Patent number: 7064122
Abstract: The subject invention features compounds having the structure: wherein X is O, S, CH2 or NR5; Y is O or S; R1 is H, substituted or unsubstituted C1-C15 alkyl, C1-C8 alkylaryl, —C(O)OR4, —C(O)NR4R5, —CR6R6?OR4, —CR6R6?OC(O)R4, —CR6R6?OC(O)NHR7, —C(O)NR10R11, —C(O)NR8R9NR8R9, —N(R5)C(O)NHR5, or CH2R4; R2 is a substituted or unsubstituted, straight chain C1—C30 alkyl or branched C3-C30 alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R3 is H or substituted or unsubstituted C1-C6 alkyl or C3-C10 cycloalkyl; R4 is H or a substituted or unsubstituted, straight chain or branched, C6-C30 alkyl, aryl, —CH2-aryl, aryl —C1-C15 alkyl, heteroaryl-C1-C15alkyl or C3-C10 cycloalkyl; R5 is H or a substituted or unsubstituted, straight chain or branched, C6-C30 alkyl, aryl C1-C30alkyl, heteroarylalkyl or cycloalkyl; R6 and R6? are each independently H, substituted or unsubstituted C1-C6 alkyl, dialkyl or C3-C10 cycloalkyl or together form a 3-7 membered ring system; R7 is H or substituted or unsubstituted
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
June 20, 2006
Assignee:
OSI Pharmaceuticals, Inc.
Inventors:
David Witter, Arlindo Castelhano
Patent number: 6620767
Abstract: The invention relates to compounds of the general formula
wherein R1 is hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl or unsubstituted or mono- to penta-substituted phenyl, whereby the substituents are selected from the group comprising C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, aryloxy, halogen, cyano and nitro, whereby if the number of substituents is greater than 1, the substituents may be identical or different; R2 is hydrogen, C1-C6-alkyl, (C1-C6-alkylene)phenyl, pyridyl, COOR6, CONR7R8COR6, allyl or CH2—O—R6; R3 is C1-C6-alkyl; R4 is unsubstituted or substituted phenyl, unsubstituted or substituted benzyl or unsubstituted or substituted heterocyclyl, whereby each of the substituents, independently of each other, is selected from the group comprising C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, aryloxy, halogen, cyano, hydroxy, amino and nitro, whereby if the number of substituents is greater than 1, the substituents may be identical or different; R6 is C1-C6
Type:
Grant
Filed:
May 28, 2002
Date of Patent:
September 16, 2003
Assignee:
Novartis Animal Health US, Inc.
Inventors:
Pierre Ducray, Jacques Bouvier