Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Nitrogen Patents (Class 549/69)
  • Patent number: 4304941
    Abstract: A method of preparing substituted acylbenzenes is disclosed. The method comprises reacting selected acylhalides or equivalents with a selected poly-substituted benzene in the presence of an acylating catalyst comprising a clay.
    Type: Grant
    Filed: August 1, 1980
    Date of Patent: December 8, 1981
    Assignee: Hoechst Roussel Pharmaceuticals, Inc.
    Inventors: Thomas B. K. Lee, Gregory M. Jobin
  • Patent number: 4304771
    Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, kydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.
    Type: Grant
    Filed: October 24, 1980
    Date of Patent: December 8, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: John T. Suh, Jerry W. Skiles, Bruce E. Williams, Alfred Schwab
  • Patent number: 4284557
    Abstract: A process is disclosed for producing d-biotin from L or DL-cystine ester via novel intermediates.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: August 18, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • Patent number: 4276290
    Abstract: This invention relates to novel anthelmintic compounds containing an arylene or divalent heterocyclic ring whose free valences are satisfied by(1) a disubstituted phosphoryl ureido or thioureido group and(2) an amino group or a substituted amido or thioamido group,to compositions containing them, and to methods of using them for the treatment of intestinal parasites in mammals and birds.
    Type: Grant
    Filed: September 6, 1979
    Date of Patent: June 30, 1981
    Assignee: Rohm and Haas Company
    Inventors: W. David Weir, Edward E. Kilbourn
  • Patent number: 4262130
    Abstract: The present invention relates to an improved process for the production of urethanes (carbamic acid esters) by the reaction of organic nitro compounds with carbon monoxide and organic compounds containing at least one hydroxy group in the presence of palladium and/or palladium compounds and a cocatalyst which consists of a mixture of one or more iron oxides and/or iron hydroxides and activating chloride-containing additives.
    Type: Grant
    Filed: January 17, 1980
    Date of Patent: April 14, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Robert Becker, Johann Grolig, Christian Rasp
  • Patent number: 4260410
    Abstract: Novel N-haloacetylphenylamino carbonyl oximes represented by the formula ##STR1## wherein Ar is phenyl or substituted phenyl; R.sup.1 is halomethyl; R.sup.2 and R.sup.3 are each independently hydrogen, alkyl, phenyl, benzyl, substituted phenyl or benzyl, haloalkyl, cyanoalkyl, alkoxyalkyl, alkylthioalkyl or thiocyanoalkyl; R.sup.4 is hydrogen or alkyl; n is 0 or 1; m is 0 or 1; R is hydrogen, alkyl, alkenyl, alkynyl, alkylthioalkyl, haloalkyl, alkoxyalkyl, cyanoalkyl, phenyl, benzyl, substituted phenyl or benzyl, or R is acyl of the formula ##STR2## wherein R.sup.5 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, acetonyl, or the group -NR'R" wherein R' and R" are independently hydrogen, alkyl or phenyl; with the proviso that R.sup.2 and R.sup.3 may be joined together to form a carbocyclic ring or a heterocyclic ring; or R and R.sup.2 may be joined together to form a heterocyclic ring; or R and R.sup.3 may be joined together to form a heterocyclic ring.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: April 7, 1981
    Assignee: Chevron Research Company
    Inventors: William L. Schinski, David C. K. Chan, Irene C. Huang
  • Patent number: 4250319
    Abstract: New dicyclic thiophene compounds having the structural formula ##STR1## wherein X is an ester or cyano group and Y is a substituted amino group. The compounds are useful as agricultural chemicals and particularly as ripeners for sugarcane.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: February 10, 1981
    Assignee: W. R. Grace & Co.
    Inventors: Joseph V. Karabinos, Louis G. Nickell
  • Patent number: 4240820
    Abstract: Novel method for regulating the growth of plants which method comprises applying to the plants or their habitat, effective amounts of heterocyclic compound of the formula ##STR1## in which R.sup.1 is alkyl or optionally substituted aryl,R.sup.2 is hydrogen, alkyl or optionally substituted aryl,R.sup.3 is hydrogen or the radical ##STR2## in which Y is oxygen or sulfur andR.sup.5 is alkyl, haloalkyl, alkoxyalkyl, aryloxyalkyl, which is optionally substituted in the aryloxy part, alkoxy, optionally substituted aryl, optionally substituted aryloxy, monoalkylamino, dialkylamino, alkenylamino, dialkenylamino, optionally substituted arylamino, a 5-membered to 7-membered heterocyclic ring, bonded via nitrogen, or the radical ##STR3## in which R.sup.6 is hydrogen or alkyl andR.sup.7 is hydrogen or alkyl, orR.sup.6 and R.sup.7, together with the adjacent nitrogen atom, are a 5-membered to 7-membered heterocyclic ring,R.sup.4 is cyano or the grouping --COR.sup.8in whichR.sup.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: December 23, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karlfried Dickore, Klaus Lurssen
  • Patent number: 4230872
    Abstract: Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.
    Type: Grant
    Filed: May 11, 1978
    Date of Patent: October 28, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael J. Klaus, Beverly A. Pawson
  • Patent number: 4211696
    Abstract: Disperse monoazo dyestuffs, free from carboxylic and sulphonic acid groups, derived from 3,5-dinitro-2-amino thiophene as disazo component and an arylamine coupling component exhibit superior properties when used to give colorations to textile materials such as secondary cellulose acetate and cellulose triacetate, polyamide and aromatic polyester textile materials, said colorations having excellent fastness to light and to wet and dry heat treatments. The dyestuffs also have high tinctorial strength and excellent dyeing and build-up properties and produce depths of shade which are relatively independent of the dyebath pH, or the temperature of the dyebath or the liquor ratio of the dyebath.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: July 8, 1980
    Assignee: Imperial Chemical Industries Limited
    Inventors: David B. Baird, Alan T. Costello, Brian R. Fishwick, Robert D. McClelland, Peter Smith
  • Patent number: 4187232
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 5-membered ring containing a single heteroatom, which may be oxygen, or sulphur, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: January 19, 1978
    Date of Patent: February 5, 1980
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, Michael R. J. Jolley, William J. Ross, Brian P. Swann
  • Patent number: 4179501
    Abstract: Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: December 18, 1979
    Assignee: The Upjohn Company
    Inventor: Jacob Szmuszkovicz
  • Patent number: 4174210
    Abstract: Novel N-haloacetylphenylamino carbonyl oximes represented by the formula ##STR1## wherein Ar is aryl, R.sup.1 is halomethyl, R.sup.2 is hydrogen, alkyl or aryl, R.sup.3 is hydrogen, alkyl or aryl, n is 0 or 1 and R is hydrogen, aryl, alkyl, alkenyl or alkynyl, with the proviso that R.sup.2 and R.sup.3 may be joined together to form a carbocyclic ring of 5 to 6 carbon atoms or a heterocyclic ring of one N, O or S hetero atom and 4 to 5 carbon atoms. The oxime compounds are useful as herbicides and plant growth regulators.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: November 13, 1979
    Assignee: Chevron Research Company
    Inventors: William L. Schinski, Irene C. Huang, David C. K. Chan