Nitrogen Or Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/72)
  • Substituted thiophenes
    Patent number: 4172082
    Abstract: 3,5-Bis(t-butyl)-4-hydroxyphenyl- and 3,5-bis(t-butyl)-4-hydroxybenzoyl-substituted thiophenes have valuable pharmacological acitivity as antiinflammatory agents.
    Type: Grant
    Filed: April 6, 1978
    Date of Patent: October 23, 1979
    Assignee: Riker Laboratories, Inc.
    Inventor: George G. I. Moore
  • Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
    Patent number: 4166061
    Abstract: A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.
    Type: Grant
    Filed: November 2, 1977
    Date of Patent: August 28, 1979
    Assignee: SmithKline Corporation
    Inventors: Antonietta R. Mastrocola, Robert L. Webb