Benzene Ring In The Acid Moiety Patents (Class 554/220)
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Patent number: 8895040Abstract: The present invention relates to cosmetic and/or personal care formulations and/or compounds. In one embodiment, the present invention relates to ester compounds that can be used in various personal care formulations and/or compounds. In another embodiment, the present invention relates to branced ester compounds having a molecular weight of at least about 1,500 daltons that can be used in various personal care formulations and/or compounds.Type: GrantFiled: June 4, 2009Date of Patent: November 25, 2014Assignee: Lubrizol Advanced Materials, Inc.Inventors: Brian J. Vondruska, Peter Frank, Anchuu Wu
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Patent number: 8841470Abstract: Chemically-modified fatty acids are prepared by reacting epoxidized fatty acids, their esters or triglyceride oils with amines of cyclic or aromatic hydrocarbons. The fatty acid derivatives produced are of the formula: wherein R is an H, branched or straight chain alkyl or alkenyl group, aromatic-containing group, glycerol, or glyceride, R? is a C3 to C29 aliphatic chain comprising one or more of the derivatized methylene groups of the formula: wherein R1 and R2 are independently selected from the group consisting of H, cyclic hydrocarbons, substituted cyclic hydrocarbons, and aryl groups, with the proviso that only one of said R1 and R2 may be H. These fatty acid derivatives have utility as antiwear/antifriction additives for industrial oils and automotive applications.Type: GrantFiled: August 24, 2011Date of Patent: September 23, 2014Assignees: The United States of America, as represented by the Secretary of Agriculture, The Penn State Research FoundationInventors: Atanu Biswas, Kenneth M. Doll, Huai Nan Cheng, Brajendra K. Sharma
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Patent number: 8772517Abstract: A composition, which is suitable for the production of stilbene compounds, can be separated from tall oil. It contains esters of pinosylvin or pinosylvin derivatives and it is concentrated in relation to these. Preferably, the composition contains esters of pinosylvin monomethyl ethers, the acid part of which is formed of an inorganic acid or an organic acid, in particular an organic acid, which is present in the crude tall oil or which is generated from this oil during the process of refining it. Typically, such acids are fatty and resin acids and lower alkane acids. With the invention, it is possible to generate, at an industrial scale, product fractions, and the pinosylvin compounds which are separated from the fractions can be used as such or they can be further modified by means of different chemical methods.Type: GrantFiled: April 14, 2009Date of Patent: July 8, 2014Assignee: Neste Oil OyjInventor: Kosti Mokkila
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Patent number: 8709276Abstract: A refrigeration composition containing at least one ester formed by esterification of a hydroxycarboxylic acid component and an alcohol component, the hydroxycarboxylic acid component chosen from hydroxycarboxylic acids comprising more than one carboxylic acid group, hydroxystearic acid, hydroxylauric acid, hydroxydecanoic acid, hydroxyarachidic acid, hydroxypalmitic acid, hydroxylinoleic acid, hydroxyerucic acid, hydroxyarachidonic acid, ricinoleic acid, and combinations thereof, and the alcohol component containing at least one alcohol; and a base oil lubricant chosen from alkylbenzenes, alkylated naphthenics, polyalkylene glycols, polyvinylethers, polyalphaolefins, mineral oils, polyol esters, and combinations thereof.Type: GrantFiled: February 27, 2012Date of Patent: April 29, 2014Assignee: Shrieve Chemical Products, Inc.Inventors: Liwen Wei, Phil Beckler
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Publication number: 20130317106Abstract: Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.Type: ApplicationFiled: April 4, 2013Publication date: November 28, 2013Applicant: The UAB Research FoundationInventors: Wayne J. Brouillette, Donald D. Muccio, Venkatram Reddy Atigadda, John M. Ruppert, Susan M. Lobo Ruppert
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Publication number: 20130172589Abstract: A surface active agent comprising an arylated methyl ester of a fatty acid, or mixture of fatty acids, derived from biodiesel or a triglyceride source is disclosed. The fatty acid mixture is condensed to methyl esters and alkylated with aromatic substituents under Friedel-Crafts conditions. The alkylated methyl esters may be alkoxylated using a catalyst derived from fatty acids, alkaline earth salts, and strong acids. The resulting nonionic surfactant may also be sulfonated to produce one class of anionic surfactants. The alkylated methyl esters may also be directly sulfonated to produce another class of anionic surfactants.Type: ApplicationFiled: September 19, 2011Publication date: July 4, 2013Applicant: Huntsman Petrochemical LLCInventors: George A. Smith, Daniel R. Weaver, Zheng Chai
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Patent number: 8268188Abstract: A refrigeration composition containing at least one ester formed by esterification of a hydroxycarboxylic acid component and an alcohol component, the hydroxycarboxylic acid component chosen from hydroxycarboxylic acids comprising more than one carboxylic acid group, hydroxystearic acid, hydroxylauric acid, hydroxydecanoic acid, hydroxyarachidic acid, hydroxypalmitic acid, hydroxylinoleic acid, hydroxyerucic acid, hydroxyarachidonic acid, ricinoleic acid, and combinations thereof, and the alcohol component containing at least one alcohol; and a base oil lubricant chosen from alkylbenzenes, alkylated naphthenics, polyalkylene glycols, polyvinylethers, polyalphaolefins, mineral oils, polyol esters, and combinations thereof.Type: GrantFiled: October 6, 2011Date of Patent: September 18, 2012Assignee: Shrieve Chemical Products, Inc.Inventors: Liwen Wei, Phil Beckler
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Patent number: 8123974Abstract: Novel refrigeration compositions are disclosed herein. In an embodiment, a refrigeration composition comprises a mixture of an ester of a hydroxycarboxylic acid. The hydroxycarboxylic acid has a chain length ranging from 8 to 22 carbon atoms. The composition also comprises a carrier fluid or base oil, selected from the group consisting of an alkylbenzene, an alkylated naphthenic, a polyalkylene glycol, a polyvinylether, a polyalphaolefin, mineral oil, a polyol ester, and combinations thereof, providing improved fluidity and heat transfer, and enhanced oil return.Type: GrantFiled: September 13, 2007Date of Patent: February 28, 2012Assignee: Shrieve Chemical Products, Inc.Inventors: Liwen Wei, Phil Beckler
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Patent number: 8008526Abstract: To improve a catalytic activity of a composite oxide, to carry out a reaction in a high yield, and to provide a synthesis reaction catalyst having excellent handling properties and a method of a synthesizing a compound using the same, a synthesis reaction catalyst containing a palladium-containing perovskite-type composite oxide having a specific surface area of 0.5 to 9.5 m2/g is used in Suzuki Cross-Couplings given by the following general scheme (14).Type: GrantFiled: March 16, 2006Date of Patent: August 30, 2011Assignee: Nitto Denko CorporationInventors: Hirohisa Tanaka, Kimiyoshi Kaneko
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Publication number: 20110092724Abstract: A composition, which is suitable for the production of stilbene compounds, can be separated from tall oil. It contains esters of pinosylvin or pinosylvin derivatives and it is concentrated in relation to these. Preferably, the composition contains esters of pinosylvin monomethyl ethers, the acid part of which is formed of an inorganic acid or an organic acid, in particular an organic acid, which is present in the crude tall oil or which is generated from this oil during the process of refining it. Typically, such acids are fatty and resin acids and lower alkane acids. With the invention, it is possible to generate, at an industrial scale, product fractions, and the pinosylvin compounds which are separated from the fractions can be used as such or they can be further modified by means of different chemical methods.Type: ApplicationFiled: April 14, 2009Publication date: April 21, 2011Applicant: Neste Oil OyjInventor: Kosti Mokkila
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Patent number: 7659333Abstract: The present invention provides a fluorinated surfactant having the general formula: [Rf—(O)t—CQH—CF2—O]n—R—G??(I) wherein Rf represents a partially or fully fluorinated aliphatic group optionally interrupted with one or more oxygen atoms, Q is CF3 or F, R is an aliphatic or aromatic hydrocarbon group, G represents a carboxylic or sulphonic acid or salt thereof, t is 0 or 1 and n is 1, 2 or 3. The surfactant is particularly useful in polymerizing fluorinated monomers in an aqueous emulsion polymerization.Type: GrantFiled: November 21, 2006Date of Patent: February 9, 2010Assignee: 3M Innovative Properties CompanyInventors: Klaus Hintzer, Michael Jürgens, Harald Kaspar, Herbert Königsmann, Kai Helmut Lochhaas, Andreas R. Maurer, Tilman C. Zipplies, Richard M. Flynn
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Patent number: 7615575Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and arteriosclerosis are disclosed.Type: GrantFiled: February 9, 2004Date of Patent: November 10, 2009Assignee: Wellstat Therapeutics CorporationInventors: Kirvin L. Hodge, Shalini Sharma, Albert C. Lee, Reid W. von Borstel
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Publication number: 20090264525Abstract: The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)t— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.Type: ApplicationFiled: July 2, 2007Publication date: October 22, 2009Applicant: MERCK PATENT GMBHInventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
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Patent number: 7595412Abstract: A novel composition and methods of its use and preparation of polybasic metal carboxylate complexes having the general formula: (A)2M.nD(OH)2.xH2O.m(B)2N wherein: A is an organic fatty acid and is selected from the group consisting of saturated C12-24 carboxylic acids, unsaturated C12-24 carboxylic acids, aromatic C12-24 carboxylic acids, alicyclic C12-24 carboxylic acids, polycarboxylic acid derivatives thereof, anhydride derivatives thereof and blends thereof, preferably stearate; M is a divalent metal cation, preferably calcium; n is a fractional or whole number from about 1 to about 10 inclusive; D is an alkali earth metal, preferably calcium; x is a fractional or whole number from about 0 to about 3 inclusive; N is a divalent metal cation other than calcium, preferably zinc; and m is a fractional or whole number from 0 to about 1.Type: GrantFiled: August 5, 2002Date of Patent: September 29, 2009Assignee: Dover Chemical CorporationInventors: Thomas Jennings, Ssatyan Kodali, W. Matthew Fender, Donald R. Stevenson
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Patent number: 7592473Abstract: In order to provide a method of synthesizing a compound in which activity of a catalyst is maintained even when the catalyst is recovered after the completion of the coupling reaction using a palladium-containing perovskite-type composite oxide as the catalyst and used repeatedly and the reaction can be carried out in a high yield, a palladium-containing perovskite-type composite oxide is used as a synthesis reaction catalyst and a reaction solvent containing an alkoxy alcohol is used as a reaction solvent in Suzuki Cross-Couplings given by the following general formula (15).Type: GrantFiled: March 16, 2006Date of Patent: September 22, 2009Assignees: Daihatsu Motor Co., Ltd., Hokko Chemical Industry Co., Ltd.Inventors: Hirohisa Tanaka, Kimiyoshi Kaneko
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Patent number: 7550613Abstract: Compounds of formula (I); wherein R1 and R2 are the same or different and may be selected from the group consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid group, a carboxylate group, or a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex or pro-drug thereof, with the provisos that the compound of formula (I) is not (all-Z)-4,7,10,13,16,19-docosahexaenoic acid (DHA), alpha-methyl DHA, alpha-methyl DHA methyl ester, alpha-methyl DHA ethyl ester or alpha-hydroxy DHA ethyl ester, are disclosed. A fatty acid composition and a pharmaceutical composition comprising such compounds are also disclosed.Type: GrantFiled: May 4, 2006Date of Patent: June 23, 2009Assignee: Pronova Biopharma Norge ASInventors: Morten Bryhn, Jan Kopecky, Anne Kristin Holmeide
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Publication number: 20080015231Abstract: A compound having a formula is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: ApplicationFiled: July 10, 2007Publication date: January 17, 2008Inventors: David W. Old, Vinh X. Ngo
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Publication number: 20040254279Abstract: The invention relates to carbonated alkaline earth metal carboxylates that are neutral, meaning they have a base value of less than 10 mg KOH/g, and that are derived from a mixture of, preferably branched, optionally cyclic, C4-C40 alk(en)yl carboxylic acids and C6-C30 alkaryl or aralkyl carboxylic acids. Also a process to make such products is claimed, as well as the use of the products to stabilize PVC.Type: ApplicationFiled: April 27, 2004Publication date: December 16, 2004Inventors: Jack James Angus Orchison, Malcolm Thomas John Mellor
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Publication number: 20040209847Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: ApplicationFiled: December 23, 2003Publication date: October 21, 2004Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6706259Abstract: The present invention deals with the certain novel esters derived from a specific 36 carbon diol and fatty acids, which unlike other esters are surprisingly stable to hydrolysis and consequently of interest in high and low pH applications.Type: GrantFiled: February 12, 2002Date of Patent: March 16, 2004Assignee: Phoenix Research Corp.Inventors: Bryce Gardner, John Imperante, Anthony J. O'Lenick, Jr.
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Publication number: 20030191332Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: ApplicationFiled: February 13, 2003Publication date: October 9, 2003Inventor: Charles N. Serhan
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Patent number: 6537531Abstract: The present invention deals with the certain novel esters derived from a specific 36 carbon diol and guerbet acids, which unlike other esters are surprisingly stable to hydrolysis and consequently of interest in high and low pH applications.Type: GrantFiled: January 8, 2002Date of Patent: March 25, 2003Assignee: Phoenix Research CorporationInventors: Bryce Gardner, John Imperante, Anthony J. O'Lenick, Jr.
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Publication number: 20030055275Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.Type: ApplicationFiled: June 20, 2002Publication date: March 20, 2003Inventor: Charles N. Serhan
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Patent number: 6420596Abstract: This invention provides a process for the selective esterfication of a tertiary alcohol(I) by an acid anhydride(II) to produce corresponding tertiary ester(III) and carboxylic acid(V), using a reusable solid catalyst(IV) comprising one or more halides of indium, gallium, zinc and iron. The process comprises: (i) contacting a mixture of (I) and (II) in the absence or presence of a non aqueous solvent with the fine particles of (IV) in a stirred batch reactor provided with a reflux water condenser at atmospheric pressure at the reaction conditions, such that the mole ratio of (II) to (I) is in the range from about 0.1 to about 10.0; the weight ratio of (IV) to (I+II) is in the range from about 0.005 to about 0.5; the reaction temperature is below about 80° C., and the reaction period is in the range from about 0.1 h to about 50 h; (ii) removing the solid catalyst(IV) from the reaction mixture by filtration; and (iii) reusing the separated solid catalyst for subsequent batch of the process.Type: GrantFiled: November 29, 2000Date of Patent: July 16, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Vasant Ramchandra Choudhary, Kshudiram Mantri, Suman Kumar Jana
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Publication number: 20020037913Abstract: Compounds having the general structure: 1Type: ApplicationFiled: September 4, 2001Publication date: March 28, 2002Inventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De
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Patent number: 6313088Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: February 7, 1997Date of Patent: November 6, 2001Assignee: Emisphere Technologies, Inc.Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Nai Fang Wang
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Patent number: 6083984Abstract: Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain .beta.-hemoglobinopathies, anemia, and cancer.Type: GrantFiled: May 25, 1999Date of Patent: July 4, 2000Assignee: Brusilow Enterprises LLCInventor: Saul W. Brusilow
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Patent number: 6031015Abstract: A dental material based on polymerizable monomers is described which contains at least one polymerizable monomer which has liquid crystalline properties. Compared with traditional materials, the dental material displays a lower decrease in volume upon polymerization and, because of its low viscosity, higher filler contents can be achieved.Type: GrantFiled: July 17, 1996Date of Patent: February 29, 2000Assignee: Ivoclar AGInventors: Helmut Ritter, Georg Draheim, Norbert Moszner, Ulrich Salz, Volker Rheinberger
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Patent number: 6025511Abstract: A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.Type: GrantFiled: March 31, 1998Date of Patent: February 15, 2000Assignees: Washington University, Johns Hopkins UniversityInventors: Jeffrey I. Gordon, George W. Gokel, Paul T. Englund
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Patent number: 5998642Abstract: A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.Type: GrantFiled: December 15, 1997Date of Patent: December 7, 1999Assignee: Washington UniversityInventors: Jeffrey I. Gordon, George W. Gokel, Paul T. Englund
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Patent number: 5968979Abstract: Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain .beta.-hemoglobinopathies, anemia, and cancer.Type: GrantFiled: January 13, 1998Date of Patent: October 19, 1999Assignee: Brusilow Enterprises LLCInventor: Saul W. Brusilow
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Patent number: 5959130Abstract: Compositions of matter comprising castor-based benzoate esters, including benzoate esters of castor oil, benzoate esters of hydrogenated castor oil, benzoate esters of cetyl ricinoleate, and benzoate esters of octyl hydroxy stearate. The benzoate esters of ricinoleic acid and hydroxy stearic acid are double esters having a fatty acid group at the respective --COOH group and a benzoate group at the --OH group. The benzoate esters are useful as vehicles or carriers, emollients or solubilizers for toiletry, cosmetic, hair and skin care formulations.Type: GrantFiled: June 27, 1997Date of Patent: September 28, 1999Assignee: Finetex, Inc.Inventors: Ismail Walele, Samad A. Syed
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Patent number: 5817845Abstract: Methods for stereospecific synthesis of 9-cis olefins and retinoids. In one particular aspect, a cis olefin is generated via a lactol ring opening with complete retention of double bond configuration.Type: GrantFiled: October 9, 1996Date of Patent: October 6, 1998Assignee: Ligand Pharmaceuticals, Inc.Inventors: Steven K. White, Chan Kou Hwang, David T. Winn
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Patent number: 5780676Abstract: Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, pyrrole, and poiyenoic acid derivatives including carbocyclic polyenoic acids. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.Type: GrantFiled: June 7, 1995Date of Patent: July 14, 1998Assignee: Ligand Pharmaceuticals IncorporatedInventors: Marcus F. Boehm, Richard A. Heyman, Lin Zhi, Chan Kou Hwang, Steve White, Alex Nadzan
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Patent number: 5767299Abstract: The invention relates to compounds of formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from: (i) saturated or unsaturated fatty acyl groups, preferably having from 14 to 24 carbon atoms, more preferably of a type found in nature; or(ii) groups of formula (II): ##STR2## wherein R.sup.4 and R.sup.5 are independently selected from hydrogen atoms, C.sub.1-4 alkyl groups and aryl groups, preferably C.sub.6-10 aryl groups; n represents the integers 0 or 1; A represents either a chemical bond or a straight or branched C.sub.1-6 alkylene chain and R.sup.6 is a triiodinated phenyl group which may also carry other substituents. The invention also relates to X-ray contrast media containing these compounds, as well as methods of enhancing X-ray images of a human subject wherein the contrast media are administered to the subject prior to imaging.Type: GrantFiled: September 18, 1995Date of Patent: June 16, 1998Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Per Strande
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Patent number: 5654452Abstract: Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific delivery to the liver. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm and having a composition simulating naturally-occuring chylomicron remnants.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Dung K. Hong
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Patent number: 5482523Abstract: Mannich condensation products prepared by the condensation of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxy, lower alkyl or lower alkoxy; R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, alkyl, phenyl, aralkyl, alkaryl, or an acyl group of the formula: ##STR2## wherein R.sub.6 is alkyl, phenyl, aralkyl or alkaryl; R.sub.7 is alkyl; u is an integer from 1 to 10; n is an integer from 5 to 100; and x is an integer from 0 to 10;with an aldehyde and a nitrogen base selected from ammonia, lower alkylamine, a polyamine and mixtures thereof.The Mannich condensation products and their fuel soluble salts are useful as fuel additives for the prevention and control of engine deposits.Type: GrantFiled: November 2, 1994Date of Patent: January 9, 1996Assignee: Chevron Chemical CompanyInventor: Richard E. Cherpeck
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Patent number: 5453525Abstract: Perhydro-5,5-8a-trimethyl-2-naphthalenone is prepared by acid cyclization of carboxylic esters of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein symbol R designates a C.sub.1 -C.sub.6 alkyl radical, X stands for a monovalent radical of formula P(O)(OR.sup.1).sub.2 or C(O)R.sup.2, R.sup.1 represents a C.sub.1 -C.sub.6 alkyl group and R.sup.2 is either a linear or branched alkyl group or a substituted or unsubstituted phenyl radical, and wherein the wavy line represents a C--C bond of cis or trans configuration, or of formula ##STR2## wherein the wavy lines and symbol R are defined as above, and R.sup.0 represents a C.sub.3 -C.sub.6 alkyl radical, preferably branched, followed by basic decarboxylation of the obtained product.Type: GrantFiled: July 27, 1994Date of Patent: September 26, 1995Assignee: Firmenich SAInventors: Roger L. Snowden, Cyril Mahaim, Dana P. Simmons
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Patent number: 5440059Abstract: A novel method for preparing an aryl-substituted fatty acid or fatty ester is disclosed. According to the method, an olefinic composition selected from among mono-unsaturated fatty acids, mono-unsaturated fatty esters and mixtures thereof is introduced to a reaction zone comprising a liquid aromatic hydrocarbon and a catalytic amount of a clay catalyst to produce a reaction that is allowed to proceed for a time and at a temperature sufficient to produce a reaction product comprising a desired yield of aryl-substituted fatty acid or fatty ester. Preferably, the introduction of the olefinic composition is conducted slowly, such as over a period of one to four, more preferably, two to four, hours. Related methods and compositions, including xylylstearic acid, are also disclosed.Type: GrantFiled: December 2, 1993Date of Patent: August 8, 1995Assignee: Petrolite CorporationInventor: Bernardus A. O. Alink
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Patent number: 5306730Abstract: A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.Type: GrantFiled: May 26, 1992Date of Patent: April 26, 1994Assignee: Kabushiki Kaisha Yakult HonshaInventors: Yoshitaka Nagai, Koutaro Takamizawa, Ryuichiro Tanaka, Hiroo Takayama, Toshizo Sakurai, Masahiko Mutai
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Patent number: 5274170Abstract: Compounds of the formula ##STR1## in which R is hydrogen or hydroxyl, R.sub.1 is alkyl, alkoxy, amino or aryl, and R.sub.2 is hydrocarbylcarbonyl or hydrocarbylsulfonyl, are highly suitable for stabilizing magenta couplers in photographic materials.Type: GrantFiled: June 15, 1992Date of Patent: December 28, 1993Assignee: Ciba-Geigy CorporationInventors: David G. Leppard, David H. Steinberg, Henri Dubas
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Patent number: 5266713Abstract: Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I ##STR1## in which X is --S--,W is CH.dbd.CH;o is 1 to 4;n is 2 to 6;m is 0 to 2;T and Z, same or different, represent oxygen or a direct bond;R.sup.2 and R.sup.3, represent hydrogen, or fluorine;A represents carboxyl, CO.sub.2 R.sub.4.sup.4, wherein R.sup.4 is lower alkylR is ##STR2## wherein Y represents carboxyl, CO.sub.2 R.sup.4, wherein R.sup.4 is lower alkylR.sup.7 and R.sup.8, same or different, represent H or lower alkyl;R.sup.9 represents --OH, --O-alkyl, NH.sub.2 or a NHCH.sub.2 CO.sub.2 H group; andR.sup.10 R3 is H.Type: GrantFiled: August 12, 1992Date of Patent: November 30, 1993Assignee: Miles Inc.Inventors: Trevor S. Abram, Peter Norman, Stephen R. Tudhope, Harold C. Kluender, Robert N. Schut, Heinrich Meier, Ulrich Rosentreter
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Patent number: 5175338Abstract: An isocarbacyclin derivative represented by the following formula [VII'] ##STR1## wherein A represents, a hydrocarbylcarboxylate group, a carboxymethoxycarbonyl group, an amide group, an acyloxymethyl group or a hydroxymethyl group; R.sup.4 represents H, a methyl group or a vinyl group; R.sup.5 represents a (substituted)alkyl group, a phenyl group, a phenoxy group or a cycloalkyl group; R.sup.e22 and R.sup.e32 represent H or a hydroxyprotecting group; n is 0 or 1;and a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 14, 1990Date of Patent: December 29, 1992Assignee: Teijin LimitedInventors: Atsuo Hazato, Toshio Tanaka, Noriaki Okamura, Kiyoshi Bannai, Seizi Kurozumi, Masaaki Suzuki, Ryoji Noyori