Nitrogen Or Sulfur Containing Patents (Class 552/626)
  • Patent number: 5149696
    Abstract: Novel 19-nor-steroids of the formula ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2## having hormonal properties and their preparation and intermediates.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: September 22, 1992
    Assignee: Roussel Uclaf
    Inventors: Andre Claussner, Lucien Nedelec, Daniel Philibert, Patrick Van De Velde
  • Patent number: 5036062
    Abstract: The present invention concerns novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are selected form the group consisting of hydrogen or lower alkyl having 1-4 carbon atoms, wherein R.sup.2 and R.sup.3 together with the N atom can also form a ring having 2-5 carbon atoms and wherein n is 0, 1 or 2, and pharmaceutically acceptable salts thereof.The compounds according to the invention are useful as anticancer agents.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: July 30, 1991
    Assignee: Pharmacia AB
    Inventors: Bertil V. Hansen, Per-Olov G. Gunnarsson, Henri R. Mollberg, Sven-.ANG.ke Johansson
  • Patent number: 4954446
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: September 4, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Patent number: 4943566
    Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: July 24, 1990
    Assignee: Roussel Uclafi
    Inventors: Lucien Nedelec, Francois Nique, Daniel Philibert, Martine Moguilewsky, Marie-Madeleine Bouton
  • Patent number: 4938897
    Abstract: Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the fluorescent substance as an active ingredient. ##STR1## (wherein n is an integer of 0, 1, 2 or 3 and R represents a residual radical of a fluorescent material.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: July 3, 1990
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kiro Asano, Humio Tamura, Tsuyoshi Saito, Hisayuki Wada, Yoichi Suzuki