Nitrogen Double Bonded Directly At The 1- Or 4- Positions Patents (Class 552/302)
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Publication number: 20150027483Abstract: The present invention relates to azomethine-type direct dyes with a tri-aromatic unit having the following formula (I): and their use for colouring keratin fibres, particularly human keratin fibres such as the hair. The invention also relates to a composition for dyeing keratin fibres comprising, in a suitable medium for dyeing, such direct dyes. Another subject of the present invention is a method for dyeing keratin fibres using said dyeing composition. Finally the present invention also relates to precursors for these direct dyes.Type: ApplicationFiled: December 13, 2012Publication date: January 29, 2015Applicant: L'OREALInventors: Stephane Sabelle, Madeline Leduc
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Publication number: 20140243509Abstract: Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores.Type: ApplicationFiled: June 18, 2013Publication date: August 28, 2014Inventors: Subhasish K. Chakraborty, Mingrui Zhang, Alan S. Waggoner
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Patent number: 8801808Abstract: One subject of the present invention is a dye composition comprising benzyl alcohol, at least one C1-C4 monoalcohol and at least one anthraquinone direct dye of formula (I) or azomethine direct dye of formula (II). The composition of the invention makes it possible to obtain colorings that are intense and resistant.Type: GrantFiled: December 19, 2011Date of Patent: August 12, 2014Assignee: L'orealInventors: Boris Lalleman, Alain Lagrange
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Publication number: 20140148606Abstract: Disclosed is a methyl violet derivative having inhibitory activity against allosteric focal adhesion kinase (FAK) and is useful as an agent for preventing or treating cancer.Type: ApplicationFiled: October 29, 2013Publication date: May 29, 2014Applicant: Korea Institute of Science and TechnologyInventors: Tae Bo SIM, Hwan KIM
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Patent number: 8083809Abstract: The invention relates to the dyeing of keratinous fibres using azomethine direct dyes of formula (I) or reduced precursors of azomethine direct dyes of formula (II) obtained from 2-chloro-3-amino-6-methylphenol. A subject-matter of the invention is a dyeing composition comprising at least one chlorinated azomethine direct dye or one reduced precursor of a chlorinated azomethine direct dye, a method for dyeing keratinous fibres which employs the said composition and their uses in the dyeing of keratinous fibres. This composition makes it possible to obtain a particularly stable and consistent colouring.Type: GrantFiled: December 9, 2008Date of Patent: December 27, 2011Assignee: L'Oreal S.A.Inventors: Madeleine Leduc, Stéphane Sabelle, Eric Metais, Christophe Rondot
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Patent number: 7645304Abstract: The subject of the present invention is the use, for dyeing in particular human keratin materials, of a specific direct azomethine dye, by dry thermal transfer. Its subject is furthermore a method for dyeing keratin materials, in which at least one direct azomethine dye contained in a dry composition, is applied to or close to the keratin materials, and a source of heat is applied, causing the thermal transfer of the direct dye(s) at the surface and/or inside the keratin materials. It relates furthermore to the dry composition and a method for preparing it.Type: GrantFiled: February 28, 2006Date of Patent: January 12, 2010Assignee: L'Oreal S.A.Inventors: Grégory Plos, Luc Gourlaouen, Jean-Dominique Bazin De Bezons
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Patent number: 7521006Abstract: Disclosed is a near-infrared absorbing compound which does not contain antimony or arsenic, and has excellent stability, especially excellent heat resistance, light resistance and moist heat resistance. Also disclosed are a near-infrared absorbing filter, which is produced by using the near-infrared absorbing compound, and has excellent resistance such as light resistance and heat resistance, an optical filter and an optical recording medium. Specifically disclosed are a diimmonium compound represented by the formula (1) below and a near-infrared absorbing filter obtained by using such a diimmonium compound. Further specifically disclosed are a near-infrared absorbing filter wherein an adhesive layer containing the diimmonium compound is arranged on a transparent supporting body, and an optical filter using such a near-infrared absorbing filter.Type: GrantFiled: September 2, 2005Date of Patent: April 21, 2009Assignee: Nippon Kayaku Kabushiki KaishaInventors: Masaaki Ikeda, Takaaki Kurata, Syouichi Kaneko, Junichi Segawa
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Patent number: 7056349Abstract: The invention relates to an agent for colouring fibres (A). Said agent is produced by mixing two constituents (A1) and (A2), and is characterised in that the constituent (A1) contains at least one quinonimine derivative of formula (I), and the constituent (A2) contains at least one compound from the group consisting of aromatic amines and phenols. The invention also relates to a method for colouring keratin fibres using the inventive agent.Type: GrantFiled: February 23, 2002Date of Patent: June 6, 2006Assignee: Wella AGInventors: Cécile Pasquier, Veronique Buclin-Charrière, Patrick Wyss
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Publication number: 20040241749Abstract: The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn2+ ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni-based labeling systems. Invention Zn-chelating compounds also do not require oxidizable thiols and therefore can be used in non-reducing environments such as the surface of living cells. In addition, the target sequence is genetically encodable and requires incorporation of only a few amino acids, unlike fusions to fluorescent proteins such as GFP.Type: ApplicationFiled: January 16, 2004Publication date: December 2, 2004Inventors: Roger Y. Tsien, Christina Hauser
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Publication number: 20030050489Abstract: A method for purifying an electronic item material, which comprises dissolving an electronic item material or its intermediate product in an organic solvent and having the solution contacted with activated clay at a temperature of 65° C. to 200° C.Type: ApplicationFiled: June 29, 2001Publication date: March 13, 2003Applicant: Hodogaya Chemical Co., Ltd.Inventors: Katsumi Abe, Tomonori Nishimura, Takanobu Watanabe, Susumu Suzuka
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Publication number: 20020111501Abstract: A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N′-dimethyl-&rgr;-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue ∘.Type: ApplicationFiled: March 11, 2002Publication date: August 15, 2002Inventor: Douglas D. Burkett
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Publication number: 20020052519Abstract: The present invention provides a new charge transport agent for use in a photosensitive layer in a positive-electrification-type electrophotographic photoconductor that can be used with high speed copying machines. The electrophotographic photoconductor of the invention includes an electrically conductive substrate and a photosensitive layer on the substrate. The photosensitive layer contains a charge generation agent and an electron transport compound described by the following general formula (I).Type: ApplicationFiled: June 18, 2001Publication date: May 2, 2002Inventor: Masami Kuroda
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Patent number: 6187937Abstract: A hydroxydiphenylamine compound can be converted to an N-phenylquinoneimine by reacting the hydroxydiphenylamine with oxygen or an oxygen containing gas in the presence of a modified activated carbon catalyst, the catalyst having had surface oxides removed therefrom.Type: GrantFiled: December 23, 1998Date of Patent: February 13, 2001Assignee: Flexsys America L.P.Inventors: Donald L. Fields, Jr., Michael K. Stern, Jayant Shivji Lodaya
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Patent number: 6114554Abstract: A phenylenediamine compound can be converted, with high selectivity, into its corresponding quinonediimine by reacting the phenylenediamine with a hypochlorite oxidation reactant.Type: GrantFiled: June 3, 1998Date of Patent: September 5, 2000Assignee: Flexsys America L.P.Inventors: Jayant Shivji Lodaya, Raymond Anton Lohr, Jr., Donald Lee Fields, Jr.
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Patent number: 6072061Abstract: A hydroxyphenylamine compound can be converted, with high yield and high selectivity, into its corresponding quinoneimine by reacting the hydroxyphenylamine with a hypochlorite oxidation reactant.Type: GrantFiled: March 19, 1999Date of Patent: June 6, 2000Assignee: Flexsys America L.P.Inventors: Donald L. Fields, Jr., Jayant S. Lodaya
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Patent number: 6043384Abstract: A hydroxyphenylamine compound can be converted, with high selectivity, into its corresponding quinoneimine by reacting the hydroxyphenylamine with hydrogen peroxide in the presence of a catalyst.Type: GrantFiled: March 19, 1999Date of Patent: March 28, 2000Assignee: Flexsys America L.P.Inventors: Donald L. Fields, Jr., Raymond Lohr, Jr., Jayant S. Lodaya
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Patent number: 5959126Abstract: A phenylenediamine compound can be converted, with high selectivity, into its corresponding quinonediimine by reacting the phenylenediamine with oxygen in the presence of a modified activated carbon catalyst in an aqueous system.Type: GrantFiled: February 12, 1998Date of Patent: September 28, 1999Assignee: Flexsys America L. P.Inventors: Raymond Anton Lohr, Jr., Otto William Maender, Donald Lee Fields, Jr.
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Patent number: 5919846Abstract: A novel colorant compound is provided which is the addition product of an organic chromophore having at least one reactive hydroxyl or amine substituent, a polyisocyanate, and a carboxylic acid, sulfonic acid, or salt of either thereof. The polyisocyanate, added in a molar excess relative to the number of such reactive substituents, reacts with the reactive hydroxyl or amine groups to provide terminal isocyanate groups. Subsequently, the carboxylic acid or salt thereof, also added in an amount excessive in relation to the number of terminal isocyanate groups, reacts therewith to from urethane moieties on the colorant. Such a compound provides excellent ink compositions upon dilution and are very soluble within all the standard ink diluents. Furthermore, such colorants provide good jettability, waterfastness, washfastness, and the like, within ink-jet applications on various types of printing substrates.Type: GrantFiled: February 19, 1998Date of Patent: July 6, 1999Assignee: Milliken Research CorporationInventors: Raj Batlaw, John W. Miley
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Patent number: 5811370Abstract: Azamethine dyes of the formula ##STR1## where W is oxygen, sulfur or a radical of the formula --NH--CO--, --NH--COO-- oder --NH--SO.sub.2 --,Z.sup.1 is C.sub.1 -C.sub.4 -alkyl with or without substitution, phenyl or C.sub.1 -C.sub.4 -alkoxy,Z.sup.2 and Z.sup.3 are each hydrogen or C.sub.1 -C.sub.4 -alkyl with or without substitution, provided --CZ.sup.1 Z.sup.2 Z.sup.3 is not linear and is not isopropyl,Z.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy,Z.sup.5 and Z.sup.6 are each C.sub.1 -C.sub.10 -alkyl with or without substitution, C.sub.3 -C.sub.4 -alkenyl, C.sub.5 -C.sub.7 -cycloalkyl, phenyl or tolyl, or together with the nitrogen atom joining them together a heterocyclic radical or Z.sup.4 and Z.sup.5 are together a bridge member, andT is a radical of a cyclic acidic--CH compound H.sub.2 T,are useful for thermal transfer.Type: GrantFiled: May 8, 1997Date of Patent: September 22, 1998Assignee: BASF AktiengesellschaftInventors: Rudiger Sens, Andreas Johann Schmidt, Stefan Beckmann, Karl-Heinz Etzbach
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Patent number: 5514819Abstract: The present invention provides a dye-donor element for use according to thermal dye sublimation transfer, said dye-donor element comprising a support provided with a dye layer containing a dye and a polymeric binder, characterized in that said dye corresponds to the following formula: ##STR1## wherein R.sup.1 to R.sup.12 are as set out in the claims and the description.Type: GrantFiled: September 20, 1994Date of Patent: May 7, 1996Assignee: Agfa-Gevaert N.V.Inventor: Luc Vanmaele
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Patent number: 5292905Abstract: A cyan dye of the formula: ##STR1## wherein X.sup.1 represents halogen; X.sup.2 represents hydrogen, alkyl, alkoxy, halogen, alkylcarbonylamino or perfluoroalkyl; R.sup.1 and R.sup.2 independently represent alkyl, phenyl, perfluoroalkyl, halogen-substituted alkyl, or halogen-substituted phenyl or alkyl-substituted phenyl; R.sub.3 represents alkyl; R.sup.4 represents alkyl, alkoxy or perfluoroalkyl; and n is an integer of 1 or more. A thermal transfer sheet comprising a substrate and an ink layer, the ink layer comprising a cyan dye of the formula described above, is also disclosed.Type: GrantFiled: March 13, 1992Date of Patent: March 8, 1994Assignee: Sony CorporationInventors: Toshihisa Inoue, Tetsuya Abe, Yoshio Fujiwara
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Patent number: 5273906Abstract: The present invention provides novel dyes for staining proteins, particularly those in electrophoretic gels. The dyes of the invention are derivatives of Coomassie.RTM. dyes. The invention also provides quantitative and qualitative methods for detecting proteins by staining the proteins with a dye of the invention.Type: GrantFiled: July 20, 1992Date of Patent: December 28, 1993Assignee: Promega CorporationInventors: John W. Shultz, David L. Leland
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Patent number: 5178637Abstract: The invention relates to the use of a 5,6-dihydroxyindoline corresponding to the formula (I): ##STR1## in which R represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, as well as the acid addition salts of these compounds for dyeing keratinous materials, in particular human keratinous materials,and to the tinctorial compositions and methods employed.Type: GrantFiled: May 31, 1991Date of Patent: January 12, 1993Assignee: L'OrealInventors: Alain Lagrange, Bernadette Luppi, Alex Junino
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Patent number: 5132438Abstract: Bichromophoric methine and azamethine transfer dyes have the formulaZ.sup.2 --Z.sup.1 --LY.sup.1 --Y.sup.2whereL is a bridge member which does not permit any conjugation of .pi.-electrons between Z.sup.1 and Y.sup.1,Y.sup.1 and Z.sup.1 are each independently of the other aminophenylene, which may be benzofused, or heterocyclyl andY.sup.2 and Z.sup.2 are each independently of the other benzoquinoeiminyl, which may be benzofused, or heterocyclyl.Type: GrantFiled: February 4, 1991Date of Patent: July 21, 1992Assignee: BASF AktiengesellschaftInventors: Volker Bach, Karl-Heinz Etzbach, Ruediger Sens
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Patent number: 5132439Abstract: The present invention provides novel dyes for staining protein, particularly those in elecrophoretic gels. The dyes of the invention are derivatives of Coomassie.RTM. dyes. The invention also provides quantitative and qualitative methods for detecting proteins which comprise staining the proteins with a dye of the invention.Type: GrantFiled: November 19, 1990Date of Patent: July 21, 1992Assignee: Promega CorporationInventors: John W. Schultz, David L. Leland
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Patent number: 5091545Abstract: The present invention relates to a process for the catalytic oxidation of hydroxy containing aromatic compounds to form the respective quinone compounds comprising contacting a hydroxy containing aromatic compound of the formula: ##STR1## with a molecular oxygen containing gas in the presence of: (a) a catalytic amount of a cobalt (II) compound,(b) a primary aliphatic amine having the nitrogen atom attached to a tertiary carbon, and(c) an alcohol selected from the group consisting of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, 2,2,2-trifluoroethanol and benzyl alcohol,wherein X is of the formula ##STR2## wherein R is individually selected from the group of radicals consisting of hydrogen, an alkyl having from about 1 to about 18 carbon atoms, an alkoxy having from about 1 to 8 carbon atoms, a phenyl and an aralkyl having 7 to 12 carbon atoms.Type: GrantFiled: March 2, 1990Date of Patent: February 25, 1992Assignee: The Goodyear Tire & Rubber CompanyInventor: Dane K. Parker
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Patent number: 5013857Abstract: Process for the preparation of sulpho-free triphenylmethane dyestuffs of the formula ##STR1## in which R.sup.1 -R.sup.3 denote hydrogen, C.sub.1 -C.sub.6 -alkyl, preferably methyl, or halogen, preferably chlorine,Y denotes hydrogen or NX.sup.5 X.sup.6,X.sup.1 -X.sup.6 denote hydrogen, C.sub.1 -C.sub.6 -alkyl, preferably methyl, ethyl, benzyl or phenyl andZ.sup.Type: GrantFiled: December 11, 1989Date of Patent: May 7, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Berneth, Roderich Raue