The Additional Ring Shares The 6,7-positions Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 552/513)
  • Process for the preparation of 17-(3-hydroxypropyl)-17-hydroxysteroids
    Patent number: 8853431
    Abstract: The present invention relates to a process for the preparation of 17?-(3-hydroxypropyl)-17?-hydroxysteroids of the formula I starting from 17-ketosteroids of the formula III via the intermediates of the formula V wherein the radicals R3, R5, R6, R7, R10, R13, R15, R16, R40, R41 and R42 have the meaning indicated in the description.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: October 7, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Claus Christian Haeselhoff, Mike Petersen
  • Process for obtaining 17-spirolactones in steroids
    Patent number: 8524693
    Abstract: The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6?,7?; 15?,16?-dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, commonly known as Drospirenone, as well as to intermediates useful in said process.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: September 3, 2013
    Assignee: Crystal Pharma, S.A.
    Inventors: Jesús Miguel Iglesias Retuerto, Luis Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen
  • Process for the preparation of drospirenone
    Patent number: 8383809
    Abstract: A process for the preparation of Drospirenone (I) according to the scheme (A) wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: February 26, 2013
    Assignee: Newchem S.p.A.
    Inventors: Erika Andriolo, Mauro Montorsi, Stefano Rancan, Edoardo Mariani, Marco Bandini, Michele Contento, Achille Umani-Ronchi
  • Methods for the preparation of drospirenone
    Patent number: 8334375
    Abstract: Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: December 18, 2012
    Assignee: Evestra, Inc.
    Inventors: Klaus Nickisch, Kirk Acosta, Bindu Santhamma
  • 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
    Publication number: 20100292184
    Abstract: The 17?-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity.
    Type: Application
    Filed: June 12, 2008
    Publication date: November 18, 2010
    Applicant: BAYER SCHERING PHARMA AG
    Inventors: Joachim Kuhnke, Jan Huebner, Rolf Bohlmann, Thomas Frenzel, Ulrich Klar, Frederik Menges, Sven Ring, Steffen Borden, Hans Peter Muhn, Katja Prelle
  • Process for preparing drospirenone and intermediate thereof
    Publication number: 20090023914
    Abstract: The present invention encompasses processes for preparing drospirenone and intermediates thereof.
    Type: Application
    Filed: May 1, 2008
    Publication date: January 22, 2009
    Inventors: Alessandro Pontiroli, Nicola Diulgheroff, Francesca Scarpitta, Roberto Arosio, Andrea Poggiali, Marco Villa
  • PROCESS FOR THE PREPARATION OF 17-(3-HYDROXYPROPYL)-17-HYDROXYSTEROIDS
    Publication number: 20090012286
    Abstract: The present invention relates to a process for the preparation of 17?-(3-hydroxypropyl)-17?-hydroxysteroids of the formula I starting from 17-ketosteroids of the formula III via the intermediates of the formula V wherein the radicals R3, R5, R6, R7, R10, R13, R15, R16, R40, R41 and R42 have the meaning indicated in the description.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 8, 2009
    Inventors: Claus-Christian HAESELHOFF, Mike Petersen
  • Androstane 17-beta-carboxamides as androgen receptor modulators
    Patent number: 7402577
    Abstract: Compounds of structural formula as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of activating the function of the androgen receptor in a patient, and in particular the method wherein the function of the androgen receptor is blocked in the prostate of a male patient or in the uterus of a female patient and activated in bone and/or muscle tissue.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: July 22, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Jiabing Wang, Mark E. Duggan, David B. Whitman
  • Activation of a diels-alder reaction of a sterol 5,7 diene
    Publication number: 20010047093
    Abstract: An improved process and composition are disclosed for isolation of steroids containing a 5,7-diene functionality from a sterol mixture that comprises formation of a Diels-Alder reaction product of the ster-5,7-dienol in the presence of at least a catalytic amount of an ethylenically unsaturated C12-C24 fatty carboxylic acid.
    Type: Application
    Filed: March 15, 2001
    Publication date: November 29, 2001
    Applicant: Monsanto Technology LLC
    Inventor: Michael M. Schwartz
  • Progestationally active 19,11-bridged 4-estrenes
    Patent number: 5703066
    Abstract: In this invention, the new etheno- and ethano-19,11-bridged 4-estrenes of general formula I ##STR1## are described, in whichW, R.sup.1, R.sup.2, R.sup.6a, R.sup.6b, R.sup.7, R.sup.14, R.sup.15, R.sup.16, R.sup.11, R.sup.11' and R.sup.19 have the meaning indicated in the description, as well as a process for their production.The new compounds have strong progestational activity and are suitable for the production of pharmaceutical agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Eckhard Ottow, Wolfgang Schwede, Wolfgang Halfbrodt, Karl-Heinrich Fritzemeier, Rolf Krattenmacher
  • Progestationally active 19,11-bridged 4-estrenes
    Patent number: 5523298
    Abstract: In this invention, the new etheno- and ethano-19,11-bridged 4-estrenes of general formula I ##STR1## are described, in which W, R.sup.1, R.sup.2, R.sup.6a, R.sup.6b, R.sup.7, R.sup.14, R.sup.15, R.sup.16, R.sup.11, R.sup.11' and R.sup.19 have the meaning indicated in the description, as well as a process for their production.The new compounds have strong progestational activity and are suitable for the production of pharmaceutical agents.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: June 4, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Eckhard Ottow, Wolfgang Schwede, Wolfgang Halfbrodt, Karl-Heinrich Fritzemeier, Rolf Krattenmacher