Additional Carbon Bonded Directly To The Nitrogen Patents (Class 552/255)
  • Publication number: 20150007851
    Abstract: Agents for coloring and/or matting keratinic fibers, in particular human hair, include in a cosmetic carrier at least one specific substituted 1,4-diaminoanthraquinone derivative of formula (I), wherein the residues (R2, R4) mutually independently denote a grouping of formula (II). The cosmetic method of using these agents can be for producing intense blue shades and for matting keratin fibers.
    Type: Application
    Filed: September 11, 2014
    Publication date: January 8, 2015
    Inventors: Antje Gebert, Astrid Kroos, Ralph Nemitz
  • Publication number: 20140114048
    Abstract: Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts. Multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.
    Type: Application
    Filed: October 15, 2013
    Publication date: April 24, 2014
    Applicant: Applied Biosystems, LLC
    Inventors: Scott BENSON, Steven MENCHEN, Krishna UPADHYA
  • Publication number: 20130101994
    Abstract: According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group and no carbon atom is substituted by two hydroxyl groups, or R2 and R3 together form a C2-6 alkylene group which with the nitrogen atom to which R2 and R3 are attached forms a heterocyclic ring; X1, X2 and X3 are independently selected from hydrogen, hydroxyl, NR1-A-NR2R3R4+(Zm?)1/m, halogeno amino, C1-4 alkoxy or C2-8 alkanoyloxy; and (Zm?)1/m is an anion of charge m; or a derivative in which the group NR1 is quaternarised.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 25, 2013
    Applicant: BIOSTATUS LIMITED
    Inventors: Paul James Smith, Rachel J. Errington, Laurence Hylton Patterson
  • Publication number: 20110060150
    Abstract: The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.
    Type: Application
    Filed: August 10, 2010
    Publication date: March 10, 2011
    Applicant: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Andrei Laikhter, Mark Aaron Behlke, Yawfui Yong, Scott Rose, Lingyan Huang
  • Patent number: 7582122
    Abstract: Disclosed herein is a mixed cationic direct dye comprising at least one anthraquinone chromophore and at least one cationic chromophore chosen from cationic azo chromophores and cationic hydrazone chromophores, wherein the at least one anthraquinone chromophore is bound to the at least one cationic chromophore by means of at least one linkage. Also disclosed herein is a dyeing composition comprising at least one mixed cationic direct dye. Further disclosed herein is a method of dyeing of keratin fibers, for example, keratin fibers, comprising applying said dyeing composition to the keratin fibers. Still further disclosed herein is a multi-compartment kit comprising at least one compartment comprising at least one dye composition and at least one second compartment comprising at least one oxidizing agent.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: September 1, 2009
    Assignee: L'Oreal S.A.
    Inventors: Nicolas Daubresse, Andrew Greaves
  • Patent number: 7550016
    Abstract: Disclosed are compounds of formula.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: June 23, 2009
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Christian Cremer, Olof Wallquist
  • Publication number: 20080168608
    Abstract: The subject of the present invention is the use, for dyeing in particular human keratin materials, of a specific direct anthraquinone dye by dry thermal transfer. Its subject is furthermore a method for dyeing keratin materials, in which at least one direct anthraquinone dye contained in a dry composition is applied to or close to the keratin materials, and a source of heat is applied, causing the thermal transfer of the direct dye(s) at the surface and/or inside the keratin materials. It relates furthermore to the dry composition and a method for preparing it.
    Type: Application
    Filed: February 28, 2006
    Publication date: July 17, 2008
    Inventors: Gregory Plos, Luc Gourlaouen, Jean-Dominique Bazin De Bezons
  • Patent number: 7304170
    Abstract: An inventive blue colorant comprising a chromophore having at least one hydroxy group-terminated polyester chain attached, through a suitable alkylamino linking group (or groups), to the 1-position, the 4-position, or both, of an anthraquinone backbone is provided. Such colorants exhibit excellent amine/base stability and thermal stability, effective colorations, excellent low extraction rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain polyurethane substrates. The polyester chain or chains can be conveniently tailored to increase the solubility or compatibility in different types of polyurethane resin precursors thereby permitting the introduction of such excellent coloring chromophores within diverse polyurethane media and/or or diverse polyurethane substrates as well as provides a liquid colorant which facilitates handling.
    Type: Grant
    Filed: June 14, 2003
    Date of Patent: December 4, 2007
    Assignee: Milliken & Company
    Inventors: Jusong Xia, Chunping Xie, Vanessa Creel
  • Patent number: 7160335
    Abstract: The present invention relates to a compound of formula I wherein R1 and R3 are each independently of the other —NHR5, NHSO2R5, —NHCOR5, —OR6 or —SR7, R2 and R4 are each independently of the other —OR6 or —SR7, with the proviso that not all of the substituents R1 to R4 are —SR7, R5 is hydrogen, alkyl, aryl, aralkyl or a group of formula —(CnH2nX)m—H wherein X is —O—, —S—, —SO2—, —NH—, —NR8—, —CONH— or —CONR8— and R8 is alkyl or aryl, n is a number from 2 to 6 and m is a number from 1 to 10, R6 is aryl or heteroaryl and R7 is alkyl, aryl, heteroaryl or a group of formula —(CnH2nX)m—H wherein X is —O—, —S—, —SO2—, —NH—, —NR8—, CONH— or —CONR8— and R8 is alkyl or aryl, to a process for the preparation thereof and to the use thereof in a method of producing mass-coloured plastics or polymeric colour particles.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: January 9, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Urs Lauk, Patric Nowack, Alfons Arquint
  • Patent number: 6986795
    Abstract: The invention relates to cationic aminodianthraquinones containing at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphatic chains containing at least one quaternized saturated ring and aliphatic chains containing at least one quaternized unsaturated ring, their use as direct dye in compositions for dyeing keratinous materials, in particular human keratinous fibers such as hair, the dyeing compositions containing them, as well as the dyeing methods using them.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: January 17, 2006
    Assignee: L'Oreal
    Inventors: Alain Genet, Alain Lagrange
  • Patent number: 6828443
    Abstract: A hybrid dye is provided that is useful for coloring keratin fibers and skin. The hybrid dye has the structure X-S-Y, where X is derived from a substantive dye, Y is derived from an oxidation dye precursor or a melanin precursor, and S is a direct bond or spacer group. The present invention also provides a composition for coloring keratin fibers that contains the hybrid dye.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: December 7, 2004
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Detlef Hollenberg, Horst Hoeffkes, Frank Naumann, David Rose, Leszek J. Wolfram, Joachim-Kurt Foitzik
  • Patent number: 6645259
    Abstract: Cationic aminoanthraquinones in which at least one cationic charge is delocalized on a 5-membered unsaturated polynitrogen-containing heterocycle, their use as a direct dye in dyeing compositions for keratinous materials, in particular for human keratinous fibers such as hair, dyeing compositions containing them, and dyeing methods using these compositions.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: November 11, 2003
    Assignee: L'Oreal S.A.
    Inventors: Alain Genet, Alain Lagrange
  • Patent number: 6635350
    Abstract: Red colorants comprising a chromophore having at least one poly(oxyalkylene) chain attached to the 1-position, as well as at least one poly(oxyalkylene) chain attached to either the 5-position or the 8-position of an anthraquinone backbone are provided. Such colorants exhibit excellent base stability, effective colorations, excellent low extraction rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain substrates, particularly polyesters. The poly(oxyalkylene) chains also increase the solubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or diverse substrates as well as provides a liquid colorant which facilitates handling. Compositions and articles comprising such colorants are provided as well as methods for producing such inventive colorants are also provided.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: October 21, 2003
    Assignee: Milliken & Company
    Inventors: Daniel M. Connor, John W. Miley, Jr.
  • Publication number: 20030055273
    Abstract: The present invention relates to novel compounds corresponding to formula (I) below: 1
    Type: Application
    Filed: April 9, 2002
    Publication date: March 20, 2003
    Applicant: L'OREAL
    Inventors: Thierry Bordier, Michel Philippe
  • Patent number: 6437149
    Abstract: Cationic aminoanthraquinones in which at least one cationic charge is delocalized on a 5-membered unsaturated polynitrogen-containing heterocycle, their use as a direct dye in dyeing compositions for keratinous materials, in particular for human keratinous fibers such as hair, dyeing compositions containing them, and dyeing methods using these compositions.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: August 20, 2002
    Assignee: L'Oreal S.A.
    Inventors: Alain Genet, Alain Lagrange
  • Patent number: 5961664
    Abstract: An anthraquinone mixture comprising three 1,4-hydroxyalkylamino-anthraquinone derivatives, wherein two of the anthraquinone compounds in the mixture are symmetric and the other anthraquinone compound is asymmetric, and wherein each of the anthraquinone compounds has similar polarities. The anthraquinone mixtures are used in compositions and methods for the direct dyeing of keratinous fibers, particularly human hair on the head.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: October 5, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventor: James S. Anderson
  • Patent number: 5882358
    Abstract: Automatic transmission fluid containing a red dye stable even in long-lived transmission fluids.
    Type: Grant
    Filed: June 12, 1996
    Date of Patent: March 16, 1999
    Assignee: United Color Manufacturing, Inc.
    Inventors: Michael J. Smith, Bharat Desai
  • Patent number: 5733880
    Abstract: A compound having the structural formula, ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or hydroxyl. R.sup.2 and R.sup.3 are independently oxo or hydrogen, one of R.sup.5 and R.sup.6 is A--B and the other is hydrogen, hydroxyl, or a group A, wherein each A is a spacer group providing --NH-- or --CO-- in the bond with B (if present); at least one A group does not provide the residue of an .alpha.-amino acid adjacent the anthraquinone nucleus and the A of any A--B moiety is joined to the anthraquinone nucleus via an --NH-- bond, and each B is a peptide group or a physiologically acceptable derivative thereof. The compounds are useful as antitumor compounds.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: March 31, 1998
    Assignee: Napier University Ventures Limited
    Inventor: David John Mincher
  • Patent number: 5639896
    Abstract: A process for the preparation of N,N'-disubstituted 1,4-diaminoanthraquinones has been found which is characterized in that 1,4-dihydroxyanthraquinones are reacted with aliphatic or aromatic amines in the presence of a hydroxycarboxylic acid as a condensation auxiliary.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: June 17, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dietmar Kalz, Reinold Schmitz, Karl-Heinz Reinhardt, Josef Schroder, Stephan Michaelis
  • Patent number: 5493036
    Abstract: The invention relates to fibre-reactive anthraquinone dyes of formula ##STR1## wherein R.sub.1, R.sub.2, B, U, R and n are as defined in claim 1. The anthraquinone dyes of formula (1) are suitable for dyeing or printing hydroxyl group containing or nitrogen-containing fibre materials and give dyeings or prints of good allround fastness properties.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: February 20, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Jean-Marie Adam
  • Patent number: 5436243
    Abstract: Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoanthraquinones, preferably 1,4-bis(N-substituted) amino anthraquinones, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: July 25, 1995
    Assignees: Research Triangle Institute Duke University, Pharmaceuticals Corporation
    Inventors: Clifford W. Sachs, Robert L. Fine, Lawrence M Ballas, R. Ivy Carroll, Robert Bell
  • Patent number: 5387704
    Abstract: Process for preparing amino- and carbamoyl-substituted anthraquinones by Diels-Alder reaction of an N-butadienylcarbamic acid ester of the formula H.sub.2 C.dbd.CH--CH.dbd.CH--NH--COOR.sup.2, wherein R.sup.2 is alkyl or phenylalkyl, with a 1,4-naphthoquinone or with 1,4-benzoquinone to form a carbamoyl-substituted hydroanthraquinone intermediate and by oxidation of this intermediate with an oxygen-containing gas in a tertiary amine and in the presence of a copper salt to obtain a carbamoyl-substituted anthraquinone product. The Diels-Alder reaction and the oxidation reaction can be carried out as a one-pot synthesis or in separate steps. The carbamic acid ester reactant provides a blocking group represented by --COOR.sup.2, and this blocking group is optionally removed by treatment of the carbamoyl-substituted anthraquinone with an alkaline hydroxide solution.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: February 7, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Ebel, Juergen Schroeder
  • Patent number: 5204370
    Abstract: The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.10 alkyl, aryl, arylalkyl, alkylaryl;n and m are independently 1, 2, or 3;A is Halogen, OH, alkoxy, OCO(NR.sub.3 R.sub.4), S--C(NH.sub.2).dbd.NR.sub.5, or when m=1, comprises an oxirane ring with the adjacent oxygen atom;R.sub.3, R.sub.4, and R.sub.5 are independently H, alkyl, or aryl;X is H, OH, NR.sub.6 R.sub.7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR.sub.8, or CONR.sub.9 R.sub.10 ; andR.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 are independently H, lower alkyl, or aryluseful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: April 20, 1993
    Assignee: Sphinx Pharmaceuticals Corporation
    Inventors: Jack B. Jiang, Mary G. Johnson
  • Patent number: 5199956
    Abstract: Polyester textile material can be dyed from supercritical CO.sub.2 with special disperse dyes.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: April 6, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Schlenker, Dieter Werthemann, Peter Liechti, Angelo D. Casa
  • Patent number: 5132327
    Abstract: Compounds of formula (I) ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen, X, NH--A--NHR and NH--A--N(O)R'R" wherein X is hydroxy, halogeno, amino, C.sub.1-4 alkoxy or C.sub.2-8 alkanoyloxy, A is a C.sub.2-4 alkylene group with a chain length between NH and NHR or N(O)R'R" of at least 2 carbon atoms and R, R' and R" are each separately selected from C.sub.1-4 alkyl groups and C.sub.2-4 hydroxyalkyl and C.sub.2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R" together are a C.sub.2-6 alkylene group which with the nitrogen atom to which R" and R" are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R.sub.1 to R.sub.4 is a group NH--A--N(O)R'R", and physiologically acceptable salts thereof are of value in the treatment of cancer.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: July 21, 1992
    Assignee: National Research Development Corporation
    Inventor: Laurence H. Patterson
  • Patent number: 5017713
    Abstract: Substituted aminoanthraquinone compounds, which are used for dye stuffs or intermediate thereof, represented by the formula (II) ##STR1## wherein R.sub.3 represents a C.sub.1 -C.sub.6 alkyl group which may be substituted, X represents a hydrogen atom, --COR.sub.1 or --SO.sub.2 R.sub.2 wherein R.sub.1 and R.sub.2 each represents a substituted or unsubstituted C.sub.1 -C.sub.4 alkyl or C.sub.6 -C.sub.12 aryl group, and Y and Z represent independently a hydrogen atom, a halogen atom, a nitro group or a C.sub.1 -C.sub.4 alkyl group, is prepared by allowing anthraquinone compounds represented by the formula ##STR2## wherein X, Y and Z are as defined above, to react with alkylating agents in organic solvents in the presence of organic quaternary ammonium salts and alkalies.
    Type: Grant
    Filed: November 8, 1989
    Date of Patent: May 21, 1991
    Assignees: Sumitomo Chemical Company, Ltd., Daiei Chemical Company, Ltd.
    Inventors: Takanori Kondo, Hiroshi Yamachika, Kunihiko Tanaka, Yasuhiro Nishida
  • Patent number: 4940692
    Abstract: Heat transferable dyes which compared with the prior art show better solubility and/or higher light fastness and good to excellent transfer properties have the formula (I) ##STR1## where X is H or CN, R.sup.1, R.sup.2, and R.sup.3 independently of one another are alkyl, alkylcarbonyloxyalkyl, alkoxycarbonyloxyalkyl, alkoxycarbonylalkyl, haloalkyl, hydroxyalkyl, cyanoalkyl, unsubstituted or alkyl-or alkoxy-substituted phenyl or benzyl or a radical of the formula--Y--O].sub.m R.sup.4 (II)where Y is C.sub.2 -C.sub.6 -alkylene, m is 1 to 6 and R.sup.4 is alkyl or phenyl, with the proviso that if X is H then R.sup.1 and R.sup.3 are each substituted or unsubstituted alkyl or substituted or unsubstituted phenyl or if X is H and R.sup.1 is H, then R.sup.3 must be substituted or unsubstituted phenyl.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: July 10, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Volker Bach, Ruediger Sens, Karl-Heinz Etzbach, Manfred Ruske
  • Patent number: 4894451
    Abstract: The disclosure describes unsymmetrical 1,4-bis-(aminoalkylamino)-anthracene-9,10-diones useful in the treatment of neoplasms. Also described is a process of preparing same starting from 1,4-dimethoxyanthracene-9,10-dione which is reacted with an aminoalkylamine. The reaction product is treated with a dialkylaminoethylamine or a N-heteroethylamine to give the unsymmetrical compound.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: January 16, 1990
    Assignee: The University of Vermont
    Inventors: A. Paul Krapcho, Miles P. Hacker, John J. Landi, Jr., J. J. McCormack, Kenneth J. Shaw