number: 4880790Abstract: Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.Type: GrantFiled: January 31, 1986Date of Patent: November 14, 1989Assignee: American Cyanamid CompanyInventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
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Patent number: 4870070Abstract: This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.Type: GrantFiled: August 10, 1987Date of Patent: September 26, 1989Assignee: American Cyanamid CompanyInventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
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Patent number: 4857539Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;Z is N or HC;R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from specified heterocyclic groups,are useful and antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.Type: GrantFiled: June 16, 1987Date of Patent: August 15, 1989Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4855468Abstract: Titanocenes with .pi.-cyclopentadienyl ligands, in which one or two carbocyclic or heterocyclic aromatic rings are bonded to the metal, the aromatic rings being substituted in at least one of the two ortho-positions relative to the metal-carbon bonds by CF.sub.2 Z (Z=F or substituted or unsubstituted alkyl), are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds. They are distinguished by a high radiation sensitivity, stability to air and thermal effects, and high effectiveness in the range from UV light to visible light.Type: GrantFiled: September 11, 1987Date of Patent: August 8, 1989Assignee: Ciba-Geigy CorporationInventors: Martin Riediker, Kurt Meier, Hans Zweifel
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Patent number: 4851549Abstract: Pigments of the general formulaF.multidot.Het (I)where F is the cation of a cationic dye which has an absorption maximum at >700 nm and may or may not contain anionic groups and Het is an anion of a heteropolyacid based on tungsten, molybdenum, vanadium or a mixture of these with phosphorus, silicon, cobalt, aluminum, manganese, chromium, nickel or a mixture of these or a copper(I)-hexacyanoferrate(II) anion, are superior to the known IR dyes in terms of thermal stability and photostability, and give optical recording media having superior properties, such as a high signal/noise ratio.Type: GrantFiled: August 23, 1988Date of Patent: July 25, 1989Assignee: BASF AktiengesellschaftInventors: Helmut Flohr, Joachim Jesse, Bernhard Albert, Peter Neumann