Processes Of Isolating, Purifying Or Recovering From Animal, Vegetable Or Fungal Sources (e.g., Wool Fat Or Grease, Lanolin, Fish Oils, Animal Tissue, Soybean Oil, Tall Oil Or Pitch, Wood Products, Sugar Cane, Soap Stocks, Yeast, Molds, Etc.) Patents (Class 552/545)
  • Patent number: 10214705
    Abstract: A method is provided for processing an organic oil in steps, including the following: A) providing a raw oil; B) degumming the raw oil by adding water or acid to the raw oil and forming at least two phases, an aqueous phase and an oil phase, and separating the aqueous phase enriched in phospholipid from the oil phase; C) adding sodium hydrogencarbonate and/or sodium acetate to the oil phase from step B, and removing alkaline-earth compounds and/or phospholipids and/or stearyl glycosides, in solution or suspension in an aqueous phase, from the oil phase.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 26, 2019
    Assignee: GEA Westfalia Separator Group GmbH
    Inventors: Steffen Hruschka, Wladislawa Boszulak
  • Patent number: 9909084
    Abstract: The present invention relates to an extraction process of an unsaponifiable fraction contained in an oil or a vegetable butter, in an oil originating from a micro-organism, in a concentrate of oil or butter or of oil originating from a micro-organism, or in a co-product of the refining industry for vegetable oils, such as deodorization exhaust and distillates of physical refining, or oils originating from micro-organisms, comprising at least: A) a transformation step of said oils, of said butter or said co-product of the refining industry for vegetable oils or oils originating from micro-organisms in hydro-alcoholic solution, especially via a saponification step, and B) an extraction step of the hydro-alcoholic solution in which the fatty fraction is separated from unsaponifiable fraction by liquid/liquid extraction, said process being characterized in that at least the liquid/liquid extraction step of the step B is performed by using a first solvent system comprising a solvent content selected from the s
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 6, 2018
    Assignee: Laboratoires Expanscience
    Inventors: Eglantine Mercier, Jacques Legrand, Alex Saunois
  • Patent number: 9884837
    Abstract: The invention relates to a method for obtaining and purifying phytosterols and/or tocopherols from distillation residue from a transesterification of vegetable oils, in particular from the vegetable oil-based fatty acid methyl ester production for the field of use of biodiesel (FAME), comprising a first transesterification stage for converting partial glycerides contained in the distillation residue; separating the glycerin phase from a reaction mixture resulting from the first transesterification stage; a second transesterification stage for converting sterol esters contained in the reaction mixture; adding water to the reaction mixture after the second transesterification stage in order to generate a multiphase system; simultaneously or sequentially separating the phases of the multiphase system into a substantially sterol-containing phase; a substantially glycerin- and methanol-containing aqueous phase; and a tocopherol-containing methyl ester phase; and obtaining phytosterols from the sterol-containing ph
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: February 6, 2018
    Assignee: VERBIO VEREINIGTE BIOENERGIE AG
    Inventors: Joachim Lemp, Nico Baade, Emanuel Pöhls
  • Patent number: 9422507
    Abstract: A process for recovering fatty acids, resin acids and sterols from tall oil pitch, said process comprising a) saponifying the tall oil pitch with an alkali to hydrolyze esters included in the pitch to free alcohols and organic acids in salt form, b) acidulating the saponified pitch with a mineral acid to convert the organic acids in salt form into free organic acids and to form an organic phase and an aqueous phase, c) separating the aqueous phase from the organic phase, d) evaporation fractionating the organic phase to obtain a distillate rich in sterols, fatty acids and resin acids, d) evaporation fractionating the organic phase to obtain a distillate rich in sterols, fatty acids and resin acids, e) evaporation fractionating the distillate to obtain a bottom fraction rich in sterols, and a distillate rich in fatty acids and resin acids, and f) subjecting the sterols in the sterol-rich bottom fraction to crystallization purification.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: August 23, 2016
    Assignee: RAVINTORAISIO OY
    Inventor: Antti Hamunen
  • Patent number: 9221869
    Abstract: There is disclosed a method for isolation and purification of phytosterols from tall oil pitch comprising the steps of: a) contacting the tall oil pitch with a solvent to form a tall oil solvent mixture; b) separating the tall oil pitch solvent mixture in at least two separate streams wherein one process stream is enriched in acidic pitch components and a second stream enriched in free- and bound sterols in the form of steryl esters; c) subjecting the stream enriched in free- and steryl esters to treatment with an alcohol under transesterification conditions wherein a reaction mixture is formed and sterols comprising the steryl esters are liberated as free sterols; and d) separating the free sterols from the reaction mixture of step c) by crystallization and extraction with one or more solvents. There are disclosed free fatty acids and resin acids separated from the tall oil pitch. Moreover, there is disclosed a manufacture and separation of fatty acid alkyl esters by the method.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: December 29, 2015
    Assignee: SUNPINE AB
    Inventors: Lars Stigsson, Valeri Naydenov
  • Publication number: 20150099871
    Abstract: A method of extracting lentinan from lentinan containing mushrooms comprising the step of contacting the mushrooms with an ionic liquid so as to obtain a lentinan rich ionic liquid solution.
    Type: Application
    Filed: March 22, 2013
    Publication date: April 9, 2015
    Inventors: Martyn Earle, Manuela Gilea
  • Patent number: 8524928
    Abstract: The invention relates to an effective process for producing plant stanol by hydrogenating plant sterol in an organic solvent at a hydrogen pressure of 1-200 bar in the presence of a hydrogenation catalyst.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: September 3, 2013
    Assignee: Raisio Nutrition Ltd.
    Inventors: Jari Ekblom, Antti Hamunen, Rami Hartonen, Marko Hirvijärvi, Juha Holma, Juha Orte
  • Patent number: 8450453
    Abstract: The invention relates to a process for recovering fatty acids, resin acids and sterols from tall oil pitch, said process comprising a) saponifying the tall oil pitch with an alkali to hydrolyse esters included in the pitch to free alcohols and organic acids in salt form, b) acidulating the saponified pitch with a mineral acid to convert the organic acids in salt form into free organic acids and to form an organic phase and an aqueous phase, c) separating the aqueous phase from the organic phase, d) evaporation fractionating the organic phase to obtain a distillate rich in sterols, fatty acids and resin acids, e) evaporation fractionating the distillate to obtain a bottom fraction rich in sterols, and a distillate rich in fatty acids and resin acids, and f) subjecting the sterols in the sterol-rich bottom fraction to crystallization purification.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: May 28, 2013
    Assignee: Ravintoraisio OY
    Inventor: Antti Hamunen
  • Patent number: 8318962
    Abstract: A process of obtaining sterols suitable for human consumption from a crude wood pulping source containing sterol esters is disclosed. The sterols are obtained at high yield and purity. In particular, a process of obtaining sterols at high yield and purity from tall oil pitch (TOP) is disclosed. The sterols obtained can be esterified to sterol esters for use in dietary supplements and as additives for food and beverage products.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: November 27, 2012
    Assignee: Cognis IP Management GmbH
    Inventors: Sang I. Kang, Joseph J. Falatek, Brian P. Thiesen, Kenneth R. Bicknell
  • Patent number: 8114447
    Abstract: The present invention relates to the use of “green” or relatively benign solvents such as ethanol, ethanol/water, isopropyl alcohol, isopropyl alcohol/water, ethyl lactate, acetone, butanol, isoamyl alcohol, or ethyl acetate to extract phytosterols from wet corn fiber. The resulting oil product contains free phytosterols and free fatty acids.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: February 14, 2012
    Assignee: Archer Daniels Midland Company
    Inventors: Charles Abbas, Anne M. Rammelsberg, Kyle Beery
  • Publication number: 20120004592
    Abstract: Tissue solubilizing compositions are provided. The compositions comprise 3-(decyl dimethyl ammonio) propane sulfonate and polyethylene glycol dodecyl ether, such as tetraethylene glycol dodecyl ether. The compositions may be useful to solubilize tissue, including skin, mucosal membrane, and other tissue. The compositions may be further useful to preserve and recover analytes contained within the solubilized skin, mucosal membrane, and other tissue.
    Type: Application
    Filed: April 27, 2011
    Publication date: January 5, 2012
    Applicant: The Regents of the University of California
    Inventors: Samir Mitragotri, Sumit Pallwal, Makoto Ogura, Russell M. Lebovitz
  • Publication number: 20110207952
    Abstract: A process for producing vegan vitamin D3 from an algal waste processing stream by saponifying the waste stream to separate out and removing unsaponifiable cholesterol and converting it to vitamin D3 by ultraviolet irradiation, while precipitating out the saponified fatty acids, triglycerides and polysaccharides.
    Type: Application
    Filed: February 15, 2011
    Publication date: August 25, 2011
    Inventor: RAFAEL AVILA
  • Publication number: 20110098493
    Abstract: The present invention provides a method of separating ergosterol from a solution containing ergosterol in water-insoluble organic solvent, comprising supplying water to the solution and precipitating ergosterol. According to the method of the present invention, ergosterol crystals can be obtained at a high yield. Moreover, controlled water supply provides granular ergosterol aggregates exhibiting good solid-liquid separation character at a high yield.
    Type: Application
    Filed: December 23, 2010
    Publication date: April 28, 2011
    Applicant: KANEKA CORPORATION
    Inventor: Hideo Kawachi
  • Patent number: 7884221
    Abstract: The present invention provides a method of separating ergosterol from a solution containing ergosterol in water-insoluble organic solvent, comprising supplying water to the solution and precipitating ergosterol. According to the method of the present invention, ergosterol crystals can be obtained at a high yield. Moreover, controlled water supply provides granular ergosterol aggregates exhibiting good solid-liquid separation character at a high yield.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: February 8, 2011
    Assignee: Kaneka Corporation
    Inventor: Hideo Kawachi
  • Publication number: 20100305342
    Abstract: A method of preparing phytosterols from tall oil pitch containing steryl esters comprises the steps of converting the steryl esters to free phytosterols while in the pitch to produce a modified pitch containing the free phytosterols; removing light ends from the modified pitch by evaporation to produce a bottom fraction containing the free phytosterols; evaporating the bottom fraction to produce a light phase distillate containing the free phytosterols; dissolving the light phase distillate in a solvent comprising an alcohol to produce a solution containing the free phytosterols; cooling the solution to produce a slurry with the free phytosterols crystallized in the slurry; and, washing and filtering the slurry to isolate the crystallized phytosterols.
    Type: Application
    Filed: August 4, 2010
    Publication date: December 2, 2010
    Inventors: Alfred Wong, Hugh Sven Oscar Norman, Angus Kirke MacMillan
  • Patent number: 7632530
    Abstract: The present invention provides an isolation process of the pure sterols from the SODD by simple acid catalyzed esterification and the separation of the reagents by distillation and water washing followed by the crystallization of phytosterols and purification. Soybean oil deodorizer distillate (SODD) and distillate from other vegetable oil refining contain free sterols, in addition to steryl esters, tocopherols squalene and unknown compounds. The process is also applicable to other vegetable oil distillate containing more than 1% phytosterols in the free form. Phytosterols thus obtained is of high purity (95-99%) and high yield (80-90%) and contains ?-sitosterol, Stigmasterol and campesterol.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: December 15, 2009
    Assignee: Council of Scientific and Industrial Research
    Inventors: Chami Arumughan, Das Retna Sobankumar, Andikkannu Sudaresan, Sreeja Sadasivan Nair, Kannan Yohesh, Leelavathy Rajam
  • Patent number: 7544822
    Abstract: The present invention relates to an improved and integrated process for the extraction and purification of tocotrienols or tocopherols, carotenoids and sterols from vegetable and other edible oils. Fatty acids in the vegetable oils are subjected to alcoholic osterification to form ester-rich layer that includes fatty acid alkyl esters, carotenoids, tocotrienols or tocopherols, and sterols. The advantages of this process are that the tocotrienols or tocopherols, carotenoids and sterols are produced efficiently without any substantial decomposition or degradation of these phytonutrients.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: June 9, 2009
    Assignee: Carotech Bhd.
    Inventor: David Sue San Ho
  • Publication number: 20090131697
    Abstract: A method of preparing phytosterols from tall oil pitch containing steryl esters comprises the steps of converting the steryl esters to free phytosterols while in the pitch to produce a modified pitch containing the free phytosterols; removing light ends from the modified pitch by evaporation to produce a bottom fraction containing the free phytosterols; evaporating the bottom fraction to produce a light phase distillate containing the free phytosterols; dissolving the light phase distillate in a solvent comprising an alcohol to produce a solution containing the free phytosterols; cooling the solution to produce a slurry with the free phytosterols crystallized in the slurry; and, washing and filtering the slurry to isolate the crystallized phytosterols.
    Type: Application
    Filed: September 18, 2008
    Publication date: May 21, 2009
    Inventors: Alfred Wong, Hugh Sven Oscar Norman, Angus Kirke MacMillan
  • Publication number: 20080262251
    Abstract: A process for recovering sterols from organic material containing sterols and sterol derivatives. In a first step (a) the organic material is reacted with at least one of polyols, polyamines, alkanolamines or monohydric alcohols to increase the amount of free sterols in the organic material; (b) reacting residual reactants, and their esters or amides with epoxydated components; and (c) separating the free sterols from the mixture by short path distillation, thin film evaporation, or flash evaporation. The recovered sterols can be further purified by a crystallization step.
    Type: Application
    Filed: May 31, 2004
    Publication date: October 23, 2008
    Inventors: Setsuo Sato, Wolfgang Albiez, Alexssander S. Araujo, Wanderson Bueno De Almeida
  • Publication number: 20080207931
    Abstract: Provided is a method for selective extraction of steroid compounds using entrapped ?-cyclodextrin polymers. Particularly, steroid hormones can be effectively selected from a biological sample by selectively extracting steroid compounds using entrapped ?-cyclodextrin polymers, prepared by adding epichlorohydrin to ?-cyclodextrin to prepare a polymer in a gel state, entrapping the polymer and pulverizing the products without using an additional device required in conventional solid-phase extraction.
    Type: Application
    Filed: November 29, 2007
    Publication date: August 28, 2008
    Inventors: Man Ho Choi, Dong Hyun Kim, Bong Chul Chung, Ju-Yeon Moon
  • Patent number: 7371876
    Abstract: The present invention describes a method for separating sterols from neutral substances comprising the sterols. The method generally starts with extracting a hydrocarbon fraction from neutral substances. The hydrocarbon fraction may be optionally washed with water. The neutral substances are separated from the hydrocarbon. The hydrocarbon fraction or the neutral substances are subjected to evaporation fractionating to obtain a sterol-rich fraction. The sterol-rich fraction is dissolved in a solvent, and the sterols are crystallized from the solvent. The obtained sterol crystals are separated from the solvent.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: May 13, 2008
    Assignee: Sterol Technologies Ltd.
    Inventors: Antti Hamunen, Keijo Ukkonen
  • Patent number: 7368138
    Abstract: The present invention relates to the use of “green” or relatively benign solvents such as ethanol, ethanol/water, isopropyl alcohol, isopropyl alcohol/water, ethyl lactate, acetone, butanol, isoamyl alcohol, or ethyl acetate to extract phytosterols from wet corn fiber. The resulting oil product contains free phytosterols and free fatty acids.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: May 6, 2008
    Assignee: Archer-Daniels-Midland Company
    Inventors: Charles Abbas, Anne M. Rammelsberg, Kyle Beery
  • Patent number: 7244856
    Abstract: Processes for recovering phytosterols are described. The processes comprise: (a) providing a liquid mixture containing a phytosterol, methanol, and one or more additional compounds, wherein the methanol is present in an amount of from 25 to 75% by weight, based on the phytosterol; (b) cooling the mixture to form phytosterol crystals; and (c) separating the phytosterol crystals from the remainder of the mixture.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: July 17, 2007
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Christophe Sicre, Rene Armengaud, Joerg Schwarzer, Bernhard Gutsche, Markus Musholt, Volkmar Jordan
  • Patent number: 7202372
    Abstract: The invention relates to a process for recovering sterols and/or wax alcohols from a crude tall oil based source material comprising sterols and/or wax alcohols in esterified form and fatty and/or rosin acids and optionally sterols and/or wax alcohols in free form, said method comprising the steps of: a) converting free acids in the source material to corresponding salts, b) removing water if present, c) transesterifying the esterified sterols and/or wax alcohols present in the dry material obtained in step a or step b to liberate sterols and/or wax alcohols, d) evaporative fractionating the transesterified material, and e) isolating sterols and/or wax alcohols from the obtained fraction(s) and/or the residue.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: April 10, 2007
    Assignee: Sterol Technologies, Ltd.
    Inventor: Antti Hamunen
  • Patent number: 7173144
    Abstract: The present invention provides a method of obtaining highly pure phytosterols practically and efficiently from crude phytosterol compositions derived from vegetable fats and oils. That is, the present invention provides a method of saponifying fatty esters contained in crude phytosterol compositions with an alkali in a mixed solvent of an lower alcohol and water, as well as a process for producing phytosterols, which comprises, after this saponifying method, cooling the reaction solution to precipitate crystals of phytosterols, and separating the obtained crystals.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: February 6, 2007
    Assignee: Kao Corporation
    Inventors: Yasuyuki Hattori, Masamitsu Horio, Jun Kono
  • Patent number: 7078544
    Abstract: A process for producing steryl or stanyl esters, comprises the steps of: a) forming a reacting mixture by contacting a lipase with a reactant mixture wherein the reactant mixture comprise sterols or stanols and one or more esters selected from the group consisting of esters of a fatty acid with a short chain aliphatic alcohol; b) separating the lipase from the reacting mixture to form a reacted mixture; and c) separating steryl or stanyl esters from the reacted mixture. The reaction is carried out in stirred reactors at pressures below atmospheric pressure and temperatures from 30 to 90° C. The separation of esters from the reacted mixtures is carried out by distillation at low pressures. A process for esterifying sterols or stanols comprise forming a reacting mixture by contacting a lipase with a reactant mixture wherein the reactant mixture comprise sterols or stanols and one or more esters selected from the group consisting of esters of a fatty acid with a short chain aliphatic alcohol.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: July 18, 2006
    Assignee: Harting, S.A.
    Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Endre Markovits Schersl, Irene Martinez Basterrechea
  • Patent number: 7037548
    Abstract: The purpose of the present invention is to extract oil from the soybean material containing soybean germ as a main component, and to utilize it. The present invention relates to a method for producing a soybean material, comprising crudely crushing selected soybeans into a size of less than ½, and separating and concentrating a soybean germ fraction by means of sieving, sorting with air, separation based on the grain shape and the like, to the soybean germ fraction produced by said method, to oil prepared from the soybean material containing soybean germ as a main component, to oil containing 0.8% by weight or more of sterols' content, and to foods containing said oil.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: May 2, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoichi Ozawa, Akihiro Nakatani, Hitoshi Sato, Osamu Mori, Yukio Akiyama, Yasushi Morinaga, Yuji Nakata
  • Patent number: 6979743
    Abstract: Processes for preparing substantially citrostadienol-free phytosterols are disclosed. The processes described include dissolving a liquid phytosterol in a hydrocarbon solvent, optionally with added methanol, and crystallizing the phytosterol compounds. Also described are the resulting phytosterols which are substantially citrostadienol-free, and preferably contain less than 0.5% by weight citrostadienol.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: December 27, 2005
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Joerg Schwarzer, Bernhard Gutsche
  • Patent number: 6956125
    Abstract: The invention relates to a process for the production of sterols from fatty acid distillation residues, characterized in that the partial glycerides are subjected to a first transesterification step under mild conditions and, after working up and the removal of impurities, the sterol esters are subjected to a second transesterification step under more extreme conditions.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: October 18, 2005
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Gerhard Wollmann, Joerg Schwarzer, Bernhard Gutsche
  • Patent number: 6844456
    Abstract: The present invention is directed to modified, hydroxy-bearing aromatic ring structures having cytoprotective activity. More specifically, in a first embodiment the present invention is directed to phenolic compounds, and in particular steriods (e.g., estrogens), wherein a non-fused polycyclic, hydrophobic substituent is attached to the hydroxy-substituted A-ring thereof. The present invention is further directed to a process for conferring cytoprotection to a population of cells involving the administration of the compound.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: January 18, 2005
    Assignee: Washington University
    Inventor: Douglas F. Covey
  • Patent number: 6815553
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: November 9, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor V. Kolomitsyn, Chris F. Edwardson
  • Patent number: 6800317
    Abstract: This invention relates to phytosterols and phytostanols, in particular to fatty acid esters of phytosterols and phytostanols with a specified fatty acid composition. The invention further relates to methods for preparation of the phytosterol and phytostanol esters and their uses.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: October 5, 2004
    Assignee: Raisio Benecol Oy
    Inventors: Ingmar Wester, Jari Ekblom
  • Patent number: 6770767
    Abstract: A method for separating neutral substances from a soap containing the neutral substances, the method including the steps of: providing a mixture containing (1) the soap containing the neutral substances, (2) water optionally containing sodium sulfate and (3) a C1-C10 hydrocarbon solvent, and heating the mixture to a temperature of at least 140° C., to obtain a soap phase and a hydrocarbon phase containing the neutral substances, the heating step being conducted in a closed system under pressure, wherein the pressure in the system is at least equal to the vapor pressure of the mixture at the temperature used in the heating step; separating the hydrocarbon phase from the soap phase; and optionally separating the neutral substances from the hydrocarbon phase.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 3, 2004
    Assignee: Sterol Techologies Ltd.
    Inventor: Antti Hamunen
  • Patent number: 6762312
    Abstract: The present invention provides a process for producing a highly pure phytosterol, at high yield in particular, by an easy treatment from a crude fatty acid ester derived from a vegetable fat and/or oil. That is, the present invention provides a process for producing phytosterol, which comprises (A) bringing a crude fatty acid product derived from a vegetable fat and/or oil including phytosterol into contact with a mixed solvent of an organic solvent and water to crystallize the phytosterol and separating the crystals from the mixed solvent; or (B) mixing a crude fatty acid ester derived from a vegetable fat and/or oil including the phytosterol and a fatty acid ester with a lower alcohol, allowing the mixture to stand at a temperature of 1 to 40° C. to precipitate crystals including the fatty acid ester and separating the crystals to take the lower alcohol solution including the phytosterol.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: July 13, 2004
    Assignee: Kao Corporation
    Inventors: Yasuyuki Hattori, Jun Kono, Masamitsu Horio
  • Patent number: 6713466
    Abstract: A food additive useful for lowering serum cholesterol in humans contains a sterol or stanol ester of a fatty acid or a dicarboxylic acid ester of a sterol or stanol made by reacting a sterol, stanol and a carboxylic acid in the presence of an effective amount of a catalyst selected from the group consisting of calcium oxide, calcium hydroxide, a calcium salt of a carboxylic acid, magnesium hydroxide and combinations thereof described herein below.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: March 30, 2004
    Assignee: Cognis Corporation
    Inventors: Norman Milstein, Manfred Biermann, Peter Leidl, Rainer von Kries
  • Publication number: 20040030166
    Abstract: This invention relates to methods for treating distillates obtained during the process of deodorizing various oils. More particularly, this invention relates to methods for recovering fatty acids, tocopherols, and sterols from a distillate obtained from the deodorizing of various oils.
    Type: Application
    Filed: March 18, 2002
    Publication date: February 12, 2004
    Inventors: Dick Copeland, W. Maurice Belcher
  • Publication number: 20030144536
    Abstract: A process for isolating and purifying phytosterols and phytostanols from tall oil pitch is disclosed which comprises the following steps:
    Type: Application
    Filed: January 28, 2002
    Publication date: July 31, 2003
    Applicant: Forbes Medi-Tech Inc.
    Inventors: William E. Sonnier, Michael E. Schultz
  • Publication number: 20030139616
    Abstract: It is intended to find an efficient method of searching for drugs affecting the cholesteryl ester cycle and establish a system of efficiently searching for defoaming agents or regression agents artherosclerotic lesion and a system of searching for therapeutic agents remedies for atherosclerosis with a mechanism different from publicly known ones.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 24, 2003
    Inventors: Ryuichi Tozawa, Hiromitsu Fuse, Shunbun Kita, Masahira Nakamura
  • Patent number: 6589760
    Abstract: The invention provides a method of separating from corn fiber a lipid fraction having phytosterol esters and phytosterols where the method has the steps of: (a) heating an aqueous mixture of unground corn fiber; (b) contacting the mixture of step (a) with at least one enzyme suitable for digesting starch for a time and at a temperature suitable to provide a mixture of an essentially destarched corn fiber and a liquid comprising soluble carbohydrates; (c) contacting the mixture of step (a) or (b) with a protease enzyme to provide a proteolyzed corn fiber and a liquid; (d) separating the liquid of step (c) from the corn fiber to provide a destarched, proteolyzed corn fiber; and (e) extracting the destarched, proteolyzed corn fiber with at least one organic solvent. A corn fiber lipid fraction/organic solvent solution having phytosterol esters and phytosterols is provided.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: July 8, 2003
    Assignee: Eastman Chemical Company
    Inventors: Charles M. Buchanan, Norma L. Buchanan, John S. Debenham, Michael C. Shelton, Matthew D. Wood
  • Publication number: 20020192732
    Abstract: Disclosed is a method for quantifying cholesterol in HDL, which does not require complex fragmentation and separation operations, and by which the HDL cholesterol in test samples containing HDL and other lipoproteins such as low density lipoprotein (LDL), very low density lipoprotein (VLDL) and chylomicron (CM) may be quantified selectively, simply and accurately. The method for quantifying cholesterol in high density lipoprotein comprises a first step of erasing cholesterol in lipoproteins other than high density lipoprotein in a test sample, and a second step of adding a surfactant which specifically acts on high density lipoprotein to the product of the first step and enzymatically quantifying cholesterol in high density lipoprotein.
    Type: Application
    Filed: July 9, 2002
    Publication date: December 19, 2002
    Applicant: Denka Seiken Co., Ltd.
    Inventors: Hiroshi Matsui, Yasuki Ito, Shuichi Ohara, Akira Fujiwara
  • Publication number: 20020183530
    Abstract: The invention relates to a method of purifying phytosterol concentrates by contacting the phytosterol concentrate with a pressurized fluid. The invention also relates to the obtained purified phytosterol concentrate, foodstuff and animal feed premixes containing the same as well as to foodstuffs and animal feeds containing phytosterol concentrate.
    Type: Application
    Filed: January 4, 2002
    Publication date: December 5, 2002
    Applicant: DANISCO SUGAR OY
    Inventors: Olli Aaltonen, Sampsa Haarasilta, Pekka Piiroinen, Markku Rantakyla, Jouko Virtanen, Antti Kaipainen
  • Publication number: 20020160990
    Abstract: The present invention relates to a phytosterol and/or a phytostanol ester compound produced from the reaction of a phytosterol and/or a phytostanol with a polyunsaturated fatty acid (PUFA), wherein the polyunsaturated fatty acid has from 18 to 22 carbon atoms and at least three carbon-carbon double bonds. Processes for producing and compositions and a process for using such compositions are also provided.
    Type: Application
    Filed: November 23, 1999
    Publication date: October 31, 2002
    Inventors: DAVID CARL BURDICK, GERARD MOINE, DANIEL RAEDERSTORFF, PETER WEBER
  • Patent number: 6465665
    Abstract: A high efficiency continuous process for the recovering high purity sterol mixtures from mixtures of neutral compounds obtained form black liquor soap skimings of the cellulose pulping industry or from tall oil pitch comprising the steps of distillation, crystallization and recirculation of the mother liquor residue.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: October 15, 2002
    Inventor: Endre Markovits Schersl
  • Patent number: 6462210
    Abstract: The present invention relates to a fractionation process of the unsaponifiable material derived from black-liquor soaps of the cellulose industry. Through this procedure fractions that essentially contain free sterols, fatty alcohols, sterol esters and fatty alcohol esters respectively are separated. Fractions containing sterols or fatty alcohols can be used as such in the alimentary, cosmetic and pharmaceutical industries or they can be used as raw materials for transforming into other useful products.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: October 8, 2002
    Assignee: Harting, S.A.
    Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas
  • Publication number: 20020082434
    Abstract: The invention relates to a process for the production of sterols from residues of the distillation of oils, characterized in that the partial glycerides are subjected to a first transesterification step and, after working up and removal of impurities, the sterol esters are subjected to a second transesterification step under more extreme conditions.
    Type: Application
    Filed: August 7, 2001
    Publication date: June 27, 2002
    Inventors: Mehdi Bonakdar, Gerhard Wollmann, Bernhard Gutsche, Joerg Schwarzer
  • Publication number: 20020072620
    Abstract: Processes for purifying compounds are disclosed which include reacting (i) a mixture of at least one tocopherol compound or sterol compound, and an alcohol having from about 10 to 30 carbons with (ii) one or more boron-containing compounds to form a second mixture of orthoborate esters, wherein the mole ratio of tocopherol, sterol and alcohol to boron is at least about 2.5:1; heating the second mixture to form a residue containing the orthoborate esters; contacting the residue with a compound capable of solvolyzing the orthoborate esters to form a third mixture including the boron-containing compound(s), the alcohol and the tocopherol and/or sterol compound(s); and recovering the tocopherol and/or sterol compound(s).
    Type: Application
    Filed: August 3, 2001
    Publication date: June 13, 2002
    Inventors: Patrick M. McCurry, Stephen W. Turner, Carl Pickens, Jan R. Varvil
  • Patent number: 6399138
    Abstract: The invention concerns concentrates of shea sterols in glycerides with more than 12.5 wt % shea sterols, the preparation thereof by enzymic hydrolysis of glycerides in shea oils or fractions thereof and the application of the concentrates in aerated food products.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: June 4, 2002
    Assignee: Loders Croklaan B.V.
    Inventors: Frederick William Cain, John Bernard Harris, Stephen Raymond Moore, Gerald Patrick McNeill, Maarten Johan Klaassen
  • Patent number: 6399796
    Abstract: An improved process and composition are disclosed for isolation of steroids containing a 5,7-diene functionality from a sterol mixture that comprises formation of a Diels-Alder reaction product of the ster-5,7-dienol in the presence of at least a catalytic amount of an ethylenically unsaturated C12-C24 fatty carboxylic acid.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: June 4, 2002
    Assignee: Roche Vitamins Inc.
    Inventor: Michael M. Schwartz
  • Patent number: 6392070
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: May 21, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko
  • Publication number: 20020058827
    Abstract: The invention relates to a process for the production of sterols from fatty acid distillation residues, characterized in that the partial glycerides are subjected to a first transesterification step under mild conditions and, after working up and the removal of impurities, the sterol esters are subjected to a second transesterification step under more extreme conditions.
    Type: Application
    Filed: August 7, 2001
    Publication date: May 16, 2002
    Inventors: Gerhard Wollmann, Joerg Schwarzer, Bernhard Gutsche