Exactly One Oxygen Bonded Directly To The Cyclopentanohydrophenanthrene Ring System (e.g., 3-keto-bisnorcholenic Acids, 3-keto-bisnor-cholene-22 Als, Etc.) Patents (Class 552/555)
And oxygen bonded directly at the 20-position of the compound (Class 552/556)
  • Compounds effective in inducing cell differentiation and process for preparing same
    Patent number: 4927815
    Abstract: This invention provides novel side chain homologs of 1.alpha.,25-dihydroxyvitamin D.sub.3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: May 22, 1990
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Andrzej Kutner