Additional Carbon Bonded Directly To The Nitrogen Patents (Class 552/255)
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Publication number: 20150007851Abstract: Agents for coloring and/or matting keratinic fibers, in particular human hair, include in a cosmetic carrier at least one specific substituted 1,4-diaminoanthraquinone derivative of formula (I), wherein the residues (R2, R4) mutually independently denote a grouping of formula (II). The cosmetic method of using these agents can be for producing intense blue shades and for matting keratin fibers.Type: ApplicationFiled: September 11, 2014Publication date: January 8, 2015Inventors: Antje Gebert, Astrid Kroos, Ralph Nemitz
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Publication number: 20140114048Abstract: Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts. Multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.Type: ApplicationFiled: October 15, 2013Publication date: April 24, 2014Applicant: Applied Biosystems, LLCInventors: Scott BENSON, Steven MENCHEN, Krishna UPADHYA
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Publication number: 20130101994Abstract: According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group and no carbon atom is substituted by two hydroxyl groups, or R2 and R3 together form a C2-6 alkylene group which with the nitrogen atom to which R2 and R3 are attached forms a heterocyclic ring; X1, X2 and X3 are independently selected from hydrogen, hydroxyl, NR1-A-NR2R3R4+(Zm?)1/m, halogeno amino, C1-4 alkoxy or C2-8 alkanoyloxy; and (Zm?)1/m is an anion of charge m; or a derivative in which the group NR1 is quaternarised.Type: ApplicationFiled: April 8, 2011Publication date: April 25, 2013Applicant: BIOSTATUS LIMITEDInventors: Paul James Smith, Rachel J. Errington, Laurence Hylton Patterson
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Publication number: 20110060150Abstract: The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.Type: ApplicationFiled: August 10, 2010Publication date: March 10, 2011Applicant: INTEGRATED DNA TECHNOLOGIES, INC.Inventors: Andrei Laikhter, Mark Aaron Behlke, Yawfui Yong, Scott Rose, Lingyan Huang
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Patent number: 7582122Abstract: Disclosed herein is a mixed cationic direct dye comprising at least one anthraquinone chromophore and at least one cationic chromophore chosen from cationic azo chromophores and cationic hydrazone chromophores, wherein the at least one anthraquinone chromophore is bound to the at least one cationic chromophore by means of at least one linkage. Also disclosed herein is a dyeing composition comprising at least one mixed cationic direct dye. Further disclosed herein is a method of dyeing of keratin fibers, for example, keratin fibers, comprising applying said dyeing composition to the keratin fibers. Still further disclosed herein is a multi-compartment kit comprising at least one compartment comprising at least one dye composition and at least one second compartment comprising at least one oxidizing agent.Type: GrantFiled: August 28, 2006Date of Patent: September 1, 2009Assignee: L'Oreal S.A.Inventors: Nicolas Daubresse, Andrew Greaves
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Patent number: 7550016Abstract: Disclosed are compounds of formula.Type: GrantFiled: June 14, 2006Date of Patent: June 23, 2009Assignee: Ciba Specialty Chemicals Corp.Inventors: Christian Cremer, Olof Wallquist
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Publication number: 20080168608Abstract: The subject of the present invention is the use, for dyeing in particular human keratin materials, of a specific direct anthraquinone dye by dry thermal transfer. Its subject is furthermore a method for dyeing keratin materials, in which at least one direct anthraquinone dye contained in a dry composition is applied to or close to the keratin materials, and a source of heat is applied, causing the thermal transfer of the direct dye(s) at the surface and/or inside the keratin materials. It relates furthermore to the dry composition and a method for preparing it.Type: ApplicationFiled: February 28, 2006Publication date: July 17, 2008Inventors: Gregory Plos, Luc Gourlaouen, Jean-Dominique Bazin De Bezons
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Patent number: 7304170Abstract: An inventive blue colorant comprising a chromophore having at least one hydroxy group-terminated polyester chain attached, through a suitable alkylamino linking group (or groups), to the 1-position, the 4-position, or both, of an anthraquinone backbone is provided. Such colorants exhibit excellent amine/base stability and thermal stability, effective colorations, excellent low extraction rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain polyurethane substrates. The polyester chain or chains can be conveniently tailored to increase the solubility or compatibility in different types of polyurethane resin precursors thereby permitting the introduction of such excellent coloring chromophores within diverse polyurethane media and/or or diverse polyurethane substrates as well as provides a liquid colorant which facilitates handling.Type: GrantFiled: June 14, 2003Date of Patent: December 4, 2007Assignee: Milliken & CompanyInventors: Jusong Xia, Chunping Xie, Vanessa Creel
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Patent number: 7160335Abstract: The present invention relates to a compound of formula I wherein R1 and R3 are each independently of the other —NHR5, NHSO2R5, —NHCOR5, —OR6 or —SR7, R2 and R4 are each independently of the other —OR6 or —SR7, with the proviso that not all of the substituents R1 to R4 are —SR7, R5 is hydrogen, alkyl, aryl, aralkyl or a group of formula —(CnH2nX)m—H wherein X is —O—, —S—, —SO2—, —NH—, —NR8—, —CONH— or —CONR8— and R8 is alkyl or aryl, n is a number from 2 to 6 and m is a number from 1 to 10, R6 is aryl or heteroaryl and R7 is alkyl, aryl, heteroaryl or a group of formula —(CnH2nX)m—H wherein X is —O—, —S—, —SO2—, —NH—, —NR8—, CONH— or —CONR8— and R8 is alkyl or aryl, to a process for the preparation thereof and to the use thereof in a method of producing mass-coloured plastics or polymeric colour particles.Type: GrantFiled: March 13, 2003Date of Patent: January 9, 2007Assignee: Ciba Specialty Chemicals CorporationInventors: Urs Lauk, Patric Nowack, Alfons Arquint
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Patent number: 6986795Abstract: The invention relates to cationic aminodianthraquinones containing at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphatic chains containing at least one quaternized saturated ring and aliphatic chains containing at least one quaternized unsaturated ring, their use as direct dye in compositions for dyeing keratinous materials, in particular human keratinous fibers such as hair, the dyeing compositions containing them, as well as the dyeing methods using them.Type: GrantFiled: April 7, 2003Date of Patent: January 17, 2006Assignee: L'OrealInventors: Alain Genet, Alain Lagrange
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Patent number: 6828443Abstract: A hybrid dye is provided that is useful for coloring keratin fibers and skin. The hybrid dye has the structure X-S-Y, where X is derived from a substantive dye, Y is derived from an oxidation dye precursor or a melanin precursor, and S is a direct bond or spacer group. The present invention also provides a composition for coloring keratin fibers that contains the hybrid dye.Type: GrantFiled: June 13, 2002Date of Patent: December 7, 2004Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Detlef Hollenberg, Horst Hoeffkes, Frank Naumann, David Rose, Leszek J. Wolfram, Joachim-Kurt Foitzik
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Patent number: 6645259Abstract: Cationic aminoanthraquinones in which at least one cationic charge is delocalized on a 5-membered unsaturated polynitrogen-containing heterocycle, their use as a direct dye in dyeing compositions for keratinous materials, in particular for human keratinous fibers such as hair, dyeing compositions containing them, and dyeing methods using these compositions.Type: GrantFiled: July 9, 2002Date of Patent: November 11, 2003Assignee: L'Oreal S.A.Inventors: Alain Genet, Alain Lagrange
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Patent number: 6635350Abstract: Red colorants comprising a chromophore having at least one poly(oxyalkylene) chain attached to the 1-position, as well as at least one poly(oxyalkylene) chain attached to either the 5-position or the 8-position of an anthraquinone backbone are provided. Such colorants exhibit excellent base stability, effective colorations, excellent low extraction rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain substrates, particularly polyesters. The poly(oxyalkylene) chains also increase the solubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or diverse substrates as well as provides a liquid colorant which facilitates handling. Compositions and articles comprising such colorants are provided as well as methods for producing such inventive colorants are also provided.Type: GrantFiled: October 16, 2001Date of Patent: October 21, 2003Assignee: Milliken & CompanyInventors: Daniel M. Connor, John W. Miley, Jr.
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Publication number: 20030055273Abstract: The present invention relates to novel compounds corresponding to formula (I) below: 1Type: ApplicationFiled: April 9, 2002Publication date: March 20, 2003Applicant: L'OREALInventors: Thierry Bordier, Michel Philippe
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Patent number: 6437149Abstract: Cationic aminoanthraquinones in which at least one cationic charge is delocalized on a 5-membered unsaturated polynitrogen-containing heterocycle, their use as a direct dye in dyeing compositions for keratinous materials, in particular for human keratinous fibers such as hair, dyeing compositions containing them, and dyeing methods using these compositions.Type: GrantFiled: November 29, 1999Date of Patent: August 20, 2002Assignee: L'Oreal S.A.Inventors: Alain Genet, Alain Lagrange
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Patent number: 5961664Abstract: An anthraquinone mixture comprising three 1,4-hydroxyalkylamino-anthraquinone derivatives, wherein two of the anthraquinone compounds in the mixture are symmetric and the other anthraquinone compound is asymmetric, and wherein each of the anthraquinone compounds has similar polarities. The anthraquinone mixtures are used in compositions and methods for the direct dyeing of keratinous fibers, particularly human hair on the head.Type: GrantFiled: July 10, 1997Date of Patent: October 5, 1999Assignee: Bristol-Myers Squibb CompanyInventor: James S. Anderson
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Patent number: 5882358Abstract: Automatic transmission fluid containing a red dye stable even in long-lived transmission fluids.Type: GrantFiled: June 12, 1996Date of Patent: March 16, 1999Assignee: United Color Manufacturing, Inc.Inventors: Michael J. Smith, Bharat Desai
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Patent number: 5733880Abstract: A compound having the structural formula, ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or hydroxyl. R.sup.2 and R.sup.3 are independently oxo or hydrogen, one of R.sup.5 and R.sup.6 is A--B and the other is hydrogen, hydroxyl, or a group A, wherein each A is a spacer group providing --NH-- or --CO-- in the bond with B (if present); at least one A group does not provide the residue of an .alpha.-amino acid adjacent the anthraquinone nucleus and the A of any A--B moiety is joined to the anthraquinone nucleus via an --NH-- bond, and each B is a peptide group or a physiologically acceptable derivative thereof. The compounds are useful as antitumor compounds.Type: GrantFiled: March 28, 1996Date of Patent: March 31, 1998Assignee: Napier University Ventures LimitedInventor: David John Mincher
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Patent number: 5639896Abstract: A process for the preparation of N,N'-disubstituted 1,4-diaminoanthraquinones has been found which is characterized in that 1,4-dihydroxyanthraquinones are reacted with aliphatic or aromatic amines in the presence of a hydroxycarboxylic acid as a condensation auxiliary.Type: GrantFiled: May 3, 1996Date of Patent: June 17, 1997Assignee: Bayer AktiengesellschaftInventors: Dietmar Kalz, Reinold Schmitz, Karl-Heinz Reinhardt, Josef Schroder, Stephan Michaelis
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Patent number: 5493036Abstract: The invention relates to fibre-reactive anthraquinone dyes of formula ##STR1## wherein R.sub.1, R.sub.2, B, U, R and n are as defined in claim 1. The anthraquinone dyes of formula (1) are suitable for dyeing or printing hydroxyl group containing or nitrogen-containing fibre materials and give dyeings or prints of good allround fastness properties.Type: GrantFiled: September 19, 1994Date of Patent: February 20, 1996Assignee: Ciba-Geigy CorporationInventor: Jean-Marie Adam
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Patent number: 5436243Abstract: Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoanthraquinones, preferably 1,4-bis(N-substituted) amino anthraquinones, and pharmaceutically acceptable salts thereof.Type: GrantFiled: November 17, 1993Date of Patent: July 25, 1995Assignees: Research Triangle Institute Duke University, Pharmaceuticals CorporationInventors: Clifford W. Sachs, Robert L. Fine, Lawrence M Ballas, R. Ivy Carroll, Robert Bell
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Patent number: 5387704Abstract: Process for preparing amino- and carbamoyl-substituted anthraquinones by Diels-Alder reaction of an N-butadienylcarbamic acid ester of the formula H.sub.2 C.dbd.CH--CH.dbd.CH--NH--COOR.sup.2, wherein R.sup.2 is alkyl or phenylalkyl, with a 1,4-naphthoquinone or with 1,4-benzoquinone to form a carbamoyl-substituted hydroanthraquinone intermediate and by oxidation of this intermediate with an oxygen-containing gas in a tertiary amine and in the presence of a copper salt to obtain a carbamoyl-substituted anthraquinone product. The Diels-Alder reaction and the oxidation reaction can be carried out as a one-pot synthesis or in separate steps. The carbamic acid ester reactant provides a blocking group represented by --COOR.sup.2, and this blocking group is optionally removed by treatment of the carbamoyl-substituted anthraquinone with an alkaline hydroxide solution.Type: GrantFiled: November 9, 1993Date of Patent: February 7, 1995Assignee: BASF AktiengesellschaftInventors: Klaus Ebel, Juergen Schroeder
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Patent number: 5204370Abstract: The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.10 alkyl, aryl, arylalkyl, alkylaryl;n and m are independently 1, 2, or 3;A is Halogen, OH, alkoxy, OCO(NR.sub.3 R.sub.4), S--C(NH.sub.2).dbd.NR.sub.5, or when m=1, comprises an oxirane ring with the adjacent oxygen atom;R.sub.3, R.sub.4, and R.sub.5 are independently H, alkyl, or aryl;X is H, OH, NR.sub.6 R.sub.7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR.sub.8, or CONR.sub.9 R.sub.10 ; andR.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 are independently H, lower alkyl, or aryluseful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.Type: GrantFiled: November 5, 1990Date of Patent: April 20, 1993Assignee: Sphinx Pharmaceuticals CorporationInventors: Jack B. Jiang, Mary G. Johnson
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Patent number: 5199956Abstract: Polyester textile material can be dyed from supercritical CO.sub.2 with special disperse dyes.Type: GrantFiled: August 28, 1991Date of Patent: April 6, 1993Assignee: Ciba-Geigy CorporationInventors: Wolfgang Schlenker, Dieter Werthemann, Peter Liechti, Angelo D. Casa
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Patent number: 5132327Abstract: Compounds of formula (I) ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen, X, NH--A--NHR and NH--A--N(O)R'R" wherein X is hydroxy, halogeno, amino, C.sub.1-4 alkoxy or C.sub.2-8 alkanoyloxy, A is a C.sub.2-4 alkylene group with a chain length between NH and NHR or N(O)R'R" of at least 2 carbon atoms and R, R' and R" are each separately selected from C.sub.1-4 alkyl groups and C.sub.2-4 hydroxyalkyl and C.sub.2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R" together are a C.sub.2-6 alkylene group which with the nitrogen atom to which R" and R" are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R.sub.1 to R.sub.4 is a group NH--A--N(O)R'R", and physiologically acceptable salts thereof are of value in the treatment of cancer.Type: GrantFiled: April 10, 1991Date of Patent: July 21, 1992Assignee: National Research Development CorporationInventor: Laurence H. Patterson
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Patent number: 5017713Abstract: Substituted aminoanthraquinone compounds, which are used for dye stuffs or intermediate thereof, represented by the formula (II) ##STR1## wherein R.sub.3 represents a C.sub.1 -C.sub.6 alkyl group which may be substituted, X represents a hydrogen atom, --COR.sub.1 or --SO.sub.2 R.sub.2 wherein R.sub.1 and R.sub.2 each represents a substituted or unsubstituted C.sub.1 -C.sub.4 alkyl or C.sub.6 -C.sub.12 aryl group, and Y and Z represent independently a hydrogen atom, a halogen atom, a nitro group or a C.sub.1 -C.sub.4 alkyl group, is prepared by allowing anthraquinone compounds represented by the formula ##STR2## wherein X, Y and Z are as defined above, to react with alkylating agents in organic solvents in the presence of organic quaternary ammonium salts and alkalies.Type: GrantFiled: November 8, 1989Date of Patent: May 21, 1991Assignees: Sumitomo Chemical Company, Ltd., Daiei Chemical Company, Ltd.Inventors: Takanori Kondo, Hiroshi Yamachika, Kunihiko Tanaka, Yasuhiro Nishida
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Patent number: 4940692Abstract: Heat transferable dyes which compared with the prior art show better solubility and/or higher light fastness and good to excellent transfer properties have the formula (I) ##STR1## where X is H or CN, R.sup.1, R.sup.2, and R.sup.3 independently of one another are alkyl, alkylcarbonyloxyalkyl, alkoxycarbonyloxyalkyl, alkoxycarbonylalkyl, haloalkyl, hydroxyalkyl, cyanoalkyl, unsubstituted or alkyl-or alkoxy-substituted phenyl or benzyl or a radical of the formula--Y--O].sub.m R.sup.4 (II)where Y is C.sub.2 -C.sub.6 -alkylene, m is 1 to 6 and R.sup.4 is alkyl or phenyl, with the proviso that if X is H then R.sup.1 and R.sup.3 are each substituted or unsubstituted alkyl or substituted or unsubstituted phenyl or if X is H and R.sup.1 is H, then R.sup.3 must be substituted or unsubstituted phenyl.Type: GrantFiled: April 3, 1989Date of Patent: July 10, 1990Assignee: BASF AktiengesellschaftInventors: Volker Bach, Ruediger Sens, Karl-Heinz Etzbach, Manfred Ruske
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Patent number: 4894451Abstract: The disclosure describes unsymmetrical 1,4-bis-(aminoalkylamino)-anthracene-9,10-diones useful in the treatment of neoplasms. Also described is a process of preparing same starting from 1,4-dimethoxyanthracene-9,10-dione which is reacted with an aminoalkylamine. The reaction product is treated with a dialkylaminoethylamine or a N-heteroethylamine to give the unsymmetrical compound.Type: GrantFiled: July 19, 1988Date of Patent: January 16, 1990Assignee: The University of VermontInventors: A. Paul Krapcho, Miles P. Hacker, John J. Landi, Jr., J. J. McCormack, Kenneth J. Shaw