Abstract: The present invention relates to a compound comprising a substituted or unsubstituted anthraquinone, or a salt or isomer thereof, for use in treating a disorder caused by or associated with dysfunctional ion channel activity. The invention finds utility in the treatment of disorders associated with smooth muscle tone and contraction, such as partial hypertension; myocardial infarction; faecal incontinence; constipation; gastro oesophageal reflux; impaired gastrointenstinal passage; urinary incontinence; erectile dysfunction; and asthma.
Type:
Application
Filed:
September 15, 2011
Publication date:
November 7, 2013
Inventors:
Noel McHale, Keith Thornbury, Subhrangsu Roy, Mark Anthony Hollywood, Gerard Patrick Sergeant
Abstract: The present invention relates to novel P2Y12 receptor antagonists useful for treating, alleviating and/or preventing diseases and disorders related to P2Y12 receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The present invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of diseases and disorders, especially the use as antithrombotic agents for inhibiting platelet aggregation.
Abstract: A hybrid dye is provided that is useful for coloring keratin fibers and skin. The hybrid dye has the structure X-S-Y, where X is derived from a substantive dye, Y is derived from an oxidation dye precursor or a melanin precursor, and S is a direct bond or spacer group. The present invention also provides a composition for coloring keratin fibers that contains the hybrid dye.
Type:
Grant
Filed:
June 13, 2002
Date of Patent:
December 7, 2004
Assignee:
Henkel Kommanditgesellschaft auf Aktien
Inventors:
Detlef Hollenberg, Horst Hoeffkes, Frank Naumann, David Rose, Leszek J. Wolfram, Joachim-Kurt Foitzik
Abstract: Dye mixtures which contain a dye of the formula ##STR1## together with a dye of the formula ##STR2## in which M.sup.+ in the dyes of the formulae (1) and (2) are ammonium cations ##STR3## which are identical to or different from one another, of an amine of the formula ##STR4## where R.sub.1 and R.sub.2 independently of one another are hydrogen, C.sub.1 --C.sub.6 alkyl or C.sub.2 --C.sub.6 alkyl substituted by hydroxyl or amino and, if appropriate, interrupted by an oxygen atom, and R.sub.3 is C.sub.2 --C.sub.6 alkyl substituted by hydroxyl or amino and, if appropriate, interrupted by an oxygen atom, afford dyeings having good fastnesses on nitrogen-containing or hydroxyl group-containing fibre materials.
Abstract: The invention relates to fibre-reactive anthraquinone dyes of formula ##STR1## wherein R.sub.1, R.sub.2, B, U, R and n are as defined in claim 1. The anthraquinone dyes of formula (1) are suitable for dyeing or printing hydroxyl group containing or nitrogen-containing fibre materials and give dyeings or prints of good allround fastness properties.
Abstract: The invention includes printing ink compositions containing an organic solution of a film-forming polymer and a dye salt of formula ##STR1## wherein R is a group of formula ##STR2## wherein R.sub.1 is C.sub.1 -.sub.4 alkyl, R.sub.2 and R.sub.3 are each independently of the other hydrogen, CH.sub.2 X, SO.sub.2 Y or NHCOZ, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.5 is CH.sub.2 X, SO.sub.2 Y or NHCOZ, X is a NHCOR.sub.6 or NR.sub.7 SO.sub.2 R.sub.6 group, Y is NR.sub.8 R.sub.9 or N(R.sub.8).sub.2, and Z is C.sub.1 -C.sub.4 alkyl or NHR.sub.9, R.sub.6 is C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl or phenyl which is substituted by C.sub.1 -C.sub.4 alkyl or halogen, R.sub.7 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.8 is hydrogen, C.sub.1 -C.sub.4 alkyl or a ##STR3## group, and R.sub.9 is hydrogen C.sub.1 -C.sub.4 alkyl or phenyl, and R', R" and R"' are alkyl radicals containing together 10 to 24 carbon atoms, or a mixture of such dye salts.
Type:
Grant
Filed:
February 14, 1994
Date of Patent:
May 16, 1995
Assignee:
Ciba-Geigy Corporation
Inventors:
Martin Tanner, Dieter Mausezahl, Paul Lienhard, Robert von Arx
Abstract: A process for the preparation of aminoanthraquinone derivatives comprises reacting (A) bromaminic acid or a metal salt thereof with (B) an amine or amide in an aqueous alkaline medium in the presence of a copper (I) salt formed by in situ reduction of a copper (II) salt.
Type:
Grant
Filed:
June 25, 1991
Date of Patent:
March 23, 1993
Assignee:
Ciba-Geigy Corporation
Inventors:
John H. Brady, Peter J. Brogden, Malcolm B. Nield