Oxygen Bonded Directly At The 6- Or 7-position Patents (Class 552/542)
  • Patent number: 5030739
    Abstract: The invention is directed to a process for the catalytic oxidation of an isoprenoid containing at least one allylic hydrogen atom, which process comprises reacting the isoprenoid with oxygen or an oxygen-containing gas in an inert solvent in the presence of a N-hydroxydicarboxylic acid imide of the formula ##STR1## wherein A-B stands for CH.sub.2 -CH.sub.2, CH.dbd.CH, an aromatic hydrocarbon residue or a group derived from one of these groups in which one or more hydrogen atoms is/are replaced by alkyl or halogen,to produce a primary of secondary hydroperoxide.The process of the invention is suitable for the manufacture of steroids, vitamins, odorant substances, carotinoids and the like.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: July 9, 1991
    Assignee: Hoffman-La Roche Inc.
    Inventors: Joseph Foricher, Claude Furbringer, Karlheinz Pfoertner
  • Patent number: 5026883
    Abstract: A compound of general formula, in substantially pure form, wherein A is a cation. A method for preparation is also disclosed, together with compositions and methods of use thereof.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: June 25, 1991
    Assignees: Yoshiki Kosuge, James Meredyth Broadbent
    Inventors: Takuo Kosuge, Kuniro Tsuji, Hitoshi Ishida, Yoshiki Kosuge
  • Patent number: 5023250
    Abstract: New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: June 11, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Timothy F. Gallagher, Ruth J. Mayer, Brian W. Metcalf