Cyano Bonded Directly To The Hetero Ring Patents (Class 549/61)
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Patent number: 8937189Abstract: Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of antidepressants.Type: GrantFiled: August 26, 2013Date of Patent: January 20, 2015Assignee: Wayne State UniversityInventor: Aloke K. Dutta
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Patent number: 8883781Abstract: The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.Type: GrantFiled: June 12, 2007Date of Patent: November 11, 2014Assignee: Vertex Pharmaceuticals IncorporatedInventors: Lev T. D. Fanning, Pramod Joshi, Paul Krenitsky, Andreas Termin, Dean Wilson, Yulian Zhang
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Publication number: 20140323502Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.Type: ApplicationFiled: February 13, 2014Publication date: October 30, 2014Inventors: Anton Franz Joseph Fliri, Randall James Gallaschun, Christopher John O'Donnell, Jacob Bradley Schwarz, Barbara Eileen Segelstein
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Patent number: 8822467Abstract: The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin.Type: GrantFiled: December 14, 2012Date of Patent: September 2, 2014Assignee: Ligand Pharmaceuticals IncorporatedInventors: Brian F. McGuinness, Koc-Kan Ho, Suresh Babu, Guizhen Dong, Jingqi Duo, Thuy X. H. Le, Kurt W. Saionz
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Patent number: 8624041Abstract: A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R1, R2, and R3 are independently a linear or branched C1-C6 alkyl group or a substituted or unsubstituted C3-C12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.Type: GrantFiled: August 18, 2006Date of Patent: January 7, 2014Assignee: Glenmark Generics Ltd.Inventors: Bobba Venkata Siva Kumar, Kosampally Srinivas, Sanjay Anantha Kale, Nitin Sharad Chandra Pradhan
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Patent number: 8609714Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.Type: GrantFiled: February 16, 2010Date of Patent: December 17, 2013Assignee: MERCK PATENT GmbHInventors: Lars Lietzau, Louise Diane Farrand, Markus Czanta, Harald Hirschmann, Michael Wittek, Izumi Saito, Brigitte Schuler
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Publication number: 20130310573Abstract: Strontium ranelate is prepared by reacting dicyclohexylammonium ranelate with strontium halide in an anhydrous solvent. Strontium ranelate thus obtained will have less than 3% moisture content.Type: ApplicationFiled: September 5, 2012Publication date: November 21, 2013Applicant: DIVI'S LABORATORIES LIMITEDInventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
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Patent number: 8569514Abstract: Strontium ranelate is prepared by reacting dicyclohexylammonium ranelate with strontium halide in an anhydrous solvent. Strontium ranelate thus obtained will have less than 3% moisture content.Type: GrantFiled: September 5, 2012Date of Patent: October 29, 2013Assignee: Divi's Laboratories, Ltd.Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
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Patent number: 8519159Abstract: 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants.Type: GrantFiled: July 15, 2010Date of Patent: August 27, 2013Assignee: Wayne State UniversityInventor: Aloke K. Dutta
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Patent number: 8513298Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.Type: GrantFiled: January 14, 2011Date of Patent: August 20, 2013Assignee: Gilead Sciences, Inc.Inventors: Eda Canales, Michael O'Neil Hanrahan Clarke, Scott E. Lazerwith, Willard Lew, Philip Anthony Morganelli, William J. Watkins
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Publication number: 20130102609Abstract: The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin.Type: ApplicationFiled: December 14, 2012Publication date: April 25, 2013Applicant: LIGAND PHARMACEUTICALS INC.Inventor: Ligand Pharmaceuticals Inc.
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Patent number: 8420812Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.Type: GrantFiled: December 23, 2009Date of Patent: April 16, 2013Assignee: SanofiInventors: Omar Rkyek, Marc Nazare, Andreas Lindenschmidt, Jorge Alonso, Matthias Urmann, Nis Halland
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Patent number: 8410163Abstract: Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.Type: GrantFiled: February 9, 2010Date of Patent: April 2, 2013Assignee: Telik, Inc.Inventors: Paul P. Beroza, Komath V. Damodaran, Stella Lui, Wenli Ma, Zhuo Wang, Hua Xu
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Publication number: 20120123131Abstract: The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. wherein R1 and R2 represents substituted or unsubstituted linear or branched C1-C6 alkyl group or C3-C12 cyclic group.Type: ApplicationFiled: August 8, 2009Publication date: May 17, 2012Inventors: Koilpillai Joseph Prabahar, Pravin Bhalchandra Kulkarni, Prashant Bhaskarrao Patil, Kapil Ramesh Hire
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Publication number: 20120101286Abstract: Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.Type: ApplicationFiled: February 9, 2010Publication date: April 26, 2012Applicant: TELIK INC.Inventors: Paul P. Beroza, Komath V. Damodaran, Stella Lui, Wenli Ma, Zhuo Wang, Hua Xu
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Publication number: 20120095024Abstract: The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).Type: ApplicationFiled: December 30, 2009Publication date: April 19, 2012Applicants: Elara Pharmaceuticals GmbH, European Molecular Biology Laboratory (EMBL)Inventors: Jorge Alonson, Arantxa Encionas Lopez, Marcel Muelbaler, Lochen Ammenn, Bernd Vendt, Joe Lewis, Christoph Schultes, Bernd Janssen
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Publication number: 20120065231Abstract: The present invention provides a compound represented by the formula (I) or its salt, solvate, or physiologically functional derivative; and a pharmaceutical composition which is useful for treatment or prevention of conditions or disorders having sensitivity to selective androgen receptor modulation, the composition comprising the above-described compound; among others:Type: ApplicationFiled: April 28, 2010Publication date: March 15, 2012Applicant: SUMITOMO CHEMICAL COMPANY LTD.Inventors: Koichiro Harada, Kozo Motonaga, Koichi Saito, Akio Tanaka
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Patent number: 8119821Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno [2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: GrantFiled: February 6, 2009Date of Patent: February 21, 2012Assignee: Senomyx, Inc.Inventors: Rhondi Shigemura, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Publication number: 20120029210Abstract: Process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates.Type: ApplicationFiled: October 11, 2011Publication date: February 2, 2012Applicant: LES LABORATOIRES SERVIERInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Patent number: 8063100Abstract: A process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates.Type: GrantFiled: September 24, 2008Date of Patent: November 22, 2011Assignee: Les Laboratoires ServierInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Publication number: 20110275834Abstract: This invention discloses Strontium Ranelate polymorph, designated as Form A, having a characteristic powdered x-ray diffraction pattern and infrared spectrum with a water content of about 1.5 to 2.5% and a process for its preparation.Type: ApplicationFiled: January 3, 2011Publication date: November 10, 2011Applicant: DIVI'S LABORATORIES, LIMITEDInventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
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Patent number: 7985769Abstract: The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.Type: GrantFiled: January 26, 2005Date of Patent: July 26, 2011Assignee: Vertex Pharmaceuticals IncorporatedInventors: Laval Chan Chun Kong, Jean Bedard, Sanjoy Kumar Das, Nghe Nguyen Ba, Oswy Z. Pereira, Thumkunta Jagadeeswar Reddy, Mohammad Arshad Siddiqui, Wuyi Wang, Constanin Yannopoulos
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Publication number: 20110105533Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.Type: ApplicationFiled: June 25, 2010Publication date: May 5, 2011Inventors: Anton F. J. Fliri, Randall James Gallaschun, Christopher John O'Donnell, Jacob Bradley Schwarz, Barbara E. Segelstein
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Publication number: 20100261900Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.Type: ApplicationFiled: December 23, 2009Publication date: October 14, 2010Applicant: sanofi-aventisInventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Jorge ALONSO, Matthias URMANN, Nis HALLAND
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Patent number: 7785556Abstract: A method of recovering ammonia by the distillation of an aqueous solution containing ammonia, carbon dioxide and hydrogen cyanide. The distillation is conducted using a distillation apparatus having at least its portion which comes into contact with the aqueous solution made of an alloy 1 or alloy 2. The alloy 1 contains 3% by weight or more of molybdenum, 15% by weight or more of nickel and 15% by weight or more of chromium. The alloy 2 contains 1% by weight or more of molybdenum, 9% by weight or less of nickel and 20% by weight or more of chromium. The use of the alloy 1 or alloy 2 prevents the corrosion of the distillation apparatus and enables the stable recovery of ammonia for a long period of time.Type: GrantFiled: October 26, 2007Date of Patent: August 31, 2010Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Kazuhiko Amakawa, Fumio Tanaka, Takuji Shitara
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Publication number: 20100210524Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.Type: ApplicationFiled: July 21, 2008Publication date: August 19, 2010Inventors: Theresa Apelqvist, Joakim Löfstedt, Thomas Norin, Mattias Wennerstål, Xiongyu Wu, Lars Hagberg
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Patent number: 7745482Abstract: Alpha crystalline form of strontium ranelate of formula (I): characterised by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.Type: GrantFiled: August 12, 2008Date of Patent: June 29, 2010Assignee: Les Laboratoires ServierInventors: Stephane Horvath, Isabelle Demuynck, Gerard Damien
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Publication number: 20100143404Abstract: Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, aryl, heterocyclyl, OR3 or N(R3)2, R3 is H, alkyl, aryl, or heterocyclyl; R4 is H, CN, halogen, CF3, CO2R3, or C(O)N(R3)2; X is S, SO2, O, or NR3; and Y is S, O, or NR3.Type: ApplicationFiled: December 29, 2004Publication date: June 10, 2010Inventors: Li-An Yeh, Gregory D. Cuny, Melissa Call, Kai Wucherpfennig, Ross L. Stein
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Publication number: 20100048666Abstract: A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing actionType: ApplicationFiled: September 10, 2007Publication date: February 25, 2010Applicant: FUJI YAKUHIN CO., LTD.Inventors: Hideo Kato, Osamu Nagata, Yoshiyuki Iwabuchi, Takahiro Sato, Junichiro Uda, Tutomu Inoue, Hiroshi Nakamura, Nobuhide Kawasaki, Ippei Tanaka, Naoki Kurita, Tomohiko Ishikawa
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Publication number: 20100041657Abstract: The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.Type: ApplicationFiled: May 11, 2006Publication date: February 18, 2010Applicant: NOVO NORDICK A/SInventors: Preben Houlberg Olesen, Holger Claus Hansen, Lise Brown Christiansen, Flemming Elmelund Nielsen, Anders Klarskov Petersen
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Patent number: 7642361Abstract: The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.Type: GrantFiled: January 5, 2005Date of Patent: January 5, 2010Assignee: Eli Lilly and CompanyInventors: Ana Maria Castano Mansanet, Esteban Dominguez-Manzanares, Ana Maria Escribano, Maria Carmen Fernandez, William Joseph Hornback, Alma Maria Jimenez-Aguado, Eric George Tromiczak, Zhipei Wu, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
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Publication number: 20090214631Abstract: A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R1, R2, and R3 are independently a linear or branched C1-C6 alkyl group or a substituted or unsubstituted C3-C12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.Type: ApplicationFiled: August 18, 2006Publication date: August 27, 2009Inventors: Bobba Venkata Siva Kumar, Kosampally Srinivas, Sanjay Anantha Kale, Nitin Sharad Chandra Pradhan
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Publication number: 20090170891Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.Type: ApplicationFiled: April 6, 2007Publication date: July 2, 2009Inventors: Steven L. Colletti, James R. Tata, Weichun Chen, Richard T. Beresis, Fa-Xiang Ding, Darby Rye Schmidt, Hong Shen, Subharekha Raghavan
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Publication number: 20090137822Abstract: The present invention relates to a process for preparing a 3-substituted thiophene represented by the formula (2): wherein R represents a cyano group, a formyl group, a carboxyl group, a hydrocarbyloxycarbonyl group which may have a substituent(s) or an acyl group which may have a substituent(s), which comprises reacting a vinyl compound represented by the formula (1): RCH?CHY??(1) wherein R has the same meaning as defined above, and Y represents a leaving group, and an ?-mercaptoacetaldehyde or a multimer thereof.Type: ApplicationFiled: May 16, 2006Publication date: May 28, 2009Inventors: Akio Matsushita, Kiyotaka Yoshii, Mizuho Oda, Masayoshi Oue, Shuji Yamada
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Publication number: 20090082578Abstract: A process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates.Type: ApplicationFiled: September 24, 2008Publication date: March 26, 2009Applicant: LES LABORATOIRES SERVIERInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Patent number: 7495024Abstract: The method of treating patients be administering phenylalkyl N-hydroxurea derivatives for combating atherosclerotic plaque and cardiovascular diseases and compositions for this use.Type: GrantFiled: August 7, 2006Date of Patent: February 24, 2009Assignee: VIA Pharmaceuticals, Inc.Inventors: Raymond Tabibiazar, Melisa Cooper, Thomas Quertermous, Adeoye Olukotun
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Publication number: 20080312314Abstract: Alpha crystalline form of strontium ranelate of formula (I): characterised by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.Type: ApplicationFiled: August 12, 2008Publication date: December 18, 2008Applicant: LES LABORATOIRES SERVIERInventors: Stephane Horvath, Isabelle Demuynck, Gerard Damien
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Patent number: 7459568Abstract: Alpha crystalline form of strontium ranelate of formula (I): characterized by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.Type: GrantFiled: May 31, 2005Date of Patent: December 2, 2008Assignee: Les Laboratoires ServierInventors: Stéphane Horvath, Isabelle Demuynck, Gérard Damien
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Patent number: 7423170Abstract: Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g. a farnesyl group) is attached to the protein in the presence of an enzyme (e.g. farnesyl protein transferase). Deactivation of the prenylation enzyme through covalent modification can therefore ultimately result in the mitigation and/or cessation of cancer cell growth. Various prenylation inhibitors having the necessary structural groups to bond covalently, or essentially irreversibly, to the prenylation enzyme include carbonyl or thiocarbonyl compounds (or masked versions of these compounds) and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group. The carbonyl or thiocarbonyl compounds also contain a nucleofugal atom or group to enhance the tendency to form covalent bonds.Type: GrantFiled: January 23, 2006Date of Patent: September 9, 2008Assignee: Arizona Biomedical Research CommissionInventors: Seth D. Rose, Scott R. Lefler, Steven R. Ottersberg, Ann Y. Kim, Karl J. Okolotowicz, Rosemarie F. Hartman
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Patent number: 7214805Abstract: The process for the industrial The synthesis of strontium ranelate of formula (I): and its hydrates.Type: GrantFiled: September 24, 2003Date of Patent: May 8, 2007Assignee: Les Laboratoires ServierInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Patent number: 7138529Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the antagonism of the glucagon receptor, such as diabetes.Type: GrantFiled: April 8, 2004Date of Patent: November 21, 2006Assignee: Hoffmann-La Roche Inc.Inventors: Shawn David Erickson, Paul Gillespie, Kevin Richard Guertin
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Patent number: 7105683Abstract: The process for the industrial the synthesis of the compound of formula (I): Application to the the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.Type: GrantFiled: September 24, 2003Date of Patent: September 12, 2006Assignee: Les Laboratoires ServierInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Patent number: 7091364Abstract: The process for the industrial synthesis of compounds of formula (I): wherein R and R?, which are the same or different, each represent linear or branched (C1–C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.Type: GrantFiled: September 24, 2003Date of Patent: August 15, 2006Assignee: Les Laboratoires ServierInventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
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Patent number: 7084170Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.Type: GrantFiled: October 15, 2002Date of Patent: August 1, 2006Assignee: Eli Lilly and CompanyInventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso De Dios
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Patent number: 7019024Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 9, 2001Date of Patent: March 28, 2006Assignee: Allelix Neuroscience Inc.Inventors: Vassil Iliya Ognyanov, Laurence A. Borden, Stanley Charles Bell, Jing Zhang
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Patent number: 7015337Abstract: The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for the thrombin inhibitor may be obtained in a high yield.Type: GrantFiled: March 15, 2002Date of Patent: March 21, 2006Assignee: LG Life Sciences Ltd.Inventors: Suk Kyoon Yoon, Bong Chan Kim, Won Hyuk Jung, Jae Chul Lee, Koo Lee, Cheol Won Park
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Patent number: 6864375Abstract: In various embodiments, chromophores are described that include novel electron acceptors, novel electron donors, and/or novel conjugated bridges that are useful in nonlinear optical applications. In some embodiments, the present invention provides chromophore architectures wherein a chromophore contains more than one electron acceptor in electronic communication with a single electron donor, and/or more than one electron donor in electronic communication with a single electron acceptor. Also described is processes for providing materials comprising the novel chromophores and polymer matrices containing the novel chromophores. Electro-optic devices described herein contain one or more of the described electron acceptors, electron donors, conjugated bridges, or chromophores.Type: GrantFiled: May 16, 2003Date of Patent: March 8, 2005Assignee: Lumera CorporationInventors: Diyun Huang, Tim Londergan, Galina K. Todorova, Jingsong Zhu
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Patent number: 6840965Abstract: The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination containing at least one p-aminophenol derivative of formula (I).Type: GrantFiled: March 9, 2001Date of Patent: January 11, 2005Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6835745Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 10, 2003Date of Patent: December 28, 2004Assignee: WyethInventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Publication number: 20040214878Abstract: A process for producing enantiomerically enriched (S)-&agr;-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrocarbyl ester, represented by the formula: 1Type: ApplicationFiled: April 23, 2003Publication date: October 28, 2004Applicant: Rhodia ChiRex, Inc.Inventor: Richard A. Silva