Abstract: The invention relates to methods to manipulate stem cells in vivo and in vitro to treat, e.g., a condition where cell or tissue repair is needed.
Abstract: Described herein is the isomerisation process of 6&bgr;-fluorosteroids into the corresponding pharmacologically active 6&agr;-fluoro derivatives, comprising the reaction of 6&bgr;-fluorosteroids, or 6&agr;/6&bgr; isomeric mixtures, with an organic base containing a diazoimino group in a suitable organic solvent.
Type:
Grant
Filed:
May 16, 2001
Date of Patent:
April 9, 2002
Assignee:
Farmabios S.r.L
Inventors:
Gianfranco Cainelli, Achille Umani-Ronchi, Michele Contento, Sergio Sandri, Marco Da Col
Abstract: The invention relates to compounds of the formula:
in which R1, R2, R3, R4, R5, R6, n and X are as defined in the specification, and to pharmaceutical compositions containing them.
These compounds are excellent progestogens which are devoid of residual androgenic activity.
Type:
Grant
Filed:
November 5, 1998
Date of Patent:
January 30, 2001
Assignee:
Laboratoire Theramex
Inventors:
Alain Piasco, Jean Lafay, R{acute over (e)}mi Delansorne, Jacques Paris, Jean-Claude Pascal
Abstract: The present invention provides:the new use of compositions of morphine and compounds of Formula II wherein ##STR1## R.sup.1 is H or Me, preferably H; R.sup.2 is OH, preferably in alpha conformation;R.sup.3 is H;or R.sup.2 and R.sup.3, taken together, are O;R.sup.4 is H or Me, preferably Me and preferably in alpha conformation;R.sup.5 is H;R.sup.6 is H;or R.sup.5 and R.sup.6, taken together, are O;R.sup.7 is H or Me, preferably H;R.sup.8 =H,OH,OAc,SH,SAc,Cl,Br,Fincluding solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof, isomers thereof, and metabolites thereof.
Type:
Grant
Filed:
February 20, 1998
Date of Patent:
April 11, 2000
Assignee:
Monash University
Inventors:
Colin Stanley Goodchild, Raymond Nadeson
Abstract: Novel potentiating steroid carbamates having the general formula (I)ST-OCONR.sub.1 R.sub.2 (I)wherein ST is a steroid or steroid derivative, of the structure (II) ##STR1## optionally containing double bonds and additional oxygen substituents; the carbamate moiety OCONR.sub.1 R.sub.
Type:
Grant
Filed:
July 22, 1998
Date of Patent:
April 4, 2000
Assignee:
Satish BATRA
Inventors:
Satish Batra, Jan-Inge Carlsson, Thomas Fex
Abstract: The present invention relates to an oligonucleotide or analog thereof conjugated to a molecule comprising a structure, which structure (a) is of substantially fixed conformation; (b) contains, is directly attached to, or is attached to a carbon atom that is directly attached to, an first amine; and (c) contains, is directly attached to, or is attached to an atom that is directly attached to a phosphate, a second amine, or a cationic sulfur. In a preferred embodiment, the structure consists of at least a nonaromatic cyclic portion or substituted derivative thereof. In a specific embodiment, the structure is a nonaromatic cyclic compound. In another embodiment, the molecule is a steroid. In yet another particular aspect, the structure is an aromatic compound. In another embodiment, the structure can bind to a nucleic acid sequence in a nonintercalative manner.
Abstract: 20 -Methyl-5,7-pregnadiene-3.beta.,21-diol derivatives of general formula I ##STR1## in which R.sub.1 means a hydrogen atom or a lower alkyl group andR.sub.2 means a lower alkyl group orR.sub.1 and R.sub.2 together represent a tetramethylene group or a pentamethylene group and a process for their production are described.
Type:
Grant
Filed:
June 18, 1992
Date of Patent:
July 4, 1995
Assignee:
Schering Aktiengesellschaft
Inventors:
Alfred Weber, Mario Kennekke, Gunter Neef
Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or .dbd.0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula ##STR3## wherein R.sub.1 and R.sub.