Carbon, Halogen Or Plural Oxygens Bonded Directly To The Anthracene Configured Ring System Patents (Class 552/290)
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Publication number: 20140221658Abstract: The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.Type: ApplicationFiled: February 3, 2014Publication date: August 7, 2014Applicant: University of South FloridaInventors: Said M. Sebti, Srikumar Chellappan, Nicholas James Lawrence
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Patent number: 8329846Abstract: Polymers may include a plurality of tetradecahydroanthracene moieties. Such polymers may be used to make food or beverage containers or medical devices. Food or beverage containers or medical devices may be coated with polymers including a plurality of tetradecahydroanthracene moieties.Type: GrantFiled: June 25, 2012Date of Patent: December 11, 2012Assignee: Empire Technology Development LLCInventors: William B. Carlson, Gregory D. Phelan
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Patent number: 8263973Abstract: This invention relates to anthracene derivatives that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such an anthracene derivative.Type: GrantFiled: December 18, 2009Date of Patent: September 11, 2012Assignee: E I du Pont de Nemours and CompanyInventors: Norman Herron, Weiying Gao, Adam Fennimore, Mark A. Guidry
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Patent number: 8227561Abstract: Polymers may include a plurality of tetradecahydroanthracene moieties. Such polymers may be used to make food or beverage containers or medical devices. Food or beverage containers or medical devices may be coated with polymers including a plurality of tetradecahydroanthracene moieties.Type: GrantFiled: May 2, 2011Date of Patent: July 24, 2012Assignee: Empire Technology Development LLCInventors: William B. Carlson, Gregory D. Phelan
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Patent number: 7253207Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.Type: GrantFiled: August 2, 2004Date of Patent: August 7, 2007Assignee: Cellgate, Inc.Inventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun
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Patent number: 6596774Abstract: The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.Type: GrantFiled: September 27, 2001Date of Patent: July 22, 2003Inventor: Hsu-Shan Huang
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Publication number: 20030135060Abstract: The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.Type: ApplicationFiled: September 27, 2001Publication date: July 17, 2003Inventor: Hsu-Shan Huang
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Publication number: 20030003397Abstract: A compound of Formula 10, an organic anti-reflective polymer having the structure of Formula 1 synthesized from the compound of Formula I and a preparation method thereof. An anti-reflective coating composition including the above organic anti-reflective polymer, as well as a preparation method of an anti-reflective coating. The anti-reflective coating comprising the disclosed polymer eliminates standing waves caused by the optical properties of lower layers on the wafer and by the changes in the thickness of the photoresist, prevents back reflection and also solves the problem of CD alteration cause by the diffracted and reflected light from such lower layers. Such advantages enable the formation of stable ultrafine patterns suitable for 64M, 256M, 1G, 4G, and 16G DRAM semiconductor devices and an increase of the production yields. Further, it is also possible to control the k value.Type: ApplicationFiled: March 13, 2002Publication date: January 2, 2003Inventors: Sung-eun Hong, Min-ho Jung, Jae-chang Jung, Geun-su Lee, Ki-ho Baik
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Patent number: 6428912Abstract: An improved multilayer light emitting device includes novel compounds for use as the electron transporting layer. In particular, the novel compounds are novel aluminum cheltates (e.g. tris(9-oxidophenalenone) aluminum [Al(9-opo)3] and tris(6-oxidobenzanthrone) aluminum [Al(6-obao)3]. These compounds are electron acceptors having improved thermal stability while in most cases and in most applications maintaining comparable efficiencies. When negatively biased, electrons are infected into the electron transporting layer. The concurrent positive bias on the anode in relation to the cathode causes holes to be injected from the cathode into the hole transporting layer. Electroluminescence is produced and confined generally near the interface between these electron and hole transporting layers an a result of the recombination of the electron and hole pairs.Type: GrantFiled: September 30, 1998Date of Patent: August 6, 2002Assignee: Agere Systems Guardian Corp.Inventor: Robert C. Haddon
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Patent number: 6369246Abstract: The invention relates to novel anthracene compounds useful in the treatment of allergic, inflammatory conditions, tumor conditions and therapeutic compositions containing such compounds. The compounds of the present invention are 9-acyloxy-substituted 1,5-dichloroanthracene or analogs thereof. According to the practice of the invention, there are provided 9-acyloxy substituted 1,5-dichloroanthracene compounds according to formula III: wherein R represents a straight or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R1, or R represents phenyl or benzyl which may be substituted with one or two groups of R2; wherein R1 is selected from the group consisting of halogen, —NO2, —OCH3, OCH2CH3, and —OCH2CH2CH3; and wherein R2 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —NO2, —OCH3, —OCH2CH3, and —OCH2CH2CH3.Type: GrantFiled: March 5, 2001Date of Patent: April 9, 2002Assignee: Dr. Keith Chan, GloboAsia, LLCInventors: Hsu-Shan Huang, Kung-Yuan Lee, Chang-Hsin Shi, Hsien-Chin Hsu
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Patent number: 5952390Abstract: Therapeutic compositions comprising 1,8-dihydoxy-10-?2-(4-methylphenyl)-1-oxoethyl!-9(10H)-anthracenone and (R,S)-1,8-dihydroxy-10-(1-oxo-4-phenylpentyl)-9(10H)-anthracenone, said compounds having substantial therapeutic activity and minimal inflammatory effect.Type: GrantFiled: May 8, 1998Date of Patent: September 14, 1999Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Klaus Muller, Wolfgang Weigrebe, Hans Reindl
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Patent number: 5922891Abstract: 2-substituted 1,8-dihydroxy-9(10h)-anthracenones, therapeutic compositions containing at least one novel 2-substituted 1,8-dihydroxy-9(10h)-anthracenone compound and methods of treating inflammatory conditions are provided.Type: GrantFiled: September 19, 1997Date of Patent: July 13, 1999Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Klaus Muller, Helge Prinz, Wolfgang Wiegrebe
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Patent number: 5864048Abstract: The present description relates to new anthraquinone-derivatives endowed with inhibitory activity of the serine proteinase enzymes, useful for the treatment of rheumatoid arthritis, acute respiratory syndrome of adult, and pulmonary emphysema, and to new processes for the preparation of rhein derivatives.Type: GrantFiled: July 31, 1997Date of Patent: January 26, 1999Assignee: Laboratoire Medidom S.A.Inventor: Guido Di Napoli
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Patent number: 5661187Abstract: Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.Type: GrantFiled: March 7, 1995Date of Patent: August 26, 1997Assignee: Teva Pharmaceutical Industries, Ltd.Inventors: Klaus Muller, Wolfgang Wiegrebe, Dieter Gurster, Susanne Peters, nee Piwek
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Patent number: 5426197Abstract: Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.Type: GrantFiled: July 19, 1993Date of Patent: June 20, 1995Assignee: Teva Pharmaceutical Industries, Ltd.Inventors: Klaus Muller, Wolfgang Wiegrebe, Dieter Gurster, Susanne Peters, nee Piwek
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Patent number: 5424421Abstract: The invention relates to the synthesis of 6-deoxykermesates, 6-deoxykermesic acid, and carminic acid, based on a reaction of a 2-halogenonapthazarin with a bis-trimethylsilyl-diene.Type: GrantFiled: March 17, 1993Date of Patent: June 13, 1995Assignee: European Colour PLCInventors: John H. P. Tyman, Alberto Fiecchi, deceased
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Patent number: 5420333Abstract: An anti-hyperlipemic agent which has a potent activity of reducing LDL and VLDL cholesterols, which are thought to be a risk factor for arteriosclerosis among total blood cholesterols, and which is excellent in the antioxidant activity on LDL, is provided. Additionally, a compound and a pharmaceutically acceptable salt thereof are disclosed, which is represented by Formula (I): ##STR1## [wherein R.sup.1 is a power alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl or aralkyl group which is optionally substituted; R.sup.2 is a group represented by the formula: --COOR' (wherein R' is a lower alkyl or aralkyl which is optionally substituted), lower alkyl or halogenated lower alkyl; or R.sup.1 and R.sup.2, together with adjacent carbonyl group, form a cyclohexanone ring represented by the formula: ##STR2## R.sup.3 is a phenyl group optionally being substituted, and, ring A is a benzene nucleus which is optionally substituted, or a heterocyclic ring containing S or O optionally being substituted].Type: GrantFiled: June 17, 1993Date of Patent: May 30, 1995Assignee: Shionogi & Co., Ltd.Inventors: Sachio Mori, Shozo Takechi, Shiro Kida, Takuji Mizui, Teruhisa Ichihashi
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Patent number: 5334665Abstract: A terminally functionalized liquid polymer is prepared by reacting a low molecular weight living diene polymer or copolymer obtained by anionic polymerization of a diene monomer or mixture of a diene monomer and a vinyl aromatic hydrocarbon monomer with a fused-ring polynuclear aromatic compound. The resultant terminally functionalized liquid diene polymers or copolymers can be utilized as dispersants for particulates such as carbon black or graphite and may also be employed as viscosity modifiers for lubricating oils or in electrorheological devices or damping devices.Type: GrantFiled: May 6, 1993Date of Patent: August 2, 1994Assignee: Bridgestone/Firestone, Inc.Inventors: David F. Lawson, Mark L. Stayer, Jr., Thomas A. Antkowiak
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Patent number: 4997961Abstract: Anthralin analogues containing a thio-substituent, especially in one or more of the positions 2-, 7- and 10- of the anthralin ring. They may be made by reacting an anthralin derivative (e.g. 10-bromoanthralin) with a thiol or a compound containing a group convertible to a thio-group. Alternatively, a 1,8-dihydroxy anthraquinone containing a thio-substituent may be reduced. Reactive intermediates may be made by introducing one or more nuclear allylic groups into a 1,8-dihydroxy anthraquinone and then converting them into a reactive form, e.g. by epoxydation or halide addition. The intermediate can then be reduced to the oxidation state corresponding to anthralin.Additional compounds, having the 10-carbon atom of the anthralin ring as part of a heterocyclic ring, may be made by oxidising anthralins containing various substituted thioalkyl groups as the 10-substituent.Type: GrantFiled: February 26, 1990Date of Patent: March 5, 1991Assignee: The Victoria University of ManchesterInventor: John M. Bruce
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Patent number: 4927845Abstract: Anthralin analogues containing a thio-substituent, especially in one or more of the positions 2-, 7- and 10- of the anthralin ring. They may be made by reacting an anthralin derivative (e.g. 10-bromoanthralin) with a thiol or a compound containing a group convertible to a thio-group. Alternatively, a 1,8-dihydroxy anthraquinone containing a thio-substituent may be reduced. Reactive intermediates may be made by introducing one or more nuclear allylic groups into a 1,8-dihydroxy anthraquinone and then converting them into a reactive form, e.g. by epoxidation or halide addition. The intermediate can then reduced to the oxidation state corresponding to anthralin.Additional products having the 10-carbon atom of the anthralin ring as part of a heterocyclic ring, may be made by anthralins containing various substitutes thioalkyl groups as the 10-substituent.The compounds are useful for treatment of psoriasis, and may be formulated in the conventional vehicles for topical application, for example petrolatum.Type: GrantFiled: August 15, 1989Date of Patent: May 22, 1990Assignee: The Victoria University of ManchesterInventor: John M. Bruce