Additional Hetero Ring Containing Patents (Class 549/59)
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Patent number: 7718679Abstract: The invention is concerned with novel heteroaryl carboxamides of formula (I) wherein A, R1, R2, X, Y, Z and m are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used for the treatment or prevention of thrombotic disorders.Type: GrantFiled: October 19, 2007Date of Patent: May 18, 2010Assignee: Hoffman-La Roche Inc.Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Bernd Kuhn, Narendra Panday, Fabienne Ricklin
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Publication number: 20100121062Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T ??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.Type: ApplicationFiled: September 25, 2009Publication date: May 13, 2010Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
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Publication number: 20100113477Abstract: The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl-naphthyl-, or thienyl-substituted diketo acids and carboxylate derivatives thereof. Also provided are methods of treating tuberculosis or other pathophysiological conditions associated with a malate synthase enzyme with the inhibitory compounds and methods of in silico design of the inhibitory compounds. In addition, the present invention provides the inhibitory compounds designed by this method. Furthermore, three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds are provided. Further still a method for stabilizing an aromatic or heteroaromatic diketo acid or its prodrug or close analog in solution by derivatizing at least the ortho position on the aromatic ring is provided.Type: ApplicationFiled: October 20, 2009Publication date: May 6, 2010Inventors: Joel S. Freundlich, James C. Sacchettini, Inna V. Kriger, Thomas R. Ioerger, Vijay Gawandi
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Patent number: 7700787Abstract: A small molecular thiophene compound consisting of a plurality of thiophene units, each thiophene unit being represented by structure (A) wherein each thiophene unit is bonded at either or both of the second ring position and the fifth ring position, wherein m is 0, 1, or 2, wherein each thiophene unit is the same or different from each other in terms of substituent number, substituent identity, and substituent position, wherein each R1 is independently selected from the group consisting of: (a) a hydrocarbon group, (b) a heteroatom containing group, and (c) a halogen, wherein there is at least one thiophene unit where R1 is present at the third ring position or the fourth ring position, or at both the third ring position and the fourth ring position, wherein for any two adjacent thiophene units as represented by structure (A1): there is excluded the simultaneous presence of the same or different R1 at the 3-position of one thiophene unit and at the 3?-position of the other thiophene unit whereiType: GrantFiled: October 30, 2007Date of Patent: April 20, 2010Assignee: Xerox CorporationInventors: Beng S Ong, Ping Liu, Maria Birau, Yiliang Wu
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Patent number: 7700643Abstract: The invention relates to novel polymerisable thieno[3,2-b]thiophenes, to their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example liquid, crystal displays, optical films, organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to field effect transistors, light emitting devices or ID tags comprising the novel compounds.Type: GrantFiled: May 13, 2005Date of Patent: April 20, 2010Assignee: Merck Patent GmbHInventors: Martin Heeney, Weimin Zhang, Iain McCulloch
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Patent number: 7692029Abstract: A star-shaped oligothiophene-arylene derivative in which an oligothiophene having p-type semiconductor characteristics is bonded to an arylene having n-type semiconductor characteristics positioned in the central moiety of the molecule and forms a star shape with the arylene, thereby simultaneously exhibiting both p-type and n-type semiconductor characteristics. Further, an organic thin film transistor using the oligothiophene-arylene derivative. The star-shaped oligothiophene-arylene derivative can be spin-coated at room temperature, leading to the fabrication of organic thin film transistors simultaneously satisfying the requirements of high charge carrier mobility and low off-state leakage current.Type: GrantFiled: April 28, 2005Date of Patent: April 6, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Kook Min Han, Eun Jeong Jeong, Chang Ju Kim, Eun Kyung Lee
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Patent number: 7687491Abstract: A compound having immunosuppressive activity with low toxicity or a pharmacological salt thereof.Type: GrantFiled: October 19, 2007Date of Patent: March 30, 2010Assignee: Daiichi Sankyo Company, LimitedInventors: Takahide Nishi, Tsuyoshi Nakamura, Yukiko Sekiguchi, Yumiko Mizuno, Takaichi Shimozato, Futoshi Nara
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Publication number: 20100076205Abstract: A dye compound is described, which is expressed by formula (I): wherein A1, A2 and A3 each independently represent a substituted or unsubstituted 1,4-phenylene or 2,5-thiophene group, and B1 and B2 each independently represent a substituted or unsubstituted aryl group. The dye compound is suitably used as a dye sensitizer in a dye sensitized solar cell (DSSC).Type: ApplicationFiled: May 19, 2009Publication date: March 25, 2010Applicant: Academia SinicaInventors: Tahsin J. Chow, Yuan-Chieh Chang
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Publication number: 20100063088Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.Type: ApplicationFiled: November 17, 2009Publication date: March 11, 2010Inventors: Jill E. WOOD, Hanno Wild, Daniel H. Rogers, John Lyons, Michael Katz, Yolanda Caringal, Robert Dally, Wendy Lee, Roger A. Smith, Cheri Blum
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Patent number: 7674397Abstract: The invention relates to new reactive mesogenic compounds with charge transport properties comprising at least two thiophene groups, their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example liquid crystal displays, optical films, organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the reactive mesogenic charge transport compounds.Type: GrantFiled: February 25, 2005Date of Patent: March 9, 2010Assignee: Merck Patent Gesellschaff mit beschrankter HaftungInventors: Martin Heeney, Weimin Zhang, Steven Tierney, David Sparrowe, Maxim Shkunov, Iain McCulloch
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Patent number: 7674815Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.Type: GrantFiled: January 29, 2007Date of Patent: March 9, 2010Assignee: Hoffmann-La Roche Inc.Inventors: Christoph Faeh, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger
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Patent number: 7671141Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.Type: GrantFiled: June 28, 2006Date of Patent: March 2, 2010Assignee: National Sun Yat-Sen UniversityInventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
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Patent number: 7670512Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.Type: GrantFiled: June 28, 2006Date of Patent: March 2, 2010Assignee: National Sun Yat-Sen UniversityInventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
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Publication number: 20100041730Abstract: This invention relates to novel macromolecular compositions having oxidation inhibition characteristics that are exhibited when added to organic material normally susceptible to oxidative degradation in the presence of air or oxygen, such a petroleum products, synthetic polymers, and elastomeric substances.Type: ApplicationFiled: October 17, 2007Publication date: February 18, 2010Inventors: Mahmood Sabahi, Vincent J. Gatto, Hassan Y. Elnagar
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Publication number: 20100039025Abstract: Disclosed herein are novel electrochromic materials. The electrochromic materials produce various colors and have bistability to achieve red-green-blue full colors. Therefore, the electrochromic materials can be used in a variety of electrochromic devices. Also disclosed herein are electrochromic devices fabricated using the electrochromic materials.Type: ApplicationFiled: April 13, 2009Publication date: February 18, 2010Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Seung Uk SON, Ji Min LEE, Chang Ho NOH
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Patent number: 7659274Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.Type: GrantFiled: January 24, 2007Date of Patent: February 9, 2010Assignee: OSI Pharmaceuticals, Inc.Inventors: Andrew Philip Crew, Douglas S. Werner, Paula A. R. Tavares
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Patent number: 7655680Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) —CO—B— wherein B is a C1-6 alkylene group and (ii) —CO—Ba— wherein Ba is a C2-6 alkenylene group, and include optical isomers and salts of the compounds.Type: GrantFiled: May 16, 2005Date of Patent: February 2, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
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Patent number: 7652020Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-? or combinations thereof.Type: GrantFiled: June 1, 2005Date of Patent: January 26, 2010Assignee: Schering CorporationInventors: Zhuyan Guo, Peter Orth, Zhaoning Zhu, Robert D. Mazzola, Tin-Yau Chan, Henry A. Vaccaro, Brian McKittrick, Joseph A. Kozlowski, Brian J. Lavey, Guowei Zhou, Sunil Paliwal, Shing-Chun Wong, Neng-Yang Shih, Pauline C. Ting, Kristin E. Rosner, Gerald W. Shipps, Jr., M. Arshad Siddiqui, David B. Belanger, Chaoyang Dai, Dansu Li, Vinay M. Girijavallabhan, Janeta Popovici-Muller, Wensheng Yu, Lianyun Zhao
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Publication number: 20100016608Abstract: Disclosed is light-driven actuator element characterized in that, inter alia, it can be reduced to micrometer size, is rapidly responsive, and reversibly changes to enable repeated use. The light-driven actuator element includes a crystal of diarylethene compound which changes shape upon photoisomerization (e.g., the compound of Structural Formula (I) below, where R1 represents a hydrogen atom or methyl group and R2 represents a methyl group). The element can be a rod-shaped or plate-like microcrystal having a size on the order of micrometer. The element bends (or contracts) on irradiation with ultraviolet light and expands to return to the original size on irradiation with visible light.Type: ApplicationFiled: October 22, 2007Publication date: January 21, 2010Inventors: Masahiro Irie, Shizuka Takami
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Publication number: 20100006824Abstract: An organic nanofiber including a gelled organic semiconductor compound. Also disclosed is an organic semiconductor transistor and a method of manufacturing an organic semiconductor transistor.Type: ApplicationFiled: July 8, 2009Publication date: January 14, 2010Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jong-in HONG, Myoung-chul UM, Jung-pyo HONG, Seong-hoon LEE
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Patent number: 7645799Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.Type: GrantFiled: November 7, 2008Date of Patent: January 12, 2010Assignee: Bristol-Myers Squibb CompanyInventors: James R. Corte, Mimi L. Quan, Joanne M. Smallheer, Donald J. P. Pinto
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Patent number: 7642276Abstract: Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.Type: GrantFiled: July 30, 2003Date of Patent: January 5, 2010Assignee: SmithKline Beecham CorporationInventors: Richard Martyn Angell, Ian Robert Baldwin, Paul Bamborough, Nigel Marc Deboeck, Timothy Longstaff, Stephen Swanson
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Patent number: 7642264Abstract: The present invention relates to compounds of formula (Ia), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, R1, R2, R3 and R4 are as defined in the description and claims.Type: GrantFiled: March 22, 2007Date of Patent: January 5, 2010Assignee: Hoffman-La Roche Inc.Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
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Publication number: 20090321686Abstract: The present invention relates to novel 1,4-bis(2-thienylvinyl)benzene derivatives, to conjugated polymers, dendrimers, blends, mixtures and formulations comprising same, and to the use thereof in electronic devices, in particular in polymeric organic light-emitting diodes.Type: ApplicationFiled: July 5, 2007Publication date: December 31, 2009Inventors: Arne Buesing, Susanne Heun, Aurélie Ludemann, Frank Egon Meyer, Niels Schulte
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Patent number: 7638513Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-? or combinations thereof.Type: GrantFiled: December 1, 2005Date of Patent: December 29, 2009Assignee: Schering CorporationInventors: M. Arshad Siddiqui, Umar Faruk Mansoor, Panduranga A. Reddy, Vincent S. Madison
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Patent number: 7632947Abstract: Pyrimidopyrimidine derivatives, organic thin film transistors using pyrimidopyrimidine derivatives and method for fabricating the same are provided. Pyrimidopyrimidine derivative structures, along with example syntheses, are provided. The pyrimidopyrimidine derivatives may be pyrimidopyrimidine oligothiophene derivatives in which an oligothiophene having p-type semiconductor characteristics may be bonded to a pyrimidopyrimidine having n-type semiconductor characteristics positioned substantially in the center of the molecules, thereby simultaneously exhibiting both p-type and n-type semiconductor characteristics. The pyrimidopyrimidine derivatives may be spin-coated at room, or ambient, temperature when applied to the fabrication of an electronic device, for example, organic thin film transistors. Organic thin film transistors using the pyrimidopyrimidine derivatives may provide higher charge carrier mobility and/or lower off-state leakage current.Type: GrantFiled: February 22, 2006Date of Patent: December 15, 2009Assignee: Samsung Electronics Co., LtdInventors: Eun Jeong Jeong, Sang Yoon Lee, Bang Lin Lee
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Patent number: 7625900Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.Type: GrantFiled: October 17, 2007Date of Patent: December 1, 2009Assignee: Gruenenthal GmbHInventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
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Publication number: 20090281171Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J, B, Y, G and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.Type: ApplicationFiled: May 6, 2009Publication date: November 12, 2009Applicant: ALLERGAN, INC.Inventor: David W. Old
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Publication number: 20090281145Abstract: The present invention provides compounds of formula (I) wherein W, R1, R5 and R6 have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric enhancers of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain, and inflammatory pain, cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke, neurological disease or injury, sleep disorders, epilepsy and depression.Type: ApplicationFiled: May 7, 2009Publication date: November 12, 2009Inventors: Pier Giovanni Baraldi, Allan R. Moorman, Romeo Romagnoli
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Publication number: 20090267061Abstract: Carbonyl-functionalized oligo/polythiophene compounds, and related semiconductor components and related device structures.Type: ApplicationFiled: April 29, 2009Publication date: October 29, 2009Inventors: Tobin J. Marks, Antonio Facchetti
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Patent number: 7601849Abstract: Nonlinear optically active compounds, macrostructures that include nonlinear optically active components, and devices including the macrostructures. The nonlinear optically active compounds include dendrimers having two or more nonlinear optically active components. In certain embodiments, the compounds and dendrimers are crosslinkable.Type: GrantFiled: August 2, 2002Date of Patent: October 13, 2009Assignee: University of WashingtonInventors: Kwan-Yue Jen, Larry R. Dalton, Hong Ma
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Patent number: 7595343Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.Type: GrantFiled: September 12, 2002Date of Patent: September 29, 2009Assignee: MethylGene, Inc.Inventors: Daniel Delorme, Soon Hyung Woo, Arkadii Vaisburg, Oscar Moradei, Silvana Leit, Stephane Raeppel, Sylvie Frechette, Giliane Bouchain
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Publication number: 20090240062Abstract: Disclosed are a compound represented by the following formula (1), which is derived from cyclopentadienone and can be used as a core material for an organic electroluminescence element or other optical devices, and preparation method thereof, and an EL element using the same.Type: ApplicationFiled: April 6, 2009Publication date: September 24, 2009Applicant: Korea Institute of Science and TechnologyInventors: Hyun-Nam Cho, Sung Hyun Jung, Seok-Jin Park, Seung-Eun Lee
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Patent number: 7592337Abstract: Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases.Type: GrantFiled: March 7, 2003Date of Patent: September 22, 2009Assignee: Merck & Co., Inc.Inventors: Chixu Chen, Nicholas D. P. Cosford, Brian W. Eastman, Dehua Huang, Steve F. Poon, Thomas S. Reger, Jeffrey R. Roppe, Nicholas D. Smith
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Patent number: 7589166Abstract: The present invention provides a thiophene-containing compound represented by Formula (I) and a thiophene-containing compound polymer using the thiophene-containing compound. In Formula (I), Ar1 represents a substituted or unsubstituted monovalent aromatic group; X represents a divalent straight-chain hydrocarbon group having 1 to 6 carbon atoms, a divalent branched-chain hydrocarbon group having 2 to 10 carbon atoms, or a substituted or unsubstituted divalent aromatic group; R1 to R5 each independently represent a hydrogen atom, an alkyl group, a cyano group, a halogen group, a substituted amino group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; 1 represents an integer from 1 to 5; and m and k each independently represent 0 or 1.Type: GrantFiled: April 14, 2006Date of Patent: September 15, 2009Assignee: Fuji Xerox Co., Ltd.Inventors: Yoshihiro Ohba, Kazuaki Sato, Yohei Nishino, Mieko Seki, Takeshi Agata, Kiyokazu Mashimo, Katsuhiro Sato, Hirohito Yoneyama, Daisuke Okuda, Hidekazu Hirose, Toru Ishii
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Patent number: 7589120Abstract: The invention relates to compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic application.Type: GrantFiled: July 10, 2007Date of Patent: September 15, 2009Assignee: Sanofi-AventisInventors: Francis Barth, Christian Congy, Jean-Philippe Ducoux, Murielle Rinaldi-Carmona
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Publication number: 20090215958Abstract: A conducting polymer including a conducting linker to connect a probe to the polymer, the linker including an unsaturated organic chain.Type: ApplicationFiled: August 11, 2006Publication date: August 27, 2009Applicant: Auckland Uniservices LimitedInventors: Jadranka Travas-Sejdic, Christian Soeller, Hui Peng, Vittorio Capno, Ralph Cooney
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Patent number: 7579417Abstract: A metallocene compound of formula (I) wherein: M is an atom of a transition metal; X, same or different, is a hydrogen atom, a halogen atom, or a R, OR, OSO2CF3, OCOR, SR, NR2 or PR2 group, wherein R is C1-C40 hydrocarbon group; L is a divalent bridging group; R1, is a C1-C40 hydrocarbon group; R3 is a C1-C40 hydrocarbon group; R2, R4, R5, R6, R7 and R8, equal to or different from each other, are hydrogen atoms or C1-C40 hydrocarbon groups.Type: GrantFiled: November 16, 2004Date of Patent: August 25, 2009Assignee: Basell Polyolefine GmbHInventors: Ilya Nifant'ev, Pavel V. Ivchenko, Ilya V. Tajdakov, Luigi Resconi
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Patent number: 7579340Abstract: The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.Type: GrantFiled: August 22, 2007Date of Patent: August 25, 2009Assignee: Pfizer IncInventors: Ronald Biediger, Jie Chen, Daxin Gao, Robert Market, Chengde Wu
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Patent number: 7576129Abstract: The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.Type: GrantFiled: February 6, 2004Date of Patent: August 18, 2009Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Masaki Asada, Kaoru Kobayashi, Masami Narita, Kazutoyo Sato, Atsushi Kinoshita, Toshihiko Nagase, Ken Yoshikawa
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Publication number: 20090203866Abstract: The present invention relates to polymers comprising repeating unit(s) of the formula (I), and their use in electronic devices. The polymers according to the invention have excellent solubility in organic solvents and excellent film-forming properties. In addition, high charge carrier mobilities and high temperature stability of the emission color are observed, if the polymers according to the invention are used in polymer light emitting diodes (PLEDs).Type: ApplicationFiled: July 18, 2007Publication date: August 13, 2009Inventors: Thomas Schafer, Klaus Müllen, Mathieu G.R. Turbiez, Martin Baumgarten
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Patent number: 7569600Abstract: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.Type: GrantFiled: May 15, 2006Date of Patent: August 4, 2009Assignee: ViroChem Pharma Inc.Inventors: Real Denis, Carl Poisson, Sanjoy Kumar Das, Irina Motorina, Rabindra Rej, Constantin G. Yannopoulos, Laval Chan Chun Kong
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Publication number: 20090182033Abstract: Compounds of formula (I) have muscarinic M3 receptor modulating activity; formula (I) wherein R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5 or a group, -Z-Y—R5, or a group -Z-NR9R10, or a group -Z-N(R9)C(O)R11; and R3 is a lone pair, or C1-C6-alkyl; R4 is selected from one of the groups of formula (a), (b), (c) or (d); formulae (a), (b), (c), (d), Z is a C1-C16-alkylene, C2-C16-alkenylene or C2-C16-alkynylene group; Y is a bond or oxygen atom; R5 is an C1-C6-alkyl, aryl, arylalkyl; aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group; R6 is C1-C6-alkyl or a hydrogen atom; R7a and R7b area C1-C6-alkyl group or halogen; n and m are independently 0, 1, 2 or 3; R8a and R8b are independently selected from the group consisting of aryl, aryl-fused-heterocycloalkyl, heteroaryl, C1-C6-alkyl, cycloalkyl and hydrogen; R8c is —OH, C1-C6-alkyl, hydroxy-C1-C6-alkyl, or a hydrogen atom; R8d is C1-C6Type: ApplicationFiled: December 14, 2006Publication date: July 16, 2009Applicant: ARGENTA DISCOVERY LTD.Inventors: Harry Finch, Nicholas Charles Ray, Monique Bodil Van Niel, Phillip Smith
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Publication number: 20090179196Abstract: The object is to provide a light-emitting transistor material which is high in both luminescent property and mobility when used as a light-emitting transistor device. A light-emitting transistor device is provided in which light emission of a specific pyrene-based organic compound is used for a light-emitting layer of a transistor device.Type: ApplicationFiled: March 20, 2007Publication date: July 16, 2009Inventors: Chihaya Adachi, Takahito Oyamada, Hiroyuki Uchiuzou, Seiji Akiyama, Takayoshi Takahashi, Kumiko Takenouchi, Masaki Shimizu, Tamejiro Hiyama, Etsuya Okamoto
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Publication number: 20090174312Abstract: The present invention provides a novel tetraphenylnaphthalene derivative, and an organic light emitting device using the same.Type: ApplicationFiled: March 9, 2007Publication date: July 9, 2009Inventors: Yeon-Hwan Kim, Dong-Hoon Lee, Hye-Young Jang, Sung-Kil Hong, Sung-Jin Yeo, Kong-Kyeom Kim, Dong-Seob Jeong
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Publication number: 20090159876Abstract: Disclosed is an adequately stable organic semiconductor material which can be used in a coating process while having high regularity and crystallinity. For obtaining such an organic semiconductor material, there is used a compound wherein 6-20 five-membered and/or six-membered aromatic rings are bound. This compound contains a partial structure represented by the formula (1) below, while having a mobility of not less than 1.0×10?3 cm2/Vs and an ionization potential in the solid state of not less than 4.8 eV and not more than 5.6 eV. (1) In the formula, R1 and R2 independently represent a hydrogen atom or a monovalent organic group. In this connection, at least one of R1 and R2 is an optionally substituted aromatic group.Type: ApplicationFiled: September 20, 2006Publication date: June 25, 2009Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Yoshihiro Ohba, Kazuaki Sato, Yoshimasa Sakai, Shinji Aramaki
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Patent number: 7541381Abstract: ?-lactamases are the most widespread resistance mechanism to ?-lactam antibiotics, such as penicillins and cephalosporins. In response to these enzymes, inhibitors have been introduced. Unfortunately, these inhibitors are also ?-lactams, and resistance to them has developed rapidly. Consequently, the present invention provides a novel structure-based approach to inhibitors of these enzymes.Type: GrantFiled: February 19, 2003Date of Patent: June 2, 2009Assignee: Northwestern UniversityInventors: Brian K. Shoichet, Rachael A. Powers
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Patent number: 7534541Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula: where n is an integer between 1 and 10, inclusive; R1 comprises a functional group selected from the group consisting of a reactive ring group, an ethylenically unsaturated group, a reactive polar group, a hydrazone group, and an azine group; R2, R3, R4, R5, and R6 comprise, each independently, H, an alkyl group, an alkenyl group, an alkynyl group, an aromatic group, a heterocyclic group, or a part of a ring group; X is a bond or a linking group; and Q is O, S, or NR where R is H, an alkyl group, an acyl group, an alkenyl group, an alkynyl group, a heterocyclic group, or an aromatic group; and (b) a charge generating compound.Type: GrantFiled: January 27, 2005Date of Patent: May 19, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Maryte Daskeviciene, Vytautas Getautis, Tadeus Lozovski, Edmundas Montrimas
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Patent number: 7534899Abstract: Disclosed are aromatic enediyne derivatives, methods of manufacturing organic semiconductor thin films from such aromatic enediyne derivatives, and methods of fabricating electronic devices incorporating such organic semiconductor thin films. Aromatic enediyne derivatives according to example embodiments provide improved chemical and/or electrical stability which may improve the reliability of the resulting semiconductor devices. Aromatic enediyne derivatives according to example embodiments may also be suitable for deposition on various substrates via solution-based processes, for example, spin coating, at temperatures at or near room temperature to form a coating film that is then heated to form an organic semiconductor thin film. The availability of this reduced temperature processing allows the use of the aromatic enediynes derivatives on large substrate surfaces and/or on substrates not suitable for higher temperature processing.Type: GrantFiled: October 19, 2006Date of Patent: May 19, 2009Assignee: Smasung Electronics Co., Ltd.Inventors: Eun Jeong Jeong, Hyun Sik Moon, Kook Min Han
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Patent number: 7531619Abstract: A method for producing a dendrimer having a structural repeating unit which is represented by formula (1) and which contains a linear portion including a thienylene moiety and a branch portion Y formed of an optionally substituted trivalent organic group.Type: GrantFiled: July 14, 2003Date of Patent: May 12, 2009Inventors: Satoru Obara, Kentaro Tada