Abstract: Disclosed is a compound of formula (I): (R1R2N)SinH2n+1 (I), wherein subscript n is an integer from 3 to 9; and each R1 and R2 independently is (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or phenyl; or R1 is H and R2 is (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or phenyl; or R1 and R2 are bonded together to be -R1a R2a wherein -R1a-R2a- is (C2-C6)alkylene. Also disclosed are a method of making, intermediates useful therein, method of using, and composition comprising the compound of formula (I).

Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.

Abstract: A problem of the present invention is to prevent a base layer beneath the layer to be irradiated with light from deterioration in property and a functional thin film from deterioration in property as the fine patterning of a functional film is performed with light irradiation. Means for solving the problem is a compound obtained by dimerizing with light irradiation a compound (A) containing a group that has photosensitivity and can be photodimerized and a group having lyophilicity and a compound (B) containing a group that has photosensitivity and can be photodimerized and a group having liquid-repellency.

Abstract: Disclosed herein is a single step catalytic process for the production of enantiomerically pure ?-Aryloxy-??-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A).

Abstract: A linear silicone polymer suitable for use in producing homopolymers, copolymers, polymerized emulsions, latex compositions, and hydrogel polymer films. In one aspect, a hydrophilic silicone monomer is of the Formula 1: W?A?m?B?nW??(1) Where, A is a divalent block comprising a silicone-containing pendant group. In one embodiment, the silicone-containing pendant group comprises polyalkylene oxide groups. The structure of the polymer can be controlled and tuned to provide a material with excellent wettability and oxygen permeability. The polymers are suitable for use in a variety of applications including in providing a film for forming contact lenses.

Abstract: Disclosed herein is a single step catalytic process for the production of enantiomerically pure ?-Aryloxy-??-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A).

Abstract: Processes for preparing and purifying lubiprostone are disclosed. Intermediates and preparation thereof are also disclosed.

Abstract: The invention relates to a compound for manufacturing watermark in a textile sheet material and the corresponding composition, material, method and use. The compound for manufacturing a watermark in a textile sheet material of formula wherein X is hexamethylene, trimethylhexamethylene, isophorone, dicyclohexylmethyl, tetramethylxylylene, tetramethylenexylene, xylylene, trimethylhexamethylene, hydrogenated 4,4?-diphenylmethylene, 1,12-dodecylene, 1,5-2-methylpentylene; 1,4-butylene; 1,4-cyclohexylene, or a compound of formula R1 is a linear aliphatic C1-C12 alkyl radical or a branched aliphatic C3-C18 alkyl radical R2 is a radical of formula wherein R4 is methoxy or ethoxy R5 and R6 are H, methoxy, ethoxy, methyl or ethyl R7 is cyclohexyl, phenyl or aliphatic C3-C6 alkyl R3 is a linear aliphatic C1-C12 alkyl radical or a branched aliphatic C3-C18 alkyl radical n is 0 or 1.

Abstract: It comprises a preparation process of entecavir comprising: submitting a (1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol (VIII) to a double esterification and to a radicalary cyclization, yielding a compound of formula (V), where either a compound of formula (VIII) is submitted to a first esterification reaction, then to a catalytic radicalary cyclization using titanocene dichloride as catalyst in the presence of Mn/2,4,6-collidine HCl or Zn/2,4,6-collidine/trimethylsilyl chloride, and finally to a second esterification reaction or, alternatively, the compound of formula (VIII) is submitted first to a catalytic radicalary cyclization, and then to an esterification reaction. Entecavir can be obtained by submitting compound (V) to a desilylation reaction to remove the TBS group and then to a Mitsunobu coupling with 2-amino-6-chloroguanine, followed by hydrolysis. It also relates to some new intermediates of the process.

Abstract: Processes for preparing and purifying lubiprostone are disclosed. Intermediates and preparation thereof are also disclosed.

Abstract: The present invention relates to a preparation method for a medicine and an intermediate compound thereof, specifically, relates to a preparation method for entecavir, an intermediate compound thereof, and a synthesis method for the intermediate compound.

Abstract: The present invention relates to method for improving the color index of an organopolysiloxanes functionalized with a benzalmalonate said method comprising the step of contacting said organopolysiloxanes functionalized with a benzalmalonate with a hydroxy carboxylic acid or a cyclic ester thereof in an organic solvent.

Abstract: The present invention relates to method for improving the color index of organopolysiloxanes functionalized with at least one UV-light absorbing group said method comprising the step of contacting said group carrying organopolysiloxanes with a hydroxy carboxylic acid or a cyclic ester thereof in an organic solvent.

Abstract: The present invention provides a fluorine-based compound and a coating composition and a film including the same. By using the fluorine-based compound according to the present invention, a film having excellent functionalities of water repellency, oil repellency, weatherability and contamination resistance can be provided.

Abstract: A problem of the present invention is to prevent a base layer beneath the layer to be irradiated with light from deterioration in property and a functional thin film from deterioration in property as the fine patterning of a functional film is performed with light irradiation. Means for solving the problem is a compound obtained by dimerizing with light irradiation a compound (A) containing a group that has photosensitivity and can be photodimerized and a group having lyophilicity and a compound (B) containing a group that has photosensitivity and can be photodimerized and a group having liquid-repellency.

Abstract: The invention relates to a compound for manufacturing watermark in a textile sheet material and the corresponding composition, material, method and use. The compound for manufacturing a watermark in a textile sheet material of formula wherein X is hexamethylene, trimethylhexamethylene, isophorone, dicyclohexylmethyl, tetramethylxylylene, tetramethylenexylene, xylylene, trimethylhexamethylene, hydrogenated 4,4?-diphenylmethylene, 1,12-dodecylene, 1,5-2-methylpentylene; 1,4-butylene; 1,4-cyclohexylene, or a compound of formula 5 R1 is a linear aliphatic C1-C12 alkyl radical or a branched aliphatic C3-C18 alkyl radical R2 is a radical of formula wherein R4 is methoxy or ethoxy R5 and R6 are H, methoxy, ethoxy, methyl or ethyl R7 is cyclohexyl, phenyl or aliphatic C3-C6 alkyl R3 is a linear aliphatic C1-C12 alkyl radical or a branched aliphatic C3-C18 alkyl radical n is 0 or 1.

Abstract: Disclosed are a radiation-polymerizable functional group-containing organosilicon compound, including (A) a norbornane skeleton structure, (B) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (C) a radiation-polymerizable functional group bonded to the norbornane skeleton structure, either directly or via a carbon atom, a hetero atom, or a combination thereof, and a method of producing the radiation-polymerizable functional group-containing organosilicon compound. Also disclosed are a haloalkyl group-containing organosilicon compound, including (D) a norbornane skeleton structure, (E) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (F) a haloalkyl group, which is bonded directly to the norbornane skeleton structure and either contains or does not contain a hetero atom, and a method of producing the haloalkyl group-containing organosilicon compound.

Abstract: There is provided new mono-(meth)acrylate functionalized silicone monomers containing carbosiloxane linkage for improved hydrolysis resistance, useful in making water absorbing silicone-hydrogel films for contact lens applications. This invention also provides homo-polymers and copolymers made from the mono-(meth)acrylate functionalized hydrophilic silicone monomers described herein. Also provided is a process for producing the monomers and polymers described herein and contact lenses produced from the same.

Abstract: The present invention relates to organosilicon polymers containing benzoic acid esters in form of particles, process for their preparation, cosmetic or dermatological composition comprising them, as well as their use for protecting a human or animal living body from UV radiation.

Abstract: A silyl (meth)acrylate compound containing a siloxy group having a bulky substituent is provided. The compound is represented by the following general formula (1): wherein R1 and R2 are independently a C3-10 monovalent branched hydrocarbon group having a hydrocarbon group at ? or ? position or a monovalent C3-10 cyclic hydrocarbon group; R3, R4, and R5 are independently an unsubstituted or substituted C1-20 hydrocarbon group or a siloxy group represented by the following general formula (2): —OSiR7R8R9??(2) wherein R7, R8, and R9 are independently an unsubstituted or substituted C1-20 hydrocarbon group; and R6 is hydrogen atom or methyl group. This compound is hydrolyzed at a reduced speed, and use of a polymer obtained by copolymerization with an alkyl methacrylate is capable of suppressing attachment of marine organisms to the ship with no or reduced biocide, and this polymer is useful for a hydrolytic self-polishing paint.

Abstract: The present invention relates to method for improving the color index of an organopolysiloxanes functionalized with a benzalmalonate said method comprising the step of contacting said organopolysiloxanes functionalized with a benzalmalonate with a hydroxy carboxylic acid or a cyclic ester thereof in an organic solvent.

Abstract: The invention concerns a new process for the preparation of prostaglandin derivatives, in particular prostaglandin F2? derivatives, for example bimatoprost, latanoprost and travoprost, the new intermediates of said process and their use in the preparation of prostagblandin derivatives.

Abstract: Disclosed are a radiation-polymerizable functional group-containing organosilicon compound, including (A) a norbornane skeleton structure, (B) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (C) a radiation-polymerizable functional group bonded to the norbornane skeleton structure, either directly or via a carbon atom, a hetero atom, or a combination thereof, and a method of producing the radiation-polymerizable functional group-containing organosilicon compound. Also disclosed are a haloalkyl group-containing organosilicon compound, including (D) a norbornane skeleton structure, (E) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (F) a haloalkyl group, which is bonded directly to the norbornane skeleton structure and either contains or does not contain a hetero atom, and a method of producing the haloalkyl group-containing organosilicon compound.

Abstract: Disclosed are a radiation-polymerizable functional group-containing organosilicon compound, including (A) a norbornane skeleton structure, (B) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (C) a radiation-polymerizable functional group bonded to the norbornane skeleton structure, either directly or via a carbon atom, a hetero atom, or a combination thereof, and a method of producing the radiation-polymerizable functional group-containing organosilicon compound. Also disclosed are a haloalkyl group-containing organosilicon compound, including (D) a norbornane skeleton structure, (E) a hydrolyzable silyl group bonded directly to the norbornane skeleton structure, and (F) a haloalkyl group, which is bonded directly to the norbornane skeleton structure and either contains or does not contain a hetero atom, and a method of producing the haloalkyl group-containing organosilicon compound.

Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y, Z and CKE are as defined in the description, to processes for their preparation and to their use as pesticides and herbicides.

Abstract: The present invention provides a fluorine-based compound and a coating composition and a film including the same. By using the fluorine-based compound according to the present invention, a film having excellent functionalities of water repellency, oil repellency, weatherability and contamination resistance can be provided.

Abstract: This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.

Abstract: A liquid crystal molecule is disclosed, having a structure represented by the following general formula (1): wherein X1 is a group selected among groups represented by the following formula (2): X2 is a group selected among groups represented by the following formula (3): X3 is represented by the following formula (4): R1 represents a linear or branched hydrocarbon group having from 4 to 16 carbon atoms; R2 represents an optionally branched organosiloxane or organosilane having from 1 to 6 silicon atoms; R3 and R4 are different from each other and each represents H, F, Cl, Br, CN, CH3, CF3 or OCH3; Y1 and Y2 each represents —, —COO—, —CH2—, —CH2O—, —C2H2—, —C2— or —CF2O—; Z1 and Z2 each represents H, F, Cl, Br, OH, NO2, CN or CF3; Z3 and Z4 each represents H, F, Cl, Br, OH, NO2, CN or CF3; Z5 and Z6 each represents H, F, Cl, Br, OH, NO2, CN or CF3, provided that Z5 and Z6 do not represent H at the same time; n represents an integer of from 1 to 6; * represents a chiral ce

Abstract: The present invention relates to a series of novel silicone polyesters which are prepared by crosslinking an alkyl dimethicone copolyol with a dimer acid. The reaction of the alkyl dimethicone copolyol and dimer acid results in a polyester having affinity to oils and that is highly lubricious on hair, skin and textile fiber.

Abstract: Compounds of formula (II), (IIIa) or (IIIb) (variables are described in the specification) are prepared by fluorination of ?,?-unsaturated alkyl silanes. These compounds are useful as building blocks in the pharmaceutical industry.

Abstract: Intermediates useful in the preparation of the antiviral agent entecavir are disclosed. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various processes useful in the preparation of entecavir are also disclosed.

Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.

Abstract: Fluorine-containing silicon compounds having the general formula (1): wherein X1, X2, and X3 each are hydrogen, hydroxyl, halogen, a straight, branched or cyclic alkoxy group of 1 to 6 carbon atoms, or a monovalent organic group of 1 to 20 carbon atoms having a straight, branched, cyclic or polycyclic skeleton, Y is a divalent organic group, R1 and R2 are each independently hydrogen or a monovalent organic group of 1 to 20 carbon atoms having a straight, branched, cyclic or polycyclic skeleton, or R1 and R2 may bond together to form a ring with the carbon atom to which they are attached silicone resins obtained from the compounds of formula (1) has an appropriate acidity to enable formation of a finer pattern while minimizing the pattern collapse by swelling when used in a resist composition.

Abstract: The present invention is directed to a class of polyesters that are lightly crosslinked polyesters made by reacting polysorbate units (linked by the reaction of their hydroxyl groups) to the carboxyl group of dimer acid. As will become clear, lightly crosslinked as used herein relates to reactions in which there is an excess of hydroxyl groups on a molar basis to carboxylic groups on the dimer acid. The polymers and a contribute softness, lubricity and antistatic properties when applied to hair, skin, textile fiber and paper.

Abstract: The present invention relates to a series of novel silicone polyesters which are prepared by crosslinking a dimethicone copolyol having at least 4 hydroxyl groups with a dimer acid. The ratio of acid groups to hydroxyl groups ranges from 0.7 to 1.4 so that a significant number of groups are reacted and a significant number of crosslink groups are achieved.

Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

Abstract: To provide a primer composition having an excellent balance between storage stability and adhesiveness, while permitting a longer open time. The primer composition includes: a compound (a) represented by the following formula (1): and an organic solvent (b).

Abstract: Siloxane bischloroformates are prepared in a continuous process by phosgenating siloxane bisphenols in a flow reactor using a substantial excess of phosgene and sodium hydroxide. While very high levels (>95%) of conversion of the siloxane bisphenol to the corresponding siloxane bischloroformate are achieved using a flow reactor according to the method of the invention, only more modest conversion (˜90%) of the siloxane bisphenol to the corresponding siloxane bischloroformate is attained when analogous batch processes are employed. The process holds promise for use in the manufacture of silicone-containing copolycarbonates which requires high purity siloxane bischloroformate intermediates.

Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Abstract: Siloxane bischloroformates are prepared in a continuous process by phosgenating siloxane bisphenols in a flow reactor using a substantial excess of phosgene and sodium hydroxide. While very high levels (>95%) of conversion of the siloxane bisphenol to the corresponding siloxane bischloroformate are achieved using a flow reactor according to the method of the invention, only more modest conversion (˜90%) of the siloxane bisphenol to the corresponding siloxane bischloroformate is attained when analogous batch processes are employed. The process holds promise for use in the manufacture of silicone-containing copolycarbonates which requires high purity siloxane bischloroformate intermediates.

Abstract: The invention relates to a method for carrying out CC-coupling reactions, in particular a Heck and Suzuki reaction, in the presence of supported palladium as the catalyst and a base in a monophase or multiphase solvent mixture. According to said method, palladium detaches itself from the support in a characteristic manner, is redeposited after the reaction and the quantity of palladium not deposited after the reaction is significantly lower than 5000 ppm, in relation to the palladium used.

Abstract: The present invention is directed to a process comprising deblocking a silane of the formula (RIC(═O)O)yC6RII6−y−z[CxH2xSi(ORIII)3−a(RIV)a]z where RI is H, CH3 or RVO; RII is H or RVO; RIII is alkyl, phenyl or acyl from 1 to 6 carbon atoms; RIV is hydrogen, alkyl or phenyl from 1 to 6 carbon atoms; RV is a linear or branched alkyl group from 1 to 4 carbon atoms; y is an integer from 1 to 3; z is an integer from 1 to 3; x is an integer from 2 to 6 and a is an integer from 0 to 2 to yield a phenolic silane. Also disclosed are processes for making a blocked silane having the above formula.

Abstract: Topically applicable, stable, UV-photoprotective cosmetic/dermatological compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of TV-A and UV-B irradiation, comprise (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane UV-sunscreen compound and (b) an effective dibenzoylmethane compound (a) photostabilizing amount of at least one benzalmalonate silane having the structural formula (I): 1

Abstract: This invention relates to trimethylsilyloxy-cyclopentane derivatives: 3-(1-Acetoxy-1-methylethyl)- 2-formyl-1-methyl-1-trimethylsilyloxy-cyclopentane; 4-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-buten-2-one; 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-1,4-dien-3-ol and alkyl 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-2,4-dienoates.

Abstract: Acetylenic maleates, fumarates and related derivative compounds are new compositions of matter having the formula:R.sub.1 O.sub.2 C--CH.dbd.CH--CO.sub.2 R.sub.2wherein R.sub.1 may be an organic moiety containing at least two carbon atoms triply bonded one to the other as:--C.tbd.C--and R.sub.2 may be hydrogen, an organic moiety, or R.sub.1 ; suitable for use as liquid injection molding inhibitors either singly or in combination with themselves or other liquid injection molding inhibitors when used for the process of liquid injection molding curable compositions enabling an increase in the size of articles manufactured therefrom, which new compositions of matter cure into the polymerizable or curable resins thereby creating new compositions of matter as cured resins from which said articles of manufacture are produced.

Abstract: Compounds of the formula ##STR1## the symbols have the meaning described in the specification.

Abstract: A subject of the invention is the products of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, identical or different, represent a linear, branched or cyclic alkyl radical, an alkenyl or alkynyl radical, containing up to 8 carbon atoms, optionally substituted by one or more halogen atoms, an aryl radical optionally substituted by one or more halogen atoms, one or more hydroxyl radicals, one or more linear or branched alkyl radicals, optionally substituted by one or more halogen atoms, one or more O-alkyl or S-alkyl radicals optionally substituted by one or more halogen atoms,X represents a hydrogen atom, a halogen atom, an alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl or S-alkynyl radical, optionally substituted by one or more halogen atoms and containing up to 11 carbon atoms, an aryl radical containing up to 14 carbon atoms, a C.tbd.N, NO.sub.2, NH.sub.2, ##STR2## CO.sub.2 alk.sub.3 radical, alk.sub.1, alk.sub.2 and alk.sub.

Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.

Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.

Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.