Nitro Or Carboxamide Containing Patents (Class 554/111)
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Patent number: 9006473Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: GrantFiled: October 8, 2012Date of Patent: April 14, 2015Assignees: The UAB Research Foundation, The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Patent number: 8937194Abstract: Activated fatty acids, topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.Type: GrantFiled: June 30, 2011Date of Patent: January 20, 2015Assignee: Nitromega Corp.Inventor: Raymond A. Miller
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Patent number: 8933255Abstract: Activated fatty acids, nutraceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: GrantFiled: December 31, 2009Date of Patent: January 13, 2015Assignee: Nitromega Corp.Inventor: Raymond A. Miller
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Publication number: 20140256814Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: ApplicationFiled: March 11, 2014Publication date: September 11, 2014Applicant: COMPLEXA, INC.Inventor: Raymond A. Miller
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Patent number: 8816107Abstract: Stable complexes are described, formed by mono- and di-functional compounds bound to nanoparticles composed of various types of transition metal oxides and of metals useful in the production processes of different types of new materials (such as for example some types of hydrophile plastics, fibers); processes for the production of the complexes are also described.Type: GrantFiled: January 3, 2007Date of Patent: August 26, 2014Assignee: Colorobbia Italia S.p.A.Inventors: Giovanni Baldi, Alfredo Ricci, Mauro Comes Franchini, Daniele Bonacchi, Marco Bitossi
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Patent number: 8636996Abstract: The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.Type: GrantFiled: May 6, 2005Date of Patent: January 28, 2014Assignee: Emisphere Technologies, IncInventors: Halina Levchik, Shingai Majuru, Brahma Singh, Jamila Harris
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Publication number: 20140024713Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.Type: ApplicationFiled: July 17, 2013Publication date: January 23, 2014Applicant: University of Utah Research FoundationInventor: Tianxin YANG
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Publication number: 20130303444Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.Type: ApplicationFiled: April 5, 2013Publication date: November 14, 2013Applicant: Emisphere Technologies, Inc.Inventors: Nikhil DHOOT, Steven DINH, Shingai MAJURU, William Elliott BAY, JoAnne P. CORVINO, Doris C. O'TOOLE
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Publication number: 20130210917Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: ApplicationFiled: October 8, 2012Publication date: August 15, 2013Applicants: THE UAB RESEARCH FOUNDATION, Morehouse School of Medicine, Inc., University College Cardiff Consultants Limited, State of Oregon Acting By and Through the Board of Education on Behalf of the University of OregonInventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Publication number: 20130178534Abstract: There is described primarily N-nonanoylvanillylamine for use in a therapeutic method as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer, as well as the non-therapeutic use of N-nonanoylvanillylamine as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer. The non-therapeutic use of corresponding substance mixtures is also further described. Finally, the invention relates also to orally consumable products (in particular foodstuffs, feeds and medicaments) comprising N-nonanoylvanillylamine, wherein the N-nonanoylvanillylamine is present in a concentration that (a) reduces the appetite and/or (b) brings about a feeling of fullness and/or (c) enhances the mood, but which concentration is low.Type: ApplicationFiled: January 8, 2013Publication date: July 11, 2013Applicant: Symrise AGInventor: Symrise AG
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Publication number: 20130137768Abstract: The present invention relates to the docosahexaenoatepanthenyl of the following formula: It also relates to a method for preparing same and to a pharmaceutical composition comprising same and to the use of same in the treatment or the prevention of cardiovascular diseases, in particular atrial fibrillation.Type: ApplicationFiled: August 11, 2011Publication date: May 30, 2013Applicant: PIERRE FABRE MEDICAMENTInventors: Frédérique Lantoine-Adam, Robert Letienne, Elisabeth Dupont-Passelaigue
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Patent number: 8450509Abstract: The invention relates to a method for synthesizing 9-aminononanoic acid or the esters thereof from natural unsaturated fatty acids, comprising at least one step of metathesis of the natural fatty acid and an oxidation step by oxidative cleaving. Said synthetic method uses widely available renewable starting materials and hence economical.Type: GrantFiled: July 9, 2009Date of Patent: May 28, 2013Assignee: Arkema FranceInventor: Jean-Luc Dubois
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Publication number: 20130059911Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: ApplicationFiled: November 1, 2012Publication date: March 7, 2013Applicant: Centre de Recherche sur les Biotechnologies MarinesInventor: Centre de Recherche sur les Biotechnologies Mari
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Publication number: 20130012583Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: ApplicationFiled: September 12, 2012Publication date: January 10, 2013Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, COMPLEXA, INC.Inventors: Bruce A. FREEMAN, Bruce BRANCHAUD
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Publication number: 20110082206Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: ApplicationFiled: October 1, 2010Publication date: April 7, 2011Inventor: Raymond A. Miller
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Patent number: 7776916Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: GrantFiled: April 26, 2005Date of Patent: August 17, 2010Assignees: The UAB Research Foundation, University of OregonInventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Publication number: 20100104629Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.Type: ApplicationFiled: September 10, 2009Publication date: April 29, 2010Applicant: ABBOTT LABORATORIESInventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
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Publication number: 20100099738Abstract: Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.Type: ApplicationFiled: September 10, 2009Publication date: April 22, 2010Applicant: ABBOTT LABORATORIESInventors: Todd M. Hansen, Robert D. Hubbard, Leiming Li, Lu Tian, Carol K. Wada, Xiaobin Zhao
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Publication number: 20090263407Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.Type: ApplicationFiled: April 16, 2009Publication date: October 22, 2009Applicant: ABBOTT LABORATORIESInventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Carol K. Wada, Lu Tian, Xiaobin Zhao
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Patent number: 7253296Abstract: The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.Type: GrantFiled: February 12, 2004Date of Patent: August 7, 2007Assignee: GenfitInventors: Raphaël Darteil, Karine Caumont-Bertrand, Jamila Najib
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Patent number: 6924309Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A? is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B? is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: GrantFiled: March 18, 2002Date of Patent: August 2, 2005Assignees: Children, Youth and Women's Health Service Incorporated, Peptech LimitedInventors: Antonio Ferrante, Christopher J. Easton, Ling Xia
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Publication number: 20040192771Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: ApplicationFiled: December 24, 2003Publication date: September 30, 2004Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6696606Abstract: A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.Type: GrantFiled: July 8, 2002Date of Patent: February 24, 2004Assignee: The Ohio State University Research FoundationInventors: Robert W. Curley, Jr., Serena M. Mershon
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Patent number: 6071510Abstract: The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present invention include N-acylated or sulfonated amino acids. These modified amino acids are used as carriers to facilitate the delivery of a cargo to a target. Such modified amino acids are well suited to form non-covalent mixtures with biologically-active agents for oral administration to animals. Methods for the preparation and administration of the modified amino acids and compositions including the same are also provided.Type: GrantFiled: April 23, 1997Date of Patent: June 6, 2000Assignee: Emisphere Technologies, Inc.Inventors: Andrea Leone-Bay, Koc-Kan Ho, Jeffery Bruce Press, Nai-Fang Wang
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Patent number: 5990165Abstract: A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R.sup.1 is --CO.sub.2 H, R.sup.2 is hydrogen or C.sub.1-4 alkyl andR.sup.3 is hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C.sub.1-4 alkyl, optionally substituted phenyl C.sub.2-10 alkenyl,(optionally substituted phenyl).sub.2 -C.sub.1-4 alkyl, optionally substituted C.sub.3-7 cycloalkyl, optionally substituted C.sub.3-7 cycloalkyl-C.sub.1-4 alkyl or optionally substituted C.sub.3-7 cycloalkyl-C.sub.2-10 alkenyl, orR.sup.2 and R.sup.3, together with the carbon atom to which they are attached, form an optionally substituted C.sub.4-7 cycloalkyl group;or a salt or ester thereof other than the compounds .gamma.-propylidene-L-glutamic acid, .gamma.-ethylidene-L-glutamic acid and .gamma.-methylidene-L-glutamic acid.Type: GrantFiled: March 24, 1998Date of Patent: November 23, 1999Assignee: Lilly, S.A.Inventors: Concepcion Pedregal Tercero, Almudena Rubio Esteban
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Patent number: 5879681Abstract: Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopoly-saccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.Type: GrantFiled: February 7, 1997Date of Patent: March 9, 1999Assignee: Emisphere Technolgies Inc.Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold
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Patent number: 5876710Abstract: Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopolysaccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.Type: GrantFiled: February 7, 1997Date of Patent: March 2, 1999Assignee: Emisphere Technologies Inc.Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold
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Patent number: 5734069Abstract: Compounds of the formula R--?C(O)O(CH.sub.2).sub.1-5 !.sub.0-1 --C(O)NH(CH.sub.2).sub.2-5 --N(R.sup.2)--(CH.sub.2).sub.2-5 --OC(O)R.sup.1 wherein R and R.sup.1 are each C.sub.8 -C.sub.22 alkyl or alkenyl and R.sup.2 is C.sub.1 -C.sub.3 alkyl or hydroxyalkyl, benzyl, or --C.sub.2 H.sub.4 OC(O)R.sup.4 wherein R.sup.4 is C.sub.8 -C.sub.22 alkyl or alkenyl, and acid salts and derivatives of such compounds quaternized with methyl, ethyl or benzyl, exhibit useful fabric softening and static reduction properties, as well as biodegradability.Type: GrantFiled: September 14, 1994Date of Patent: March 31, 1998Assignee: Sherex Chemical Co., Inc.Inventors: Christopher Joseph Toney, Floyd D. Friedli
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Patent number: 5659049Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Patent number: 5508444Abstract: Novel substituted cis-1,2-dihydroxy-cyclohexadiene compounds, useful as intermediates in the production of compounds for use as intermediates in the production of agrochemicals and pharmaceuticals, and a microbial process for the preparation thereof.Type: GrantFiled: November 17, 1994Date of Patent: April 16, 1996Assignee: Zeneca LimitedInventors: Andrew J. Blacker, Martin Brown, Martin C. Bowden
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Patent number: 5439937Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R.sup.1 is alkyl;R.sup.2 is hydrogen, alkyl;R.sup.6 is alkyl;n is 1 to 5;p is 0 to 6;x is 0 or 2; andR.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.Type: GrantFiled: March 3, 1994Date of Patent: August 8, 1995Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Stephen H. Docter, Stella S. Yu
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Patent number: 5174917Abstract: N-ethyl hydroxamic acids, preferably containing at least 10 carbon atoms, useful as metal chelants for use in organic solvent extractant solutions such as kerosene to extract metals from aqueous solutions by forming complexes of the extracted metal with the N-ethyl hydroxamic acid. Metals can be stripped from complexes of N-ethyl hydroxamic acids at higher concentrations into lower strength acid stripping agents. The N-ethyl hydroxamic acid-containing organic solvent extraction solutions exhibit rapid phase separation from aqueous solutions and resistance to forming emulsions.Type: GrantFiled: July 19, 1991Date of Patent: December 29, 1992Assignee: Monsanto CompanyInventor: Bruce F. Monzyk