Halogen In The Acid Moiety Patents (Class 554/225)
  • Patent number: 10230121
    Abstract: The invention relates to copolymers comprising: at least one recurrent unit of the following formula (I): at least one recurrent unit of the following formula (II): and at least one recurrent unit of the following formula (III): wherein: R1 and R2 represent, independently of each other, an alkylene group; Z1 is a group of formula —PO3R3R4, R3 and R4 representing, independently of each other, a hydrogen atom, an alkyl group or a cation; Z2 is a group of formula —SO2R5, R5 representing an alkyl group or an aryl group; X and Y represent, independently of each other, a halogen atom or a perfluorocarbon group.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: March 12, 2019
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Pierrick Buvat, Janick Bigarre, Julien Souquet-Grumey, Ghislain David, Etienne Labalme, Cédric Loubat, Gilles Boutevin
  • Patent number: 9918620
    Abstract: According to an embodiment, there is provided an optical transmission element comprising: a fiber including a core made of a first glass and a cladding made of a second glass and covering an outer periphery of the core; and a covering layer covering an outer periphery of the cladding and including a plurality of nonionic surfactant molecules wherein each of the nonionic surfactant molecules is hydrogen-bonded to the cladding.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: March 20, 2018
    Assignee: OLYMPUS CORPORATION
    Inventors: Akihito Miyata, Yuki Ishikawa
  • Patent number: 8067625
    Abstract: The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)t— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: November 29, 2011
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
  • Patent number: 7994346
    Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: August 9, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Danja Grossbach, William Guilford, Michael Sander
  • Patent number: 7763743
    Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: July 27, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Danja Grossbach, William Guilford, Michael Sander
  • Patent number: 7659333
    Abstract: The present invention provides a fluorinated surfactant having the general formula: [Rf—(O)t—CQH—CF2—O]n—R—G??(I) wherein Rf represents a partially or fully fluorinated aliphatic group optionally interrupted with one or more oxygen atoms, Q is CF3 or F, R is an aliphatic or aromatic hydrocarbon group, G represents a carboxylic or sulphonic acid or salt thereof, t is 0 or 1 and n is 1, 2 or 3. The surfactant is particularly useful in polymerizing fluorinated monomers in an aqueous emulsion polymerization.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: February 9, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: Klaus Hintzer, Michael Jürgens, Harald Kaspar, Herbert Königsmann, Kai Helmut Lochhaas, Andreas R. Maurer, Tilman C. Zipplies, Richard M. Flynn
  • Patent number: 7569609
    Abstract: Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl subsituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: August 4, 2009
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shuichi Ohuchida, Kazuo Kishimoto, Narito Tateishi, Hiroyuki Ohno
  • Patent number: 7569608
    Abstract: Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: August 4, 2009
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shuichi Ohuchida, Kazuo Kishimoto, Narito Tateishi, Hiroyuki Ohno
  • Patent number: 7550613
    Abstract: Compounds of formula (I); wherein R1 and R2 are the same or different and may be selected from the group consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid group, a carboxylate group, or a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex or pro-drug thereof, with the provisos that the compound of formula (I) is not (all-Z)-4,7,10,13,16,19-docosahexaenoic acid (DHA), alpha-methyl DHA, alpha-methyl DHA methyl ester, alpha-methyl DHA ethyl ester or alpha-hydroxy DHA ethyl ester, are disclosed. A fatty acid composition and a pharmaceutical composition comprising such compounds are also disclosed.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 23, 2009
    Assignee: Pronova Biopharma Norge AS
    Inventors: Morten Bryhn, Jan Kopecky, Anne Kristin Holmeide
  • Patent number: 7176240
    Abstract: The compound of the formula (I): wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together a saturated heterocyclic ring or amino acid residues; and non-toxic salts thereof and acid addition salts thereof.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 13, 2007
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shuichi Ohuchida, Kazuo Kishimoto, Narito Tateishi, Hiroyuki Ohno
  • Patent number: 6893564
    Abstract: The present invention relates to a novel class of shaped bodies containing metal-organic frameworks. Said metal-organic frameworks comprise at least one metal ion and at least one at least bidentate organic compound and contain at least one type of micro- and mesopores or micro- or mesopores. Said shaped bodies comprise at least one metal-organic framework material and may optionally contain further substances, in particular at least one supporting material.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: May 17, 2005
    Assignees: BASF Aktiengesellschaft, The Regents of the University of Michigan
    Inventors: Ulrich Mueller, Lisa Lobree, Michael Hesse, Omar Yaghi, Mohamed Eddaoudi
  • Patent number: 6664406
    Abstract: The present invention relates to a nervonic acid derivatives of formula (I) CH3—(CH2)7—CH═CH—(CH2)13—C(O)—O—(CH2)3—OR  (I) wherein R is hydrogen (H) or a residue of a carboxylic acid; or a salt of the compound where R is H; or a bioprecursor, prodrug thereof. Those compounds wherein R is other than H have pharmacological activity, in particular anti-inflammatory and immunomodulatory effects. Those compounds wherein R is H can be used to prepare the pharmacologically active derivatives.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: December 16, 2003
    Assignee: Croda International PLC
    Inventors: Keith Coupland, Yann Raoul
  • Publication number: 20030130347
    Abstract: The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general formula (1): 1
    Type: Application
    Filed: October 29, 2002
    Publication date: July 10, 2003
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: JaeChon Jo, HeeAn Kwon, HyunSuk Lim, JaeYoung Choi, Kazumi Morikawa, Yoshitake Kanbe, Masahiro Nishimoto, MyungHwa Kim, Yoshikazu Nishimura
  • Patent number: 6476243
    Abstract: Perfluorinated esters of alkanoyl-L-carnitine of the formula (I): are useful as cationic lipids for the intracellular delivery of pharmacologically active compounds.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: November 5, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mosè Santaniello, Lucia Critelli, Nazareno Scafetta, Maria Grazia Cima, Maria Ornella Tinti, Claudio Pisano, Andrea Pucci
  • Patent number: 6362352
    Abstract: Sulfur heteroatom substitution at the C4 position of 18F-labeled fatty acids yields a tracer that is retained in proportion to the beta-oxidation rates in mammalian tissue, particularly hypoxic myocardium. Most preferably, the invention is embodied in an [18F]fluoro-4-thia-fatty acid having a chain length of between 8 to 20 carbon atoms. The 18F-labeled 4-thia fatty acids of this invention find particular utility the radiolabelling of tissue sites (e.g., myocardium) for purposes of positron emission tomography.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: March 26, 2002
    Assignee: Duke University
    Inventors: Timothy R. DeGrado, Shuyan Wang
  • Patent number: 6310007
    Abstract: The compound 7,10,12-trihydroxy-8(E)-octadecenoic acid (TOD) has been produced by bioconversion of ricinoleic acid by Pseudomonas aeruginosa PR3. TOD and derivatives thereof are useful for controlling biological organisms, such as fungi and insects.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: October 30, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Tsung Min Kuo, Ching T. Hou
  • Patent number: 6201021
    Abstract: Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl subsituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: March 13, 2001
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shuichi Ohuchida, Kazuo Kishimoto, Narito Tateishi, Hiroyuki Ohno
  • Patent number: 6175024
    Abstract: A method of preparing an ester of a carboxylic acid functionalized with a moiety selected from the group consisting of halides, sulfonates, ethers, hydroxyl, amines, and aldehydes, said method comprising: (a) providing either a carboxylic acid having a vinyl group or an ester thereof; (b) functionalizing the vinyl carbon closest to the carboxyl group with said moiety, wherein said functionalizing comprises cleaving said vinyl group.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: January 16, 2001
    Assignee: AlliedSignal Inc.
    Inventors: William J. Boyle, Jr., Indira Reddy, Zhenrong Qian, Heng Eric Su, David Ryckman
  • Patent number: 6133472
    Abstract: Fluorine containing oxyvinyl compounds characterized by having one or more oxyvinyl groups separated from fluorine containing groups by at least one alkylene group having 2-8 carbon atoms and by at least one oxygen atom in addition to the oxygen on the oxyvinyl. In general the compounds of the invention have the generic formula:Rz(L).sub.a (Ry).sub.b OROCH.dbd.CH.sub.2.Where L is .dbd.CHCOOROCH.dbd.CH.sub.2 ; a is number of 0 to about 1; R.sub.y is --CO--; b is a number of 0 to about 1; R is cycloalkane or (CH.sub.2).sub.x --, where x is a number of about 2 through about 10; R.sub.z is R.sub.f C.sub.n H.sub.m where R.sub.f is a fluorinated alkylene moiety of about 1 to about 12 carbon atoms which may be linear or branch chained and may contain a further --OROCH.dbd.CH.sub.2 group; n is an integer of about 1 through about 6; and m is an integer of n to 2n.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: October 17, 2000
    Assignee: AlliedSignal Inc.
    Inventors: David Nalewajek, David Bradley, John Schabel, Robert Blomquist
  • Patent number: 6124357
    Abstract: Iodinated fatty acid esters, iodinated fatty acids and fluid pharmaceutical-grade stable derivatives thereof are produced by iodohydrination in an organic medium using alkylsilylated derivatives, such as trimethylsilyl chloride or trimethylchlorosilane, that react with an alkaline iodide such as sodium iodide, whereafter hydroiodic acid is formed in situ by exposure to water and the hydroiodic acid is reacted with fatty acid esters and particularly rapeseed oil fatty acid methyl esters that may be used as a biofuel for gasoline engines to provide a low-cost product, and are used therapeutically, in particular for treating goitre linked to iodine deficiency.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: September 26, 2000
    Inventors: Louis Jung, Yves Ingenbleek
  • Patent number: 5917067
    Abstract: A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized .alpha.-olefins or acrylic esters. The process comprises an addition step, an oxidation step, an isomerization step, and one or more hydrogenation steps. The process allows to use raw materials that are available at low cost and to achieve high selectivity and high yield with industrially simple steps. The process includes the production of new intermediate products, including 2-oxepanone-7-substituted products.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: June 29, 1999
    Assignee: Industrie Chimiche Caffaro S.P.A.
    Inventors: Livius Cotarca, Paolo Maggioni, Alfonso Nardelli, Stefano Sguassero
  • Patent number: 5852196
    Abstract: A novel compound, 12,13,17-trihydroxy-9(Z)-octadecenoic acid (THOA) was produced from linoleic acid by microbial transformation at 25% yield. The newly isolated microbial strain catalyzing this transformation was identified as Clavibacter sp. ALA2 (Accession No. NRRL B-21660). THOA and its derivatives have application as antifungal agents.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: December 22, 1998
    Assignee: The United States of America as represented by the Secretary of the Agriculture
    Inventor: Ching T. Hou
  • Patent number: 5817845
    Abstract: Methods for stereospecific synthesis of 9-cis olefins and retinoids. In one particular aspect, a cis olefin is generated via a lactol ring opening with complete retention of double bond configuration.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: October 6, 1998
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Steven K. White, Chan Kou Hwang, David T. Winn
  • Patent number: 5767299
    Abstract: The invention relates to compounds of formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from: (i) saturated or unsaturated fatty acyl groups, preferably having from 14 to 24 carbon atoms, more preferably of a type found in nature; or(ii) groups of formula (II): ##STR2## wherein R.sup.4 and R.sup.5 are independently selected from hydrogen atoms, C.sub.1-4 alkyl groups and aryl groups, preferably C.sub.6-10 aryl groups; n represents the integers 0 or 1; A represents either a chemical bond or a straight or branched C.sub.1-6 alkylene chain and R.sup.6 is a triiodinated phenyl group which may also carry other substituents. The invention also relates to X-ray contrast media containing these compounds, as well as methods of enhancing X-ray images of a human subject wherein the contrast media are administered to the subject prior to imaging.
    Type: Grant
    Filed: September 18, 1995
    Date of Patent: June 16, 1998
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Per Strande
  • Patent number: 5654452
    Abstract: Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific delivery to the liver. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm and having a composition simulating naturally-occuring chylomicron remnants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 5, 1997
    Assignee: Molecular Biosystems, Inc.
    Inventors: Rolf Lohrmann, Dung K. Hong
  • Patent number: 5498786
    Abstract: This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: March 12, 1996
    Assignee: Pfizer Inc.
    Inventors: Sarah E. Kelly, George Chang
  • Patent number: 5481013
    Abstract: Compounds of the formula ##STR1## in which A is oxygen, sulfur or --NR.sub.1 --;B is C.sub.2 -C.sub.6 alkylene,D-E is --O--E, --S--E, --O--CH.sub.2 --E, --O--C(.dbd.O)--E, --O--C(.dbd.O)--O--E, --O--C(.dbd.O)--N(H)--E or --O--C(.dbd.S)--N(H)--E;E is phenyl; phenyl which is substituted by one to three substituents; a five-membered aromatic heterocycle having one to three hetero atoms; a five-membered aromatic heterocycle which has one to three hetero atoms and which is substituted by one or two substituents; a six-membered aromatic heterocycle which has one to three nitrogen atoms; or a six-membered aromatic heterocycle which has one to three nitrogen atoms and which is substituted by one or two substituents;L is halogen or methyl;X is fluorine;Y is chlorine or fluorine;Z is hydrogen, fluorine or methyl;m is the number zero, one, two, three, four or five;n is the number zero, one or two andR.sub.1 is hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: January 2, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Maienfisch, Thomas Pitterna, Manfred Boger
  • Patent number: 5424468
    Abstract: This specification provides a polymeric material useful for manufacturing contact lenses having improved oxygen permeability. The contact lenses prepared from the polymeric material of the invention show improved hydrophilicity and enhanced oxygen permeability as compared with that made of the conventional fluoroalkyl-containing polymeric materials.
    Type: Grant
    Filed: February 1, 1994
    Date of Patent: June 13, 1995
    Assignee: Korea Institute of Science and Technology
    Inventors: Kwang U. Kim, Tae S. Park, Seung S. Hwang, Jong C. Lee, Moo S. Lee, Seong M. Cheong