Carbon Bonded Directly At Alpha Position (i.e., 1-, 4-, 5- Or 8-position) Patents (Class 552/267)
  • Patent number: 7132403
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: November 7, 2006
    Assignees: Board of Trustees of Michigan State University, Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6903076
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: June 7, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6875746
    Abstract: Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: wherein R1 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R2 is a group containing 1-12 carbons selected from the group consisting of alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate and combinations thereof; and R3 is a group containing 1 to 12 carbons selected from the group consisting of methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, and combinations thereof.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 5, 2005
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Robert H. Cichewicz, Navindra P. Seeram, Yanjun Zhang
  • Patent number: 6838443
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: January 4, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6828450
    Abstract: This invention provides analogs of triptycene which are useful as anticancer drugs, as well as for other uses. The potency of these compounds is in a similar magnitude as daunomycin, a currently used anticancer drug. Each compound of the invention produces one or more desired effects (blocking nucleoside transport, inhibiting nucleic acid or protein syntheses, decreasing the proliferation and viability of cancer cells, inducing DNA fragmentation or retaining their effectiveness against multidrug-resistant tumor cells).
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: December 7, 2004
    Assignee: Kansas State University Research Foundation
    Inventors: Duy Hua, Jean-Pierre Perchellet
  • Patent number: 6800615
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: October 5, 2004
    Assignees: Board of Trustees of Michigan State University, The Regent of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040059124
    Abstract: Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.
    Type: Application
    Filed: September 3, 2003
    Publication date: March 25, 2004
    Inventors: Michael John Cyr, Max Allen Weaver, Gerry Foust Rhodes, Jason Clay Pearson, Phillip Michael Cook
  • Publication number: 20040058346
    Abstract: The present invention provides a polynucleotide cleavage agent switched on by photo-irradiation and a method of cleaving or decomposing a polynucleotide such as DNA or RNA using this agent switched on in this manner. More specifically, said polynucleotide cleavage agent switched on by photo-irradiation comprises cyclopropane or a 2,2-dihalogeno-cyclopropane ring between “A” unit and “B” unit, wherein said “A” unit is an aromatic group having an electron withdrawing property and is excited by photo-irradiation, and said “B” unit is a hydrophilic functional group. Said polynucleotide cleavage agent may further contain “C” unit which can recognize DNA sequences, and also a spacer molecule, if desired.
    Type: Application
    Filed: March 5, 2003
    Publication date: March 25, 2004
    Applicant: TOTTORI UNIVERSITY
    Inventors: Toshiyuki Itoh, Keiko Ninomiya, Masahiko Shishido
  • Publication number: 20040030159
    Abstract: Compounds useful as surface coating agents, including compounds of the formula: 1
    Type: Application
    Filed: July 14, 2003
    Publication date: February 12, 2004
    Inventor: Dale G. Swan
  • Patent number: 5650399
    Abstract: Anthraquinone derivatives are constructed for alkylation of target molecules. The anthraquinone derivative includes an anthraquinone ring system which has been modified by the addition of inducibly reactive substituents at positions on the ring system. The anthraquinone ring system can be selectively activated for alkylation of a target molecule. The substituents may be from 1 to 4 methyl groups, whereupon activation is achieved by a photochemical signal. In an additional alternative embodiment, the inducible reactive substituents may include both methyl groups and substituted methylene groups. In this embodiment, the activation of the anthraquinone derivative is achieved by photochemical and/or reductive signals. Alternatively, the substituents may be from 1 to 8 methyl groups modified to include a reactive group, whereupon activation is achieved by a chemical or enzymatic reductive signal. The anthraquinone derivatives of the invention may be used for non-specific modification of target molecules.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: July 22, 1997
    Assignee: The Research Foundation of State University of New York
    Inventors: Steven E. Rokita, Hyunmin Kang
  • Patent number: 5030387
    Abstract: An organic conductive complex comprising an electron donor and an electron acceptor, the electron donor being an anthraquinone derivative represented by formula (1): ##STR1## wherein X.sup.1, X.sup.2, X.sup.3 and X.sup.4, which may be the same or different, each represents an electron donating group.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: July 9, 1991
    Assignee: Sumitomo Electric Industries Ltd.
    Inventors: Masaru Matsuoka, Teijiro Kitao, Yo Shimizu
  • Patent number: 4924015
    Abstract: Anthraquinones having .alpha.,.alpha.-(dialkyl)alkyl groups which are functionally substituted, for example by --COOH or --CONH--NH.sub.2, are described. Compositions which contain such anthraquinones, an aminoalcohol and an epoxy resin with or without a hardener are suitable for preparing metallic coatings and images on the cured composition by exposure to light and currentless metal deposition.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: May 8, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Frederick H. Howell, Rudolf Duthaler, Jurgen Finter, Konrad Oertle, Visvanathan Ramanathan