Abstract: Novel 19-nor-steroids of the formula ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2## having hormonal properties and their preparation and intermediates.
Type:
Grant
Filed:
February 23, 1990
Date of Patent:
September 22, 1992
Assignee:
Roussel Uclaf
Inventors:
Andre Claussner, Lucien Nedelec, Daniel Philibert, Patrick Van De Velde
Abstract: The present invention concerns novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are selected form the group consisting of hydrogen or lower alkyl having 1-4 carbon atoms, wherein R.sup.2 and R.sup.3 together with the N atom can also form a ring having 2-5 carbon atoms and wherein n is 0, 1 or 2, and pharmaceutically acceptable salts thereof.The compounds according to the invention are useful as anticancer agents.
Type:
Grant
Filed:
June 13, 1989
Date of Patent:
July 30, 1991
Assignee:
Pharmacia AB
Inventors:
Bertil V. Hansen, Per-Olov G. Gunnarsson, Henri R. Mollberg, Sven-.ANG.ke Johansson
Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
Type:
Grant
Filed:
July 14, 1989
Date of Patent:
September 4, 1990
Assignee:
SmithKline Beecham Corporation
Inventors:
Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.
Abstract: Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the fluorescent substance as an active ingredient. ##STR1## (wherein n is an integer of 0, 1, 2 or 3 and R represents a residual radical of a fluorescent material.