Abstract: The invention relates to fatty acid guanidine or salicylate guanidine derivatives; compositions comprising an effective amount of a fatty acid guanidine or salicylate guanidine derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid guanidine or salicylate guanidine derivative.
Type:
Grant
Filed:
April 27, 2012
Date of Patent:
October 6, 2015
Assignee:
Catabasis Pharmaceuticals, Inc.
Inventors:
Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu, Amal Ting
Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
Type:
Grant
Filed:
September 17, 2007
Date of Patent:
March 31, 2009
Assignee:
Multi Formulations Ltd
Inventors:
Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom
Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
Type:
Grant
Filed:
September 17, 2007
Date of Patent:
March 31, 2009
Assignee:
Multi Formulations Ltd
Inventors:
Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom
Abstract: The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH3—(CH2)n—CH—(CH2)m CO2H where n=4 to 9 m−8 to 16. More particularly, the present invention relates to a process for he preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.
Type:
Application
Filed:
March 28, 2002
Publication date:
February 5, 2004
Inventors:
Vishwa Nath Gupta, Vikram Bhardwaj, Bhupinder Singh, Bal Krishan Chandan, Krishan Avtar Suri, Naresh Kumar Satti, Om Parkash Suri, Sukhdev Swami Handa
Abstract: An improved process for preparing phenyl esters of alkanoyloxyacetic acids in which phenyl chloroacetate is reacted with the salt of a carboxylic acid.
Type:
Grant
Filed:
March 25, 1991
Date of Patent:
August 10, 1993
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Bijan Amini, Donald J. Dumas, Ronald A. Fong, George C. Sonnichsen