Acyclic Carbon-to-carbon Unsaturation In The Acid Moiety (e.g., Ricinoleic Acid, Castor Oil, Etc.) Patents (Class 554/219)
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CASTOR OIL FATTY ACID BASED ESTOLIDE ESTERS AND THEIR DERIVATIVES AS POTENTIAL LUBRICANT BASE STOCKS
Publication number: 20110282084Abstract: Castor oil was hydrolysed to castor fatty acids and self condensed to get a ricinoleic acid-based estolide of about acid value. The carboxylic group of the estolide on subsequent esterification with linear or branched chain alcohols and also on acetylation of free hydroxy group yielded castor oil fatty acids based estolide esters and their acetates. All the products were evaluated for total acid number (TAN), viscosity, viscosity index, pour point, flash point, and copper strip corrosion and found to be potential lubricant basestocks.Type: ApplicationFiled: May 14, 2009Publication date: November 17, 2011Applicant: Council of Scientific & Industrial ResearchInventors: Satya Bhaskar Potula, Venkata Padmaja Korlipara, Venkata Surya Koppeswara Rao Bhamidipati, Saravanan Krishnasamy, Badari Narayana Prasad Rachapudi -
Publication number: 20110268800Abstract: A preparation having at least one unsaturated fatty acid and the use of at least one unsaturated fatty acid having a chain length of 18 or 20 carbon atoms and of plant drugs containing the unsaturated fatty acid as a free fatty acid or a fatty acid radical of a triglyceride. The fatty acid has a chain length of 18 carbon atoms which are provided with 1 to 3 double bonds and the fatty acid has a chain length of 20 carbon atoms which are provided with 1 to 4 double bonds. The double bond or one of the double bonds are located in position 9 or 11 of the carbon chain. The unsaturated fatty acid is supplied in the all-cis configuration. The at least one unsaturated fatty acid prevents and/or treats or is used for producing a preparation for preventing and/or treating thrombosis and thromboembolic diseases.Type: ApplicationFiled: June 21, 2011Publication date: November 3, 2011Applicant: LTS Lohmann Therapie-Systeme AGInventor: Hans-Rainer Hoffmann
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Patent number: 7994346Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.Type: GrantFiled: November 3, 2006Date of Patent: August 9, 2011Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Danja Grossbach, William Guilford, Michael Sander
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Patent number: 7985820Abstract: A non-water soluble polymeric surfactant is prepared by reacting a polymerized/bodied unsaturated oil with maleic anhydride followed by a further partial or complete reaction with an amine to form an amide; or an alcohol to form an ester.Type: GrantFiled: October 15, 2007Date of Patent: July 26, 2011Assignee: Sun Chemical CorporationInventors: Ramasamy Krishnan, Kenneth Smith, Neil Young, Inessa Gurevich
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Publication number: 20110178047Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.Type: ApplicationFiled: December 29, 2010Publication date: July 21, 2011Applicant: MARTEK BIOSCIENCES CORPORATIONInventors: Linda Arterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Mary Van Elswyk
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Patent number: 7973187Abstract: Natural oil based halogenated compounds that are useful as flame retardants for polymeric materials, such as polyurethanes. Novel compositions of matter, novel processes for preparing such compositions of matter, and end use applications of the novel compositions of matter. The process comprises the reaction of natural oil hydroxylates with halogenated reactive materials such as halogenated anhydrides of organic acids or their esters in the presence of a titanium catalyst.Type: GrantFiled: March 10, 2009Date of Patent: July 5, 2011Assignee: BioBased Technologies, LLCInventor: Ning Luo
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Publication number: 20110150981Abstract: A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, Wand R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR5; wherein R5 is alkyl or haloalkyl, and A is O, SType: ApplicationFiled: April 22, 2009Publication date: June 23, 2011Applicant: Bangor UniversityInventors: Mark Stephen Baird, Juma' a Raheem Najeem Al-Dulayymi, Cornelias Theunissen, Gani Koza, Seppe Vander Beken, Johan Adriann March Grooten
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Publication number: 20110118347Abstract: A compound of the formula CH3(CH2)n—RA—(CH2)m-(CH?CH)q—(CH2)p—X wherein RA=(a); q=0 or 1; m and p are independently selected integers of at least 1; n=0 or an integer of at least 1; X is a polar group selected from —CO2RS, where Rs?H, Na, K, —NHRI, —NRIRII or RIII; —CH3OH; —CH3NH2; —CH3NHRI; or —CH3NRIRII; wherein RI, RII and RIII are independently selected from C1-C6 alkyl or an aryl group, preferably a hydrophilically substituted C1-C6 alkyl or aryl group, or RIII is an esterified glycol; and wherein 20>m+n+p+2q?2; is useful for the treatment of ringworm infection caused by Trichophyton tonsurans.Type: ApplicationFiled: May 29, 2009Publication date: May 19, 2011Applicant: Vernolix LimitedInventor: Michael William Fowler
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Publication number: 20110112191Abstract: Disclosed are novel oxylipins that are derived from ?-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.Type: ApplicationFiled: January 19, 2011Publication date: May 12, 2011Applicant: Martek Biosciences, CorporationInventors: Linda Mary Arterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Dutt Vinjamoori
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Publication number: 20100267828Abstract: The present disclosure relates to compounds of the general formula (I): wherein R1 and R2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; or any pharmaceutically acceptable salt, solvate, complex, or pro-drug thereof; and their use as medicaments for the treatment of various diseases and conditions, for example, reduction of elevated triglyceride levels, i.e., hypertriglyceridemia, reduction of non-HDL cholesterol, reduction of glucose and HbA1c, and improvement of insulin resistance. The present disclosure also relates to a pharmaceutical composition comprising compounds of formula (I), as well as to processes for preparing compounds according to formula (I).Type: ApplicationFiled: October 30, 2008Publication date: October 21, 2010Inventors: Anne Kristin Holmeide, Ragnar Hovland
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Patent number: 7763743Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.Type: GrantFiled: November 3, 2006Date of Patent: July 27, 2010Assignee: Bayer Schering Pharma AGInventors: Danja Grossbach, William Guilford, Michael Sander
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Publication number: 20100168455Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.Type: ApplicationFiled: July 15, 2009Publication date: July 1, 2010Applicants: Carnegie Institution of Washington, Monsanto Company, Inc.Inventors: Chris SOMERVILLE, Pierre BROUN, Frank VAN DE LOO, Sekhar S. BODDUPALLI
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Publication number: 20100159540Abstract: Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ?-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.Type: ApplicationFiled: March 26, 2008Publication date: June 24, 2010Inventors: Ana Rodriguez, Bernd Spur
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Patent number: 7737178Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.Type: GrantFiled: December 18, 2008Date of Patent: June 15, 2010Assignee: The Brigham and Woman's Hospital, Inc.Inventors: Charles N. Serhan, Clary B. Clish
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Publication number: 20100130718Abstract: The invention relates to new diols and polyols which are hydroxypropyl esters of hydroxycarboxylic or polycarboxylic acids. The new diols and polyols are useful as monomer compounds and reactive solvents.Type: ApplicationFiled: March 26, 2008Publication date: May 27, 2010Applicant: COGNIS IP MANAGEMENT GMBHInventors: Joaquin Bigorra Llosas, Luis Llaurdo, Francesc Gusi
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Publication number: 20100084603Abstract: A process for the preparation of new polyols and polyesters from a natural oil or other unsaturated fatty acid esters is described. The process involves ozone cleavage of double bonds in the fatty acid chains of the oils along with coupling of a hydroxylated compound such as a mono-alcohol, a diol, or a polyol to the cleaved ends of the molecules resulting from the cleavage with a base. The resulting polyols and polyesters are as intermediates for polymers.Type: ApplicationFiled: September 15, 2009Publication date: April 8, 2010Applicants: Board of Trustees of Michigan State University, Bioplastic Polymers and Composites, LLCInventors: Ramani Narayan, Daniel Graiver, Kenneth W. Farminer, Phuong T. Tran, Tam Tran
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Publication number: 20090281199Abstract: [Problems] Among cleansing cosmetics for the purpose of removing makeup, the aqueous type cleansing cosmetics containing no oil at all or a small amount of oil have had a disadvantage that remover capability is weak even though they give reduced oily feel after cleansing. The liquid oil-based makeup remover has a low viscosity so that there has been a disadvantage in usefulness that the liquid oil-based makeup remover drips off upon taking on hand. An object of the present invention is to provide a composition for cosmetics which is excellent in usefulness, has excellent affinity to makeup soil, quickly suspends soil, and is excellent in stability and rinsability.Type: ApplicationFiled: June 12, 2006Publication date: November 12, 2009Inventors: Shinichiro Hiyama, Yoshihiko Takase, Shuji Hibino
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Publication number: 20090281185Abstract: Leukotriene B4, 5S,12R-dihydroxy-6,8,10,14(Z,E,E,Z)-eicosatetraenoic acid, is a twenty carbon tetra-unsaturated fatty acid. No crystal forms of leukotriene B4 (LTB4) are known in the art. The present inventors have discovered a crystal form of LTB4 and the present invention therefore relates to crystal forms of LTB4 in general, and the novel crystal form A of LTB4 in particular.Type: ApplicationFiled: March 30, 2007Publication date: November 12, 2009Inventor: Karol Horvath
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Patent number: 7595341Abstract: The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ?-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.Type: GrantFiled: April 30, 2008Date of Patent: September 29, 2009Assignees: Resolvyx Pharmacuticals, Inc., The Brigham and Women's HospitalInventors: Daniel W. Goodman, Michael R. Hanley, Stuart L. Bursten, Charles N. Serhan
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Publication number: 20090238784Abstract: The invention relates to unsaturated fatty hydroxy acid derivatives of formula (I), wherein Rn is independent from each other H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom, R1 is H, F, Cl, Br or CF3, R is H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom and 3=n=14. Said derivatives is suitable for producing an anti-radical, anti-inflammatory and antipruritic dermocosmetologic composition and/or for treating keratinisation and pigmentation troubles and/or for improving healing.Type: ApplicationFiled: October 20, 2006Publication date: September 24, 2009Applicant: Pierre Fabre Dermo-CosmetiqueInventors: Marie Charveron, Roger Tarroux, Pascal Bordat
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Publication number: 20090234037Abstract: Natural oil based halogenated compounds that are useful as flame retardants for polymeric materials, such as polyurethanes. Novel compositions of matter, novel processes for preparing such compositions of matter, and end use applications of the novel compositions of matter. The process comprises the reaction of natural oil hydroxylates with halogenated reactive materials such as halogenated anhydrides of organic acids or their esters in the presence of a titanium catalyst.Type: ApplicationFiled: March 10, 2009Publication date: September 17, 2009Inventor: Ning Luo
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Patent number: 7579494Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: GrantFiled: August 13, 2007Date of Patent: August 25, 2009Assignee: The Brigham and Women's Hospital, Inc.Inventor: Charles N. Serhan
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Publication number: 20090156845Abstract: The invention relates to acrylate modified, natural fatty acid based hybride polymers, and to a method for their preparation. The invention also relates to the use of the modified natural fatty acid based hybride polymers as binding agents especially in water based coatings, adhesives and composites and as environmentally friendly wood impregnating agents. The acrylate-modified natural fatty acid based hybride polymer is a block polymer formed of acrylate segments and fatty acid segments.Type: ApplicationFiled: March 2, 2007Publication date: June 18, 2009Applicant: Valtion teknillinen tutkimuskesusInventors: Nina Heiskanen, Pia Willberg, Salme Koskimies, Janne Hulkko, Pirita Ushanov, Sirkka-Liisa Maunu
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Publication number: 20090149538Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.Type: ApplicationFiled: December 18, 2008Publication date: June 11, 2009Inventors: Charles N. Serhan, Clary B. Clish
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Publication number: 20090131701Abstract: A process for enzymatic production of glyceride compositions, specifically industrially practicable production of triglycerides, including conjugated linoleic and linolenic acid triglycerides, and the compositions produced by such process. An enzymatic reaction zone is first utilized, in which a mixture of glycerol and fatty acids or fatty acid derivatives is reacted in the presence of an enzymatic catalyst to form 1,3 diglycerides. The mixture is then circulated through a second thermal rearrangement zone, maintained at a higher temperature, to promote rearrangement of the 1,3 diglycerides to 1,2 diglycerides. Triglycerides are produced by re-circulating the mixture through the enzymatic production zone.Type: ApplicationFiled: January 29, 2004Publication date: May 21, 2009Applicant: STEPAN COMPANYInventors: Jenifer Heydinger Galante, Steven L. Clauss, Randal J. Bernhardt, Alfred K. Schultz
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Patent number: 7491836Abstract: New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.Type: GrantFiled: April 13, 2004Date of Patent: February 17, 2009Assignee: AstraZeneca ABInventors: Christian von Corswant, Karl Hult, Erik Söderlind, Fredrik Viklund
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Publication number: 20080227993Abstract: The present invention is a method for making a class of molecules synthesized from unsaturated plant oils, and the synthesized class of molecules, such that when compounded with saturated plant oils they improve the physical properties such as low temperature behavior, measured as cold filter plug point and cloud point for biodiesel fuels and pour point for oils and lubricants, as well as other physical properties including viscosity and viscosity index, so that the physical properties of the combined materials approach the physical properties of unsaturated plant oils and find use as base material feed stocks for “Green” fuel, oil, and lubricant products.Type: ApplicationFiled: March 17, 2007Publication date: September 18, 2008Inventor: Matthew Mark Zuckerman
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Publication number: 20080139831Abstract: An emulsion stabilizer is disclosed having a water tolerance value of between more than about 1.0 and equal or less than about 11.0.Type: ApplicationFiled: October 15, 2007Publication date: June 12, 2008Applicant: Sun Chemical CorporationInventors: Nobuo Harui, Hideo Ishii
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Patent number: 7378444Abstract: The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ?-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.Type: GrantFiled: June 13, 2003Date of Patent: May 27, 2008Assignees: Brigham and Women's Hospital, Inc., Resolvyx Pharmaceuticals, Inc.Inventors: Daniel W. Goodman, Michael R. Hanley, Stuart L. Bursten, Charles N. Serhan
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Patent number: 7294728Abstract: Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.Type: GrantFiled: September 8, 2005Date of Patent: November 13, 2007Inventor: Charles N. Serhan
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Patent number: 7227031Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: GrantFiled: April 13, 2005Date of Patent: June 5, 2007Assignee: The Brigham and Women's Hospial, Inc.Inventor: Charles N. Serhan
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Patent number: 7053230Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.Type: GrantFiled: September 12, 2003Date of Patent: May 30, 2006Inventors: Charles N. Serhan, Clary B. Clish
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Patent number: 6960674Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: GrantFiled: February 13, 2003Date of Patent: November 1, 2005Assignee: The Brigham & Women's Hospital, Inc.Inventor: Charles N. Serhan
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Patent number: 6903135Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from, thromboembolic stroke.Type: GrantFiled: February 27, 2003Date of Patent: June 7, 2005Assignees: Board of Regents, The University of Texas System, New York Medical College, The University of Vermont and State Agricultural CollegeInventors: John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
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Patent number: 6897257Abstract: A process for synthesizing copolymers of ethylenically unsaturated monomers with ethylenically unsaturated derivatives of fatty acids and/or oils via emulsion polymerization techniques is performed in two stages. One or more suitable ethylenically unsaturated monomers are polymerized in the first stage of an emulsion polymerization. The ethylenically unsaturated derivatives of fatty acids and/or oils are blended with other monomers and polymerized in a second stage of the polymerization reaction. A suitable surfactant is added to the polymerization mixture to facilitate formation of the emulsion. In a preferred embodiment, the surfactant is a hybrid surfactant, i.e., one having both anionic and non-ionic characteristics.Type: GrantFiled: April 8, 2002Date of Patent: May 24, 2005Assignee: The University of Southern MississippiInventors: Shelby F. Thames, Oliver W. Smith, Sheng Chen, Catherine C. Blackwell
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Patent number: 6727314Abstract: A composition comprising a polymer, wherein the polymer comprises at least one of: i) a blend of a first polymer comprising a reaction product of acetoacetoxyethyl (meth)acrylate monomer and a second polymer comprising a reaction product of castor oil (meth)acrylate monomer, and ii) a third polymer comprising a reaction product of acetoacetoxyethyl (meth)acrylate monomer and castor oil (meth)acrylate monomer. These polymer compositions can be cured by at least one of auto-oxidation and actinic radiation. Optionally, at least a portion of the acetoacetoxyethyl (meth)acrylate moieties in the polymer can be converted to a corresponding enamine by reaction with at least one of ammonia and an amine.Type: GrantFiled: December 13, 2001Date of Patent: April 27, 2004Assignee: BASF AGInventors: Armin Burghart, Robert Shane Porzio, Dieter Urban
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Patent number: 6710082Abstract: A thickener composition containing a reaction product of a hydroxycarboxylic acid selected from the group consisting of tartaric acid, malic acid, citric acid and mixtures thereof, and a fatty alcohol polyglycol ether corresponding to formula I: R1O(CH2CH2O)nH (I) wherein R1 is an alkyl and/or alkenyl group containing from 6 to 22 carbon atoms, and n is a number from 20 to 150.Type: GrantFiled: May 25, 1999Date of Patent: March 23, 2004Assignee: Cognis Deutschland GbmH & Co. KGInventors: Rafael Pi Subirana, Ester Prat Queralt, Joaquim Bigorra Llosas
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Patent number: 6700006Abstract: Novel compounds derived from traditional semi- drying and non-drying oils featuring internally plasticizing and crosslinkable properties are disclosed and claimed. Preferred embodiments include acrylate or methacrylate esters of hydroxy long-chain olefinic compounds derived from castor oil or lesquerella oil. A process for the preparation of the novel compounds is also disclosed, which involves esterification reaction of ethylenically unsaturated carboxylic acids or its derivatives with substituted hydroxy long-chain olefinic compounds. These compounds are suitable for forming latices, which form films at low minimum film forming temperatures (MFT) ranging from −5 to 10° C. and cure to above ambient glass transition (Tg) polymers without the use of traditional organic cosolvents which contribute to environmental pollution via volatile organic compounds (VOCs) emissions. These latices are therefore useful in waterborne coatings, contact and pressure sensitive adhesives, and inks.Type: GrantFiled: April 10, 2001Date of Patent: March 2, 2004Assignee: University of Southern MississippiInventors: Shelby Freland Thames, Kamlesh Gopichand Panjnani, Rajan Hariharan, Zhiyu Wang
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Patent number: 6653493Abstract: Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.Type: GrantFiled: March 9, 2001Date of Patent: November 25, 2003Assignee: The Brigham and Women's HospitalInventor: Charles N. Serhan
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Patent number: 6624223Abstract: Novel latex or emulsion compositions containing internally plasticizing and crosslinkable monomers derived from traditional semi-drying or non-drying oils are disclosed and claimed. The monomers are ethylenically unsaturated esters of long-chain olefinic compounds. Preferred embodiments include latex formed from acrylate or methacrylate esters of hydroxy fatty acid esters derived from castor oil or lesquerella oil. A process for the synthesis of the latex composition is also disclosed, which involves (a) an esterification reaction of ethylenically unsaturated carboxylic acid or its derivatives with a substituted hydroxy long-chain olefinic compound; (b) subsequent polymerization of the so formed ethylenically unsaturated ester of a long-chain olefinic compound in an aqueous phase with at least one other copolymerizable monomer; and (c) blending so formed polymer with at least one drier and a surfactant to form the novel latex or emulsion compositions.Type: GrantFiled: December 14, 1999Date of Patent: September 23, 2003Assignee: University of Southern MississippiInventors: Shelby Freland Thames, Zhiyu Wang, Elizabeth H. Brister, Rajan Hariharan, Corey L. King, Kamlesh Gopichand Panjnani
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Patent number: 6599972Abstract: Novel latex or emulsion compositions containing internally plasticizing and crosslinkable monomers derived from traditional semi-drying or non-drying oils are disclosed and claimed. The monomers are ethylenically unsaturated derivatives of long-chain olefinic compounds. Preferred embodiments include latex formed from acrylate or methacrylate esters of fatty alcohols. A process for the synthesis of the latex composition is also disclosed, which involves (a) polymerization of the ethylenically unsaturated derivatives of a long-chain olefinic compound in an aqueous phase with at least one other copolymerizable monomer; and (b) blending of so formed polymer with at least one drier and a surfactant to form the novel latex or emulsion compositions. These compositions form films at low minimum film forming temperatures (MFT) ranging from −5 to 10° C.Type: GrantFiled: January 12, 2001Date of Patent: July 29, 2003Assignee: University of Southern MississippiInventors: Shelby Freland Thames, Kamlesh Gopichand Panjnani, Olan Stanley Fruchey
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Publication number: 20030139376Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): 1Type: ApplicationFiled: October 22, 2002Publication date: July 24, 2003Applicant: Schering AktiengesellschaftInventors: John G. Bauman, William J. Guilford, John F. Parkinson, Werner Skuballa, Babu Subramanyam
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Patent number: 6582941Abstract: The present invention relates to the Schizochytrium genus SR21 strain and a microorganism belonging to the same species as does said SR21 strain or having substantially the same fungological properties as does said SR21 strain, the said SR21 strain and microorganism having the ability to produce the (n-3) series of docosahexaenoic acid (DHA) and the (n-6) series of docosapentaenoic acid (DPA), and the invention also relates to a process for preparing the (n-3) series of DHA and the (n-6) series of DPA utilizing said microorganisms. The microorganisms according to the present invention are superior in their proliferation character and their propensity to produce fat, and have the ability to produce the (n-3) series of DHA and the (n-6) series of DPA very well. Accordingly, it is possible to effectively produce the (n-3) series of DHA and/or the (n-6) series of DPA, which are useful in the fields of foods and pharmaceuticals, using the microorganisms according to the present invention.Type: GrantFiled: December 29, 1997Date of Patent: June 24, 2003Assignees: Japan as represented by Director-General of Agency of Industrial Science and Technology, Suntory LimitedInventors: Toshihiro Yokochi, Toro Nakahara, Takanori Higashihara, Satohiro Tanaka, Toshiaki Yaguchi
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Patent number: 6437160Abstract: 3-heteroatom substituted and two carbon homologs of 15-HETE, and their derivatives, compositions and methods of their use for treating dry eye are disclosed.Type: GrantFiled: September 20, 2001Date of Patent: August 20, 2002Assignee: Alcon Universal Ltd.Inventors: Peter G. Klimko, Mark R. Hellberg, Gustav Graff
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Patent number: 6433202Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: GrantFiled: March 14, 2000Date of Patent: August 13, 2002Assignee: Brigham and Women's HospitalInventor: Charles N. Serhan
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Publication number: 20020082435Abstract: Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.Type: ApplicationFiled: March 9, 2001Publication date: June 27, 2002Inventor: Charles N. Serhan
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Patent number: 6407272Abstract: Secondary alcohol esters of hydroxyacids, e.g., ricinoleate esters of secondary alcohols, are prepared by reacting an ester of a hydroxyacid with a secondary alcohol, in the presence of an organometallic transesterification catalyst. Under these reaction conditions, a high proportion of the starting ester of a hydroxyacid is converted into a secondary alcohol ester of the hydroxyacid, while minimizing the formation of by-products including estolide. The product esters and composition containing same may be used as a lubricity agent or as a friction modifier in a lubricant composition.Type: GrantFiled: January 10, 2000Date of Patent: June 18, 2002Assignee: Arizona Chemical CompanyInventors: Lloyd A. Nelson, Charley M. Pollock, Gregory J. Achatz
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Publication number: 20020055538Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.Type: ApplicationFiled: February 16, 2001Publication date: May 9, 2002Inventors: Charles N. Serhan, Clary B. Clish
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Patent number: 6359158Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.Type: GrantFiled: May 14, 1999Date of Patent: March 19, 2002Assignees: University of Vermont and State Agricultural College, The University of Texas System Board of Regents, New York Medical CollegeInventors: John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
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Publication number: 20020007080Abstract: Novel compounds derived from traditional semi-drying and non-drying oils featuring internally plasticizing and crosslinkable properties are disclosed and claimed. Preferred embodiments include acrylate or methacrylate esters of hydroxy long-chain olefinic compounds derived from castor oil or lesquerella oil. A process for the preparation of the novel compounds is also disclosed, which involves esterification reaction of ethylenically unsaturated carboxylic acids or its derivatives with substituted hydroxy long-chain olefinic compounds. These compounds are suitable for forming latices, which form films at low minimum film forming temperatures (MFT) ranging from −5 to 10° C. and cure to above ambient glass transition (Tg) polymers without the use of traditional organic cosolvents which contribute to environmental pollution via volatile organic compounds (VOCs) emissions. These latices are therefore useful in waterborne coatings, contact and pressure sensitive adhesives, and inks.Type: ApplicationFiled: April 10, 2001Publication date: January 17, 2002Applicant: University of Southern MississippiInventors: Shelby Freland Thames, Kamlesh Gopichand Panjnani, Rajan Hariharan, Zhiyu Wang