Abstract: The invention is directed to a process for the catalytic oxidation of an isoprenoid containing at least one allylic hydrogen atom, which process comprises reacting the isoprenoid with oxygen or an oxygen-containing gas in an inert solvent in the presence of a N-hydroxydicarboxylic acid imide of the formula ##STR1## wherein A-B stands for CH.sub.2 -CH.sub.2, CH.dbd.CH, an aromatic hydrocarbon residue or a group derived from one of these groups in which one or more hydrogen atoms is/are replaced by alkyl or halogen,to produce a primary of secondary hydroperoxide.The process of the invention is suitable for the manufacture of steroids, vitamins, odorant substances, carotinoids and the like.
Type:
Grant
Filed:
August 31, 1990
Date of Patent:
July 9, 1991
Assignee:
Hoffman-La Roche Inc.
Inventors:
Joseph Foricher, Claude Furbringer, Karlheinz Pfoertner
Abstract: A compound of general formula, in substantially pure form, wherein A is a cation. A method for preparation is also disclosed, together with compositions and methods of use thereof.
Type:
Grant
Filed:
March 29, 1989
Date of Patent:
June 25, 1991
Assignees:
Yoshiki Kosuge, James Meredyth Broadbent
Abstract: New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.
Type:
Grant
Filed:
August 24, 1989
Date of Patent:
June 11, 1991
Assignee:
SmithKline Beecham Corporation
Inventors:
Jerry L. Adams, Timothy F. Gallagher, Ruth J. Mayer, Brian W. Metcalf