Heavy Metal Or Aluminum Containing Material Utilized Patents (Class 552/207)
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Publication number: 20110257421Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.Type: ApplicationFiled: June 30, 2011Publication date: October 20, 2011Applicant: Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Darrell J. Koza
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Publication number: 20110082305Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.Type: ApplicationFiled: December 14, 2010Publication date: April 7, 2011Applicant: Trustees of Tufts CollegeInventors: Mark L. Nelson, Glen Rennie, Darrell Koza
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Publication number: 20100160656Abstract: 7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.Type: ApplicationFiled: December 10, 2009Publication date: June 24, 2010Inventors: Mark L. Nelson, Mohamed Y. Ismail
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Patent number: 7067681Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.Type: GrantFiled: July 9, 2003Date of Patent: June 27, 2006Assignee: Trustees of Tufts CollegeInventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
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Publication number: 20040033996Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.Type: ApplicationFiled: July 9, 2003Publication date: February 19, 2004Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
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Patent number: 5218130Abstract: 4-substituted anthracyclinones of formula (I) ##STR1## wherein R represents a hydrogen atom or a straight or branched alkyl, alkenyl or alkynyl group having from 1 to 10 carbon atoms, are intermediates in the preparation of antitumor anthracycline glycosides of formula (IX): ##STR2## wherein R is as defined above and R.sub.1 is a hydrogen atom or a hydroxy group, and pharmaceutically acceptable salts thereof.Type: GrantFiled: January 25, 1991Date of Patent: June 8, 1993Assignee: Farmitalia Carlo Erba S r lInventors: Walter Cabri, Silvia De Bernardinis, Franco Francalanci, Sergio Penco
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Patent number: 5103029Abstract: 4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1'-bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.Type: GrantFiled: April 6, 1989Date of Patent: April 7, 1992Assignee: Farmitalia Carlo Erba S.r.l.Inventors: Walter Cabri, Silvia de Bernardinis, Franco Francalanci, Sergio Penco
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Patent number: 5049683Abstract: A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.Type: GrantFiled: July 12, 1990Date of Patent: September 17, 1991Assignee: Houba, Inc.Inventor: George Krsek
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Patent number: 4990636Abstract: A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C.sub.1 -C.sub.4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogeneous hydrogenation catalyst in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.Type: GrantFiled: February 9, 1990Date of Patent: February 5, 1991Assignee: Ranbaxy Laboratories LimitedInventors: Jagmohan Khanna, Kiran Bala, Inder P. S. Grover
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Patent number: 4973719Abstract: A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline, in the presence of hydriodotetrakis (triphenylphosphine) rhodium (I) as a homogenous hydrogenation catalyst. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.Type: GrantFiled: October 28, 1988Date of Patent: November 27, 1990Assignee: Ranbaxy Laboratories LimitedInventors: Jagmohan Khanna, Kiran Bala, Inder P. S. Grover
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Patent number: 4911865Abstract: The present invention refers to complexes prepared by reacting rhodium trinitrate with a suitable hydrazine and a suitable tertiary phosphine, more specifically to the compounds di(.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)rhodium (I)]dinitrate and .mu.-3-carbopentazane-N.sup.1, N.sup.4 :N.sup.2, N.sup.5 -bis[bis(triphenylphosphine)rhodium (I)]dinitrate, which are homogenous hydrogenation catalysts and their application in the hydrogenation of the exocyclic methylene group of acid addition salts of 6-demethyl-6-deoxy-6-methylene-5-hydroxytetracycline (methacycline) to prepare .alpha.-6-deoxy-5-hydroxy-tetracycline (doxycycline).Type: GrantFiled: March 13, 1989Date of Patent: March 27, 1990Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax, Indira Ghatak, Michael Hursthouse
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Patent number: 4902447Abstract: A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C.sub.1 -C.sub.4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogeneous hydrogenation catalyst in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.Type: GrantFiled: October 28, 1988Date of Patent: February 20, 1990Assignee: Ranbaxy Laboratories LimitedInventors: Jagmohan Khanna, Kiran Bala, Inder P. S. Grover