Plural Carbon-to-carbon Unsaturation In The Acid Moiety (e.g., Polyunsaturated Fatty Acids, Etc.) Patents (Class 554/224)
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Patent number: 8853437Abstract: An object of the present invention is to provide a compound having a novel structure for overcoming the defects of conventional steroid agents and NSAIDs. It is found that the particular dihydroxy bodies of eicosapentaenoic acid and docosahexaenoic acid, which have not conventionally been known (11,18-dihydroxy eicosapentaenoic acid (11,18-diHEPE), 17,18-dihydroxy eicosapentaenoic acid (17,18-diHEPE) etc.), have activity of inhibiting neutrophil, thereby solving the object. The present invention unexpectedly remarkably inhibits infiltration into a tissue of, and activation of neutrophil found out at acute inflammation. The compound of the present invention is a compound which has not conventionally been known. Therefore, utility as a new therapeutic is provided.Type: GrantFiled: February 19, 2010Date of Patent: October 7, 2014Assignee: The University of TokyoInventors: Makoto Arita, Hiroyuki Arai, Yousuke Isobe, Ryo Taguchi
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Patent number: 8846972Abstract: The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylated salicylate derivative.Type: GrantFiled: February 26, 2010Date of Patent: September 30, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Chi B. Vu, Jean E. Bemis, Michael R. Jirousek, Jill C. Milne, Jesse J. Smith
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Publication number: 20140275596Abstract: Provided herein are exemplary algal fatty acid compositions comprising by dry weight approximately 0.5% to approximately 99% C20:5 n3 Eicosapentaenoic acid (EPA) and approximately 0.5% to approximately 99% C16:1 n7 palmitoleic acid (POA). Further exemplary algal fatty acid compositions may comprise (in addition to the above) one or more of the following by dry weight: between approximately 0% and 99% arachidonic acid; between approximately 0% and 99% docosahexaenoic acid; and/or less than approximately 10% saturated fatty acids (including 0% saturated fatty acids or substantially saturated fatty acid free). Further exemplary saturated fatty acyl moiety-rich algal compositions may be in a form of an ethyl ester (EE), a mono, di- or triacylglycerol (MAG, DAG, TAG), a phospholipid (PL), a galactolipid (GL), free fatty Acid (FFA), or a sulfoquinovosyl diacylglycerol (SQDG).Type: ApplicationFiled: September 12, 2013Publication date: September 18, 2014Applicant: Aurora Algae, Inc.Inventors: James Astwood, Leslie van der Meulen, Michelle Collins, Jeffrey Gerard Hippler
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Publication number: 20140275483Abstract: Provided herein are exemplary total algal oil compositions comprising by total weight between approximately 0% and 99% EPA, and one or more of the following: between approximately 0% and 99% POA, less than approximately 20% saturated fats (including 0% saturated fats or substantially saturated fat free), between approximately 0% and 99% ARA, and/or between approximately 0% and 99% DHA. According to further exemplary total algal oil compositions, the saturated fats may comprise PA. Also provided herein are exemplary total algal oil compositions comprising by total weight at least 20% EPA and one or more of the following: at least 17% POA, approximately 0% to 20% saturated fats, less than approximately 10% ARA, and/or substantially no DHA.Type: ApplicationFiled: September 12, 2013Publication date: September 18, 2014Applicant: Aurora Algae, Inc.Inventors: Jeffrey Gerard Hippler, Michelle L. Collins, Andrew Thompson
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Publication number: 20140252129Abstract: A device and composition for spraying on dry pet food, such as pellets, with an oil composition containing Omega 3 compounds, where the device uses an aerosol sprayer device of the bag on valve type, and the product to be sprayed, can combine different oils and pharmaceutical grade fish oils concentrates which contain Omega 3, improving the pellet pet food organoleptic characteristics, its taste and simplifying the administration to the pet of all the advantages the compound containing Omega 3, provides.Type: ApplicationFiled: March 4, 2014Publication date: September 11, 2014Inventors: RODRIGO FERNANDO DURRUTY ORTEGA, GONZALO FERNANDO ACUÑA FERRARI, RODRIGO MAURICIO NUÑEZ LARA
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Publication number: 20140256973Abstract: The present invention relates to the production of a triacylglycerol oil that is produced from a Pythium species of alga. In one embodiment, the algal species contains at least about 20 weight percent total lipids and contains at least about 10 weight percent of its total fatty acids as eicosapentaenoic acid (EPA) and less than about 5 weight percent of its total fatty acids as arachidonic acid (ARA). In another embodiment, the present invention relates to various methods to produce eicosapentaenoic acid (EPA) from a Pythium species of algae. In particular, Pythium irregulare can be utilized as a viable production organism.Type: ApplicationFiled: March 7, 2013Publication date: September 11, 2014Applicant: Algysis LLCInventors: Charles L. Roe, James P. Wynn
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Publication number: 20140256812Abstract: The present invention relates to novel antimicrobial compounds, methods of their production as well as uses thereof.Type: ApplicationFiled: February 12, 2014Publication date: September 11, 2014Applicant: Agency for Science, Technology and ResearchInventors: Lianhui Zhang, Yinyue Deng, Jien Wu
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Publication number: 20140243540Abstract: A method of extracting oil from algae by drying algae paste to a predetermined moisture content, contacting the algae paste with a polar solvent to make an algae-solvent solution and extracting oils from the algae paste into a solvent-oil solution, and separating extracted algae from the solvent-oil solution. An oil of whole and unhydrolyzed phospholipids, whole and unhydrolyzed glycolipids, lysolipids, and carotenoids extracted by the above method. An omega-3 fatty acid of docosahexanoic acids (DNAs) and eicosapentaenoic acids (EPAs) extracted from the above method. Isolated nutraceutical grade and pharmaceutical grade oil derived from algae and being free of toxins extracted by the above method. Isolated oil derived from algae including at least one omega-3 fatty acid of DHA and EPA at least partially in the form of whole and unhydrolyzed phospholipids and whole and unhydrolyzed glycolipids extracted by the above method.Type: ApplicationFiled: February 28, 2014Publication date: August 28, 2014Inventors: Kiran L. Kadam, Brian Leslie Goodall
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Publication number: 20140242238Abstract: A method of extracting oil from algae by drying algae paste to a predetermined moisture content, contacting the algae paste with a polar solvent to make an algae-solvent solution and extracting oils from the algae paste into a solvent-oil solution, and separating extracted algae from the solvent-oil solution. An oil of whole and unhydrolyzed phospholipids, whole and unhydrolyzed glycolipids, lysolipids, and carotenoids extracted by the above method. An omega-3 fatty acid of docosahexanoic acids (DNAs) and eicosapentaenoic acids (EPAs) extracted from the above method. Isolated nutraceutical grade and pharmaceutical grade oil derived from algae and being free of toxins extracted by the above method. Isolated oil derived from algae including at least one omega-3 fatty acid of DHA and EPA at least partially in the form of whole and unhydrolyzed phospholipids and whole and unhydrolyzed glycolipids extracted by the above method.Type: ApplicationFiled: November 19, 2013Publication date: August 28, 2014Inventors: Kiran L. Kadam, Brian Leslie Goodall
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Patent number: 8816111Abstract: The present invention relates to extracted plant lipid, comprising fatty acids in an esterified form.Type: GrantFiled: June 14, 2013Date of Patent: August 26, 2014Assignees: Commonwealth Scientific and Industrial Research Organisation, Grains Research and Development CorporationInventors: James Robertson Petrie, Surinder Pal Singh, Robert Charles de Feyter
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Patent number: 8816110Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: GrantFiled: November 1, 2012Date of Patent: August 26, 2014Assignee: SCF Pharma Inc.Inventor: Samuel Fortin
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Patent number: 8809560Abstract: This invention relates generally to trans-,trans-conjugated linoleic acid compositions and use thereof, and in particular to trans-,trans-conjugated linoleic acid produced from photoisomerization of soy oil in the presence of an antioxidant, and used in pharmaceutical, nutraceutical and human and animal food compositions for improved health. The invention also relates generally to a method for treatment and prevention of health-related disorders of obesity by administration of pharmaceutical, nutraceutical and/or food compositions containing and/or prepared from trans-,trans-conjugated linoleic acid-rich soy oil.Type: GrantFiled: May 15, 2012Date of Patent: August 19, 2014Assignee: Board of Trustees of the University of ArkansasInventors: Andrew Proctor, Reddy Yettella Yenkata Ramesh, Latha Devareddy, Robert R. Beitle
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Patent number: 8802874Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.Type: GrantFiled: July 8, 2013Date of Patent: August 12, 2014Assignee: University of Southern CaliforniaInventor: Nicos A. Petasis
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Patent number: 8802880Abstract: A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises: performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA; subjecting the second stream of eluent to a concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA. The water-to-organic ratio of the depleted portion is lower than the water-to-organic ratio of the second stream of eluent. The process also includes: at least partially recycling the depleted portion for use in the main step of chromatographic separation.Type: GrantFiled: May 17, 2013Date of Patent: August 12, 2014Assignee: Group NovasepInventors: Philippe Adam, Eric Valéry, Jean Bléhaut
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Publication number: 20140221676Abstract: In various embodiments, the present invention provides pharmaceutical compositions comprising fatty acids and methods for treating subjects using same.Type: ApplicationFiled: February 5, 2014Publication date: August 7, 2014Applicant: Amarin Pharmaceuticals Ireland LimitedInventors: Rene Braeckman, William Stirtan, Paresh Soni
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Patent number: 8790906Abstract: The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid sequences of SEQ ID NOs: 2 and 7 of the present invention.Type: GrantFiled: March 25, 2010Date of Patent: July 29, 2014Assignee: Suntory Holdings LimitedInventor: Misa Ochiai
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Publication number: 20140205569Abstract: The invention provides methods for preventing and treating osteoarthritis, preventing and treating the degradation of articular cartilage, and promoting and maintaining joint health in an animal. The methods comprise administering DGLA to the animals, preferably in amounts of from about 0.01 to about 100 mg/kg/day.Type: ApplicationFiled: December 15, 2011Publication date: July 24, 2014Inventor: Nierissa NIELSEN
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Publication number: 20140194636Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA prodType: ApplicationFiled: July 6, 2012Publication date: July 10, 2014Applicant: BASF Pharma (Callanish) LimitedInventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
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Publication number: 20140171674Abstract: A dietary regimen for mitigating cardiovascular disease risk in a subject, the regimen comprising consumption of at least one of a functional food composition comprising high oleic canola oil, a dietary supplement comprising high oleic canola oil, and a nutraceutical composition comprising high oleic canola oil, whereby the subject consumes at least 14 mg/100 g of body weight every 24-hour diurnal period.Type: ApplicationFiled: December 18, 2013Publication date: June 19, 2014Applicant: University of ManitobaInventors: Thomas NETTICADAN, Carla TAYLOR, Sijo Joseph THANDAPILLY
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Publication number: 20140154393Abstract: The invention is generally directed to conjugated linoleic acid (CLA)-rich vegetable oil production from linoleic rich oils by heterogeneous catalysis. A heterogeneous catalytic vacuum distillation process is used under high temperature conditions to isomerize linoleic acid in triacylglyceride vegetable oils to CLA to produce CLA-rich oils. After processing, the catalyst may be removed by filtration or centrifugation to obtain high quality, CLA-rich oils. The CLA-rich oils may then serve as a potent and bioactive nutraceutical and can be incorporated into various food products, such as a CLA-rich dressing, margarine or chips.Type: ApplicationFiled: December 3, 2012Publication date: June 5, 2014Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Andrew Proctor, Utkarsh Shah
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Patent number: 8735379Abstract: The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.Type: GrantFiled: March 22, 2012Date of Patent: May 27, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
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Patent number: 8735378Abstract: The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.Type: GrantFiled: March 22, 2012Date of Patent: May 27, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
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Publication number: 20140142331Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Inventors: Paul W. BEHRENS, John M. THOMPSON, Kirk APT, Joseph W. PFEIFER, James P. WYNN, James Casey LIPPMEIER, Jaouad FICHTALI, Jon HANSEN
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Publication number: 20140142169Abstract: The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising a sn-2 monoacylglycerol derivative, wherein the sn-1 and sn-3 positions are blocked by protective groups. The acyl group may be a fatty acid, for example one with anti-inflammatory properties.Type: ApplicationFiled: January 24, 2014Publication date: May 22, 2014Applicant: NESTEC S.A.Inventors: Bruce Bistrian, Frederic Destaillats, Cristina Cruz-Hernandez, Fabiola Dionisi, Isabelle Masserey-Elmelegy, Manuel Oliveira, Julie Celine Moulin
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Patent number: 8729293Abstract: The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.Type: GrantFiled: March 22, 2012Date of Patent: May 20, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
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Publication number: 20140128627Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the PUFA product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first anType: ApplicationFiled: July 6, 2012Publication date: May 8, 2014Applicant: BASF Pharma (Callanish ) LimitedInventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
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Publication number: 20140127289Abstract: In various embodiments, the present invention provides pharmaceutical compositions comprising fatty acids and methods for treating subjects using same.Type: ApplicationFiled: November 28, 2011Publication date: May 8, 2014Applicant: ARMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
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Publication number: 20140113823Abstract: This invention relates to the use of aromatic esters as adjuvants in compositions, particularly for agrochemical use, as well to compositions comprising such an aromatic ester, in combination with at least one agrochemical and at least one surfactant. The invention further extends to methods of making and using such compositions. In particular the present invention relates to such compositions when formulated as, or comprised by, an emulsion concentrate (EC), an emulsion in water (EW), a suspension of particles in water (SC), a microcapsule formulation (CS), a suspension of particles with an emulsion (SE), a dispersion concentrate (DC) or an oil suspension (OD).Type: ApplicationFiled: April 13, 2012Publication date: April 24, 2014Applicant: SYNGENTA LIMITEDInventors: Gordon Alastair Bell, Julia Lynne Ramsay, Raul Minguez Molina, David Stock, Gary Charles Walter
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Patent number: 8697749Abstract: In view of the situation that a clinically acceptable medical agent which has the action of preventing and relieving the lipotoxicity with no significant side effects is not yet provided, such medical agent is provided. An agent for relieving lipotoxicity which comprises an unsaturated fatty acid containing 18 to 22 carbon atoms and having a degree of unsaturation of 3 to 6 or a derivative thereof as its effective component.Type: GrantFiled: April 28, 2009Date of Patent: April 15, 2014Assignee: Mochida Pharmaceutical Co., Ltd.Inventors: Hitoshi Shimano, Toyonori Kato
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Publication number: 20140088317Abstract: The present invention relates to various methods to produce a variety of omega-3 fatty acids from various species of alga using crude glycerol as a substrate for algal growth. In one embodiment, the present invention relates to various methods to produced docosahexaenoic acid (DHA) from a Schizochytrium, Phaeodactylum, Thraustochytrid, Ulkenia, and/or Labyrinthulea species of alga. In another embodiment, the present invention relates to various methods to produced eicosapentaenoic acid (EPA) from a Schizochytrium, Phaeodactylum, Thraustochytrid, Ulkenia, and/or Labyrinthulea species of alga. In one instance, the methods of the present invention utilize crude glycerol as at least a portion of the culture medium for the various micro-organisms disclosed herein to enable the production of one or more omega-3 fatty acids.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicant: Virginia Polytechnic Institute and State UniversityInventor: Zhiyou Wen
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Publication number: 20140088120Abstract: The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.Type: ApplicationFiled: September 26, 2013Publication date: March 27, 2014Applicant: TANGENT REPROFILING LIMITEDInventors: Suzanne Dilly, Gregory Stoloff, Paul Taylor
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Publication number: 20140066644Abstract: A method for lowering content of a sterol in a highly unsaturated fatty acid-concentrated oil in a method to concentrate a highly unsaturated fatty acid by using a lipase reaction, may include removing the free form of the sterol from a raw material oil that includes a highly unsaturated fatty acid-containing glyceride prior to performing the lipase reaction; and thereafter concentrating the highly unsaturated fatty acid in the glyceride by using a lipase that is less reactive for the highly unsaturated fatty acid.Type: ApplicationFiled: March 2, 2012Publication date: March 6, 2014Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Nobushige Doisaki, Hideo Ikemoto, Kazuhiko Hata, Shinji Tokiwa, Kazunori Matsushima
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Publication number: 20140051876Abstract: Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative. The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base. [in the formula, R1 represents a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkenyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkynyl group that may be substituted by a C6-10 aryl group, or a C6-10 aryl group, R2 represents a hydrogen atom, or a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, R3 represents a C1-6 linear or branched alkyl group, a C6-10 aryl group, or a halogen atom, and X represents a halogen atom, and multiple R1s may be the same or different].Type: ApplicationFiled: April 26, 2012Publication date: February 20, 2014Applicants: MANAC Incorporated, KOWA COMPANY, LTD.Inventors: Shinji Ina, Takahiro Yamazaki, Junichi Sakata, Koji Ezaki, Katsuhiro Sakamoto
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Publication number: 20140053299Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.Type: ApplicationFiled: February 20, 2013Publication date: February 20, 2014Applicant: DSM IP Assets B.V.Inventor: DSM IP Assets B.V.
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Publication number: 20140050838Abstract: The present invention relates to fungal ?-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the ?-15 fatty acid desaturases are also described herein.Type: ApplicationFiled: May 20, 2013Publication date: February 20, 2014Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: HOWARD GLENN DAMUDE, NARENDRA S. YADAV
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Patent number: 8653288Abstract: A process for making a deodorized edible oil or fat having a low level of bound MCPD (monochloro propanediol esters) and/or low level of bound 3-MCPD is described. The process comprises a step of contacting the oil or fat to a carboxymethyl cellulose or an ion exchange resin. The carboxymethyl cellulose can be a Blanose® cellulose gum and the resin can be a cationic resin. A deodorized vegetable oil or fat and a food product made there from is described. The food product can be an infant formula. It exhibits low levels of bound MCPD and/or low level of bound 3-MCPD. In one embodiment the oil or fat has a reduced level of free fatty acid as well as a limpid aspect and no off-flavors.Type: GrantFiled: July 19, 2010Date of Patent: February 18, 2014Assignee: Nestec S.A.Inventors: Constantin Bertoli, Francois Cauville, Annemarie Johanna Hendrika Schoonman
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Publication number: 20140031572Abstract: Methods for increasing C18 to C20 elongation conversion efficiency and/or ?4 desaturation conversion efficiency in long-chain polyunsaturated fatty acid [“LC-PUFA”]-producing recombinant oleaginous microbial host cells are provided herein, based on over-expression of acyl-CoA:lysophospholipid acyltransferases [“LPLATs”] (e.g., Ale1, LPAAT, LPCAT). Production host cells and oils produced by the methods of the invention are also claimed.Type: ApplicationFiled: August 2, 2013Publication date: January 30, 2014Applicant: E I Du Pont De Nemours And CompanyInventors: Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20140018559Abstract: The present invention generally relates to the field of refined oils. In particular, the present invention relates to refined plant oils substantially free of chlorinated contaminants, such as monochloropropanediol (MCPD), in particular 3-MCPD diesters, and to a process to produce such oils. To achieve this, plant material is washed to remove chlorine donors before a crude oil is produced that subsequently is further refined.Type: ApplicationFiled: March 23, 2012Publication date: January 16, 2014Applicant: Nestec S.A.Inventors: Kornel Nagy, Komel Nagy, Frederic Destaillats, Brian Craft
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Publication number: 20140018558Abstract: The present invention provides Docosahexaenoic acid (DHA) in its free fatty acid form and a process of isolation thereof from oils and fats of natural origin having Docosahexaenoic acid (DHA) attached to triglycerides. The DHA isolated using the process of the present invention is in free flowing powder form which is directly compressible. Further, the DHA in powder form is free from triglycerides. The DHA powder of the present invention has purity more than 90%. The DHA in its free fatty acid powder form offers excellent bioavailability and stability at room temperature.Type: ApplicationFiled: April 27, 2012Publication date: January 16, 2014Inventor: Nandakishore Jeevanrao Duragkar
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Publication number: 20140011776Abstract: The invention provides compositions and methods for treating or preventing cancer with an inventive composition. The invention relates to the fields of biomedicine, pharmacology, and molecular biology.Type: ApplicationFiled: June 28, 2013Publication date: January 9, 2014Applicant: KEAN UNIVERSITYInventors: Evros Vassiliou, James Robert Merritt
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Publication number: 20140012024Abstract: A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.Type: ApplicationFiled: March 16, 2012Publication date: January 9, 2014Applicant: PHENOMENOME DISCOVERIES INC.Inventors: Mohamed Amin Khan, Paul L. Wood
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Patent number: 8623916Abstract: The present invention relates to compounds of the following formula (I): where n is an integer between 1 and 15, m is 0, 1, 2 or 3, and R is the hydrocarbon chain of a polyunsaturated fatty acid selected from among omega 3 and omega 6, as well as to pharmaceutical or cosmetic compositions containing same, to a method for preparing and using same, in particular for treating acne and seborrhoeic dermatitis.Type: GrantFiled: December 21, 2009Date of Patent: January 7, 2014Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Daniel Redoules, Sylvie Daunes-Marion, Marie-Françoise Aries
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Publication number: 20140005425Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: Golden Omega S.A.Inventors: Tomas Francis Harting Glade, Miguel Angel Diaz Fuenzalida, Alejandro Markovits Rojas
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Patent number: 8618165Abstract: Compounds of formula (I); wherein R1 and R2 are the same or different and may be selected from the group consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid group, a carboxylate group, or a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex or pro-drug thereof, with the provisos that the compound of formula (I) is not (all-Z)-4,7,10,13,16,19-docosahexaenoic acid (DHA), alpha-methyl DHA, alpha-methyl DHA methyl ester, alpha-methyl DHA ethyl ester or alpha-hydroxy DHA ethyl ester, are disclosed. A fatty acid composition and a pharmaceutical composition comprising such compounds are also disclosed.Type: GrantFiled: September 6, 2011Date of Patent: December 31, 2013Assignee: Pronova Biopharma Norge ASInventors: Morten Bryhn, Jan Kopecky, Anne Kristin Holmeide
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Patent number: 8614074Abstract: A process for the preparation of a composition comprising the cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) comprises: providing a mixture comprising cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) in which one of the cis9, trans11 and trans10, cis12 isomers is present in a first weight ratio X of at least 1.3:1 with respect to the other isomer; and subjecting the mixture to crystallization to form a composition comprising the cis9, trans11 and trans10, cis12 isomers in which one of the cis9, trans11 and trans10, cis12 isomers is present at a second weight ratio Y with respect to the other isomer, wherein Y is greater than X.Type: GrantFiled: April 4, 2007Date of Patent: December 24, 2013Assignee: Stepan Specialty Products, LLCInventors: Victoria Taran, Krishnadath Bhaggan, Jeroen Monster
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Publication number: 20130338388Abstract: The present invention relates to extracted plant lipid, comprising fatty acids in an esterified form.Type: ApplicationFiled: June 14, 2013Publication date: December 19, 2013Applicants: Commonwealth Scientific and Industrial Research Organisation, Nuseed Pty Ltd, Grains Research and Development CorporationInventors: James Robertson Petrie, Surinder Pal Singh, Robert Charles de Feyter
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Publication number: 20130338386Abstract: The invention relates generally to the expression of desaturase enzymes in transgenic corn plants and compositions derived therefrom. In particular, the invention relates to the production of oils with improved omega-3 fatty acid profiles in corn plants and the seed oils produced thereby. Such oils may contain stearidonic acid, which is not naturally found in corn plants and has been shown to have beneficial effects on health.Type: ApplicationFiled: February 19, 2013Publication date: December 19, 2013Applicant: Monsanto Technology LLCInventor: Monsanto Technology LLC
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Publication number: 20130338387Abstract: The present invention relates to a process for producing ethyl esters of polyunsaturated fatty acids, comprising transesterifying triacylglycerols in extracted plant lipid.Type: ApplicationFiled: June 14, 2013Publication date: December 19, 2013Applicants: Commonwealth Scientific and Industrial Research Organisation, Nuseed Pty Ltd, GRAINS RESEARCH AND DEVELOPMENT CORPORATIONInventors: James Robertson Petrie, Surinder Pal Singh, Robert Charles de Feyter
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Publication number: 20130331588Abstract: The present invention relates to a method for working up a mixture which contains esters of EPA and/or DHA with monohydric alcohols having 1 to 6 carbon atoms, esters of other fatty acids with monohydric alcohols having 1 to 6 carbon atoms, and free cholesterol, wherein the method comprises adding a transesterification catalyst to the mixture, converting at least some of the free cholesterol into esterified cholesterol and thereafter distilling the mixture, wherein the distillation is carried out in such a manner that a product is obtained which contains EPA and/or DHA, both in the form of esters thereof with monohydric alcohols having 1 to 6 carbon atoms, in a higher relative amount, based on all fatty acids in free or bound form present in the product, than said mixture. In addition, the present invention relates to a product which is obtainable by the method according to the invention, wherein the product contains 10 to 99.Type: ApplicationFiled: March 3, 2012Publication date: December 12, 2013Applicant: Cognis IP Management GmbHInventors: Dieter Hietsch, Peter Horlacher
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Publication number: 20130320255Abstract: Amphiphilic copolymers formed from plant oil-derived vinyl ether monomers and polyethylene glycol alkyl vinyl ethers are provided. Nanoparticles coated with these amphiphilic polymers are well-suited for water remediation applications.Type: ApplicationFiled: May 17, 2013Publication date: December 5, 2013Applicant: NDSU Research FoundationInventors: Bret Ja Chisholm, AChintya Bezbaruah, Harjyoti Kalita