Tetracyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/42)
  • Publication number: 20110288306
    Abstract: ??-di-R-substituted fused thiophene (DCXFT4) compounds, and a method for making a compound of the formula (V): where each R is a C4 to C25 hydrocarbylene, the method including di-acylating tetra-bromo dithiophene (I); contacting the bromo-dithiophene compound (II) with a 2-mercaptoacetate to form cyclized fused thiophene (III); converting fused thiophene (III) to the corresponding diacid (IV); and decarboxylating the diacid (IV) to the fused thiophene (V), of the formulas as defined herein.
    Type: Application
    Filed: May 18, 2010
    Publication date: November 24, 2011
    Inventors: Mingqian He, Jieyu Hu, James R. Matthews, Weijun Niu
  • Publication number: 20110266526
    Abstract: Compounds comprising a triphenylene moiety and a benzo- or dibenzo-moiety are provided. In particular, the benzo- or dibenzo-moiety has a fused substituent. These compounds may be used in organic light emitting devices, particularly in combination with yellow, orange and red emitters, to provide devices with improved properties.
    Type: Application
    Filed: January 11, 2011
    Publication date: November 3, 2011
    Applicant: Universal Display Corporation
    Inventors: Bin Ma, James Fiordelsiso, Yonggang Wu, Raymond Kwong
  • Publication number: 20110224445
    Abstract: There are provided a novel compound having a good field mobility, a method of producing of the compound, an organic semiconductor material containing the novel compound, and an organic semiconductor device. The novel compound which is represented by the following general formula (1), (2), (3) or (4) (where Z represents a sulfur atom or a selenium atom, and R represents a hydrogen atom, an alkyl group or a phenyl group in general formulae) has a structure having two benzene rings of naphthalene bonded with a thiophene ring and a selenophene ring, respectively. These compounds have a conjugate system in molecules due to an interaction between it orbitals, and show a strong molecular interaction through a sulfur atom or a selenium atom contained in a thiophene ring or a selenophene ring in each molecule, thereby having a good field mobility.
    Type: Application
    Filed: October 30, 2009
    Publication date: September 15, 2011
    Inventor: Kazuo Takimiya
  • Publication number: 20110204295
    Abstract: Disclosed are a heterocyclic compound characterized by being represented by formula (1), and a composition of the compound. Also disclosed is an organic electronic device using the compound. (In formula (1), X1, X2 and X3 each independently represents a sulfur atom or a selenium atom; and R1-R6 each independently represents an aromatic hydrocarbon group, an aliphatic hydrocarbon group, a halogen atom, a hydroxyl group, an alkoxyl group, a mercapto group, an alkylthio group, a boronic acid group, a nitro group, a substituted amino group, an amide group, an acyl group, a carboxyl group, an acyloxy group, a cyano group, a sulfo group, a sulfamoyl group, an alkylsulfamoyl group, a carbamoyl group, an alkylcarbamoyl group or a hydrogen atom, provided that all the R1-R6 are not hydrogen atoms at the same time.) The compound represented by formula (1) is suitable for use in an organic electronic device such as an organic EL element, an organic transistor element and a liquid crystal element.
    Type: Application
    Filed: November 20, 2009
    Publication date: August 25, 2011
    Applicants: HIROSHIMA UNIVERSITY, NIPPON KAYAKU KABUSHIKI KAISHA
    Inventors: Hirokazu Kuwabara, Masaaki Ikeda, Kazuo Takimiya
  • Publication number: 20110178065
    Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 21, 2011
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel Chu, Bing Wang, Tao Ye
  • Publication number: 20110168992
    Abstract: The present invention relates to a novel compound, a method for manufacturing the same, and an organic electronic device using the same, and the novel compound according to the present invention may act as a hole injection, hole transport, electron injection and transport, or light emitting material in an organic light emitting device and an organic electronic device, and the device according to the present invention shows excellent properties in terms of efficiency, a driving voltage, and stability.
    Type: Application
    Filed: September 23, 2009
    Publication date: July 14, 2011
    Inventors: Jae-Soon Bae, Ji-Eun Kim, Jeung-Gon Kim, Jun-Gi Jang
  • Publication number: 20110144094
    Abstract: This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: February 16, 2011
    Publication date: June 16, 2011
    Inventors: José Maria Cid-Núñez, Antonius Adrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez
  • Publication number: 20110095270
    Abstract: There is provided an electroactive material having Formula I wherein: Q is the same or different at each occurrence and can be O, S, Se, Te, NR, SO, SO2, or SiR3; R is the same or different at each occurrence and can be hydrogen, alkyl, aryl, alkenyl, or alkynyl; R1 through R8 are the same or different and can be hydrogen, alkyl, aryl, halogen, hydroxyl, aryloxy, alkoxy, alkenyl, alkynyl, amino, alkylthio, phosphino, silyl, —COR, —COOR, —PO3R2, —OPO3R2, or CN.
    Type: Application
    Filed: December 17, 2008
    Publication date: April 28, 2011
    Inventor: HONG MENG
  • Publication number: 20110082278
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 7, 2011
    Inventor: Mingqian He
  • Patent number: 7910653
    Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: March 22, 2011
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7893191
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: February 22, 2011
    Assignee: Corning Incorporated
    Inventor: Mingqian He
  • Publication number: 20110040107
    Abstract: A [1]benzothieno[3,2-b][1]benzothiophene compound expressed by General Formula (I): General Formula (I) where X and Y are each independently a hydrogen atom; a halogen atom; or a functional group having a straight or branched aliphatic alkyl group optionally having a halogen atom, a functional group having an alicyclic alkyl group optionally having a halogen atom, a functional group having a straight or branched aliphatic alkenyl group optionally having a halogen atom, a functional group having an alicyclic alkenyl group optionally having a halogen atom, a functional group having a carboxyl group, or a functional group having a thiol group, as a partial structure; and X and Y are the same or each independently different, provided that at least one of X and Y has a straight or branched aliphatic alkenyl group, an alicyclic alkenyl group, a carboxyl group or a thiol group, as a partial structure.
    Type: Application
    Filed: April 15, 2009
    Publication date: February 17, 2011
    Inventors: Daisuke Goto, Masafumi Torii, Tamotsu Horiuchi, Tamotsu Aruga, Hiroshi Ikuno, Toshiya Sagisaka, Satoshi Yamamoto, Takeshi Orito, Masataka Mohri, Takashi Okada, Takuji Kato, Shinji Mutsumoto
  • Publication number: 20110031488
    Abstract: A compound for an organic thin film transistor having a structure shown by the following formula (1): X1-L-Ar-L-X2 ??(1) wherein L is —C?C—, or —CH?CH— in a trans configuration, X1 and X2 are independently an alkyl group having 2 to 30 carbon atoms or a haloalkyl group having 1 to 30 carbon atoms, and Ar is a substituted or unsubstituted aromatic hydrocarbon group having 14 to 60 ring carbon atoms which is a condensed ring of three or more rings, or a substituted or unsubstituted aromatic heterocyclic group having 11 to 60 ring atoms which is a condensed ring of three or more rings.
    Type: Application
    Filed: April 2, 2009
    Publication date: February 10, 2011
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Masatoshi Saito, Yuki Nakano, Hiroaki Nakamura
  • Publication number: 20110031487
    Abstract: A compound for an organic thin film transistor having a structure shown by the following formula (1): X1-L-Ar-L-X2??(1) wherein L is —C?C—, or —CH?CH— in a trans configuration, X1 and X2 are independently a substituted or unsubstituted aromatic heterocyclic group having 5 to 60 ring atoms, and their bonding positions to L are in heterocycles, Ar is a substituted or unsubstituted aromatic hydrocarbon group having 6 to 60 ring carbon atoms, or a substituted or unsubstituted aromatic heterocyclic group having 5 to 60 ring atoms, and at least one of X1, X2 and Ar is a bi- or higher-fused ring.
    Type: Application
    Filed: April 2, 2009
    Publication date: February 10, 2011
    Applicant: Idemitsu Kosan Co., Ltd.
    Inventors: Masatoshi Saito, Yuki Nakano, Hiroaki Nakamura
  • Publication number: 20110024731
    Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.
    Type: Application
    Filed: October 5, 2010
    Publication date: February 3, 2011
    Applicant: National University of Corp. Hiroshima University
    Inventors: Kazuo TAKIMIYA, Yoshihito Kunugi, Yasushi Konda
  • Publication number: 20110020566
    Abstract: A charge transporting, liquid crystal photoalignment material comprising a charge transporting moiety connected through covalent chemical bonds to a surface derivatising moiety, and a photoalignment moiety connected through covalent chemical bonds to a surface derivatising moiety.
    Type: Application
    Filed: February 16, 2009
    Publication date: January 27, 2011
    Inventor: Gene Carl Koch
  • Patent number: 7868086
    Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: January 11, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Publication number: 20110003966
    Abstract: This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suitable photochromic or electrochromic conditions. The electrochromic conversion may be catalytic. The application also relates to ultra-high density homopolymers prepared using ring-opening methathesis polymerization (ROMP) where the central ring of the 1,2-bis(3-thienyl)-cyclopentene is incorporated directly into the polymer backbone. The monomer units may be readily functionalized to enable the synthesis of polymers with diverse structural and electronic properties.
    Type: Application
    Filed: July 1, 2010
    Publication date: January 6, 2011
    Applicant: SWITCH MATERIALS INC.
    Inventors: Neil R. Branda, Andrea Peters, Anthony J. Wigglesworth
  • Publication number: 20100331325
    Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: August 5, 2010
    Publication date: December 30, 2010
    Inventors: José Maria CID-NÚÑEZ, Antonius Adrianus Hendrikus Petrus MEGENS, Andrés Avelino TRABANCO-SUÁREZ, Mohamed KOUKNI, Georges Joseph Cornelius HOORNAERT, Frans Josef Cornelius COMPERNOLLE, Tomasz KOZLECKI, Hua MAO, Sushil Chandra JHA, Francisco Javier FERNÁNDEZ-GADEA
  • Publication number: 20100305288
    Abstract: Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 2, 2010
    Inventors: Mingqian He, Thomas Mark Leslie, Weijun Niu
  • Patent number: 7838612
    Abstract: Described herein are aromatic sulfonimide compositions that can be used to prepare polymers useful as membranes in electrochemical cells.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 23, 2010
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7838623
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: November 23, 2010
    Assignee: Corning Incorporated
    Inventor: Mingqian He
  • Patent number: 7838594
    Abstract: Aromatic sulfonimide ionene compositions useful as monomers for polymers in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 23, 2010
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7834198
    Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: November 16, 2010
    Assignee: National University of Corporation Hiroshima University
    Inventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
  • Patent number: 7799785
    Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 21, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: José Maria Cid-Núñez, Antonius Andrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernández-Gadea
  • Patent number: 7795299
    Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 14, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
  • Patent number: 7670512
    Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: March 2, 2010
    Assignee: National Sun Yat-Sen University
    Inventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
  • Patent number: 7671141
    Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: March 2, 2010
    Assignee: National Sun Yat-Sen University
    Inventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
  • Patent number: 7662313
    Abstract: This invention provides compositions and devices having structurally ordered nanostructures, as well as methods for producing structurally ordered nanostructures.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: February 16, 2010
    Assignee: NANOSYS, Inc.
    Inventors: Jeffery A. Whiteford, Mihai Buretea, Erik Scher, Steve Empedocles, Andreas Meisel
  • Publication number: 20100032655
    Abstract: Disclosed is a field-effect transistor characterized by using a compound represented by the formula (1) below as a semiconductor material. (In the formula (1), X1 and X2 independently represent a sulfur atom, a selenium atom or a tellurium atom; and R1 and R2 independently represent an unsubstituted or halogeno-substituted C1-C36 aliphatic hydrocarbon group.
    Type: Application
    Filed: October 19, 2007
    Publication date: February 11, 2010
    Inventors: Kazuo Takimiya, Hideaki Ebata, Hirokazu Kuwabara, Masaaki Ikeda, Tatsuto Yui
  • Publication number: 20100010237
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof
    Type: Application
    Filed: September 17, 2009
    Publication date: January 14, 2010
    Inventor: Mingqian He
  • Publication number: 20100006824
    Abstract: An organic nanofiber including a gelled organic semiconductor compound. Also disclosed is an organic semiconductor transistor and a method of manufacturing an organic semiconductor transistor.
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jong-in HONG, Myoung-chul UM, Jung-pyo HONG, Seong-hoon LEE
  • Publication number: 20100006830
    Abstract: An organic semiconductor compound based on a 2,7-bis-(vinyl)[1]benzothieno[3,2-b]benzothiophene backbone, an organic semiconductor thin film, an organic thin film transistor and methods of forming the same are provided, the organic semiconductor compound including a vinyl group derived from a phosphonate derivative represented by Formula 1 and an aldehyde derivative represented by Formula 2 below:
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Inventors: Jong-in Hong, Myoung-chul Um, Jeong-hun Kwak, Chang-hee Lee
  • Publication number: 20090221687
    Abstract: Novel tetracyclic dibenzo(e,h)azulene compounds of formula I; their pharmacologically acceptable derivatives; process and intermediates for their preparation; pharmaceutical compositions containing them and their activity and use in the treatment of central nervous system (CNS) diseases and conditions in humans and animals.
    Type: Application
    Filed: February 1, 2006
    Publication date: September 3, 2009
    Inventors: Milan Mesic, Mladen Mercep, Dijana Pesic, Renata Rupcic, Barbara Stanic
  • Patent number: 7572395
    Abstract: The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: August 11, 2009
    Assignee: Nanosys, Inc
    Inventors: Jeffery A. Whiteford, Mihai A. Buretea, Erik C. Scher
  • Patent number: 7572393
    Abstract: The present invention provides polymeric compositions that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: August 11, 2009
    Assignee: Nanosys Inc.
    Inventors: Jeffery A. Whiteford, Mihai A. Buretea, Linh Nguyen, Erik Scher
  • Publication number: 20090023721
    Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: May 24, 2006
    Publication date: January 22, 2009
    Inventors: Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Jose Maria Cid-Nunez, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki
  • Publication number: 20090001357
    Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.
    Type: Application
    Filed: January 18, 2006
    Publication date: January 1, 2009
    Applicant: National University of Corp. Hiroshima University
    Inventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
  • Publication number: 20080287450
    Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: December 6, 2005
    Publication date: November 20, 2008
    Inventors: Jose Maria Cid-Nunez, Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea
  • Patent number: 7435834
    Abstract: The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-?(TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 14, 2008
    Assignee: GlaxoSmithKline Istrazivacki Center Zagreb D.O.O.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec
  • Publication number: 20080242875
    Abstract: A method for the degradation of polycyclic aromatic compounds is disclosed that involves dissolving ozone in a bipolar solvent comprising a non-polar solvent in which is of sufficiently non-polar character to solubilized the polycyclic aromatic compounds, and a polar-water-compatible solvent which is fully miscible with the non-polar solvent to form a single phase with the non-polar solvent. The bipolar solvent with dissolved ozone is contacted with the polycyclic aromatic compounds to solubilize the polycyclic aromatic compounds and react the dissolved polycyclic aromatic compounds with the ozone to degrade the dissolved polycyclic aromatic compounds to oxygenated intermediates. The bipolar solvent is then mixed with sufficient water to form separate non-polar and polar phases, the non-polar phase comprising the non-polar solvent and the polar phase comprising the non-polar solvent and the oxygenated intermediates.
    Type: Application
    Filed: March 24, 2008
    Publication date: October 2, 2008
    Inventors: P.K. Andy Hong, David A. Wavrek, Jiun-Chi Chao, Yu Zeng
  • Publication number: 20080214838
    Abstract: Described are oligotetracenes of formula I which may either be unsubstituted or carry one or more substituents R and R? which are selected from the group comprising halogen, CN, alkyl or alkoxy radicals containing 1 to 18 carbon atoms, aryl radicals containing up to 10 carbon atoms which may also contain one or more heteroatoms, and/or fluorinated or perfluorinated alkyl or alkoxy radicals containing 1 to 18 carbon atoms, where n is an integer from 1 to 20, preferably 1 to 6, very particularly preferably 1 or 2, and X stands for a single bond, an alklyene group containing 1 to 6 carbon atoms, a hydrocarbon chain having one or more conjugated double bonds, an aryl group, or a system composed of one or more condensed aromatic rings. In the oligotetracenes according to the invention, one or more of the condensed aromatic six-atom rings may be substituted by a five-atom ring which may also contain a heteroatom.
    Type: Application
    Filed: June 21, 2006
    Publication date: September 4, 2008
    Inventors: Matthias Rehahn, Michael Roth, Heinz Von Seggern, Roland Schmechel, Marcus Ahles
  • Patent number: 7420065
    Abstract: Provided are novel hetero-polycyclic compounds having a specific structure, color-changing material compositions comprising (A) a fluorescent coloring matter comprising at least one of the hetero-polycyclic compounds described above and (B) a binder material, color-changing films comprising the above hetero-polycyclic compounds, coloring matters comprising the above hetero-polycyclic compounds, and pigments or dyes comprising the hetero-polycyclic compounds described above, and provided are color-changing material compositions which are not deteriorated in a color-changing performance even after used for long time and which are prevented from being unusable due to deposition of coloring matters during storage and color-changing films produced by using the same, and novel hetero-polycyclic compounds, coloring matters and pigments or dyes which actualize them.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: September 2, 2008
    Assignees: Idemitsu Kosan Co., Ltd., Techno Network Shikoku Co., Ltd.
    Inventors: Katsuhira Yoshida, Yousuke Ooyama, Satoshi Hachiya
  • Publication number: 20080142793
    Abstract: Organic semiconducting devices and applications exhibit high performance largely due to a treatment substrate interacting with an asymmetric linear compound. According to an example, an organic compound arrangement includes a treated substrate and an asymmetric linear compound on the treated substrate. The compound includes an acene and a thiophene unit fused to the acene and exhibits high mobility and, in some applications, a correspondingly high on/off ratio. The compound arrangement is suitable for implementation with a variety of semiconducting applications, such as thin-film applications, solar applications and transistor applications.
    Type: Application
    Filed: November 13, 2007
    Publication date: June 19, 2008
    Inventors: Ming L. Tang, Zhenan Bao, Toshihiro Okamoto
  • Patent number: 7384974
    Abstract: A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: June 10, 2008
    Assignee: Taisha Pharmaceutical Co., Ltd.
    Inventors: Minoru Taguchi, Ryo Suzuki, Ayako Mikami
  • Publication number: 20080100207
    Abstract: Provided are a cyclopentaphenanthrene-based compound and an organoelectroluminescent device employing the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.
    Type: Application
    Filed: July 18, 2007
    Publication date: May 1, 2008
    Inventors: Sang-Hoon Park, Yu-Jin Kim, Jhun-Mo Son
  • Patent number: 7271264
    Abstract: The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), —OSO2(C2-C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl- 1-pyrrolidinyl, dimethyl-1-pyrrolidiny, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3 X is —S— or —HC?CH—; G is —O—, —S—, —SO—, SO2, or —N(R5)—, wherein R5 is —H or C1-C4 alkyl; and Y is —O—, —S—, —NH—, —NMe—, or —CH2—; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: September 18, 2007
    Assignee: Eli Lilly and Company
    Inventors: Ronald Jay Hinklin, Owen Brendan Wallace
  • Patent number: 7253292
    Abstract: A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: August 7, 2007
    Assignee: Basell Polyolefine GmbH
    Inventors: Ilya E. Nifant'ev, Igor A Kashulin, Pavel V. Ivchenko, Peter A. A. Klusener, Frans M. Kornorffer, Kees P. De Kloe, Jos J. H. Rijsemus
  • Patent number: 7119206
    Abstract: The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1–C4 alkyl), —OCOC6H5, —OCO(C1–C6 alkyl), or —OSO2(C2–C6 alkyl); R0, R2 and R3 are each independently —H, —OH, —O(C1–C4 alkyl), —OCOC6H5, —OCO(C1–C6 alkyl), —OSO2(C2–C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; X is S— or —HC?CH—; and Y is O—, —S—, —NH—, —NMe—, or —CH2—; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: October 10, 2006
    Assignee: Eli Lilly and Company
    Inventor: Owen Brendan Wallace
  • Patent number: 6949206
    Abstract: The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: September 27, 2005
    Assignee: Nanosys, Inc.
    Inventors: Jeffery A. Whiteford, Mihai A. Buretea, Erik Scher