The 17 Alpha-position Substituent Contains Acyclic Carbon-to-carbon Unsaturation Patents (Class 552/631)
  • Patent number: 9314016
    Abstract: The present invention relates to a device for controlling rodents. More specifically, the present invention relates to a device consisting of a combination of a solid and a pulpy bait (commonly known as ‘fresh bait’ or ‘ paste bait’ in rodent control practice), wherein the solid part is a shaped paraffinized rodenticide bait with a rodenticide concentration which is lower than or equal to the rodenticide concentration of the combination and contains the pulpy rodenticide bait with a rodenticide concentration which is higher than or equal to the rodenticide concentration of the combination. The rodent control device according to the invention has an enhanced acceptance by the rodents and can preferably be fixed by a hole formed in the solid part preventing the rodents to take it away. Furthermore, the present invention relates to the preparation and use of such rodent control device.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: April 19, 2016
    Inventors: Dániel Bajomi, János Daru, Attila Halasi, Vince Pozsár, József Schmidt, János Szilágyi, László Takács, József Tomcsik
  • Patent number: 8357675
    Abstract: The invention relates to 17?-(5-hydroxy-C5-hydrocarbyl)-1,3,5(10)-estratrien-3,17?-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17?-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5?-esters and 3,5?-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-? or 3,5?-esterifÊcation.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: January 22, 2013
    Assignee: Euticals S.p.A.
    Inventors: Gillian Ashcroft, Mario Brufani, Francesca Ceccacci, Paolo Maria Farina, Luigi Filocamo, Barbara Garofalo, Roberta Joudioux, Adriana Maggi, Rinaldo Marini Bettolo, Luisa Maria Migneco
  • Publication number: 20110046599
    Abstract: Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.
    Type: Application
    Filed: June 26, 2008
    Publication date: February 24, 2011
    Inventor: Agis Kydonieus
  • Patent number: 7893284
    Abstract: The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: February 22, 2011
    Assignee: Sterix Limited
    Inventors: Matthew Leese, Atul Purohit, Michael John Reed, Simon Paul Newman, Surinder Kuman Chander, Fabrice Jourdan, Barry Victor Lloyd Potter
  • Publication number: 20030064973
    Abstract: The method of treating or preventing a disease in a human male or a male animal caused by a decreased production of androgens, such as testosterone, in the human male or male animal includes administering an effective amount of a glucocorticoid receptor antagonist to the human male or the male animal in order to increase production of the androgens. These diseases include male sexual dysfunction, infertility and hypogonadism. Novel androgen receptor antagonist compounds and methods of synthesis are also described.
    Type: Application
    Filed: August 13, 2002
    Publication date: April 3, 2003
    Inventors: Vladimir Patchev, Lothar Sobek, Gerd Schubert
  • Patent number: 5554602
    Abstract: The disclosed invention is drawn to the organometallic oestrogen complex of formula (I): ##STR1## in which A is a C.sub.1-7 alkylene radical or C.sub.2-7 alkenylene or alkynylene radical; M.sub.x is one or more identical or different transition metals; L'.sub.y is one or more identical or different ligands complexing the metal(s) of M.sub.x ; and L is a ligand for covalently coupling M.sub.x to A; and R is H or a C.sub.1-7 alkyl or alkoxy group which may be optionally substituted, particularly with one or more halogens. These complexes are useful for the treatment of hormone-dependent cancers. Also, when the metals of the complex M.sub.x are radioactive isotopes suitable for imaging, the complexes are useful as imaging agents.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: September 10, 1996
    Assignee: LaRegion Wallone
    Inventors: Siden Top, Anne Vessieres, G'erard Jaquen, Jacques Quivy